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The map label for this gene is hrcA

Identifier: 13473879

GI number: 13473879

Start: 3666364

End: 3667446

Strand: Reverse

Name: hrcA

Synonym: mll4621

Alternate gene names: 13473879

Gene position: 3667446-3666364 (Counterclockwise)

Preceding gene: 13473885

Following gene: 13473878

Centisome position: 52.12

GC content: 65.65

Gene sequence:

>1083_bases
ATGACCAAGGCAATCGATCCGGGTTCGCAGCCGCTGGCACTTCAATCACTCGACATGCGCTCTCGCGACATCTTCCGGCG
CATCGTCGATTCCTATCTGAGGGACGGCGAACCCGTGGGCTCGCGCAGCCTGTCGCGCATCCTGCCGTCCTCGCTGTCGC
CGGCCACCATCCGCAATGTAATGAGCGACCTCGAGCATCTCGGGCTGATTTACGCGCCGCACATCTCCGCCGGCCGGCTG
CCGACGCAAGCGGGCCTGCGCTTCTTCGTCGATGCCTTCATGGAGCTTGGCGACCTCTCCGACGAGGAGCGCCGCACCAT
CGAGGCGCAGGTGCGGGCCTCAGGCTCGGGCGCGACGCTGGAGCACATGCTGACCGAGGCCAGCCAGATGCTGTCGGGCA
TGTCGCGCGGCGCCGGCCTGGTGCTAGCCGCCAAGAACGAGGTGGCGCTGAAGCATATCGAATTCATCCAGCTGGAGCCG
ACCAAGGCGCTTGCCGTGCTGGTGTCGCAGAATGGCGACGTCGAGAACCGCGTCGTCGAGCTGCCGGCGGGCATCACCGT
CTCGCAGCTGCACGAGGCCTCGAATTTCCTCAACGCCCATATTCGCGGCCGTACACTGGCCGAGGCGCGCACCGAAATCG
CGCGCATCAAGGAAGAGACGAGAGCGGCCCTCGACACGCTGTCGCAGGACCTCGTCGAGAAGGGGCTGGCTGTGTGGGCG
GGCGCCGAAAGCGGCCTGCCGGCACGGCTCATCGTGCGCGGCCGCGCCAATCTGCTCGAAAACGTCACCGCCCAGGCCGA
TATCGAATTGCTGCGCCATCTGTTCGAGGACATGGAGACGCAGGACGGGCTGATCCAGCTGCTCGACCTCGCCGAGCAGG
GATCGGGCGTGCGCATCTTCATCGGTTCGGAAAACAAGCTTTTCTCCCTGTCGGGCTCGTCGCTGGTGGTCGCGCCCTAT
CGCGACAAGGATGCCCGCGTCGTCGGCGCGCTCGGCGTCATCGGCCCGACCCGGCTGAACTACGCCCGCATCGTGCCGAT
GGTCGATTATACCGCGCAGCTGATATCGCGCATGTTAAGGTAG

Upstream 100 bases:

>100_bases
GGCAGCGCGCAAAGGAAAACGGACCGTGCGATCCGATACAGAGACCGGTTGCGCCCACCGTGCCGAAGTCTATATCCTGA
ACCAGGAGGTTTTTGGCCGA

Downstream 100 bases:

>100_bases
GACCCCGAACGGCAAGAGACGGGCAGCGAGGAGAAAAACAATGGCGCTCGAAGAACTCAAGGCCCGGATCAGCCTGCTGC
TCGAGGAGATGGTCAACCAG

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTKAIDPGSQPLALQSLDMRSRDIFRRIVDSYLRDGEPVGSRSLSRILPSSLSPATIRNVMSDLEHLGLIYAPHISAGRL
PTQAGLRFFVDAFMELGDLSDEERRTIEAQVRASGSGATLEHMLTEASQMLSGMSRGAGLVLAAKNEVALKHIEFIQLEP
TKALAVLVSQNGDVENRVVELPAGITVSQLHEASNFLNAHIRGRTLAEARTEIARIKEETRAALDTLSQDLVEKGLAVWA
GAESGLPARLIVRGRANLLENVTAQADIELLRHLFEDMETQDGLIQLLDLAEQGSGVRIFIGSENKLFSLSGSSLVVAPY
RDKDARVVGALGVIGPTRLNYARIVPMVDYTAQLISRMLR

Sequences:

>Translated_360_residues
MTKAIDPGSQPLALQSLDMRSRDIFRRIVDSYLRDGEPVGSRSLSRILPSSLSPATIRNVMSDLEHLGLIYAPHISAGRL
PTQAGLRFFVDAFMELGDLSDEERRTIEAQVRASGSGATLEHMLTEASQMLSGMSRGAGLVLAAKNEVALKHIEFIQLEP
TKALAVLVSQNGDVENRVVELPAGITVSQLHEASNFLNAHIRGRTLAEARTEIARIKEETRAALDTLSQDLVEKGLAVWA
GAESGLPARLIVRGRANLLENVTAQADIELLRHLFEDMETQDGLIQLLDLAEQGSGVRIFIGSENKLFSLSGSSLVVAPY
RDKDARVVGALGVIGPTRLNYARIVPMVDYTAQLISRMLR
>Mature_359_residues
TKAIDPGSQPLALQSLDMRSRDIFRRIVDSYLRDGEPVGSRSLSRILPSSLSPATIRNVMSDLEHLGLIYAPHISAGRLP
TQAGLRFFVDAFMELGDLSDEERRTIEAQVRASGSGATLEHMLTEASQMLSGMSRGAGLVLAAKNEVALKHIEFIQLEPT
KALAVLVSQNGDVENRVVELPAGITVSQLHEASNFLNAHIRGRTLAEARTEIARIKEETRAALDTLSQDLVEKGLAVWAG
AESGLPARLIVRGRANLLENVTAQADIELLRHLFEDMETQDGLIQLLDLAEQGSGVRIFIGSENKLFSLSGSSLVVAPYR
DKDARVVGALGVIGPTRLNYARIVPMVDYTAQLISRMLR

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_RHILO (Q98DN7)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105447.1
- GeneID:   1228108
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll4621
- NMPDR:   fig|266835.1.peg.3551
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 39210; Mature: 39078

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKAIDPGSQPLALQSLDMRSRDIFRRIVDSYLRDGEPVGSRSLSRILPSSLSPATIRNV
CCCCCCCCCCCCEEHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHH
MSDLEHLGLIYAPHISAGRLPTQAGLRFFVDAFMELGDLSDEERRTIEAQVRASGSGATL
HHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEECCCCHHH
EHMLTEASQMLSGMSRGAGLVLAAKNEVALKHIEFIQLEPTKALAVLVSQNGDVENRVVE
HHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHEEEEEECCCCEEEEEEECCCCCCCEEEE
LPAGITVSQLHEASNFLNAHIRGRTLAEARTEIARIKEETRAALDTLSQDLVEKGLAVWA
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
GAESGLPARLIVRGRANLLENVTAQADIELLRHLFEDMETQDGLIQLLDLAEQGSGVRIF
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEE
IGSENKLFSLSGSSLVVAPYRDKDARVVGALGVIGPTRLNYARIVPMVDYTAQLISRMLR
ECCCCCEEEECCCEEEEEECCCCCCEEEEHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TKAIDPGSQPLALQSLDMRSRDIFRRIVDSYLRDGEPVGSRSLSRILPSSLSPATIRNV
CCCCCCCCCCCEEHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHH
MSDLEHLGLIYAPHISAGRLPTQAGLRFFVDAFMELGDLSDEERRTIEAQVRASGSGATL
HHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEECCCCHHH
EHMLTEASQMLSGMSRGAGLVLAAKNEVALKHIEFIQLEPTKALAVLVSQNGDVENRVVE
HHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHEEEEEECCCCEEEEEEECCCCCCCEEEE
LPAGITVSQLHEASNFLNAHIRGRTLAEARTEIARIKEETRAALDTLSQDLVEKGLAVWA
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
GAESGLPARLIVRGRANLLENVTAQADIELLRHLFEDMETQDGLIQLLDLAEQGSGVRIF
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEE
IGSENKLFSLSGSSLVVAPYRDKDARVVGALGVIGPTRLNYARIVPMVDYTAQLISRMLR
ECCCCCEEEECCCEEEEEECCCCCCEEEEHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968