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The map label for this gene is mscS [H]

Identifier: 13473416

GI number: 13473416

Start: 3202973

End: 3203824

Strand: Direct

Name: mscS [H]

Synonym: mlr4006

Alternate gene names: 13473416

Gene position: 3202973-3203824 (Clockwise)

Preceding gene: 13473405

Following gene: 13473422

Centisome position: 45.52

GC content: 63.97

Gene sequence:

>852_bases
ATGCCGATCGATCCGCAAAACACCCTTCTCACCGTCCAGGCCGGCCTGGCGCAGCTCAGCACGCTGATCGTCTCCTATTC
CTTCTCGGCCATCGGAGCCATCATCCTGCTGGTGGTCGGCTACATCGTCGCCGGCCTCGCCGAGCGCTCGATCTTCGCCG
GCCTCGGCCATATCCATGGTTTCGACGCGACGCTGCGGCATTTCTTTTCCAAGATCGTCCGCTACGCCATCCTGATCCTC
GTCGTCATCATGGTGCTCGGCCAGTTCGGCGTGCAGACCGCCTCGATCATCGCCGCGATCGGCGCCATCGGCCTTGCCAT
CGGCCTGGCGCTGCAAGGCACGCTGCAGAACATCGCCGCCGGTATCATGCTTCTGGCGCTGCGGCCGTTCCGCATCGGTG
AGTCCGTCGAAGTCGGCGCCATATCAGGCTCGATCGAGGAGATCGGCCTGTTCGCCACCAGGCTCAGGACCGCCGACGGC
GTCTACATACTGGCGCCCAATTCGACGCTGTGGAACCAGCCAGTGCGTAATTTTTCGCGCAACGGCGTGCGCCGCAGCGA
CATCAGCTTGAGCATCGGTTCGTGGAACGACATCGACGGCGCCCAGAAGACATTGCTTGCCATTGCCGGCGTCGACAAGC
GCATCCGTCGTGAACCGGCGCCGGTCGCCTTCGTGGCCAGCCTCGGCGACACGACCGTTTCGCTTACCTTGCGCTATTGG
ACTTCGGCGGCCGACTACTTCTCCACGAATATCGACATGACGAAGCGCGCAAAGCAGGCTTTCGACGCAGAGGGCATCTC
CATCCCGCTGCCGCCGCCGGAAGCGCCGGCGCCGGAGGCCCGCAAGCAGTAG

Upstream 100 bases:

>100_bases
ACTCGCCGGTTGCCCGCTTGTTCCCTACGGGGCGCAAAAAAGATCGGAACCGAGGCGTCTGGCATGGGTTATCGGCTGAC
CGACCAACCGGAATCCCGCC

Downstream 100 bases:

>100_bases
GCGATGGCGGGGCGCCCGGAGCGGTTTCCCTACGGCCTTGCGAAGAAAAACAGCCTTCAATCCTTGGTCCGGCCTGCGAT
CTCTTCCGGCGCATAGGCGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPIDPQNTLLTVQAGLAQLSTLIVSYSFSAIGAIILLVVGYIVAGLAERSIFAGLGHIHGFDATLRHFFSKIVRYAILIL
VVIMVLGQFGVQTASIIAAIGAIGLAIGLALQGTLQNIAAGIMLLALRPFRIGESVEVGAISGSIEEIGLFATRLRTADG
VYILAPNSTLWNQPVRNFSRNGVRRSDISLSIGSWNDIDGAQKTLLAIAGVDKRIRREPAPVAFVASLGDTTVSLTLRYW
TSAADYFSTNIDMTKRAKQAFDAEGISIPLPPPEAPAPEARKQ

Sequences:

>Translated_283_residues
MPIDPQNTLLTVQAGLAQLSTLIVSYSFSAIGAIILLVVGYIVAGLAERSIFAGLGHIHGFDATLRHFFSKIVRYAILIL
VVIMVLGQFGVQTASIIAAIGAIGLAIGLALQGTLQNIAAGIMLLALRPFRIGESVEVGAISGSIEEIGLFATRLRTADG
VYILAPNSTLWNQPVRNFSRNGVRRSDISLSIGSWNDIDGAQKTLLAIAGVDKRIRREPAPVAFVASLGDTTVSLTLRYW
TSAADYFSTNIDMTKRAKQAFDAEGISIPLPPPEAPAPEARKQ
>Mature_282_residues
PIDPQNTLLTVQAGLAQLSTLIVSYSFSAIGAIILLVVGYIVAGLAERSIFAGLGHIHGFDATLRHFFSKIVRYAILILV
VIMVLGQFGVQTASIIAAIGAIGLAIGLALQGTLQNIAAGIMLLALRPFRIGESVEVGAISGSIEEIGLFATRLRTADGV
YILAPNSTLWNQPVRNFSRNGVRRSDISLSIGSWNDIDGAQKTLLAIAGVDKRIRREPAPVAFVASLGDTTVSLTLRYWT
SAADYFSTNIDMTKRAKQAFDAEGISIPLPPPEAPAPEARKQ

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=262, Percent_Identity=36.2595419847328, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI1786670, Length=235, Percent_Identity=25.1063829787234, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787591, Length=237, Percent_Identity=24.8945147679325, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI2367355, Length=250, Percent_Identity=23.6, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 30139; Mature: 30008

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIDPQNTLLTVQAGLAQLSTLIVSYSFSAIGAIILLVVGYIVAGLAERSIFAGLGHIHG
CCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FDATLRHFFSKIVRYAILILVVIMVLGQFGVQTASIIAAIGAIGLAIGLALQGTLQNIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIMLLALRPFRIGESVEVGAISGSIEEIGLFATRLRTADGVYILAPNSTLWNQPVRNFSR
HHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHH
NGVRRSDISLSIGSWNDIDGAQKTLLAIAGVDKRIRREPAPVAFVASLGDTTVSLTLRYW
CCCEECCCEEEECCCCCCCHHHHHHHHHHCCHHHHHCCCCCEEEEEECCCCEEEEEEHHH
TSAADYFSTNIDMTKRAKQAFDAEGISIPLPPPEAPAPEARKQ
HHHHHHHHCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
PIDPQNTLLTVQAGLAQLSTLIVSYSFSAIGAIILLVVGYIVAGLAERSIFAGLGHIHG
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FDATLRHFFSKIVRYAILILVVIMVLGQFGVQTASIIAAIGAIGLAIGLALQGTLQNIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIMLLALRPFRIGESVEVGAISGSIEEIGLFATRLRTADGVYILAPNSTLWNQPVRNFSR
HHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHH
NGVRRSDISLSIGSWNDIDGAQKTLLAIAGVDKRIRREPAPVAFVASLGDTTVSLTLRYW
CCCEECCCEEEECCCCCCCHHHHHHHHHHCCHHHHHCCCCCEEEEEECCCCEEEEEEHHH
TSAADYFSTNIDMTKRAKQAFDAEGISIPLPPPEAPAPEARKQ
HHHHHHHHCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]