Click here to switch to the map view.

The map label for this gene is ilvX [H]

Identifier: 13473079

GI number: 13473079

Start: 2874762

End: 2876315

Strand: Reverse

Name: ilvX [H]

Synonym: mll3567

Alternate gene names: 13473079

Gene position: 2876315-2874762 (Counterclockwise)

Preceding gene: 13473080

Following gene: 13473077

Centisome position: 40.88

GC content: 67.25

Gene sequence:

>1554_bases
ATGAATGGCGCCGATGTCCTGTGCGACGTGCTGCTGGCCAATGATGTGACGGTCTGCTTCGCCAATCCCGGCACCTCCGA
AATGCACTTCGTCGCCGCACTCGACCGCAAGCCTGAGATGCGCTGCGTGCTCGGCCTGTTCGAGGGCGTGGTGACGGGCG
CCGCCGACGGCTATGCGCGCATGACCGACCGCCCGGCCGCGACTTTGCTGCATACCGGCCCGGGCCTGGCCAATGGGCTG
GCCAACATGCACAACGCCCGGCGTGCGTTCAGCCCGATGATCAACATCGTCGGCGACCACGCCTCCTATCATTTGCCGCT
CGACGCACCGCTGACCAGCGACATCGAGGGTTTGGCGGCGCCGATGTCCAACTGGGTGCGGCGCATTGCCGGGCCAGAAG
ACGTCCAACCGGCAGCGGAGGCGGCTTTCCGCGCCTCGCTGACGCCGCCAGGTGTCACCACGCTGATCCTGCCGGCGGAT
GCGGCCTGGGGCGATGCTGCCCCGGCCTCGCCGGGCAAGGTCGTGCTTCCGCCGCCGCCGGCCGTCGATAGGGACGCCGT
GCGCGAGGTCGCCTCGGCGATCCGTGCGGCTCAGGGGCGTGTCGGCATAATCGTTCGCGGCCGAGCGGCGCGCGCCGATG
CGCTCGAGATCGCCGGCCAGATTTCGACGGCCTTCGATGTCCGCCTGTTCGGCGAGGTCCTGATCGCCCGGATGCAACGC
GGGCGTGGGCGCGTCGCACCCACACGCATCCCCTATCCGATCGATGTGGCGACGGCGCTGCTGGCAGATATCGACGTACT
GGTGCTGGTCGGCGGCAAGGAGCCGGTTGCCTTCTTCGCCTATCCGGGAAAACCGGGACGGCTTGTGCGCGACGACTGCC
AGGTGCTGACGCTCGCTGCTCATGGCGATGATCTGCATGCGGCGCTGGAAGCGCTGCGCGACGAACTCGGCGTCAAACCA
TCGCTACAGGCTGACTTCGCAACCGCTTTTCCCGACGAGGCTGCGCCGAGCGGCGGGCTGACGGACGATGCCATCGCGCT
GTCGGTGGCGCGCAAGTTGCCGGATAATGCGATCGTCTGCGACGAGGCGGTCACCTCGGCCAGGCGTTTCTTCGCCCTGT
CGGCCTTTGCCGCGCCGCATGATTACATGATGGGCACCGGCGGATCGATCGGCGGCGGCATTCCGATGGCGACAGGAGCG
GCGATCGCGTGTCCAGACCGCAAGGTGATCAATCTGGAGGCCGACGGCAGCGGCATGTACACGGTGCAGGGCCTGTGGAC
GCAAGCGCGGGAAAATCTCGACGTGGTGACCATCGTCTTTTCCAACCGCACCTACGCGATCCTGCATGGCGAGATGAAGA
ATGTCGGCGTCAACGCGATCGGCGAGAACGCCAGGCGCATGCTCGACCTCGACCATCCCGCGCTGGACTGGGTGTCGCTG
GCCAAGGGCATGGGCGTGGAGGCAGCGCGCGCCGACACATGCGAACGCTTCGATGCGCTGCTGGACAGTGCCCTGTCGCG
GCGCGGGCCGTTCCTGATCGAAGCAGTGATCTGA

Upstream 100 bases:

>100_bases
GCCCCCTTCTGCAACTGGATCATGCCAAAAGCAGCGGCAGGATATTGCCGTGCGGACATCGCTAGGTGCAATTGGTTCTC
ATGACTTGGAGAAAAATTGC

Downstream 100 bases:

>100_bases
CCGCGCCTCGGAGGGGCAGGGCGGACTGACCTTACCAGCGGGTCTTTTCGCCGGGCGCCGATGGTTCGATCGCCAGCGCG
TGCACGCCGGCCTTCAGTTC

Product: hypothetical protein

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase large subunit; AHAS [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MNGADVLCDVLLANDVTVCFANPGTSEMHFVAALDRKPEMRCVLGLFEGVVTGAADGYARMTDRPAATLLHTGPGLANGL
ANMHNARRAFSPMINIVGDHASYHLPLDAPLTSDIEGLAAPMSNWVRRIAGPEDVQPAAEAAFRASLTPPGVTTLILPAD
AAWGDAAPASPGKVVLPPPPAVDRDAVREVASAIRAAQGRVGIIVRGRAARADALEIAGQISTAFDVRLFGEVLIARMQR
GRGRVAPTRIPYPIDVATALLADIDVLVLVGGKEPVAFFAYPGKPGRLVRDDCQVLTLAAHGDDLHAALEALRDELGVKP
SLQADFATAFPDEAAPSGGLTDDAIALSVARKLPDNAIVCDEAVTSARRFFALSAFAAPHDYMMGTGGSIGGGIPMATGA
AIACPDRKVINLEADGSGMYTVQGLWTQARENLDVVTIVFSNRTYAILHGEMKNVGVNAIGENARRMLDLDHPALDWVSL
AKGMGVEAARADTCERFDALLDSALSRRGPFLIEAVI

Sequences:

>Translated_517_residues
MNGADVLCDVLLANDVTVCFANPGTSEMHFVAALDRKPEMRCVLGLFEGVVTGAADGYARMTDRPAATLLHTGPGLANGL
ANMHNARRAFSPMINIVGDHASYHLPLDAPLTSDIEGLAAPMSNWVRRIAGPEDVQPAAEAAFRASLTPPGVTTLILPAD
AAWGDAAPASPGKVVLPPPPAVDRDAVREVASAIRAAQGRVGIIVRGRAARADALEIAGQISTAFDVRLFGEVLIARMQR
GRGRVAPTRIPYPIDVATALLADIDVLVLVGGKEPVAFFAYPGKPGRLVRDDCQVLTLAAHGDDLHAALEALRDELGVKP
SLQADFATAFPDEAAPSGGLTDDAIALSVARKLPDNAIVCDEAVTSARRFFALSAFAAPHDYMMGTGGSIGGGIPMATGA
AIACPDRKVINLEADGSGMYTVQGLWTQARENLDVVTIVFSNRTYAILHGEMKNVGVNAIGENARRMLDLDHPALDWVSL
AKGMGVEAARADTCERFDALLDSALSRRGPFLIEAVI
>Mature_517_residues
MNGADVLCDVLLANDVTVCFANPGTSEMHFVAALDRKPEMRCVLGLFEGVVTGAADGYARMTDRPAATLLHTGPGLANGL
ANMHNARRAFSPMINIVGDHASYHLPLDAPLTSDIEGLAAPMSNWVRRIAGPEDVQPAAEAAFRASLTPPGVTTLILPAD
AAWGDAAPASPGKVVLPPPPAVDRDAVREVASAIRAAQGRVGIIVRGRAARADALEIAGQISTAFDVRLFGEVLIARMQR
GRGRVAPTRIPYPIDVATALLADIDVLVLVGGKEPVAFFAYPGKPGRLVRDDCQVLTLAAHGDDLHAALEALRDELGVKP
SLQADFATAFPDEAAPSGGLTDDAIALSVARKLPDNAIVCDEAVTSARRFFALSAFAAPHDYMMGTGGSIGGGIPMATGA
AIACPDRKVINLEADGSGMYTVQGLWTQARENLDVVTIVFSNRTYAILHGEMKNVGVNAIGENARRMLDLDHPALDWVSL
AKGMGVEAARADTCERFDALLDSALSRRGPFLIEAVI

Specific function: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1790104, Length=548, Percent_Identity=23.9051094890511, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787096, Length=481, Percent_Identity=22.4532224532225, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 54297; Mature: 54297

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGADVLCDVLLANDVTVCFANPGTSEMHFVAALDRKPEMRCVLGLFEGVVTGAADGYAR
CCCHHHHHHHHHHCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHH
MTDRPAATLLHTGPGLANGLANMHNARRAFSPMINIVGDHASYHLPLDAPLTSDIEGLAA
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHH
PMSNWVRRIAGPEDVQPAAEAAFRASLTPPGVTTLILPADAAWGDAAPASPGKVVLPPPP
HHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCC
AVDRDAVREVASAIRAAQGRVGIIVRGRAARADALEIAGQISTAFDVRLFGEVLIARMQR
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRGRVAPTRIPYPIDVATALLADIDVLVLVGGKEPVAFFAYPGKPGRLVRDDCQVLTLAA
CCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCEECCCCEEEEEEE
HGDDLHAALEALRDELGVKPSLQADFATAFPDEAAPSGGLTDDAIALSVARKLPDNAIVC
CCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEE
DEAVTSARRFFALSAFAAPHDYMMGTGGSIGGGIPMATGAAIACPDRKVINLEADGSGMY
HHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCCEE
TVQGLWTQARENLDVVTIVFSNRTYAILHGEMKNVGVNAIGENARRMLDLDHPALDWVSL
EEHHHHHHHHCCCCEEEEEECCCEEEEEECCHHHCCCCHHCHHHHHHCCCCCCHHHHHHH
AKGMGVEAARADTCERFDALLDSALSRRGPFLIEAVI
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
>Mature Secondary Structure
MNGADVLCDVLLANDVTVCFANPGTSEMHFVAALDRKPEMRCVLGLFEGVVTGAADGYAR
CCCHHHHHHHHHHCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHH
MTDRPAATLLHTGPGLANGLANMHNARRAFSPMINIVGDHASYHLPLDAPLTSDIEGLAA
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHH
PMSNWVRRIAGPEDVQPAAEAAFRASLTPPGVTTLILPADAAWGDAAPASPGKVVLPPPP
HHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCC
AVDRDAVREVASAIRAAQGRVGIIVRGRAARADALEIAGQISTAFDVRLFGEVLIARMQR
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRGRVAPTRIPYPIDVATALLADIDVLVLVGGKEPVAFFAYPGKPGRLVRDDCQVLTLAA
CCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCEECCCCEEEEEEE
HGDDLHAALEALRDELGVKPSLQADFATAFPDEAAPSGGLTDDAIALSVARKLPDNAIVC
CCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEE
DEAVTSARRFFALSAFAAPHDYMMGTGGSIGGGIPMATGAAIACPDRKVINLEADGSGMY
HHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCCEE
TVQGLWTQARENLDVVTIVFSNRTYAILHGEMKNVGVNAIGENARRMLDLDHPALDWVSL
EEHHHHHHHHCCCCEEEEEECCCEEEEEECCHHHCCCCHHCHHHHHHCCCCCCHHHHHHH
AKGMGVEAARADTCERFDALLDSALSRRGPFLIEAVI
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]