Click here to switch to the map view.

The map label for this gene is vipA [H]

Identifier: 13472841

GI number: 13472841

Start: 2611512

End: 2612786

Strand: Direct

Name: vipA [H]

Synonym: mlr3262

Alternate gene names: 13472841

Gene position: 2611512-2612786 (Clockwise)

Preceding gene: 13472840

Following gene: 13472842

Centisome position: 37.12

GC content: 60.63

Gene sequence:

>1275_bases
GTGATCGGATTGGGCTATGTCGGGCTGCCGCTGGCGGTTGCGACCGCACGTGCCGGCTTCCCGGTATCCGGCTTCGACAT
CGAAGCCCGGAAGGTCGAGCGCCTGAACAACGGCCAATCCTACATTGAGGCGGTAACGTCGACTGCCCTTGCCGGCGAGG
TGGCTAGCGGACGGTTCCGCGCCACTGCGGATTTTGCCGAATTGACCGTCTGCGATGTCATCATCATCTGCGTTCCAACA
CCGCTGACGAAACACCGTGAGCCGGACCTCTCCTTCGTCAGGAACACGGCAGGCACCATCGCGAAGCATCTGCGTCTCGG
CCAGCTGATCGTGCTGGAATCGACCACCTATCCCGGCACCACCGACGATGTGATCAAGCCCATATTGGAAGAAACCGGCT
TGCAGTCGAAGATAGATTTCTTCCTCGGCTTCTCGCCCGAACGCGAGGATCCCGGCAACCGCAGCTTTGAAGTCGCGACG
ATCCCCAAGGTCGTGGCAGGCGACGGCGTTGACGCGGCGACGCTCGTGCAGGCTTTCTACCAGGGCGTGATCGAGACCGT
CGTTCCGGTTTCCACCACGGCGACCGCCGAGGCGGTCAAGTTGACGGAAAACATCTTCCGCTCGGTCAATATAGCCCTCG
TCAACGAGTTGAAAATCGTGCTCGGTGCGATGGGCATCGATATCTGGGAGGTGATCGAGGCGGCGAAGACCAAGCCCTTC
GGCTACATGCCTTTCTATCCTGGCCCCGGACTTGGCGGGCACTGCGTTCCGATCGATCCCTTCTACCTGACATGGAAGGC
GCGCGAATACGAACTGCCCACCCGCTTCATCGAGCTGGCGGCAGAGATCAACACGGCCATGCCACGTCATGTGGTCGATG
AACTGGCGAAAGCTCTGGACCGGCGCTGCGGCAAGGCGCTCAGCCGCTCGCGCATTCTCATCATCGGGCTGGCCTATAAA
AAGAATGTGCCCGACATCCGCGAAAGCCCCTCACTGCGGCTCATTGAACTCATCGAGGAATGGGGCGGCAAGGCGGAATT
CCACGACCCGCATGTCACCGAGATCCCGACCACACGGGAGCATATGGCGATCAAGGGGCGTCGCTCGGTCGAATTGACCG
AGGCGGCCTTGAAGGATTTCGATGCTGTCGTCGTTGCAACCGACCACGACGCAATCGACTATCAGGCGATCGCCGATCAC
GCTCTTCTGATCGTCGACACACGCAACGTTTTTGGCCGACTCGGGCTAGCCCGGGAGACGGTGGTGAAGGCTTGA

Upstream 100 bases:

>100_bases
AGCCTGTCCGAATTGACGGAAGAACAGATTTTTGGACGCCTCACGATCGACATATGACCGTCTTCTGAGCCGGATTTCGA
CACGCGCTGCGCAAGTCGGC

Downstream 100 bases:

>100_bases
CGGCGTCCGGGTCGGCGAATTTATTTCCCGATGTCAGGATCGTGGTTGCACTCTGCCGGCAGCCTCGCCACATGATGCCC
CACGAGATAGATGCAATTAC

Product: nucleotide-sugar dehydrogenase (UDP-glucose/GDP-mannose dehydrogenase)

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MIGLGYVGLPLAVATARAGFPVSGFDIEARKVERLNNGQSYIEAVTSTALAGEVASGRFRATADFAELTVCDVIIICVPT
PLTKHREPDLSFVRNTAGTIAKHLRLGQLIVLESTTYPGTTDDVIKPILEETGLQSKIDFFLGFSPEREDPGNRSFEVAT
IPKVVAGDGVDAATLVQAFYQGVIETVVPVSTTATAEAVKLTENIFRSVNIALVNELKIVLGAMGIDIWEVIEAAKTKPF
GYMPFYPGPGLGGHCVPIDPFYLTWKAREYELPTRFIELAAEINTAMPRHVVDELAKALDRRCGKALSRSRILIIGLAYK
KNVPDIRESPSLRLIELIEEWGGKAEFHDPHVTEIPTTREHMAIKGRRSVELTEAALKDFDAVVVATDHDAIDYQAIADH
ALLIVDTRNVFGRLGLARETVVKA

Sequences:

>Translated_424_residues
MIGLGYVGLPLAVATARAGFPVSGFDIEARKVERLNNGQSYIEAVTSTALAGEVASGRFRATADFAELTVCDVIIICVPT
PLTKHREPDLSFVRNTAGTIAKHLRLGQLIVLESTTYPGTTDDVIKPILEETGLQSKIDFFLGFSPEREDPGNRSFEVAT
IPKVVAGDGVDAATLVQAFYQGVIETVVPVSTTATAEAVKLTENIFRSVNIALVNELKIVLGAMGIDIWEVIEAAKTKPF
GYMPFYPGPGLGGHCVPIDPFYLTWKAREYELPTRFIELAAEINTAMPRHVVDELAKALDRRCGKALSRSRILIIGLAYK
KNVPDIRESPSLRLIELIEEWGGKAEFHDPHVTEIPTTREHMAIKGRRSVELTEAALKDFDAVVVATDHDAIDYQAIADH
ALLIVDTRNVFGRLGLARETVVKA
>Mature_424_residues
MIGLGYVGLPLAVATARAGFPVSGFDIEARKVERLNNGQSYIEAVTSTALAGEVASGRFRATADFAELTVCDVIIICVPT
PLTKHREPDLSFVRNTAGTIAKHLRLGQLIVLESTTYPGTTDDVIKPILEETGLQSKIDFFLGFSPEREDPGNRSFEVAT
IPKVVAGDGVDAATLVQAFYQGVIETVVPVSTTATAEAVKLTENIFRSVNIALVNELKIVLGAMGIDIWEVIEAAKTKPF
GYMPFYPGPGLGGHCVPIDPFYLTWKAREYELPTRFIELAAEINTAMPRHVVDELAKALDRRCGKALSRSRILIIGLAYK
KNVPDIRESPSLRLIELIEEWGGKAEFHDPHVTEIPTTREHMAIKGRRSVELTEAALKDFDAVVVATDHDAIDYQAIADH
ALLIVDTRNVFGRLGLARETVVKA

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=456, Percent_Identity=24.3421052631579, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI296040438, Length=364, Percent_Identity=23.6263736263736, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI48994968, Length=429, Percent_Identity=32.4009324009324, Blast_Score=205, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17560350, Length=449, Percent_Identity=25.8351893095768, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17136908, Length=436, Percent_Identity=25.4587155963303, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46276; Mature: 46276

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGLGYVGLPLAVATARAGFPVSGFDIEARKVERLNNGQSYIEAVTSTALAGEVASGRFR
CCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEE
ATADFAELTVCDVIIICVPTPLTKHREPDLSFVRNTAGTIAKHLRLGQLIVLESTTYPGT
ECCHHHHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCC
TDDVIKPILEETGLQSKIDFFLGFSPEREDPGNRSFEVATIPKVVAGDGVDAATLVQAFY
HHHHHHHHHHHCCCCHHHHHEECCCCCCCCCCCCCEEEEECCHHCCCCCCCHHHHHHHHH
QGVIETVVPVSTTATAEAVKLTENIFRSVNIALVNELKIVLGAMGIDIWEVIEAAKTKPF
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
GYMPFYPGPGLGGHCVPIDPFYLTWKAREYELPTRFIELAAEINTAMPRHVVDELAKALD
CCCCCCCCCCCCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RRCGKALSRSRILIIGLAYKKNVPDIRESPSLRLIELIEEWGGKAEFHDPHVTEIPTTRE
HHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
HMAIKGRRSVELTEAALKDFDAVVVATDHDAIDYQAIADHALLIVDTRNVFGRLGLARET
HHEECCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHCCCEEEEEECHHHHHHHCCHHHH
VVKA
HHCC
>Mature Secondary Structure
MIGLGYVGLPLAVATARAGFPVSGFDIEARKVERLNNGQSYIEAVTSTALAGEVASGRFR
CCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEE
ATADFAELTVCDVIIICVPTPLTKHREPDLSFVRNTAGTIAKHLRLGQLIVLESTTYPGT
ECCHHHHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCC
TDDVIKPILEETGLQSKIDFFLGFSPEREDPGNRSFEVATIPKVVAGDGVDAATLVQAFY
HHHHHHHHHHHCCCCHHHHHEECCCCCCCCCCCCCEEEEECCHHCCCCCCCHHHHHHHHH
QGVIETVVPVSTTATAEAVKLTENIFRSVNIALVNELKIVLGAMGIDIWEVIEAAKTKPF
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
GYMPFYPGPGLGGHCVPIDPFYLTWKAREYELPTRFIELAAEINTAMPRHVVDELAKALD
CCCCCCCCCCCCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RRCGKALSRSRILIIGLAYKKNVPDIRESPSLRLIELIEEWGGKAEFHDPHVTEIPTTRE
HHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
HMAIKGRRSVELTEAALKDFDAVVVATDHDAIDYQAIADHALLIVDTRNVFGRLGLARET
HHEECCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHCCCEEEEEECHHHHHHHCCHHHH
VVKA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]