Click here to switch to the map view.

The map label for this gene is lysC [H]

Identifier: 13472972

GI number: 13472972

Start: 2774591

End: 2775844

Strand: Reverse

Name: lysC [H]

Synonym: mll3437

Alternate gene names: 13472972

Gene position: 2775844-2774591 (Counterclockwise)

Preceding gene: 13472973

Following gene: 13472971

Centisome position: 39.45

GC content: 63.88

Gene sequence:

>1254_bases
ATGGCGCGTATCGTGATGAAATTCGGCGGAACCTCCGTCGCCGACATCGCCCGCATCCGCAATGTGGCGCGTCACGTCAA
ACGCGAGGTCGACGCCGGCCATGAGGTGGCGGTGGTGGTTTCGGCGATGGCCGGCAAGACCAACGAGCTGGTCGGCTGGA
CGCGCGAGGCCTCGCCGATGCACGACGCACGCGAATATGACGCGGTGGTCGCTTCCGGCGAACAGGTCACCGCCGGTCTG
CTCGCCATCACCTTGCAGAACATGGGCGTGCATGCCCGGTCCTGGCAGGGCTGGCAGATCCCGATCAAGACCGACAATGC
ACATGGCGCGGCGCGCATCCTCGACATTGACGGCGCCTTCCTGATCAAGCGTTTCGGCGAGGGCCAGGTGGCCGTCATCG
CCGGCTTCCAGGGCATCGGGCCGGACAATCGCATCGCGACCCTCGGCCGCGGCGGTTCCGACACCAGCGCGGTCGCCATC
GCCGCGGCGGTCAAGGCCGATCGCTGCGACATCTACACCGACGTCGACGGGGTCTACACCACCGATCCGCGCATCGAGCC
CAAGGCGCGGCGGCTGGCCAAGATCTCTTTCGAGGAAATGCTTGAAATGGCCTCGCTCGGCGCCAAGGTTCTGCAGGTGC
GTTCGGTCGAGCTTGCCATGGTGCACAGGGTGCGTACCTTCGTGCGGTCGTCCTTCGACGATCCCGATGCGCCCGGAATG
GGGGATTTGCTCAATCCTCCGGGAACGCTCATTTGCGACGAGGAAGAGATCGTGGAACAGCAGGTCGTCACCGGAATTGC
CTACGCCAAGGACGAGGCCCAGATTTCGCTGCGCCGCGTCGGCGACCGCCCTGGCGTCGCCGCCGGCATTTTCGGGCCGC
TGGCCGAAGCCAACATCAATGTCGACATGATCGTCCAGAACATCTCCGAGGACGGCAAGTTCACCGACATGACCTTCACC
GTGCCTTCGGGTGACGTCGACAAGGCGCTGGCCGTGCTCGACCGGCTGAAGGCCGAGGTCGGCTATGATGTCGTGCAGTC
GGAAGCCGGCATGTCGAAGGTTTCGGTCATCGGCATCGGCATGAGGAGCCACGCCGGTGTCGCCGCCACCGCTTTCAAGG
CACTGGCCGACAAGGCGATCAATATCCGCGCCATCACCACCTCCGAGATCAAGATTTCGATACTGATCGACGGTCCGTAC
ACCGAACTTGCGGTTCGCACTTTGCATTCCGTCTACGGTCTGGATAAGCAGTAG

Upstream 100 bases:

>100_bases
ATTTGGCTAAGGAGGCCGCGCATTCAGCGGCCGGCGCCAGCCGGGCGCTTTCCTTCGTTTTCGGCTTCAGGCCGGCTTCA
GTCAAAGGCATTTCGCTTCC

Downstream 100 bases:

>100_bases
CAAGACTGAATCAGTTGTTGCGCGCATGCCGGCAGCGGCGGAAACTGCGCCGGCAAGTGTTTCATTGGAGAAGAAGCCGC
GATGCGTGACCAGGCCAGTG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MARIVMKFGGTSVADIARIRNVARHVKREVDAGHEVAVVVSAMAGKTNELVGWTREASPMHDAREYDAVVASGEQVTAGL
LAITLQNMGVHARSWQGWQIPIKTDNAHGAARILDIDGAFLIKRFGEGQVAVIAGFQGIGPDNRIATLGRGGSDTSAVAI
AAAVKADRCDIYTDVDGVYTTDPRIEPKARRLAKISFEEMLEMASLGAKVLQVRSVELAMVHRVRTFVRSSFDDPDAPGM
GDLLNPPGTLICDEEEIVEQQVVTGIAYAKDEAQISLRRVGDRPGVAAGIFGPLAEANINVDMIVQNISEDGKFTDMTFT
VPSGDVDKALAVLDRLKAEVGYDVVQSEAGMSKVSVIGIGMRSHAGVAATAFKALADKAINIRAITTSEIKISILIDGPY
TELAVRTLHSVYGLDKQ

Sequences:

>Translated_417_residues
MARIVMKFGGTSVADIARIRNVARHVKREVDAGHEVAVVVSAMAGKTNELVGWTREASPMHDAREYDAVVASGEQVTAGL
LAITLQNMGVHARSWQGWQIPIKTDNAHGAARILDIDGAFLIKRFGEGQVAVIAGFQGIGPDNRIATLGRGGSDTSAVAI
AAAVKADRCDIYTDVDGVYTTDPRIEPKARRLAKISFEEMLEMASLGAKVLQVRSVELAMVHRVRTFVRSSFDDPDAPGM
GDLLNPPGTLICDEEEIVEQQVVTGIAYAKDEAQISLRRVGDRPGVAAGIFGPLAEANINVDMIVQNISEDGKFTDMTFT
VPSGDVDKALAVLDRLKAEVGYDVVQSEAGMSKVSVIGIGMRSHAGVAATAFKALADKAINIRAITTSEIKISILIDGPY
TELAVRTLHSVYGLDKQ
>Mature_416_residues
ARIVMKFGGTSVADIARIRNVARHVKREVDAGHEVAVVVSAMAGKTNELVGWTREASPMHDAREYDAVVASGEQVTAGLL
AITLQNMGVHARSWQGWQIPIKTDNAHGAARILDIDGAFLIKRFGEGQVAVIAGFQGIGPDNRIATLGRGGSDTSAVAIA
AAVKADRCDIYTDVDGVYTTDPRIEPKARRLAKISFEEMLEMASLGAKVLQVRSVELAMVHRVRTFVRSSFDDPDAPGMG
DLLNPPGTLICDEEEIVEQQVVTGIAYAKDEAQISLRRVGDRPGVAAGIFGPLAEANINVDMIVQNISEDGKFTDMTFTV
PSGDVDKALAVLDRLKAEVGYDVVQSEAGMSKVSVIGIGMRSHAGVAATAFKALADKAINIRAITTSEIKISILIDGPYT
ELAVRTLHSVYGLDKQ

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=299, Percent_Identity=33.7792642140468, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1790455, Length=464, Percent_Identity=29.3103448275862, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790376, Length=482, Percent_Identity=23.6514522821577, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320893, Length=374, Percent_Identity=25.668449197861, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44549; Mature: 44418

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIVMKFGGTSVADIARIRNVARHVKREVDAGHEVAVVVSAMAGKTNELVGWTREASPM
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCHHEEECCCCCCC
HDAREYDAVVASGEQVTAGLLAITLQNMGVHARSWQGWQIPIKTDNAHGAARILDIDGAF
HHHHHHHHHHCCCCHHHHHHEEEEHHHCCCEEECCCCCEEEEEECCCCCCEEEEECCCHH
LIKRFGEGQVAVIAGFQGIGPDNRIATLGRGGSDTSAVAIAAAVKADRCDIYTDVDGVYT
HHHHCCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHEEEEEHHCCCCCCEEECCCCEEE
TDPRIEPKARRLAKISFEEMLEMASLGAKVLQVRSVELAMVHRVRTFVRSSFDDPDAPGM
CCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GDLLNPPGTLICDEEEIVEQQVVTGIAYAKDEAQISLRRVGDRPGVAAGIFGPLAEANIN
CCCCCCCCCEEECHHHHHHHHHHHHHHEECCCHHEEEECCCCCCCEEHHHHCCHHHCCCC
VDMIVQNISEDGKFTDMTFTVPSGDVDKALAVLDRLKAEVGYDVVQSEAGMSKVSVIGIG
CEEHEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEEEC
MRSHAGVAATAFKALADKAINIRAITTSEIKISILIDGPYTELAVRTLHSVYGLDKQ
CCCCCCHHHHHHHHHHCCCEEEEEEEECCEEEEEEECCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ARIVMKFGGTSVADIARIRNVARHVKREVDAGHEVAVVVSAMAGKTNELVGWTREASPM
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCHHEEECCCCCCC
HDAREYDAVVASGEQVTAGLLAITLQNMGVHARSWQGWQIPIKTDNAHGAARILDIDGAF
HHHHHHHHHHCCCCHHHHHHEEEEHHHCCCEEECCCCCEEEEEECCCCCCEEEEECCCHH
LIKRFGEGQVAVIAGFQGIGPDNRIATLGRGGSDTSAVAIAAAVKADRCDIYTDVDGVYT
HHHHCCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHEEEEEHHCCCCCCEEECCCCEEE
TDPRIEPKARRLAKISFEEMLEMASLGAKVLQVRSVELAMVHRVRTFVRSSFDDPDAPGM
CCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GDLLNPPGTLICDEEEIVEQQVVTGIAYAKDEAQISLRRVGDRPGVAAGIFGPLAEANIN
CCCCCCCCCEEECHHHHHHHHHHHHHHEECCCHHEEEECCCCCCCEEHHHHCCHHHCCCC
VDMIVQNISEDGKFTDMTFTVPSGDVDKALAVLDRLKAEVGYDVVQSEAGMSKVSVIGIG
CEEHEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEEEC
MRSHAGVAATAFKALADKAINIRAITTSEIKISILIDGPYTELAVRTLHSVYGLDKQ
CCCCCCHHHHHHHHHHCCCEEEEEEEECCEEEEEEECCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]