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The map label for this gene is recQ [H]

Identifier: 13473449

GI number: 13473449

Start: 3236892

End: 3238727

Strand: Reverse

Name: recQ [H]

Synonym: mll4050

Alternate gene names: 13473449

Gene position: 3238727-3236892 (Counterclockwise)

Preceding gene: 13473451

Following gene: 13473448

Centisome position: 46.03

GC content: 66.61

Gene sequence:

>1836_bases
ATGTCGGCACAGGCTGCGAGTGTTCGGGCGGAGGATCCCAAGCGGCGCGTCCTGAAGGACGTGTTCGGCTTCGATGATTT
CCGCCCCGGCCAGGCCGATGTCATCGACGCGCTGCTCTGCGGGCGCCATGTGCTGGCGGTCATGCCGACGGGTGCGGGCA
AATCGCTCTGCTACCAGGTGCCGGCGCTGGTCATGGGCGGGCTCGCCCTGGTCGTGTCGCCGCTGGTGGCGCTGATGCAG
GACCAGGTCGCCGCCTTGCGGCTGGCGGGCGTCGGCGCCGATACGATCAATTCCTCGCTCGACCGCGAGGCAAATGTCGC
GGCCTGGCGCCGCGTGGCATCAGGCCAGACGCGGCTGCTCTACCTGGCGCCGGAACGGTTGATGACCGAGCGCATGCTCG
AGGCGCTTTCCAGGCTCGAGGTCAGCCTGGTCGCCATCGACGAGGCGCATTGCATCTCGCAATGGGGGCCGGCGTTCCGG
CCCGAGTATGAGGACCTGTCGCGGCTGCGGCACATCTTCCCCAACGTGCCAATCATCGCGGTGACGGCGACGGCGGATGA
GAGCACGCGCAGCGATATCGAGGCACGGCTGTTCGCCGAGCGGGTCGAAACGCTGGTGCTGGGGTTCGACCGTCCCAACA
TCAAGCTCGCCATCGAATCCAAGCAGGACAGCAAGCGGCAATTGCTGCGTTTCATCGAGCGCCACCCAGGCAAGAGCGGC
ATCGTCTACTGCCTGTCGCGCAAGAAGACGGAGGAGATGGCGGCCTTCCTCGAGAAGAACGGCGTCACCGCGCTCGCCTA
TCATGCCGGGATGAGCAAGGAGGCGCGCGAGGCCAATCAAAACGCTTTCATGACACTGTCCGGTGTCGTCATGGTGGCGA
CCATCGCCTTCGGCATGGGCATCGACAAGCCCGACGTCGCCTATGTCTTCCACACCGACATGCCGGGCAGCCTGGAAGCC
TATTATCAGGAGATCGGTCGCGCCGGCCGCGACGGGCGCAAGGCCGAAGCGCATATGCTCTATGGCCTAGGCGACATCCG
CATGCGGCGGCTGTTCATCGACGACGAGGATGCAGCGGTGGAGCACAAGAAGCGCGCACATCGCCGGCTCGACACGCTGA
TCGGCTATTGCGAGACGGCGCAGTGCCGGCGCCAGGTGCTGCTTGGCTATTTCGGTGAGGATGCCTCGCCTTGCGGCAAT
TGCGACAATTGCCTCGACCAGGTGCCGCGCGCCGATGGCGGCGCGGAAGCGCGCATCATCCTGGCCGCGGTCGCGCAGAG
CGGCGAGCGCTTCGGCGCCGCCCATGTCATTGACATCCTGCTTGGCCATGAGACCGAGAAGATCCTTGCCCGCGGTCACC
AGAAGCTCGCCAGCTTCGGCAGCGGCGCGGCGCACAAGAAGGATCTCCTGACATCGCTGATCCGGCAGCTCGTCGCCGGC
GGGTTCCTGGAACCGGACCCTAACGGCCATGGCGGCCTCGCCATCGCCGAAAAGGGTCATGCGCTTGGCCGGGGCGAACT
GCCGTTCCACTACCGTGTCGAGATGCGCAGCCGCGCCTTGCGCAAGATGCGGGCGGCCGAGGGTTCGGGTGCCGAAGGCG
TCGACGCCTCGCTGCTGGCCACGCTCAAATCCCTGCGGCTGCGCCTGGCCAAGGAACGCCAGGTGCCGGCCTATGTGGTG
TTTTCCGACCGGACGCTGATCGACATGGCCGAACGCCGCCCGCGCGACCTCGACGCCTTCGCCGAGGTCAATGGCGTGGG
AGGGGCGAAGCTCGAGGAATTCGGCCAGGTTTTTCTGAGTGCGATCGCGGCGCATCGGGCGGGTGGGGCGGGCTGA

Upstream 100 bases:

>100_bases
GCAGCTGCGCTACTCCAAGGCACCACGCGGAGAGCATCTTGATCGATTCCCACATCCTCTCCCATCCCCGAAAAATCGCT
TCTCGTCCGGTGTCCGCCTG

Downstream 100 bases:

>100_bases
AGGCGACACGCCTCAAGTGGACGCACTCCGGCGTCGGACGGCAGCGTTGCGCCACTTGCCGGCGTCAGCACCTCAAGGCG
CGAACGTCTGTTGTGATGCC

Product: DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MSAQAASVRAEDPKRRVLKDVFGFDDFRPGQADVIDALLCGRHVLAVMPTGAGKSLCYQVPALVMGGLALVVSPLVALMQ
DQVAALRLAGVGADTINSSLDREANVAAWRRVASGQTRLLYLAPERLMTERMLEALSRLEVSLVAIDEAHCISQWGPAFR
PEYEDLSRLRHIFPNVPIIAVTATADESTRSDIEARLFAERVETLVLGFDRPNIKLAIESKQDSKRQLLRFIERHPGKSG
IVYCLSRKKTEEMAAFLEKNGVTALAYHAGMSKEAREANQNAFMTLSGVVMVATIAFGMGIDKPDVAYVFHTDMPGSLEA
YYQEIGRAGRDGRKAEAHMLYGLGDIRMRRLFIDDEDAAVEHKKRAHRRLDTLIGYCETAQCRRQVLLGYFGEDASPCGN
CDNCLDQVPRADGGAEARIILAAVAQSGERFGAAHVIDILLGHETEKILARGHQKLASFGSGAAHKKDLLTSLIRQLVAG
GFLEPDPNGHGGLAIAEKGHALGRGELPFHYRVEMRSRALRKMRAAEGSGAEGVDASLLATLKSLRLRLAKERQVPAYVV
FSDRTLIDMAERRPRDLDAFAEVNGVGGAKLEEFGQVFLSAIAAHRAGGAG

Sequences:

>Translated_611_residues
MSAQAASVRAEDPKRRVLKDVFGFDDFRPGQADVIDALLCGRHVLAVMPTGAGKSLCYQVPALVMGGLALVVSPLVALMQ
DQVAALRLAGVGADTINSSLDREANVAAWRRVASGQTRLLYLAPERLMTERMLEALSRLEVSLVAIDEAHCISQWGPAFR
PEYEDLSRLRHIFPNVPIIAVTATADESTRSDIEARLFAERVETLVLGFDRPNIKLAIESKQDSKRQLLRFIERHPGKSG
IVYCLSRKKTEEMAAFLEKNGVTALAYHAGMSKEAREANQNAFMTLSGVVMVATIAFGMGIDKPDVAYVFHTDMPGSLEA
YYQEIGRAGRDGRKAEAHMLYGLGDIRMRRLFIDDEDAAVEHKKRAHRRLDTLIGYCETAQCRRQVLLGYFGEDASPCGN
CDNCLDQVPRADGGAEARIILAAVAQSGERFGAAHVIDILLGHETEKILARGHQKLASFGSGAAHKKDLLTSLIRQLVAG
GFLEPDPNGHGGLAIAEKGHALGRGELPFHYRVEMRSRALRKMRAAEGSGAEGVDASLLATLKSLRLRLAKERQVPAYVV
FSDRTLIDMAERRPRDLDAFAEVNGVGGAKLEEFGQVFLSAIAAHRAGGAG
>Mature_610_residues
SAQAASVRAEDPKRRVLKDVFGFDDFRPGQADVIDALLCGRHVLAVMPTGAGKSLCYQVPALVMGGLALVVSPLVALMQD
QVAALRLAGVGADTINSSLDREANVAAWRRVASGQTRLLYLAPERLMTERMLEALSRLEVSLVAIDEAHCISQWGPAFRP
EYEDLSRLRHIFPNVPIIAVTATADESTRSDIEARLFAERVETLVLGFDRPNIKLAIESKQDSKRQLLRFIERHPGKSGI
VYCLSRKKTEEMAAFLEKNGVTALAYHAGMSKEAREANQNAFMTLSGVVMVATIAFGMGIDKPDVAYVFHTDMPGSLEAY
YQEIGRAGRDGRKAEAHMLYGLGDIRMRRLFIDDEDAAVEHKKRAHRRLDTLIGYCETAQCRRQVLLGYFGEDASPCGNC
DNCLDQVPRADGGAEARIILAAVAQSGERFGAAHVIDILLGHETEKILARGHQKLASFGSGAAHKKDLLTSLIRQLVAGG
FLEPDPNGHGGLAIAEKGHALGRGELPFHYRVEMRSRALRKMRAAEGSGAEGVDASLLATLKSLRLRLAKERQVPAYVVF
SDRTLIDMAERRPRDLDAFAEVNGVGGAKLEEFGQVFLSAIAAHRAGGAG

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=637, Percent_Identity=34.2229199372057, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI14591902, Length=462, Percent_Identity=35.2813852813853, Blast_Score=295, Evalue=9e-80,
Organism=Homo sapiens, GI14591904, Length=462, Percent_Identity=35.2813852813853, Blast_Score=295, Evalue=9e-80,
Organism=Homo sapiens, GI110735439, Length=501, Percent_Identity=35.3293413173653, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI169218196, Length=501, Percent_Identity=35.3293413173653, Blast_Score=274, Evalue=2e-73,
Organism=Homo sapiens, GI148612816, Length=427, Percent_Identity=38.1733021077283, Blast_Score=252, Evalue=8e-67,
Organism=Homo sapiens, GI51242943, Length=398, Percent_Identity=38.6934673366834, Blast_Score=238, Evalue=2e-62,
Organism=Homo sapiens, GI51242947, Length=398, Percent_Identity=38.6934673366834, Blast_Score=238, Evalue=2e-62,
Organism=Homo sapiens, GI284005309, Length=353, Percent_Identity=38.5269121813031, Blast_Score=202, Evalue=1e-51,
Organism=Homo sapiens, GI7661920, Length=351, Percent_Identity=22.5071225071225, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI222352149, Length=354, Percent_Identity=20.9039548022599, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI41327771, Length=368, Percent_Identity=23.6413043478261, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI48994977, Length=608, Percent_Identity=43.9144736842105, Blast_Score=503, Evalue=1e-143,
Organism=Escherichia coli, GI87082221, Length=347, Percent_Identity=26.8011527377522, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI25145561, Length=498, Percent_Identity=36.5461847389558, Blast_Score=299, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI71987997, Length=413, Percent_Identity=37.2881355932203, Blast_Score=273, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI71987993, Length=413, Percent_Identity=37.2881355932203, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI32564293, Length=497, Percent_Identity=34.0040241448692, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17552866, Length=435, Percent_Identity=35.4022988505747, Blast_Score=249, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17537549, Length=355, Percent_Identity=24.7887323943662, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71995724, Length=351, Percent_Identity=23.0769230769231, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17507121, Length=351, Percent_Identity=22.7920227920228, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115533224, Length=323, Percent_Identity=23.2198142414861, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17555296, Length=106, Percent_Identity=33.0188679245283, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=485, Percent_Identity=35.2577319587629, Blast_Score=306, Evalue=6e-84,
Organism=Saccharomyces cerevisiae, GI6320224, Length=339, Percent_Identity=22.7138643067847, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324217, Length=330, Percent_Identity=23.3333333333333, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321360, Length=361, Percent_Identity=22.4376731301939, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24646066, Length=632, Percent_Identity=34.6518987341772, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24664226, Length=401, Percent_Identity=34.9127182044888, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24664230, Length=397, Percent_Identity=34.2569269521411, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI62472181, Length=397, Percent_Identity=34.2569269521411, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI21358123, Length=356, Percent_Identity=35.1123595505618, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI28574962, Length=334, Percent_Identity=25.748502994012, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21355075, Length=358, Percent_Identity=22.3463687150838, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24644483, Length=338, Percent_Identity=21.8934911242604, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281361218, Length=338, Percent_Identity=21.8934911242604, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24644481, Length=338, Percent_Identity=21.8934911242604, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24644479, Length=338, Percent_Identity=21.8934911242604, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24644487, Length=338, Percent_Identity=21.8934911242604, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551833, Length=338, Percent_Identity=21.8934911242604, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24644485, Length=338, Percent_Identity=21.8934911242604, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24645031, Length=343, Percent_Identity=21.2827988338192, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 66547; Mature: 66416

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQAASVRAEDPKRRVLKDVFGFDDFRPGQADVIDALLCGRHVLAVMPTGAGKSLCYQV
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHH
PALVMGGLALVVSPLVALMQDQVAALRLAGVGADTINSSLDREANVAAWRRVASGQTRLL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEE
YLAPERLMTERMLEALSRLEVSLVAIDEAHCISQWGPAFRPEYEDLSRLRHIFPNVPIIA
EECHHHHHHHHHHHHHHHCEEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEE
VTATADESTRSDIEARLFAERVETLVLGFDRPNIKLAIESKQDSKRQLLRFIERHPGKSG
EEECCCCCHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCHHHHHHHHHHHCCCCCC
IVYCLSRKKTEEMAAFLEKNGVTALAYHAGMSKEAREANQNAFMTLSGVVMVATIAFGMG
EEEEECCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCCEEEHHHHHHHHHHHHHCC
IDKPDVAYVFHTDMPGSLEAYYQEIGRAGRDGRKAEAHMLYGLGDIRMRRLFIDDEDAAV
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHEECCCHHHEEEEEECCCHHHH
EHKKRAHRRLDTLIGYCETAQCRRQVLLGYFGEDASPCGNCDNCLDQVPRADGGAEARII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHH
LAAVAQSGERFGAAHVIDILLGHETEKILARGHQKLASFGSGAAHKKDLLTSLIRQLVAG
HHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
GFLEPDPNGHGGLAIAEKGHALGRGELPFHYRVEMRSRALRKMRAAEGSGAEGVDASLLA
CCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHH
TLKSLRLRLAKERQVPAYVVFSDRTLIDMAERRPRDLDAFAEVNGVGGAKLEEFGQVFLS
HHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHH
AIAAHRAGGAG
HHHHHCCCCCC
>Mature Secondary Structure 
SAQAASVRAEDPKRRVLKDVFGFDDFRPGQADVIDALLCGRHVLAVMPTGAGKSLCYQV
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHH
PALVMGGLALVVSPLVALMQDQVAALRLAGVGADTINSSLDREANVAAWRRVASGQTRLL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEE
YLAPERLMTERMLEALSRLEVSLVAIDEAHCISQWGPAFRPEYEDLSRLRHIFPNVPIIA
EECHHHHHHHHHHHHHHHCEEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEE
VTATADESTRSDIEARLFAERVETLVLGFDRPNIKLAIESKQDSKRQLLRFIERHPGKSG
EEECCCCCHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCHHHHHHHHHHHCCCCCC
IVYCLSRKKTEEMAAFLEKNGVTALAYHAGMSKEAREANQNAFMTLSGVVMVATIAFGMG
EEEEECCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCCEEEHHHHHHHHHHHHHCC
IDKPDVAYVFHTDMPGSLEAYYQEIGRAGRDGRKAEAHMLYGLGDIRMRRLFIDDEDAAV
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHEECCCHHHEEEEEECCCHHHH
EHKKRAHRRLDTLIGYCETAQCRRQVLLGYFGEDASPCGNCDNCLDQVPRADGGAEARII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHH
LAAVAQSGERFGAAHVIDILLGHETEKILARGHQKLASFGSGAAHKKDLLTSLIRQLVAG
HHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
GFLEPDPNGHGGLAIAEKGHALGRGELPFHYRVEMRSRALRKMRAAEGSGAEGVDASLLA
CCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHH
TLKSLRLRLAKERQVPAYVVFSDRTLIDMAERRPRDLDAFAEVNGVGGAKLEEFGQVFLS
HHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHH
AIAAHRAGGAG
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]