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The map label for this gene is thiE [H]

Identifier: 13473350

GI number: 13473350

Start: 3140900

End: 3141595

Strand: Direct

Name: thiE [H]

Synonym: mlr3913

Alternate gene names: 13473350

Gene position: 3140900-3141595 (Clockwise)

Preceding gene: 13473349

Following gene: 13473351

Centisome position: 44.64

GC content: 66.24

Gene sequence:

>696_bases
ATGCAACCATCTTCGCCCGGCATAGGCGAAACCCGGGATCGAAGAACCATGAACGACGCCACACCCCCAAATCGTTGCCG
CATCGTGCTGATCGCGCCGCCCGGCGTGCCGGCCGCGCGCATCGCCACCGCATTCGACGGCGGCGATGTCGCCTCGCTGA
TCCTGCCCGAGAACGGCATGGACGAGGCTTCCTTCCAGGCCTTTGCCGAACAGATCGTGCCGACGGCCCAGGCTGCGGGC
GTGGCCGTGATCATCGCCGGCGACACCCGCATTGCCGGCCGTGTCCAGGCCGACGGCATCCATGTCGAGACGTCCAAGGC
CGAACTCGCCGAGACGATCGAACATTTCCAGGCGAAGATGATGGTCGGCGCCGGCGGCGCCAAGAAGCGTGACGACGCGC
TCGAGCTTGGCGAGGTCAGGCCCGACTACATCTTCTTCGGCCGCTTCGGCTATGACAACAAGCCGGAGCCGCATCCGCGC
AACCTGTCGCTGGGCGAGTGGTGGGCGCAGATGATCCAGATCCCCTGCATCGTCATGGCCGGATCCGATCTGGCTTCCGT
CGAGGAAGTGGCTGCCACCGGCGCCGAGTTCGTCGCGTTGTCGAGCGCGGTGTTCGCCGACGGTGTCGATCCGAAAACGG
CCGTGGCCCGAGCCAACGCATTGCTCGACGAAACCGCGCCGCGCTTCGAGGACTGA

Upstream 100 bases:

>100_bases
AGCCGGTCAAGTAAGGCAGGCACTCCGGCCGCCCCGGCGGTCAGGAAAAGCGATCCCGACTGCCCGCCTGTTCAAAGCGG
GCAGTTTGCTCTATGCCGCA

Downstream 100 bases:

>100_bases
TGTGGCTCCGGTAAGGCTTCCCCTTCAGGCCTTGCTTGCAGCGGTCATGATCCAGACCGCCGCCGCCGAAACCATACCCT
TGCCGCCGCCCATGCCTGAA

Product: thiamine-phosphate pyrophosphorylase

Products: NA

Alternate protein names: TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MQPSSPGIGETRDRRTMNDATPPNRCRIVLIAPPGVPAARIATAFDGGDVASLILPENGMDEASFQAFAEQIVPTAQAAG
VAVIIAGDTRIAGRVQADGIHVETSKAELAETIEHFQAKMMVGAGGAKKRDDALELGEVRPDYIFFGRFGYDNKPEPHPR
NLSLGEWWAQMIQIPCIVMAGSDLASVEEVAATGAEFVALSSAVFADGVDPKTAVARANALLDETAPRFED

Sequences:

>Translated_231_residues
MQPSSPGIGETRDRRTMNDATPPNRCRIVLIAPPGVPAARIATAFDGGDVASLILPENGMDEASFQAFAEQIVPTAQAAG
VAVIIAGDTRIAGRVQADGIHVETSKAELAETIEHFQAKMMVGAGGAKKRDDALELGEVRPDYIFFGRFGYDNKPEPHPR
NLSLGEWWAQMIQIPCIVMAGSDLASVEEVAATGAEFVALSSAVFADGVDPKTAVARANALLDETAPRFED
>Mature_231_residues
MQPSSPGIGETRDRRTMNDATPPNRCRIVLIAPPGVPAARIATAFDGGDVASLILPENGMDEASFQAFAEQIVPTAQAAG
VAVIIAGDTRIAGRVQADGIHVETSKAELAETIEHFQAKMMVGAGGAKKRDDALELGEVRPDYIFFGRFGYDNKPEPHPR
NLSLGEWWAQMIQIPCIVMAGSDLASVEEVAATGAEFVALSSAVFADGVDPKTAVARANALLDETAPRFED

Specific function: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) [H]

COG id: COG0352

COG function: function code H; Thiamine monophosphate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TMP-PPase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF02581 TMP-TENI [H]

EC number: =2.5.1.3 [H]

Molecular weight: Translated: 24475; Mature: 24475

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPSSPGIGETRDRRTMNDATPPNRCRIVLIAPPGVPAARIATAFDGGDVASLILPENGM
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHEEECCCCCEEEEEECCCCC
DEASFQAFAEQIVPTAQAAGVAVIIAGDTRIAGRVQADGIHVETSKAELAETIEHFQAKM
CHHHHHHHHHHHCCCCCCCCEEEEEECCCEEECEEEECCEEEECHHHHHHHHHHHHHHHH
MVGAGGAKKRDDALELGEVRPDYIFFGRFGYDNKPEPHPRNLSLGEWWAQMIQIPCIVMA
EECCCCCCCCCCHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEE
GSDLASVEEVAATGAEFVALSSAVFADGVDPKTAVARANALLDETAPRFED
CCCHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQPSSPGIGETRDRRTMNDATPPNRCRIVLIAPPGVPAARIATAFDGGDVASLILPENGM
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHEEECCCCCEEEEEECCCCC
DEASFQAFAEQIVPTAQAAGVAVIIAGDTRIAGRVQADGIHVETSKAELAETIEHFQAKM
CHHHHHHHHHHHCCCCCCCCEEEEEECCCEEECEEEECCEEEECHHHHHHHHHHHHHHHH
MVGAGGAKKRDDALELGEVRPDYIFFGRFGYDNKPEPHPRNLSLGEWWAQMIQIPCIVMA
EECCCCCCCCCCHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEE
GSDLASVEEVAATGAEFVALSSAVFADGVDPKTAVARANALLDETAPRFED
CCCHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA