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The map label for this gene is htpX

Identifier: 13473484

GI number: 13473484

Start: 3276575

End: 3277585

Strand: Direct

Name: htpX

Synonym: mlr4097

Alternate gene names: 13473484

Gene position: 3276575-3277585 (Clockwise)

Preceding gene: 13473481

Following gene: 13473485

Centisome position: 46.57

GC content: 65.68

Gene sequence:

>1011_bases
ATGAACACTCTTCGCACCGCCATGCTTCTAGCCGCGATGACGGCGCTGTTCATGGGCGTCGGCTTCCTGATCGGCGGTTC
GGGCGGCATGATGATCGCGCTGCTGATCGCCGCCGGCACCAATCTGTTCAGCTACTGGAACGCCGACAAGATGGTGCTGT
CGATGAACCGCGCCGTCGAGGTCGACGAGAAGAATGCGCCGGAATATTACGCCATCGTCCAGGCGCTGGCCAAGCAGGCC
GGGCTGCCGATGCCCAGGACCTATCTGATCGACAATCCGCAGCCCAATGCCTTCGCCACCGGCCGCAATCCGCAGAACGC
GGCGGTCGCCGCCTCCACCGGCCTGTTGCAGCGGCTGACCCATGAAGAGGTCGCGGCTGTCATGGCGCACGAACTCGCGC
ACGTCCAGCACCGCGACACGCTGACCATGACCATCGTCGCCACCTTTGCCGGTGCCATCTCGATGCTGGGCAATTTCGCT
TTTTTCCTCGGCGGCAACCGCGACAACAACCCGTTCGGCTTTGTCGGCGTGTTGGCGGCGATGATCGTGGCGCCCTTTGC
CGCGATGATCGTGCAGATGGCGGTCAGCCGCACCCGCGAATACGAGGCCGACCGGCGCGGCGCCGAAATCTGTGGACACC
CGCTCTGGCTGGCATCGGCGCTTGACAAGATCGCCCGCGGCGCCGAACGCATTCCCAACCCCGATGCGGAGCGCAATCCG
GCGATGGCGCATCTCTTCATCATCAATCCTCTGCACGGCGAGCGCATGGACAATCTGTTCTCCACCCACCCCAGCACCGA
CAACCGCATCGCCGCGTTGCAGGAGATGGCACAGCAGATGGCGGGCGGCACCCAAGCCGCCCCGCGCCCGACACCTAGGC
AGGCCGGGGAACAACAGCCGTCCGGCCCGTGGGGCCAGGCCCCTCAAGCAGAACAGCCGGCGGAGCCGGAAAGGCCGAAG
GCCAACCCATGGGGACGCAATCCGACCGGGCCCAAAGGCCGATGGTCGTGA

Upstream 100 bases:

>100_bases
ATTCCACGCGGATTGAAACAGCGGCAGGTGTTTCCCATCATATAGCCATGAACCCACGACGATCGACCCCTCTTCACCAT
CATCTGGATAGGAGCAGACG

Downstream 100 bases:

>100_bases
GCGTGGCGGGACCTCGACGCGCAGGCTCAGGCGATCAGGACCATAGAGACGGCGGCGAATTCGTCGCCGGTCTCGCCGCC
CGCAAGGCGGCGGCGCGGCT

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MNTLRTAMLLAAMTALFMGVGFLIGGSGGMMIALLIAAGTNLFSYWNADKMVLSMNRAVEVDEKNAPEYYAIVQALAKQA
GLPMPRTYLIDNPQPNAFATGRNPQNAAVAASTGLLQRLTHEEVAAVMAHELAHVQHRDTLTMTIVATFAGAISMLGNFA
FFLGGNRDNNPFGFVGVLAAMIVAPFAAMIVQMAVSRTREYEADRRGAEICGHPLWLASALDKIARGAERIPNPDAERNP
AMAHLFIINPLHGERMDNLFSTHPSTDNRIAALQEMAQQMAGGTQAAPRPTPRQAGEQQPSGPWGQAPQAEQPAEPERPK
ANPWGRNPTGPKGRWS

Sequences:

>Translated_336_residues
MNTLRTAMLLAAMTALFMGVGFLIGGSGGMMIALLIAAGTNLFSYWNADKMVLSMNRAVEVDEKNAPEYYAIVQALAKQA
GLPMPRTYLIDNPQPNAFATGRNPQNAAVAASTGLLQRLTHEEVAAVMAHELAHVQHRDTLTMTIVATFAGAISMLGNFA
FFLGGNRDNNPFGFVGVLAAMIVAPFAAMIVQMAVSRTREYEADRRGAEICGHPLWLASALDKIARGAERIPNPDAERNP
AMAHLFIINPLHGERMDNLFSTHPSTDNRIAALQEMAQQMAGGTQAAPRPTPRQAGEQQPSGPWGQAPQAEQPAEPERPK
ANPWGRNPTGPKGRWS
>Mature_336_residues
MNTLRTAMLLAAMTALFMGVGFLIGGSGGMMIALLIAAGTNLFSYWNADKMVLSMNRAVEVDEKNAPEYYAIVQALAKQA
GLPMPRTYLIDNPQPNAFATGRNPQNAAVAASTGLLQRLTHEEVAAVMAHELAHVQHRDTLTMTIVATFAGAISMLGNFA
FFLGGNRDNNPFGFVGVLAAMIVAPFAAMIVQMAVSRTREYEADRRGAEICGHPLWLASALDKIARGAERIPNPDAERNP
AMAHLFIINPLHGERMDNLFSTHPSTDNRIAALQEMAQQMAGGTQAAPRPTPRQAGEQQPSGPWGQAPQAEQPAEPERPK
ANPWGRNPTGPKGRWS

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=298, Percent_Identity=34.8993288590604, Blast_Score=108, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_RHILO (Q98ET0)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105051.1
- ProteinModelPortal:   Q98ET0
- MEROPS:   M48.004
- GeneID:   1227712
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr4097
- NMPDR:   fig|266835.1.peg.3155
- HOGENOM:   HBG739460
- OMA:   RRGAEIC
- ProtClustDB:   PRK01345
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 36205; Mature: 36205

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 131-131

Signals:

None

Transmembrane regions:

HASH(0x1282cf68)-; HASH(0x12b6571c)-; HASH(0x12f80c88)-; HASH(0x132624ec)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLRTAMLLAAMTALFMGVGFLIGGSGGMMIALLIAAGTNLFSYWNADKMVLSMNRAVE
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCCHHEEECCCCEE
VDEKNAPEYYAIVQALAKQAGLPMPRTYLIDNPQPNAFATGRNPQNAAVAASTGLLQRLT
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEECCCCCCCCHHHHHHHHHHHHH
HEEVAAVMAHELAHVQHRDTLTMTIVATFAGAISMLGNFAFFLGGNRDNNPFGFVGVLAA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHH
MIVAPFAAMIVQMAVSRTREYEADRRGAEICGHPLWLASALDKIARGAERIPNPDAERNP
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
AMAHLFIINPLHGERMDNLFSTHPSTDNRIAALQEMAQQMAGGTQAAPRPTPRQAGEQQP
CEEEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCC
SGPWGQAPQAEQPAEPERPKANPWGRNPTGPKGRWS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure
MNTLRTAMLLAAMTALFMGVGFLIGGSGGMMIALLIAAGTNLFSYWNADKMVLSMNRAVE
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCCHHEEECCCCEE
VDEKNAPEYYAIVQALAKQAGLPMPRTYLIDNPQPNAFATGRNPQNAAVAASTGLLQRLT
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEECCCCCCCCHHHHHHHHHHHHH
HEEVAAVMAHELAHVQHRDTLTMTIVATFAGAISMLGNFAFFLGGNRDNNPFGFVGVLAA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHH
MIVAPFAAMIVQMAVSRTREYEADRRGAEICGHPLWLASALDKIARGAERIPNPDAERNP
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
AMAHLFIINPLHGERMDNLFSTHPSTDNRIAALQEMAQQMAGGTQAAPRPTPRQAGEQQP
CEEEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCC
SGPWGQAPQAEQPAEPERPKANPWGRNPTGPKGRWS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11214968