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The map label for this gene is gcvT [H]

Identifier: 13474013

GI number: 13474013

Start: 3810590

End: 3811717

Strand: Direct

Name: gcvT [H]

Synonym: mlr4790

Alternate gene names: 13474013

Gene position: 3810590-3811717 (Clockwise)

Preceding gene: 13474012

Following gene: 13474017

Centisome position: 54.16

GC content: 64.63

Gene sequence:

>1128_bases
ATGGAGACCTTCTTGGCTGAGCGGCGTTCCCCCTTCTACAGCAGCATCGTCGGGCTCGGTGCGACCATGGGTCGGGTCGG
CGGCGATTTCATCTCGGCCAAATACTATTCCGGCGTCACCGACGAGCACCTGAACACGCGCGCCAATGTCGGCGTGCAGG
ATCTCAGCACCATGGGCAAGATGGACATCAAGGGGCCGGACGCCGAGGCGCTGGTCAACCATGTCATCGTCAACGATGCC
GTGGCGATGAAGCCGGGCCAGGTCCGCTATTCCACAGTCTGCCGCGAGGATGGCGGCATCATGGACGACCTTACCGTGTT
CCGGCTGGGGCCGGAGCATTTCATGCTGGTCACCGGCTCGGTCAACCGCCTGAAGATGCTGCCCTGGCTGCAGCACCATG
CCCAGGGCCGCAAGGCCTACGTCACCGACATTACCGCCGCCGTCGCCTTCCCGACCATCCAGGGCCCGCGTTCGCGCGAA
CTGTTGAAGGCGATGATCTCAGATGCCGATCTGGACGGTCTCAAGCGCTGGGCGTTCACCTCAGGCCATGTCAACGGCAC
GCGCGTCCTGATCTCCCGCACCGGCGTGACCGGCGAACTCGGCTTCGAACTCTTCGTGCCGGCCGACGAGGCGGCCTCGG
TCTGGGATACGCTGATGCGGGCCGGCAAGGACTTCGGCCTGAAACCCTATGGCGTGCTGGCGATGTTCACGCTCGGCCTG
GAAAAGGCCTATCCGGCGCATGGCATCGACATGGACGAGACCCGCACGCCGTTCCATGTCGGCCTCGACCGCTGGATCAA
GTTCGACAAGGGCGATTTCATCGGCCGCGAAGCGCTGCTCAAGATCCGTGACAAGGGCCTCGACGAGCGCTGGACCGGGC
TGATCCTCGACGGCAACAAACCGGCGGCGACGGACGCCAGGGTTTTGGCCGATGGCGAGGATGCCGGCATCGTCACCTAC
AGTGACCACGGCTATTCCCTCGGCAAGGTGCTGGCCACTGCGCATCTGCGGCTGCCCTTCACGGCCATCGGCACCGAACT
CAGCATCGACATCGACGGCAGGCCGACCCGCGCGGTCGTGGCGCCGATGCCGTTCTTCGATCCGGAAGGGGTTAGGTTGA
GAGGCTAG

Upstream 100 bases:

>100_bases
GCTCACGGACCTGAATGTCCGCTGCGCTCCGGTTCTCGAAACCACCTTCATATGACTCGCCAGAGCGAATTTCGAAACGG
TCTCCGGACTGCAATGAATG

Downstream 100 bases:

>100_bases
CCCGGCTCGCGCCGACGGACGCATGCTTCGGTAGTTGGCCGGAACGCCCATCGCTTCGTCATCCTCGGGTCTCCGCGACG
CCGCTTCGCGGCTGCTCCGC

Product: aminomethyltransferase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
METFLAERRSPFYSSIVGLGATMGRVGGDFISAKYYSGVTDEHLNTRANVGVQDLSTMGKMDIKGPDAEALVNHVIVNDA
VAMKPGQVRYSTVCREDGGIMDDLTVFRLGPEHFMLVTGSVNRLKMLPWLQHHAQGRKAYVTDITAAVAFPTIQGPRSRE
LLKAMISDADLDGLKRWAFTSGHVNGTRVLISRTGVTGELGFELFVPADEAASVWDTLMRAGKDFGLKPYGVLAMFTLGL
EKAYPAHGIDMDETRTPFHVGLDRWIKFDKGDFIGREALLKIRDKGLDERWTGLILDGNKPAATDARVLADGEDAGIVTY
SDHGYSLGKVLATAHLRLPFTAIGTELSIDIDGRPTRAVVAPMPFFDPEGVRLRG

Sequences:

>Translated_375_residues
METFLAERRSPFYSSIVGLGATMGRVGGDFISAKYYSGVTDEHLNTRANVGVQDLSTMGKMDIKGPDAEALVNHVIVNDA
VAMKPGQVRYSTVCREDGGIMDDLTVFRLGPEHFMLVTGSVNRLKMLPWLQHHAQGRKAYVTDITAAVAFPTIQGPRSRE
LLKAMISDADLDGLKRWAFTSGHVNGTRVLISRTGVTGELGFELFVPADEAASVWDTLMRAGKDFGLKPYGVLAMFTLGL
EKAYPAHGIDMDETRTPFHVGLDRWIKFDKGDFIGREALLKIRDKGLDERWTGLILDGNKPAATDARVLADGEDAGIVTY
SDHGYSLGKVLATAHLRLPFTAIGTELSIDIDGRPTRAVVAPMPFFDPEGVRLRG
>Mature_375_residues
METFLAERRSPFYSSIVGLGATMGRVGGDFISAKYYSGVTDEHLNTRANVGVQDLSTMGKMDIKGPDAEALVNHVIVNDA
VAMKPGQVRYSTVCREDGGIMDDLTVFRLGPEHFMLVTGSVNRLKMLPWLQHHAQGRKAYVTDITAAVAFPTIQGPRSRE
LLKAMISDADLDGLKRWAFTSGHVNGTRVLISRTGVTGELGFELFVPADEAASVWDTLMRAGKDFGLKPYGVLAMFTLGL
EKAYPAHGIDMDETRTPFHVGLDRWIKFDKGDFIGREALLKIRDKGLDERWTGLILDGNKPAATDARVLADGEDAGIVTY
SDHGYSLGKVLATAHLRLPFTAIGTELSIDIDGRPTRAVVAPMPFFDPEGVRLRG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=352, Percent_Identity=31.25, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI44662838, Length=371, Percent_Identity=28.0323450134771, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI194306651, Length=313, Percent_Identity=27.4760383386581, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI257796258, Length=362, Percent_Identity=27.3480662983425, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI197927446, Length=331, Percent_Identity=27.7945619335347, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI21361378, Length=331, Percent_Identity=27.7945619335347, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI257796256, Length=323, Percent_Identity=26.9349845201238, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1789272, Length=362, Percent_Identity=31.2154696132597, Blast_Score=132, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI32563613, Length=340, Percent_Identity=28.8235294117647, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71994045, Length=289, Percent_Identity=27.681660899654, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71994052, Length=289, Percent_Identity=27.681660899654, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17560118, Length=340, Percent_Identity=27.3529411764706, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320222, Length=380, Percent_Identity=24.2105263157895, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI20130091, Length=374, Percent_Identity=28.0748663101604, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28571104, Length=279, Percent_Identity=31.1827956989247, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI20129441, Length=373, Percent_Identity=26.8096514745308, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40956; Mature: 40956

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METFLAERRSPFYSSIVGLGATMGRVGGDFISAKYYSGVTDEHLNTRANVGVQDLSTMGK
CCCHHHHHCCCHHHHHHHHHHHHHHCCCCCEEHHHHCCCCHHHCCCCCCCCHHHHHHHCC
MDIKGPDAEALVNHVIVNDAVAMKPGQVRYSTVCREDGGIMDDLTVFRLGPEHFMLVTGS
CCCCCCCHHHHHHHHHHCCCEECCCCCEEEEEEECCCCCCCCCEEEEEECCCEEEEEECC
VNRLKMLPWLQHHAQGRKAYVTDITAAVAFPTIQGPRSRELLKAMISDADLDGLKRWAFT
CCCEEHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHEEE
SGHVNGTRVLISRTGVTGELGFELFVPADEAASVWDTLMRAGKDFGLKPYGVLAMFTLGL
CCCCCCEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
EKAYPAHGIDMDETRTPFHVGLDRWIKFDKGDFIGREALLKIRDKGLDERWTGLILDGNK
HHCCCCCCCCCCCCCCCCEECHHHHEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEECCC
PAATDARVLADGEDAGIVTYSDHGYSLGKVLATAHLRLPFTAIGTELSIDIDGRPTRAVV
CCCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHEECCCEEECCEEEEEECCCCCEEEE
APMPFFDPEGVRLRG
ECCCCCCCCCCEECC
>Mature Secondary Structure
METFLAERRSPFYSSIVGLGATMGRVGGDFISAKYYSGVTDEHLNTRANVGVQDLSTMGK
CCCHHHHHCCCHHHHHHHHHHHHHHCCCCCEEHHHHCCCCHHHCCCCCCCCHHHHHHHCC
MDIKGPDAEALVNHVIVNDAVAMKPGQVRYSTVCREDGGIMDDLTVFRLGPEHFMLVTGS
CCCCCCCHHHHHHHHHHCCCEECCCCCEEEEEEECCCCCCCCCEEEEEECCCEEEEEECC
VNRLKMLPWLQHHAQGRKAYVTDITAAVAFPTIQGPRSRELLKAMISDADLDGLKRWAFT
CCCEEHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHEEE
SGHVNGTRVLISRTGVTGELGFELFVPADEAASVWDTLMRAGKDFGLKPYGVLAMFTLGL
CCCCCCEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
EKAYPAHGIDMDETRTPFHVGLDRWIKFDKGDFIGREALLKIRDKGLDERWTGLILDGNK
HHCCCCCCCCCCCCCCCCEECHHHHEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEECCC
PAATDARVLADGEDAGIVTYSDHGYSLGKVLATAHLRLPFTAIGTELSIDIDGRPTRAVV
CCCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHEECCCEEECCEEEEEECCCCCEEEE
APMPFFDPEGVRLRG
ECCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA