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The map label for this gene is hpt [H]

Identifier: 13473038

GI number: 13473038

Start: 2839857

End: 2840399

Strand: Reverse

Name: hpt [H]

Synonym: mll3520

Alternate gene names: 13473038

Gene position: 2840399-2839857 (Counterclockwise)

Preceding gene: 13473039

Following gene: 82791994

Centisome position: 40.37

GC content: 61.69

Gene sequence:

>543_bases
ATGCCAATCGTACGCGACAAGGACATCGAAGTCCTGTTTTCAGCGTCGGCAATCGCGCGGCGCAATCTCGAGCTCGCCAA
GGAGATCGCCGGGCACGACTATCACGATCTGCTGGTGATTTCGGTGCTGAAGGGCTCGTTCATCTTCGCCGCCGACCTGA
TTCGCGCCATGCATGATGTCGGCCTGTCGCCCGAGGTCGAGTTCATCTTCATTTCCAGCTATGGCGCCGGCACCACCAGC
GGCGAGGTGAGGGTGCTGCGCGACATCGACAATGAGGTCGCCGGCCGTGACGTGCTGCTGATCGACGACATTCTGGAGTC
GGGTAAGACACTGACCTTCACCCGCGACCTGATGCTGTCGCGCGGCGCGAAAAGCTGTTCCATCGCCGTGCTGCTCGACA
AGCGCATGCGCCGCCAGACGGCGCTGGTCGCCGACTATGTCGGCTTCGACTGCCCCGATTATTTCGTCGTCGGTTACGGC
ATGGACGTCGCGCACGCCTTCCGCGAATTGCCGTTCGTGGGTGTCGTGAAAGGCGATGCGTGA

Upstream 100 bases:

>100_bases
GGTTCTCGGAAACCACCGTTTTCGGCTCGGCCTGACCTGAATCTCAACACACGCTCGGTGTGAAGGCGTTTGGGTAAAAA
AAACTTGAGGGGGCGAAAAA

Downstream 100 bases:

>100_bases
GGCCACGGCCTTGCGCCGACAAGTTCTGAAAAAGCCCTTAACGGCGCCGGAAAAATAGCCCGGTCAGGGGCTGGGTGCTT
TCAGGAAAAGTCAACTTTTC

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MPIVRDKDIEVLFSASAIARRNLELAKEIAGHDYHDLLVISVLKGSFIFAADLIRAMHDVGLSPEVEFIFISSYGAGTTS
GEVRVLRDIDNEVAGRDVLLIDDILESGKTLTFTRDLMLSRGAKSCSIAVLLDKRMRRQTALVADYVGFDCPDYFVVGYG
MDVAHAFRELPFVGVVKGDA

Sequences:

>Translated_180_residues
MPIVRDKDIEVLFSASAIARRNLELAKEIAGHDYHDLLVISVLKGSFIFAADLIRAMHDVGLSPEVEFIFISSYGAGTTS
GEVRVLRDIDNEVAGRDVLLIDDILESGKTLTFTRDLMLSRGAKSCSIAVLLDKRMRRQTALVADYVGFDCPDYFVVGYG
MDVAHAFRELPFVGVVKGDA
>Mature_179_residues
PIVRDKDIEVLFSASAIARRNLELAKEIAGHDYHDLLVISVLKGSFIFAADLIRAMHDVGLSPEVEFIFISSYGAGTTSG
EVRVLRDIDNEVAGRDVLLIDDILESGKTLTFTRDLMLSRGAKSCSIAVLLDKRMRRQTALVADYVGFDCPDYFVVGYGM
DVAHAFRELPFVGVVKGDA

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=160, Percent_Identity=35, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI9910262, Length=179, Percent_Identity=32.4022346368715, Blast_Score=90, Evalue=1e-18,
Organism=Escherichia coli, GI87081689, Length=172, Percent_Identity=40.6976744186046, Blast_Score=137, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17510817, Length=184, Percent_Identity=32.6086956521739, Blast_Score=89, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19786; Mature: 19655

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIVRDKDIEVLFSASAIARRNLELAKEIAGHDYHDLLVISVLKGSFIFAADLIRAMHDV
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHC
GLSPEVEFIFISSYGAGTTSGEVRVLRDIDNEVAGRDVLLIDDILESGKTLTFTRDLMLS
CCCCCEEEEEEECCCCCCCCCCEEEEECCCHHHCCCEEEEEHHHHHCCCEEEEEHHHHHH
RGAKSCSIAVLLDKRMRRQTALVADYVGFDCPDYFVVGYGMDVAHAFRELPFVGVVKGDA
CCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCEEEEEECCC
>Mature Secondary Structure 
PIVRDKDIEVLFSASAIARRNLELAKEIAGHDYHDLLVISVLKGSFIFAADLIRAMHDV
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHC
GLSPEVEFIFISSYGAGTTSGEVRVLRDIDNEVAGRDVLLIDDILESGKTLTFTRDLMLS
CCCCCEEEEEEECCCCCCCCCCEEEEECCCHHHCCCEEEEEHHHHHCCCEEEEEHHHHHH
RGAKSCSIAVLLDKRMRRQTALVADYVGFDCPDYFVVGYGMDVAHAFRELPFVGVVKGDA
CCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]