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The map label for this gene is typA [H]

Identifier: 13473495

GI number: 13473495

Start: 3293001

End: 3294830

Strand: Reverse

Name: typA [H]

Synonym: mll4112

Alternate gene names: 13473495

Gene position: 3294830-3293001 (Counterclockwise)

Preceding gene: 13473498

Following gene: 13473492

Centisome position: 46.83

GC content: 63.77

Gene sequence:

>1830_bases
ATGAAACTCCGTAATATCGCGATCATCGCGCACGTCGACCATGGAAAGACCACCCTTGTCGACCAGCTTTTGAAGCAGTC
CGGCTCCTTCCGTGACAATCAGCGCGTCGCCGAGCGCGCCATGGATTCCAACGACCTGGAAAAGGAGCGCGGCATCACCA
TCCTGGCCAAGGCGACCTCGGTCGACTGGAAGGACACCCGCATCAACATCGTCGACACACCCGGCCACGCCGATTTCGGC
GGCGAGGTCGAGCGCATCCTGTCGATGGTGGATTCGGCCATCGTGCTCGTCGACGCCGCCGAGGGCCCGATGCCGCAGAC
CAAATTCGTCGTCGGCAAGGCGCTCAAGGTCGGCCTGAAGCCGATCGTCGTCATCAACAAGATCGACCGGCCGGACGCTA
GGCATGTCGAGGTGGTCAACGAGGTGTTCGACCTGTTCGCCGCGCTCGACGCCACCGACGAACAGCTCGACTTCCCGATC
CTCTACGGTTCTGGCCGCGACGGCTGGGTTTCGGAAAATCCGGAAGGCCCGAAGGACCAGCAGCTTGCGCCGCTGTTCGA
TCTCATCATCAAGCATGTGCCGGCACCGACCGTCCATCCCGGTCCGTTCCGCATGATCGGCACCATCCTGGAAGCCAATC
CCTTCCTCGGCCGCATCATCACCGGCCGTATCGAATCCGGCACGCTGAAGGCCAACCAGGCGGTCAAGGTGCTGCACCAT
GACGGCACCCAGATCGAAACCGGCCGCATCTCGAAAATCCTGGCTTTCCGCGGCCTCGAGCGCCAGCCGATCGAGGAAGC
CCAGGCGGGCGATATCGTCGCCATCGCCGGCCTGTCCAAGGGTACCGTCGCCGACACGTTCTGCGACCTGGCGGTGACCG
AGGCGCTGCATGCGCAGCCGATCGATCCGCCGACCGTGACCATGTCCTTCCTCGTCAATGACAGCCCGCTCGCCGGCACC
GAAGGCGACAAGGTGACCAGCCGCGTCATCCGCGACCGCCTGCTGCGCGAGGCCGAAGGCAATGTCGCGCTGAAGATCGA
GGAGTCGCCCGACAAGGATTCGTTCTTCGTCTCCGGCCGAGGCGAATTGCAGCTCGCCGTGCTGATCGAGACGATGCGCC
GCGAAGGCTTTGAAATCGCCGTGTCGCGTCCGCGCGTTGTCATGCAGAAGGGCGAGAACGGCGAATTGCTGGAGCCGGTC
GAGGAAGTCGTCATCGACGTCGACGAGGAACATGCCGGCGTGGTCGTGCAGAAGATGTCTGAGCGCAAGGCCGAGATGGT
CGAACTGCGTCCTTCCGGCGGCAACCGCCAGCGCATCGTCTTCCACGCACCGACGCGCGGCCTCATCGGCTACCAGTCGG
AACTTCTGACCGACACGCGCGGCACCGCCGTGATGAACCGGCTGTTCCATGCCTACGAGCCCTACAAGGGCGAACTGCCC
GGCCGCACCAACGGCGTGCTGATCTCCAACGAGCAGGGCGAATCGGTCGCCTACGCCATGTGGAACCTGGAAGATCGCGG
CCCGATGGTCATCGATCCGGGCGTCAAGGTCTACCAGGGCATGATCATCGGCATCCACTCCCGCGACAACGACCTCGAAG
TGAACGTGCTGAAGGGCAAGAAGCTGACCAACATCCGCGCCGCCGGCAAGGACGAAGCGGTCAAGCTCACCCCGCCGATC
CGCATGACGCTGGAACGCGCGCTGGCCTGGATCCAGGACGACGAACTGGTCGAGGTGACGCCGAAGACCATCCGGCTGCG
CAAACTCTATCTCGACCCGAACGAGCGCAAGCGTTTCGAGAAGTCGTCCAAGGTGGTCGGCGCGGCATAG

Upstream 100 bases:

>100_bases
GCTTCCCCTTTCGCAACTGCGAAAAACCCTGTATGAGCCGCGCAACCGAAAGAGGCAGCGCCTTTGGCCTGCTGCCTGCA
ACGCTTCCGAGACCCAGAAC

Downstream 100 bases:

>100_bases
TTTTTTCTTCCGACGGTTTCCGAGAGGGGCGGAGCACCAAGTGCTCCGCCCCTCTCTCGTTTACCCGCCGGCAGCACAGA
TGATCGCTTCGTGATCCGGC

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: Tyrosine phosphorylated protein A [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MKLRNIAIIAHVDHGKTTLVDQLLKQSGSFRDNQRVAERAMDSNDLEKERGITILAKATSVDWKDTRINIVDTPGHADFG
GEVERILSMVDSAIVLVDAAEGPMPQTKFVVGKALKVGLKPIVVINKIDRPDARHVEVVNEVFDLFAALDATDEQLDFPI
LYGSGRDGWVSENPEGPKDQQLAPLFDLIIKHVPAPTVHPGPFRMIGTILEANPFLGRIITGRIESGTLKANQAVKVLHH
DGTQIETGRISKILAFRGLERQPIEEAQAGDIVAIAGLSKGTVADTFCDLAVTEALHAQPIDPPTVTMSFLVNDSPLAGT
EGDKVTSRVIRDRLLREAEGNVALKIEESPDKDSFFVSGRGELQLAVLIETMRREGFEIAVSRPRVVMQKGENGELLEPV
EEVVIDVDEEHAGVVVQKMSERKAEMVELRPSGGNRQRIVFHAPTRGLIGYQSELLTDTRGTAVMNRLFHAYEPYKGELP
GRTNGVLISNEQGESVAYAMWNLEDRGPMVIDPGVKVYQGMIIGIHSRDNDLEVNVLKGKKLTNIRAAGKDEAVKLTPPI
RMTLERALAWIQDDELVEVTPKTIRLRKLYLDPNERKRFEKSSKVVGAA

Sequences:

>Translated_609_residues
MKLRNIAIIAHVDHGKTTLVDQLLKQSGSFRDNQRVAERAMDSNDLEKERGITILAKATSVDWKDTRINIVDTPGHADFG
GEVERILSMVDSAIVLVDAAEGPMPQTKFVVGKALKVGLKPIVVINKIDRPDARHVEVVNEVFDLFAALDATDEQLDFPI
LYGSGRDGWVSENPEGPKDQQLAPLFDLIIKHVPAPTVHPGPFRMIGTILEANPFLGRIITGRIESGTLKANQAVKVLHH
DGTQIETGRISKILAFRGLERQPIEEAQAGDIVAIAGLSKGTVADTFCDLAVTEALHAQPIDPPTVTMSFLVNDSPLAGT
EGDKVTSRVIRDRLLREAEGNVALKIEESPDKDSFFVSGRGELQLAVLIETMRREGFEIAVSRPRVVMQKGENGELLEPV
EEVVIDVDEEHAGVVVQKMSERKAEMVELRPSGGNRQRIVFHAPTRGLIGYQSELLTDTRGTAVMNRLFHAYEPYKGELP
GRTNGVLISNEQGESVAYAMWNLEDRGPMVIDPGVKVYQGMIIGIHSRDNDLEVNVLKGKKLTNIRAAGKDEAVKLTPPI
RMTLERALAWIQDDELVEVTPKTIRLRKLYLDPNERKRFEKSSKVVGAA
>Mature_609_residues
MKLRNIAIIAHVDHGKTTLVDQLLKQSGSFRDNQRVAERAMDSNDLEKERGITILAKATSVDWKDTRINIVDTPGHADFG
GEVERILSMVDSAIVLVDAAEGPMPQTKFVVGKALKVGLKPIVVINKIDRPDARHVEVVNEVFDLFAALDATDEQLDFPI
LYGSGRDGWVSENPEGPKDQQLAPLFDLIIKHVPAPTVHPGPFRMIGTILEANPFLGRIITGRIESGTLKANQAVKVLHH
DGTQIETGRISKILAFRGLERQPIEEAQAGDIVAIAGLSKGTVADTFCDLAVTEALHAQPIDPPTVTMSFLVNDSPLAGT
EGDKVTSRVIRDRLLREAEGNVALKIEESPDKDSFFVSGRGELQLAVLIETMRREGFEIAVSRPRVVMQKGENGELLEPV
EEVVIDVDEEHAGVVVQKMSERKAEMVELRPSGGNRQRIVFHAPTRGLIGYQSELLTDTRGTAVMNRLFHAYEPYKGELP
GRTNGVLISNEQGESVAYAMWNLEDRGPMVIDPGVKVYQGMIIGIHSRDNDLEVNVLKGKKLTNIRAAGKDEAVKLTPPI
RMTLERALAWIQDDELVEVTPKTIRLRKLYLDPNERKRFEKSSKVVGAA

Specific function: Probably interacts with the ribosomes in a GTP dependent manner. GTPase that mediates interactions between enteropathogenic E.coli (EPEC) and epithelial cells [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=310, Percent_Identity=30.3225806451613, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI94966754, Length=132, Percent_Identity=43.1818181818182, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI18390331, Length=134, Percent_Identity=43.2835820895522, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI25306287, Length=134, Percent_Identity=42.5373134328358, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI19923640, Length=134, Percent_Identity=42.5373134328358, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI25306283, Length=143, Percent_Identity=40.5594405594406, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4503483, Length=204, Percent_Identity=31.8627450980392, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI34147630, Length=277, Percent_Identity=29.6028880866426, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=39.6396396396396, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=39.6396396396396, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=39.6396396396396, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI217272892, Length=181, Percent_Identity=33.1491712707182, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI217272894, Length=181, Percent_Identity=33.1491712707182, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI94966752, Length=81, Percent_Identity=41.9753086419753, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI48994988, Length=605, Percent_Identity=56.3636363636364, Blast_Score=661, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=505, Percent_Identity=26.5346534653465, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1789738, Length=153, Percent_Identity=39.2156862745098, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1790412, Length=286, Percent_Identity=29.7202797202797, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789737, Length=286, Percent_Identity=29.7202797202797, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1790835, Length=148, Percent_Identity=31.7567567567568, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17557151, Length=488, Percent_Identity=25.4098360655738, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17556745, Length=143, Percent_Identity=42.6573426573427, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17533571, Length=201, Percent_Identity=35.3233830845771, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71988819, Length=128, Percent_Identity=39.84375, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71988811, Length=128, Percent_Identity=39.84375, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17506493, Length=214, Percent_Identity=31.3084112149533, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17552882, Length=185, Percent_Identity=32.4324324324324, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17556456, Length=287, Percent_Identity=28.9198606271777, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI25141371, Length=289, Percent_Identity=28.3737024221453, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=501, Percent_Identity=26.7465069860279, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324707, Length=201, Percent_Identity=37.3134328358209, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=201, Percent_Identity=37.3134328358209, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323098, Length=209, Percent_Identity=34.4497607655502, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324761, Length=271, Percent_Identity=30.9963099630996, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322359, Length=149, Percent_Identity=40.2684563758389, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324166, Length=182, Percent_Identity=36.8131868131868, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24582462, Length=146, Percent_Identity=40.4109589041096, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI78706572, Length=526, Percent_Identity=26.425855513308, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI221458488, Length=161, Percent_Identity=39.7515527950311, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28574573, Length=140, Percent_Identity=42.1428571428571, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI281363316, Length=270, Percent_Identity=29.2592592592593, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17864358, Length=270, Percent_Identity=29.2592592592593, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24585711, Length=148, Percent_Identity=36.4864864864865, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24585713, Length=148, Percent_Identity=36.4864864864865, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24585709, Length=148, Percent_Identity=36.4864864864865, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=36.5671641791045, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921738, Length=275, Percent_Identity=29.4545454545455, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45553807, Length=274, Percent_Identity=25.1824817518248, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI45553816, Length=274, Percent_Identity=25.1824817518248, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24651721, Length=274, Percent_Identity=25.1824817518248, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI17864154, Length=274, Percent_Identity=25.1824817518248, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67129; Mature: 67129

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRNIAIIAHVDHGKTTLVDQLLKQSGSFRDNQRVAERAMDSNDLEKERGITILAKATS
CCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHCCEEEEEEECC
VDWKDTRINIVDTPGHADFGGEVERILSMVDSAIVLVDAAEGPMPQTKFVVGKALKVGLK
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHCCCC
PIVVINKIDRPDARHVEVVNEVFDLFAALDATDEQLDFPILYGSGRDGWVSENPEGPKDQ
EEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCC
QLAPLFDLIIKHVPAPTVHPGPFRMIGTILEANPFLGRIITGRIESGTLKANQAVKVLHH
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEECEECCCEEECCCEEEEEEC
DGTQIETGRISKILAFRGLERQPIEEAQAGDIVAIAGLSKGTVADTFCDLAVTEALHAQP
CCCEEECCHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
IDPPTVTMSFLVNDSPLAGTEGDKVTSRVIRDRLLREAEGNVALKIEESPDKDSFFVSGR
CCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECC
GELQLAVLIETMRREGFEIAVSRPRVVMQKGENGELLEPVEEVVIDVDEEHAGVVVQKMS
CCEEEHHHHHHHHCCCCEEEECCCEEEEECCCCCCHHHHHHHHHEECCCCCCCHHHHHHH
ERKAEMVELRPSGGNRQRIVFHAPTRGLIGYQSELLTDTRGTAVMNRLFHAYEPYKGELP
HCCCEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
GRTNGVLISNEQGESVAYAMWNLEDRGPMVIDPGVKVYQGMIIGIHSRDNDLEVNVLKGK
CCCCCEEEECCCCCEEEEEEEECCCCCCEEECCCCCEECEEEEEEECCCCCEEEEEECCC
KLTNIRAAGKDEAVKLTPPIRMTLERALAWIQDDELVEVTPKTIRLRKLYLDPNERKRFE
EEEEEECCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEECCCEEEEEEEEECCCHHHHHH
KSSKVVGAA
HHCCCCCCC
>Mature Secondary Structure
MKLRNIAIIAHVDHGKTTLVDQLLKQSGSFRDNQRVAERAMDSNDLEKERGITILAKATS
CCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHCCEEEEEEECC
VDWKDTRINIVDTPGHADFGGEVERILSMVDSAIVLVDAAEGPMPQTKFVVGKALKVGLK
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHCCCC
PIVVINKIDRPDARHVEVVNEVFDLFAALDATDEQLDFPILYGSGRDGWVSENPEGPKDQ
EEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCC
QLAPLFDLIIKHVPAPTVHPGPFRMIGTILEANPFLGRIITGRIESGTLKANQAVKVLHH
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEECEECCCEEECCCEEEEEEC
DGTQIETGRISKILAFRGLERQPIEEAQAGDIVAIAGLSKGTVADTFCDLAVTEALHAQP
CCCEEECCHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
IDPPTVTMSFLVNDSPLAGTEGDKVTSRVIRDRLLREAEGNVALKIEESPDKDSFFVSGR
CCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECC
GELQLAVLIETMRREGFEIAVSRPRVVMQKGENGELLEPVEEVVIDVDEEHAGVVVQKMS
CCEEEHHHHHHHHCCCCEEEECCCEEEEECCCCCCHHHHHHHHHEECCCCCCCHHHHHHH
ERKAEMVELRPSGGNRQRIVFHAPTRGLIGYQSELLTDTRGTAVMNRLFHAYEPYKGELP
HCCCEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
GRTNGVLISNEQGESVAYAMWNLEDRGPMVIDPGVKVYQGMIIGIHSRDNDLEVNVLKGK
CCCCCEEEECCCCCEEEEEEEECCCCCCEEECCCCCEECEEEEEEECCCCCEEEEEECCC
KLTNIRAAGKDEAVKLTPPIRMTLERALAWIQDDELVEVTPKTIRLRKLYLDPNERKRFE
EEEEEECCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEECCCEEEEEEEEECCCHHHHHH
KSSKVVGAA
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9622352 [H]