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The map label for this gene is proA

Identifier: 13473419

GI number: 13473419

Start: 3206110

End: 3207396

Strand: Reverse

Name: proA

Synonym: mll4009

Alternate gene names: 13473419

Gene position: 3207396-3206110 (Counterclockwise)

Preceding gene: 13473420

Following gene: 13473418

Centisome position: 45.59

GC content: 66.67

Gene sequence:

>1287_bases
ATGCTGAAGCTGCATGAAAAATCCGGGGATGACACCGTGGCGCTGATGGCCGATATCGGCCGCCGCGCCCGCGCCGCCGC
TCGACCGCTGGCCATCGCCCCCACCGCTGCCAAGAATGCCGCGCTGCTTGCCATGGCGGACGCGATCGTCGCCAGACAGC
AGGACATTCTCGACGCCAATGCCATCGATGTCTCGAATGGCGAGGAAGCCGGGCTGTCCGCCTCCTTCATGGACCGGCTG
AAGCTCACTCCGGCGCGCATCCGCGCGATGGCCGACGGCATCCGTGAAATCGCTGAACTCAAGGATCCGGTCGGCGACGT
GATCGCCGCCTGGGAGCGGCCGAACGGCCTGCGGATCGAGCGCGTGCGCACGCCGCTCGGCGTCGTCGGCGTCATCTATG
AGAGCCGGCCGAACGTGACGGCGGATGCCGGTGCGCTCTGCCTCAAGGCCGGCAATCCGGTGATCCTGCGCGGCGGTTCG
GATTCGCTCAATTCCTCCGCTGCCATCCATGCCTGCCTGGTCGAGGGCCTGAAGGCCGCCGGCCTGCCGGAAGACGCCAT
CCAGCTGGTGCCGACCACCGACCGCGCCGCTGTCGGCGAGATGCTGAAGGGGCTGGGTGGTGCGCTCGACGTCATCATTC
CGCGCGGCGGCAAAAGCCTGGTCGGGCGGGTGCAGAGCGAGGCGCGGGTGCCGGTCTTCGCCCATCTCGAAGGCATTTGC
CATCTCTACATCGACCGCTCCGCCGATCTCGACATGGCGGTCAAGATTGCCGTCAACGCCAAGATGCGGCGCACCGGGGT
CTGCGGCGCCGCCGAAACGCTGCTTGTCGACCGCGCGGTGGCGTCCACGCACCTGGTGCCGATCCTCGATGCGCTCCGCG
CCGCCGGCTGCGAGATCCATGCCGATCAAGAGGTGCTGAAGGTGTTTTTCGACGCCAAGCCGGCGACCGATGCCGACTGG
GTGACCGAATATCTCGACGCCATCATCGCGGTGAAGCTGGTCGACGGCATCGGTGGCGCGATCGAGCATATCGAGACCTT
CTCCTCGCATCACACCGAGGCGATCATCGCCGAGGATCCGAAGGCCGTGGAGCGGTTCTTCAACGAGATCGATTCGGCGA
TCCTGCTGCATAATGCCTCGACTCAGTTCGCCGATGGCGGCGAGTTCGGCATGGGCGCCGAGATCGGCATCGCCACCGGC
AAGATGCATGCGCGCGGGCCGGTCGGCGTGGAGCAGCTGACCTCGTTCAAATATCGCGTGCGCGGGTCGGGACAGGTGAG
GCCTTGA

Upstream 100 bases:

>100_bases
GATCGAAACCGTGCTCGGCTACGAAGCGCGTTCAGCGATGATCCACCGCGACGACCTCGTGGTGAGTCACGCTGGGGGCG
ACATAAGCGGAGGATGAGCC

Downstream 100 bases:

>100_bases
CGTTTTTCGTCGATAGAGCCTGAGGCGTTGCGCGCGCGGACCCCCCTCTGCCCTGCCGGCCCCCCCCTCAAGGGGGGAGA
TTGGCTGTTGTTTCTGCTTT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLKLHEKSGDDTVALMADIGRRARAAARPLAIAPTAAKNAALLAMADAIVARQQDILDANAIDVSNGEEAGLSASFMDRL
KLTPARIRAMADGIREIAELKDPVGDVIAAWERPNGLRIERVRTPLGVVGVIYESRPNVTADAGALCLKAGNPVILRGGS
DSLNSSAAIHACLVEGLKAAGLPEDAIQLVPTTDRAAVGEMLKGLGGALDVIIPRGGKSLVGRVQSEARVPVFAHLEGIC
HLYIDRSADLDMAVKIAVNAKMRRTGVCGAAETLLVDRAVASTHLVPILDALRAAGCEIHADQEVLKVFFDAKPATDADW
VTEYLDAIIAVKLVDGIGGAIEHIETFSSHHTEAIIAEDPKAVERFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATG
KMHARGPVGVEQLTSFKYRVRGSGQVRP

Sequences:

>Translated_428_residues
MLKLHEKSGDDTVALMADIGRRARAAARPLAIAPTAAKNAALLAMADAIVARQQDILDANAIDVSNGEEAGLSASFMDRL
KLTPARIRAMADGIREIAELKDPVGDVIAAWERPNGLRIERVRTPLGVVGVIYESRPNVTADAGALCLKAGNPVILRGGS
DSLNSSAAIHACLVEGLKAAGLPEDAIQLVPTTDRAAVGEMLKGLGGALDVIIPRGGKSLVGRVQSEARVPVFAHLEGIC
HLYIDRSADLDMAVKIAVNAKMRRTGVCGAAETLLVDRAVASTHLVPILDALRAAGCEIHADQEVLKVFFDAKPATDADW
VTEYLDAIIAVKLVDGIGGAIEHIETFSSHHTEAIIAEDPKAVERFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATG
KMHARGPVGVEQLTSFKYRVRGSGQVRP
>Mature_428_residues
MLKLHEKSGDDTVALMADIGRRARAAARPLAIAPTAAKNAALLAMADAIVARQQDILDANAIDVSNGEEAGLSASFMDRL
KLTPARIRAMADGIREIAELKDPVGDVIAAWERPNGLRIERVRTPLGVVGVIYESRPNVTADAGALCLKAGNPVILRGGS
DSLNSSAAIHACLVEGLKAAGLPEDAIQLVPTTDRAAVGEMLKGLGGALDVIIPRGGKSLVGRVQSEARVPVFAHLEGIC
HLYIDRSADLDMAVKIAVNAKMRRTGVCGAAETLLVDRAVASTHLVPILDALRAAGCEIHADQEVLKVFFDAKPATDADW
VTEYLDAIIAVKLVDGIGGAIEHIETFSSHHTEAIIAEDPKAVERFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATG
KMHARGPVGVEQLTSFKYRVRGSGQVRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=410, Percent_Identity=36.5853658536585, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI62912457, Length=410, Percent_Identity=36.5853658536585, Blast_Score=257, Evalue=1e-68,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=41.6666666666667, Blast_Score=323, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17569967, Length=419, Percent_Identity=36.0381861575179, Blast_Score=264, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI17569969, Length=419, Percent_Identity=36.0381861575179, Blast_Score=264, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6324899, Length=430, Percent_Identity=36.046511627907, Blast_Score=273, Evalue=4e-74,
Organism=Drosophila melanogaster, GI21357643, Length=407, Percent_Identity=35.8722358722359, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_RHILO (Q98EZ5)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_104986.1
- ProteinModelPortal:   Q98EZ5
- SMR:   Q98EZ5
- GeneID:   1227647
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll4009
- NMPDR:   fig|266835.1.peg.3090
- HOGENOM:   HBG318080
- OMA:   GICGAME
- ProtClustDB:   PRK00197
- BRENDA:   1.2.1.41
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45122; Mature: 45122

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKLHEKSGDDTVALMADIGRRARAAARPLAIAPTAAKNAALLAMADAIVARQQDILDAN
CCEECCCCCCCEEHHHHHHCHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCC
AIDVSNGEEAGLSASFMDRLKLTPARIRAMADGIREIAELKDPVGDVIAAWERPNGLRIE
CEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEE
RVRTPLGVVGVIYESRPNVTADAGALCLKAGNPVILRGGSDSLNSSAAIHACLVEGLKAA
EECCCCCEEEEEEECCCCCCCCCCEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHC
GLPEDAIQLVPTTDRAAVGEMLKGLGGALDVIIPRGGKSLVGRVQSEARVPVFAHLEGIC
CCCHHHHEEECCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHHCEE
HLYIDRSADLDMAVKIAVNAKMRRTGVCGAAETLLVDRAVASTHLVPILDALRAAGCEIH
EEEEECCCCCCEEEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
ADQEVLKVFFDAKPATDADWVTEYLDAIIAVKLVDGIGGAIEHIETFSSHHTEAIIAEDP
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCH
KAVERFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRV
HHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCEEEEE
RGSGQVRP
CCCCCCCC
>Mature Secondary Structure
MLKLHEKSGDDTVALMADIGRRARAAARPLAIAPTAAKNAALLAMADAIVARQQDILDAN
CCEECCCCCCCEEHHHHHHCHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCC
AIDVSNGEEAGLSASFMDRLKLTPARIRAMADGIREIAELKDPVGDVIAAWERPNGLRIE
CEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEE
RVRTPLGVVGVIYESRPNVTADAGALCLKAGNPVILRGGSDSLNSSAAIHACLVEGLKAA
EECCCCCEEEEEEECCCCCCCCCCEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHC
GLPEDAIQLVPTTDRAAVGEMLKGLGGALDVIIPRGGKSLVGRVQSEARVPVFAHLEGIC
CCCHHHHEEECCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHHCEE
HLYIDRSADLDMAVKIAVNAKMRRTGVCGAAETLLVDRAVASTHLVPILDALRAAGCEIH
EEEEECCCCCCEEEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
ADQEVLKVFFDAKPATDADWVTEYLDAIIAVKLVDGIGGAIEHIETFSSHHTEAIIAEDP
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCH
KAVERFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRV
HHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCEEEEE
RGSGQVRP
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968