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The map label for this gene is ruvC

Identifier: 13473342

GI number: 13473342

Start: 3134818

End: 3135327

Strand: Reverse

Name: ruvC

Synonym: mll3901

Alternate gene names: 13473342

Gene position: 3135327-3134818 (Counterclockwise)

Preceding gene: 13473343

Following gene: 13473341

Centisome position: 44.56

GC content: 65.1

Gene sequence:

>510_bases
ATGGGGGACGCGATTCGCATCATCGGCATCGATCCGGGGCTCAGGCGCACCGGCTGGGGCATCGTCGAGAGCCTCGGCAA
TTCCTTGCGCTTCGTCGCGTCCGGCACCGTGCGCTCCGAGGACAAGGCGGCGCTGGCGACGCGGCTCTGCCAATTGCATG
ACGGGCTCGCCGAAGTCCTGCATGCAGCAATGCCGCATGAGGCGGCCGTCGAACAGACTTTCGTCAACAAGGATGCCGTG
GCAACATTGAAGCTCGGCCAGGCGCGCGGCATCGCCATGCTGGTGCCGGCGCGTGCCGGCCTTGTCGTCGCCGAATATGC
ACCCAATGCGGTGAAGAAGGCGGTCATCGGCGTCGGCCATGGCGACAAGAAGCAGATCCACATGATGGTGAAGGTGCTGC
TGCCGAAAGCGACCTTCGACACCGAACACGCCGCCGACGCGCTGGCTATCGCGATTTGCCACGCGCATCACCGCCAGAGC
GCTGCCTACCGGATGGCGCTTGCCGGATAA

Upstream 100 bases:

>100_bases
CAACTGAGCGGCTTCGGACTATTTCCGGTTCGATAGGCCTCCGTTTCCGGTTTGTTCACATTTCGCTGGCATCGCTGTCC
CCCGGAGGTAAAGTGACCGG

Downstream 100 bases:

>100_bases
CGATGTTCTTGACTTGTTCACGTTGTGAGGATAAGTAATACCATAGAGGTATTACCATGCGCGTGACCACCAAAGGGCAA
GTGACAATCCCCAAACCGAT

Product: Holliday junction resolvase

Products: NA

Alternate protein names: Holliday junction nuclease ruvC; Holliday junction resolvase ruvC

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MGDAIRIIGIDPGLRRTGWGIVESLGNSLRFVASGTVRSEDKAALATRLCQLHDGLAEVLHAAMPHEAAVEQTFVNKDAV
ATLKLGQARGIAMLVPARAGLVVAEYAPNAVKKAVIGVGHGDKKQIHMMVKVLLPKATFDTEHAADALAIAICHAHHRQS
AAYRMALAG

Sequences:

>Translated_169_residues
MGDAIRIIGIDPGLRRTGWGIVESLGNSLRFVASGTVRSEDKAALATRLCQLHDGLAEVLHAAMPHEAAVEQTFVNKDAV
ATLKLGQARGIAMLVPARAGLVVAEYAPNAVKKAVIGVGHGDKKQIHMMVKVLLPKATFDTEHAADALAIAICHAHHRQS
AAYRMALAG
>Mature_168_residues
GDAIRIIGIDPGLRRTGWGIVESLGNSLRFVASGTVRSEDKAALATRLCQLHDGLAEVLHAAMPHEAAVEQTFVNKDAVA
TLKLGQARGIAMLVPARAGLVVAEYAPNAVKKAVIGVGHGDKKQIHMMVKVLLPKATFDTEHAADALAIAICHAHHRQSA
AYRMALAG

Specific function: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leav

COG id: COG0817

COG function: function code L; Holliday junction resolvasome, endonuclease subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvC family

Homologues:

Organism=Escherichia coli, GI1788170, Length=155, Percent_Identity=41.9354838709677, Blast_Score=105, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVC_RHILO (Q98F72)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_104909.1
- ProteinModelPortal:   Q98F72
- SMR:   Q98F72
- GeneID:   1227570
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll3901
- NMPDR:   fig|266835.1.peg.3013
- HOGENOM:   HBG437552
- OMA:   RTGWGVI
- ProtClustDB:   PRK00039
- BRENDA:   3.1.22.4
- HAMAP:   MF_00034
- InterPro:   IPR012337
- InterPro:   IPR002176
- PRINTS:   PR00696
- TIGRFAMs:   TIGR00228

Pfam domain/function: PF02075 RuvC; SSF53098 RNaseH_fold

EC number: =3.1.22.4

Molecular weight: Translated: 17840; Mature: 17709

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS01321 RUVC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDAIRIIGIDPGLRRTGWGIVESLGNSLRFVASGTVRSEDKAALATRLCQLHDGLAEVL
CCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
HAAMPHEAAVEQTFVNKDAVATLKLGQARGIAMLVPARAGLVVAEYAPNAVKKAVIGVGH
HHHCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCEEEEECCCHHHHHHHEECCC
GDKKQIHMMVKVLLPKATFDTEHAADALAIAICHAHHRQSAAYRMALAG
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure 
GDAIRIIGIDPGLRRTGWGIVESLGNSLRFVASGTVRSEDKAALATRLCQLHDGLAEVL
CCEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
HAAMPHEAAVEQTFVNKDAVATLKLGQARGIAMLVPARAGLVVAEYAPNAVKKAVIGVGH
HHHCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCEEEEECCCHHHHHHHEECCC
GDKKQIHMMVKVLLPKATFDTEHAADALAIAICHAHHRQSAAYRMALAG
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968