Click here to switch to the map view.

The map label for this gene is cobS [H]

Identifier: 13473076

GI number: 13473076

Start: 2872530

End: 2873624

Strand: Reverse

Name: cobS [H]

Synonym: mll3563

Alternate gene names: 13473076

Gene position: 2873624-2872530 (Counterclockwise)

Preceding gene: 13473077

Following gene: 13473075

Centisome position: 40.84

GC content: 60.73

Gene sequence:

>1095_bases
GTGTCGCTTTCCAACTTTCATAAGGTTGGAAAAGGCTCTAAGACCGCCCCCGAACAAAATCGATTGCCGGCGAAACGGGA
CGTTTCGCCCGTGGAGACGTTGAGAGATATGAACAAGGTCGATCGCGACATCGCCAACCTGCCCGACACGACGGTGTCGG
TGAAGGACAAATTCGGCTTCGACTCCAAGATGGTGGTGCCGGCCTATTCGGTGACATCAGAACATGTGCCTGACGTCGAT
CCGGACTATCTGTTCGACAAGGCAACGACGCTGGCGATCCTGGCCGGCTTTGCCTACAATCGCCGCGTCATGGTGTCGGG
CTATCACGGCACCGGCAAGTCGACCCATATCGAACAGGTCGCCGCCCGTCTCAATTGGCCCTGCGTGCGCGTCAACCTCG
ACAGCCATGTCAGCCGTATCGACCTCGTCGGCAAGGACGCGATCGTGGTCAAGGACGGCTTGCAGATCACCGAATTCCGC
GACGGCATCCTGCCCTGGGCCTACCAGCACAATGTCGCGCTGTGCTTCGACGAATATGATGCCGGCCGCCCGGATGTGAT
GTTCGTCATCCAGCGCGTGCTGGAATCCTCGGGCCGGCTGACGCTGCTCGACCAGAGCCGGGTCATCCGTCCGCATCCGG
CGTTCCGGCTGTTCTCGACCGCCAACACGGTCGGACTCGGCGACACGACCGGCCTTTATCACGGCACGCAGCAGATCAAC
CAGGCGCAGATGGACCGCTGGTCGATCGTCACCACGCTGAACTATCTGCCGCACGACAATGAAGTGAACATCGTGCTGGC
CAAGGCCAAGCACTATCGCGACACCAAGGGCAAGGACATCGTCAACAAGATGGTGCGCGTCGCCGACATGACGCGCTCGG
CCTTCATCAATGGCGACCTGTCGACGGTGATGAGCCCGCGTACGGTCATCACCTGGGCCGAGAACGCAGAGATCTTCGGC
AATATCGGTATGGCGTTCCGGCTGACCTTCCTCAACAAGTGCGACGAGCTGGAGCGTTCGGTGGTGGCCGAATTCTACCA
GCGCGCCTTCGGCGAGGATCTGCCCGAGAGCGCCGCCAACGTGGTGCTGGGGTAA

Upstream 100 bases:

>100_bases
GAATGGTGGCGACAGAGGTTCGGAAGACCGGTTCCGCGATGTGCTGCAGGCCTATCGCGTGCTCAAACAGGCGGGCCTGT
GCTGAGCGACCCTACGGTTT

Downstream 100 bases:

>100_bases
CATCACTCAATGGGAACAACCCGTCGGACGTTCCTGTGGAGTTTTTCAATCCTCTGCTTTGGTTTCGGACAGGCAGCCAT
GGCCAAGGACGAACCATTCA

Product: cobS protein

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobS [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSLSNFHKVGKGSKTAPEQNRLPAKRDVSPVETLRDMNKVDRDIANLPDTTVSVKDKFGFDSKMVVPAYSVTSEHVPDVD
PDYLFDKATTLAILAGFAYNRRVMVSGYHGTGKSTHIEQVAARLNWPCVRVNLDSHVSRIDLVGKDAIVVKDGLQITEFR
DGILPWAYQHNVALCFDEYDAGRPDVMFVIQRVLESSGRLTLLDQSRVIRPHPAFRLFSTANTVGLGDTTGLYHGTQQIN
QAQMDRWSIVTTLNYLPHDNEVNIVLAKAKHYRDTKGKDIVNKMVRVADMTRSAFINGDLSTVMSPRTVITWAENAEIFG
NIGMAFRLTFLNKCDELERSVVAEFYQRAFGEDLPESAANVVLG

Sequences:

>Translated_364_residues
MSLSNFHKVGKGSKTAPEQNRLPAKRDVSPVETLRDMNKVDRDIANLPDTTVSVKDKFGFDSKMVVPAYSVTSEHVPDVD
PDYLFDKATTLAILAGFAYNRRVMVSGYHGTGKSTHIEQVAARLNWPCVRVNLDSHVSRIDLVGKDAIVVKDGLQITEFR
DGILPWAYQHNVALCFDEYDAGRPDVMFVIQRVLESSGRLTLLDQSRVIRPHPAFRLFSTANTVGLGDTTGLYHGTQQIN
QAQMDRWSIVTTLNYLPHDNEVNIVLAKAKHYRDTKGKDIVNKMVRVADMTRSAFINGDLSTVMSPRTVITWAENAEIFG
NIGMAFRLTFLNKCDELERSVVAEFYQRAFGEDLPESAANVVLG
>Mature_363_residues
SLSNFHKVGKGSKTAPEQNRLPAKRDVSPVETLRDMNKVDRDIANLPDTTVSVKDKFGFDSKMVVPAYSVTSEHVPDVDP
DYLFDKATTLAILAGFAYNRRVMVSGYHGTGKSTHIEQVAARLNWPCVRVNLDSHVSRIDLVGKDAIVVKDGLQITEFRD
GILPWAYQHNVALCFDEYDAGRPDVMFVIQRVLESSGRLTLLDQSRVIRPHPAFRLFSTANTVGLGDTTGLYHGTQQINQ
AQMDRWSIVTTLNYLPHDNEVNIVLAKAKHYRDTKGKDIVNKMVRVADMTRSAFINGDLSTVMSPRTVITWAENAEIFGN
IGMAFRLTFLNKCDELERSVVAEFYQRAFGEDLPESAANVVLG

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG0714

COG function: function code R; MoxR-like ATPases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24415404, Length=244, Percent_Identity=23.3606557377049, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161076560, Length=185, Percent_Identity=25.9459459459459, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161076562, Length=185, Percent_Identity=25.9459459459459, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011704
- InterPro:   IPR006537 [H]

Pfam domain/function: PF07728 AAA_5 [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 40667; Mature: 40536

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSNFHKVGKGSKTAPEQNRLPAKRDVSPVETLRDMNKVDRDIANLPDTTVSVKDKFGF
CCCHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
DSKMVVPAYSVTSEHVPDVDPDYLFDKATTLAILAGFAYNRRVMVSGYHGTGKSTHIEQV
CCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHH
AARLNWPCVRVNLDSHVSRIDLVGKDAIVVKDGLQITEFRDGILPWAYQHNVALCFDEYD
HHHCCCCEEEEEHHHCCCEEEECCCCEEEEECCCEEEHHHCCCCCEEECCCEEEEEECCC
AGRPDVMFVIQRVLESSGRLTLLDQSRVIRPHPAFRLFSTANTVGLGDTTGLYHGTQQIN
CCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHCCHHHHH
QAQMDRWSIVTTLNYLPHDNEVNIVLAKAKHYRDTKGKDIVNKMVRVADMTRSAFINGDL
HHHHHHHEEEEEEECCCCCCCEEEEEEECHHCCCCCCHHHHHHHHHHHHHHHHHEECCCH
STVMSPRTVITWAENAEIFGNIGMAFRLTFLNKCDELERSVVAEFYQRAFGEDLPESAAN
HHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VVLG
CCCC
>Mature Secondary Structure 
SLSNFHKVGKGSKTAPEQNRLPAKRDVSPVETLRDMNKVDRDIANLPDTTVSVKDKFGF
CCHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
DSKMVVPAYSVTSEHVPDVDPDYLFDKATTLAILAGFAYNRRVMVSGYHGTGKSTHIEQV
CCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHH
AARLNWPCVRVNLDSHVSRIDLVGKDAIVVKDGLQITEFRDGILPWAYQHNVALCFDEYD
HHHCCCCEEEEEHHHCCCEEEECCCCEEEEECCCEEEHHHCCCCCEEECCCEEEEEECCC
AGRPDVMFVIQRVLESSGRLTLLDQSRVIRPHPAFRLFSTANTVGLGDTTGLYHGTQQIN
CCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHCCHHHHH
QAQMDRWSIVTTLNYLPHDNEVNIVLAKAKHYRDTKGKDIVNKMVRVADMTRSAFINGDL
HHHHHHHEEEEEEECCCCCCCEEEEEEECHHCCCCCCHHHHHHHHHHHHHHHHHEECCCH
STVMSPRTVITWAENAEIFGNIGMAFRLTFLNKCDELERSVVAEFYQRAFGEDLPESAAN
HHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VVLG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]