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The map label for this gene is serA [H]

Identifier: 13473965

GI number: 13473965

Start: 3753235

End: 3753888

Strand: Direct

Name: serA [H]

Synonym: mlr4731

Alternate gene names: 13473965

Gene position: 3753235-3753888 (Clockwise)

Preceding gene: 13473964

Following gene: 13473968

Centisome position: 53.34

GC content: 64.53

Gene sequence:

>654_bases
ATGCTGGCGGTTGCCAAACAACTTGGCACGTGGACGCCCGAATTAATGCGGCGTGGCGGGTGGCGCGGCCTGACCCATGG
CGCGACGCTGCGCGGCGCCACCGTCGGCATCCTCGGCCTCGGTCGCATCGGCCGTGGCGTGGCGCAACGGCTCTCGGGCT
GGGAGACCCGCATCCTTGCCTACGATCCCTTCCTGAAGGAAGCGCCTCCAGGCATCGAACTCGTCGACTTCTTCACCCTG
GTGGAGCAATCCGACTTCCTGACGCTGCACGCAACGCCGAGCCCGGAAAACCATCACATCCTGAACGCCGCCGCGTTCGC
GAAGATGAAACCGTCAGCCATCGTCGTCAACACCGGGCGCGGATCGCTGATCGACTACACAGCCCTGCGCGCAGCGCTGG
TCAATGGCCAAATCGCGGGTGCGGCGCTCGACGTGTTCGACCAGGAGCCGCCGAAGACCGACGATCCGTTGTTTTCGCTA
CCCAACGTCTTGTGCACGCCGCATGTCGCGGCCTGGACCACAGAAGGAACTCAGGCTATCGGCTGGCATGCGGCCAAGAA
CCTGTGGGCCATGATGAGCGGCGAAGGACAAGCCGATATCGTCAACCCGCAAGCAAAGCAGCGCAGGAGTGCGGCCTCGG
TCAGCGACGTGTGA

Upstream 100 bases:

>100_bases
ACAGCATCGACATAGACGCCGCCACGGAGCACGGCATTCTGGTTTCGAGCACGCCGAACGATTTCAAATCTTCACGGTCA
GCGAGCACGCGGTCGCCCTG

Downstream 100 bases:

>100_bases
CTTCAGAGGTTGCGTGAATGGCCAACCCCTTCTGCCTCAATTGTTGGACCGCAAGGCCATCATGGTGAATCCTGAACTTT
GCCGAGGAATAGGTCCAGGC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MLAVAKQLGTWTPELMRRGGWRGLTHGATLRGATVGILGLGRIGRGVAQRLSGWETRILAYDPFLKEAPPGIELVDFFTL
VEQSDFLTLHATPSPENHHILNAAAFAKMKPSAIVVNTGRGSLIDYTALRAALVNGQIAGAALDVFDQEPPKTDDPLFSL
PNVLCTPHVAAWTTEGTQAIGWHAAKNLWAMMSGEGQADIVNPQAKQRRSAASVSDV

Sequences:

>Translated_217_residues
MLAVAKQLGTWTPELMRRGGWRGLTHGATLRGATVGILGLGRIGRGVAQRLSGWETRILAYDPFLKEAPPGIELVDFFTL
VEQSDFLTLHATPSPENHHILNAAAFAKMKPSAIVVNTGRGSLIDYTALRAALVNGQIAGAALDVFDQEPPKTDDPLFSL
PNVLCTPHVAAWTTEGTQAIGWHAAKNLWAMMSGEGQADIVNPQAKQRRSAASVSDV
>Mature_217_residues
MLAVAKQLGTWTPELMRRGGWRGLTHGATLRGATVGILGLGRIGRGVAQRLSGWETRILAYDPFLKEAPPGIELVDFFTL
VEQSDFLTLHATPSPENHHILNAAAFAKMKPSAIVVNTGRGSLIDYTALRAALVNGQIAGAALDVFDQEPPKTDDPLFSL
PNVLCTPHVAAWTTEGTQAIGWHAAKNLWAMMSGEGQADIVNPQAKQRRSAASVSDV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=209, Percent_Identity=37.799043062201, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI61743967, Length=217, Percent_Identity=35.4838709677419, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4557497, Length=217, Percent_Identity=35.4838709677419, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI145580578, Length=199, Percent_Identity=34.6733668341709, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI4557499, Length=199, Percent_Identity=34.6733668341709, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI145580575, Length=175, Percent_Identity=36, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI6912396, Length=190, Percent_Identity=35.2631578947368, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI87082289, Length=184, Percent_Identity=40.7608695652174, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1787645, Length=190, Percent_Identity=38.4210526315789, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1789279, Length=179, Percent_Identity=32.9608938547486, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI87081824, Length=175, Percent_Identity=33.7142857142857, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25147481, Length=193, Percent_Identity=36.2694300518135, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17532191, Length=183, Percent_Identity=32.2404371584699, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=212, Percent_Identity=33.9622641509434, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=202, Percent_Identity=34.6534653465347, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=164, Percent_Identity=37.8048780487805, Blast_Score=104, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321253, Length=184, Percent_Identity=30.9782608695652, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=182, Percent_Identity=39.010989010989, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646446, Length=200, Percent_Identity=36.5, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24646448, Length=200, Percent_Identity=36.5, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24646452, Length=200, Percent_Identity=36.5, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24646450, Length=200, Percent_Identity=36.5, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI28571528, Length=185, Percent_Identity=36.2162162162162, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI62472511, Length=200, Percent_Identity=36.5, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574286, Length=174, Percent_Identity=36.2068965517241, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24585516, Length=172, Percent_Identity=34.3023255813954, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI45552429, Length=174, Percent_Identity=34.4827586206897, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28574284, Length=174, Percent_Identity=34.4827586206897, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45551003, Length=174, Percent_Identity=34.4827586206897, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24585514, Length=174, Percent_Identity=34.4827586206897, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28574282, Length=174, Percent_Identity=34.4827586206897, Blast_Score=104, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 23243; Mature: 23243

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAVAKQLGTWTPELMRRGGWRGLTHGATLRGATVGILGLGRIGRGVAQRLSGWETRILA
CCCCHHHHCCCCHHHHHCCCCCCCCCCCEECCCEEEEEEHHHHHHHHHHHHCCCCEEEEE
YDPFLKEAPPGIELVDFFTLVEQSDFLTLHATPSPENHHILNAAAFAKMKPSAIVVNTGR
ECCHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEHHHHHHHCCCCEEEEECCC
GSLIDYTALRAALVNGQIAGAALDVFDQEPPKTDDPLFSLPNVLCTPHVAAWTTEGTQAI
CCCHHHHHHHHHHHCCCCCCCEEEHHCCCCCCCCCCHHHCCCHHHCCCCEEEECCCCCHH
GWHAAKNLWAMMSGEGQADIVNPQAKQRRSAASVSDV
HHHHHHHHHEEECCCCCCEEECCHHHHHHHCCCCCCC
>Mature Secondary Structure
MLAVAKQLGTWTPELMRRGGWRGLTHGATLRGATVGILGLGRIGRGVAQRLSGWETRILA
CCCCHHHHCCCCHHHHHCCCCCCCCCCCEECCCEEEEEEHHHHHHHHHHHHCCCCEEEEE
YDPFLKEAPPGIELVDFFTLVEQSDFLTLHATPSPENHHILNAAAFAKMKPSAIVVNTGR
ECCHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEHHHHHHHCCCCEEEEECCC
GSLIDYTALRAALVNGQIAGAALDVFDQEPPKTDDPLFSLPNVLCTPHVAAWTTEGTQAI
CCCHHHHHHHHHHHCCCCCCCEEEHHCCCCCCCCCCHHHCCCHHHCCCCEEEECCCCCHH
GWHAAKNLWAMMSGEGQADIVNPQAKQRRSAASVSDV
HHHHHHHHHEEECCCCCCEEECCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]