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The map label for this gene is 13472825

Identifier: 13472825

GI number: 13472825

Start: 2591946

End: 2593013

Strand: Reverse

Name: 13472825

Synonym: mll3241

Alternate gene names: NA

Gene position: 2593013-2591946 (Counterclockwise)

Preceding gene: 13472826

Following gene: 13472824

Centisome position: 36.85

GC content: 64.33

Gene sequence:

>1068_bases
ATGTCGGTACTGCCTTTCTTAAGAATTTACGCGCCGCTCAACGCGGTGCTGGCTGCGCCTGGGTTGCTGGCGGTGGCTGC
GCTCACGATACCGGACATGTCCGGACGAAGCAGACTGGCTCTGGCTGCCCTGCTCGCTGTCATCTGGGGCGCCTATCTCC
TGCAACTGGCCGCGACGCTGCTCAAGCGCCGGGCGGGAGTCGTACGGGACAGGACGCCCAAAATCGCCATCGATGTGCTC
GCAGTCTTGGTTCCACTCGCCGCATTTCTGCTCGACGGCTCGCCTGACTGGAGCCTCTACTGTGCTGTCTGGCTGCTGAA
ACCGCTGCGCGACTCGACTTTCTTCCCGGTCCTGGGCAGGGTCCTGGCCAACGAAGCACGCAATCTGATCGGCGTCACCA
CGCTCTTCGGCGTCGTTCTGTTCGCAGTGGCGCTCGCAGCCTATGTCATCGAGCGCGATATCCAACCGGAAAAGTTCGGC
AGCATTCCCCAGGCAATGTGGTGGGCGGTGGTCACGCTGTCCACCACCGGCTATGGGGACACTATCCCGCAAAGCTTCGC
CGGCCGCGTCCTTGCCGGGGCGGTCATGATGAGTGGCATCGGCATCTTCGGACTCTGGGCCGGCATTCTTGCCACAGGCT
TCTATCAAGAAGTCCGTCGCGGGGATTTCGTCCGCAATTGGCAATTGGTCGCCGCCGTGCCGTTGTTTCAGAAGCTCGGC
CCGGCCGTGCTGGTCGAGATCGTGCGCGCCTTAAGAGCCCGCACGGTGCCGGCGGGCGCCGTGATCTGCCGCATTGGCGA
GCCCGGCGATCGGATGTTCTTCGTCGTGGAGGGGAGCGTCAGCGTCGCGACGCCGAATCCGGTGGAGCTTGGCCCTGGCG
CCTTCTTCGGCGAGATGGCGCTGATCAGCGGCGAACCGCGTTCGGCGACCGTCAGCGCCGCAACGACGGTCTCACTCCTG
TCGCTGCATTCGGCGGATTTCCAGATGTTGTGCAGCAGCAGCCCGGAGATCGCGGAAATCTTCCGCAAGACCGCGCTCGA
GCGTCGCGGCGCTGCGGCGAGCGCTTGA

Upstream 100 bases:

>100_bases
AGTTAACCCTGGGTGAAGCAGATCGCAGCGACAGCAAGCCCTTTGCGCTTGCCTTGAAGGCATCCTATTCTGGAGGATAG
TAGCCGCTCGTGGGCATACA

Downstream 100 bases:

>100_bases
CCGTTTCCTCGGCGATCAGCCCGAAATGCTGAAGGCGAAATGTTATTCCCTGCAGGCGGAAATGCTTCTCTGGCGCACCG
GCTACCGTGCCGATCCGCTG

Product: hypothetical protein

Products: NA

Alternate protein names: MlotiK1 channel

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MSVLPFLRIYAPLNAVLAAPGLLAVAALTIPDMSGRSRLALAALLAVIWGAYLLQLAATLLKRRAGVVRDRTPKIAIDVL
AVLVPLAAFLLDGSPDWSLYCAVWLLKPLRDSTFFPVLGRVLANEARNLIGVTTLFGVVLFAVALAAYVIERDIQPEKFG
SIPQAMWWAVVTLSTTGYGDTIPQSFAGRVLAGAVMMSGIGIFGLWAGILATGFYQEVRRGDFVRNWQLVAAVPLFQKLG
PAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVELGPGAFFGEMALISGEPRSATVSAATTVSLL
SLHSADFQMLCSSSPEIAEIFRKTALERRGAAASA

Sequences:

>Translated_355_residues
MSVLPFLRIYAPLNAVLAAPGLLAVAALTIPDMSGRSRLALAALLAVIWGAYLLQLAATLLKRRAGVVRDRTPKIAIDVL
AVLVPLAAFLLDGSPDWSLYCAVWLLKPLRDSTFFPVLGRVLANEARNLIGVTTLFGVVLFAVALAAYVIERDIQPEKFG
SIPQAMWWAVVTLSTTGYGDTIPQSFAGRVLAGAVMMSGIGIFGLWAGILATGFYQEVRRGDFVRNWQLVAAVPLFQKLG
PAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVELGPGAFFGEMALISGEPRSATVSAATTVSLL
SLHSADFQMLCSSSPEIAEIFRKTALERRGAAASA
>Mature_354_residues
SVLPFLRIYAPLNAVLAAPGLLAVAALTIPDMSGRSRLALAALLAVIWGAYLLQLAATLLKRRAGVVRDRTPKIAIDVLA
VLVPLAAFLLDGSPDWSLYCAVWLLKPLRDSTFFPVLGRVLANEARNLIGVTTLFGVVLFAVALAAYVIERDIQPEKFGS
IPQAMWWAVVTLSTTGYGDTIPQSFAGRVLAGAVMMSGIGIFGLWAGILATGFYQEVRRGDFVRNWQLVAAVPLFQKLGP
AVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVELGPGAFFGEMALISGEPRSATVSAATTVSLLS
LHSADFQMLCSSSPEIAEIFRKTALERRGAAASA

Specific function: Cyclic nucleotide-regulated potassium channel activated by cAMP

COG id: COG1226

COG function: function code P; Kef-type K+ transport systems, predicted NAD-binding component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cyclic nucleotide-binding domain

Homologues:

Organism=Homo sapiens, GI26638655, Length=121, Percent_Identity=34.7107438016529, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI26638653, Length=121, Percent_Identity=34.7107438016529, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI236462242, Length=114, Percent_Identity=32.4561403508772, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI28373065, Length=112, Percent_Identity=33.0357142857143, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI236461942, Length=112, Percent_Identity=33.0357142857143, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI236461719, Length=112, Percent_Identity=33.0357142857143, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI236462079, Length=112, Percent_Identity=33.0357142857143, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI32479525, Length=129, Percent_Identity=35.6589147286822, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI32479527, Length=141, Percent_Identity=34.0425531914894, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI26051260, Length=173, Percent_Identity=26.0115606936416, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4826784, Length=124, Percent_Identity=32.258064516129, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI27436974, Length=124, Percent_Identity=32.258064516129, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI26051262, Length=112, Percent_Identity=30.3571428571429, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI26051266, Length=112, Percent_Identity=30.3571428571429, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI26051268, Length=114, Percent_Identity=29.8245614035088, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI26051264, Length=112, Percent_Identity=30.3571428571429, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4826782, Length=136, Percent_Identity=30.8823529411765, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI27436981, Length=200, Percent_Identity=27, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI9789987, Length=195, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4885407, Length=123, Percent_Identity=34.1463414634146, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI25952087, Length=113, Percent_Identity=35.3982300884956, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI4758630, Length=133, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI27436988, Length=160, Percent_Identity=34.375, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17544122, Length=163, Percent_Identity=27.6073619631902, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71989381, Length=114, Percent_Identity=32.4561403508772, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71989376, Length=114, Percent_Identity=32.4561403508772, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71989369, Length=114, Percent_Identity=32.4561403508772, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25147242, Length=139, Percent_Identity=30.9352517985612, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71989361, Length=114, Percent_Identity=32.4561403508772, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71986008, Length=114, Percent_Identity=35.0877192982456, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25147238, Length=139, Percent_Identity=30.9352517985612, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71986003, Length=114, Percent_Identity=35.0877192982456, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71986011, Length=114, Percent_Identity=35.0877192982456, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193206869, Length=107, Percent_Identity=29.9065420560748, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32564066, Length=131, Percent_Identity=34.3511450381679, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25148255, Length=107, Percent_Identity=29.9065420560748, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994134, Length=98, Percent_Identity=37.7551020408163, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994313, Length=116, Percent_Identity=31.0344827586207, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI221330117, Length=121, Percent_Identity=33.8842975206612, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281363095, Length=121, Percent_Identity=33.8842975206612, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI221330119, Length=116, Percent_Identity=34.4827586206897, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI281363097, Length=121, Percent_Identity=33.8842975206612, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI116007764, Length=113, Percent_Identity=36.283185840708, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24656294, Length=113, Percent_Identity=36.283185840708, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281365536, Length=113, Percent_Identity=36.283185840708, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24656289, Length=113, Percent_Identity=36.283185840708, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161084970, Length=128, Percent_Identity=28.90625, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737641, Length=128, Percent_Identity=28.90625, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24642910, Length=113, Percent_Identity=36.283185840708, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45555859, Length=113, Percent_Identity=36.283185840708, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45549143, Length=113, Percent_Identity=36.283185840708, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CNGK1_RHILO (Q98GN8)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_104392.1
- PDB:   1U12
- PDB:   1VP6
- PDB:   2K0G
- PDB:   2ZD9
- PDB:   3BEH
- PDB:   3CL1
- PDB:   3CLP
- PDB:   3CO2
- PDBsum:   1U12
- PDBsum:   1VP6
- PDBsum:   2K0G
- PDBsum:   2ZD9
- PDBsum:   3BEH
- PDBsum:   3CL1
- PDBsum:   3CLP
- PDBsum:   3CO2
- ProteinModelPortal:   Q98GN8
- SMR:   Q98GN8
- DIP:   DIP-29507N
- GeneID:   1227053
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll3241
- NMPDR:   fig|266835.1.peg.2496
- HOGENOM:   HBG299487
- OMA:   MMSGIGI
- ProtClustDB:   CLSK783733
- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR013099
- InterPro:   IPR003091
- InterPro:   IPR014710
- Gene3D:   G3DSA:2.60.120.10
- PRINTS:   PR00169
- SMART:   SM00100

Pfam domain/function: PF00027 cNMP_binding; PF07885 Ion_trans_2; SSF51206 cNMP_binding

EC number: NA

Molecular weight: Translated: 37736; Mature: 37605

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00888 CNMP_BINDING_1; PS00889 CNMP_BINDING_2; PS50042 CNMP_BINDING_3

Important sites: BINDING 348-348

Signals:

None

Transmembrane regions:

HASH(0xfbdffa4)-; HASH(0x11938fb4)-; HASH(0x115e2a8c)-; HASH(0xf6c0244)-; HASH(0xfa54ed4)-; HASH(0x107b6f40)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLPFLRIYAPLNAVLAAPGLLAVAALTIPDMSGRSRLALAALLAVIWGAYLLQLAATL
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LKRRAGVVRDRTPKIAIDVLAVLVPLAAFLLDGSPDWSLYCAVWLLKPLRDSTFFPVLGR
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
VLANEARNLIGVTTLFGVVLFAVALAAYVIERDIQPEKFGSIPQAMWWAVVTLSTTGYGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHEEECCCCCC
TIPQSFAGRVLAGAVMMSGIGIFGLWAGILATGFYQEVRRGDFVRNWQLVAAVPLFQKLG
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHC
PAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVELGPGAFFGEMA
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCEEECCCCCCCCCCCCHHHCCC
LISGEPRSATVSAATTVSLLSLHSADFQMLCSSSPEIAEIFRKTALERRGAAASA
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure 
SVLPFLRIYAPLNAVLAAPGLLAVAALTIPDMSGRSRLALAALLAVIWGAYLLQLAATL
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LKRRAGVVRDRTPKIAIDVLAVLVPLAAFLLDGSPDWSLYCAVWLLKPLRDSTFFPVLGR
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
VLANEARNLIGVTTLFGVVLFAVALAAYVIERDIQPEKFGSIPQAMWWAVVTLSTTGYGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHEEECCCCCC
TIPQSFAGRVLAGAVMMSGIGIFGLWAGILATGFYQEVRRGDFVRNWQLVAAVPLFQKLG
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHC
PAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVELGPGAFFGEMA
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCEEECCCCCCCCCCCCHHHCCC
LISGEPRSATVSAATTVSLLSLHSADFQMLCSSSPEIAEIFRKTALERRGAAASA
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11214968