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The map label for this gene is sir2 [H]

Identifier: 13472815

GI number: 13472815

Start: 2580385

End: 2582055

Strand: Reverse

Name: sir2 [H]

Synonym: mll3230

Alternate gene names: 13472815

Gene position: 2582055-2580385 (Counterclockwise)

Preceding gene: 13472816

Following gene: 13472814

Centisome position: 36.7

GC content: 62.6

Gene sequence:

>1671_bases
ATGTACCGTTACGATGAGTTCGACCACGATTTTGTTCAGGCCCGCGTCGCCGAGTTCAGCGACCAGGTCCAGCGCCGGCT
GTCCGGCGAGATATCAGAGGACCAGTTCCGGCCGCTGCGGCTGATGAACGGCGTCTATCTGCAGCTTCACGCTTATATGC
TGCGTATCGCGGTGCCTTACGGCACGCTGAACGGCAAGCAGCTGCGCATGCTCGGCCACATCGCCCGCAAATACGACAAG
GGCTACGGCCATTTCACCACGCGCCAGAACATCCAGTTCAACTGGCCGGCGCTGTCGGACATTCCGGCGATCCTCGCCGA
TCTGGCAAGTGTGGAGATGCACGCCATCCAGACCAGCGGCAACTGCATCCGCAACGTCACCGCCGACCACTTTGCCGGTG
CCGCCGCCGACGAGGTCGCCGATCCGCGTCCCTATGCGGAAATCCTGCGGCAATGGTCCTCGGTGCATCCGGAATTCTCG
TTCCTGCCCAGGAAATTCAAGATCGCGGTGACCGGGGCAGAGCGCGACCGCGCTGCCATCCAGACGCACGATATCGGCCT
GCACCTGAAGAAGAACGCCGCCGGCGAGCTCGGTTTCGCTGTCTATGTCGGTGGCGGCCAGGGCCGCACGCCGATGGTGG
CAAGGAAGATCCGCGACTTCCTGCCGGAAGCCGACCTTCTGTCCTACTGCACGGCGATCCTGCGCGTTTACAACCTCTAT
GGCCGCCGCGACAACAAGTACAAGGCACGCATCAAGATCCTGGTGCACGAGACCGGCGTCGAGGAGATCACCCGCCAGGT
CGAGGCCGAATGGCAGGACTTGAAGGACGCCGAGCTGAAGCTGCCGGATGCCGATATCCGCGCCATCCAAGCCTATTTCG
CGCCGCCGGAACTGGCTGATCGGCCGGAAGGCGACCAGGCGGTCAAGCTGGCGCGTCTTGATTCCAAAGGCTTCTCGGAG
TGGCTCGACCAGAATGTGGTGACGCACCGCCATCCCGATTATGCGGCGGTGACGATTTCGCTCAAGGGCATCGGCGAGGT
GCCGGGCGATGCTTCCGACAGCCAGATGGAAGCGATTGCCGACATCGCCGAGAAATACGCCTTCGACGAGCTGCGCGTCA
GCCATGAGCAGAACCTGATCCTGCCGCATGTGGCGCGCGCCGACCTCAAGGCGGTCTACGACGCGCTGGTCGATATCGGG
CTGGCGACGGCCAACTCCAATTTGATATCGGACATCATCTCGTGCCCCGGCCTCGACTATTGCGCGCTGGCCACCGCACG
CTCGATCCCGATCGCGCAGGAAATCTCGCAACGCTTCGCCTCGCTGGAGCGGCAGCGTGAGATCGGCGAACTGAAGCTGA
AGATCTCCGGCTGCATCAATGCCTGCGGCCATCACCATGTCGGCCATATCGGCATCCTCGGCGTCGAGAAGAAGGGCTCC
GAGCTCTATCAAGTGACGCTGGGCGGTTCGGCCGATGAGAACACGTCGGTCGGCGAGATCATCGGCCGCGGCTTCTCGTC
GGAAGAGATCACCGACGCCATCGAGCAGATCGTCGAAACCTATCTCGGCCTCCGGCTCAACCCACAGGAAAAATTCATCG
ACGCATACCGCCGTGTCGGTCCCGCGCCGTTCAAGGAGGCGCTCTATGCTGGCGAAACCAAGGCCGCTTGA

Upstream 100 bases:

>100_bases
CGCCGGCCCGACCATCCGCGGCGATCTCGGCAAGCAGGCCGAGCGGGCGGCATAGTCAGGATTTGAGTGAAACGGGCGGA
CGCGCCCTGAAAGACGAAGC

Downstream 100 bases:

>100_bases
CCATATCGGCGATGCAGATGACGGCGTCGCCGCCAAGGCGGCGGGGCTCGATGCGCTGTACGGCCATCTGAAGCCGCTCG
AGATCATCGAACGCTCGGCC

Product: sulfite reductase hemoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MYRYDEFDHDFVQARVAEFSDQVQRRLSGEISEDQFRPLRLMNGVYLQLHAYMLRIAVPYGTLNGKQLRMLGHIARKYDK
GYGHFTTRQNIQFNWPALSDIPAILADLASVEMHAIQTSGNCIRNVTADHFAGAAADEVADPRPYAEILRQWSSVHPEFS
FLPRKFKIAVTGAERDRAAIQTHDIGLHLKKNAAGELGFAVYVGGGQGRTPMVARKIRDFLPEADLLSYCTAILRVYNLY
GRRDNKYKARIKILVHETGVEEITRQVEAEWQDLKDAELKLPDADIRAIQAYFAPPELADRPEGDQAVKLARLDSKGFSE
WLDQNVVTHRHPDYAAVTISLKGIGEVPGDASDSQMEAIADIAEKYAFDELRVSHEQNLILPHVARADLKAVYDALVDIG
LATANSNLISDIISCPGLDYCALATARSIPIAQEISQRFASLERQREIGELKLKISGCINACGHHHVGHIGILGVEKKGS
ELYQVTLGGSADENTSVGEIIGRGFSSEEITDAIEQIVETYLGLRLNPQEKFIDAYRRVGPAPFKEALYAGETKAA

Sequences:

>Translated_556_residues
MYRYDEFDHDFVQARVAEFSDQVQRRLSGEISEDQFRPLRLMNGVYLQLHAYMLRIAVPYGTLNGKQLRMLGHIARKYDK
GYGHFTTRQNIQFNWPALSDIPAILADLASVEMHAIQTSGNCIRNVTADHFAGAAADEVADPRPYAEILRQWSSVHPEFS
FLPRKFKIAVTGAERDRAAIQTHDIGLHLKKNAAGELGFAVYVGGGQGRTPMVARKIRDFLPEADLLSYCTAILRVYNLY
GRRDNKYKARIKILVHETGVEEITRQVEAEWQDLKDAELKLPDADIRAIQAYFAPPELADRPEGDQAVKLARLDSKGFSE
WLDQNVVTHRHPDYAAVTISLKGIGEVPGDASDSQMEAIADIAEKYAFDELRVSHEQNLILPHVARADLKAVYDALVDIG
LATANSNLISDIISCPGLDYCALATARSIPIAQEISQRFASLERQREIGELKLKISGCINACGHHHVGHIGILGVEKKGS
ELYQVTLGGSADENTSVGEIIGRGFSSEEITDAIEQIVETYLGLRLNPQEKFIDAYRRVGPAPFKEALYAGETKAA
>Mature_556_residues
MYRYDEFDHDFVQARVAEFSDQVQRRLSGEISEDQFRPLRLMNGVYLQLHAYMLRIAVPYGTLNGKQLRMLGHIARKYDK
GYGHFTTRQNIQFNWPALSDIPAILADLASVEMHAIQTSGNCIRNVTADHFAGAAADEVADPRPYAEILRQWSSVHPEFS
FLPRKFKIAVTGAERDRAAIQTHDIGLHLKKNAAGELGFAVYVGGGQGRTPMVARKIRDFLPEADLLSYCTAILRVYNLY
GRRDNKYKARIKILVHETGVEEITRQVEAEWQDLKDAELKLPDADIRAIQAYFAPPELADRPEGDQAVKLARLDSKGFSE
WLDQNVVTHRHPDYAAVTISLKGIGEVPGDASDSQMEAIADIAEKYAFDELRVSHEQNLILPHVARADLKAVYDALVDIG
LATANSNLISDIISCPGLDYCALATARSIPIAQEISQRFASLERQREIGELKLKISGCINACGHHHVGHIGILGVEKKGS
ELYQVTLGGSADENTSVGEIIGRGFSSEEITDAIEQIVETYLGLRLNPQEKFIDAYRRVGPAPFKEALYAGETKAA

Specific function: This Enzyme Catalyzes The 6-Electron Reduction Of Sulfite To Sulfide. This Is One Of Several Activities Required For The Biosynthesis Of L-Cysteine From Sulfate. [C]

COG id: COG0155

COG function: function code P; Sulfite reductase, beta subunit (hemoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family [H]

Homologues:

None

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005117
- InterPro:   IPR006067
- InterPro:   IPR006066 [H]

Pfam domain/function: PF01077 NIR_SIR; PF03460 NIR_SIR_ferr [H]

EC number: =1.8.7.1 [H]

Molecular weight: Translated: 61815; Mature: 61815

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRYDEFDHDFVQARVAEFSDQVQRRLSGEISEDQFRPLRLMNGVYLQLHAYMLRIAVPY
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCC
GTLNGKQLRMLGHIARKYDKGYGHFTTRQNIQFNWPALSDIPAILADLASVEMHAIQTSG
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHEEECCC
NCIRNVTADHFAGAAADEVADPRPYAEILRQWSSVHPEFSFLPRKFKIAVTGAERDRAAI
CHHHCCCHHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCHHCCCCEEEEEEECCCCCCHHE
QTHDIGLHLKKNAAGELGFAVYVGGGQGRTPMVARKIRDFLPEADLLSYCTAILRVYNLY
EEECCCEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GRRDNKYKARIKILVHETGVEEITRQVEAEWQDLKDAELKLPDADIRAIQAYFAPPELAD
CCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHCCCCCCCC
RPEGDQAVKLARLDSKGFSEWLDQNVVTHRHPDYAAVTISLKGIGEVPGDASDSQMEAIA
CCCCCHHEEEHHHCCCHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHH
DIAEKYAFDELRVSHEQNLILPHVARADLKAVYDALVDIGLATANSNLISDIISCPGLDY
HHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCH
CALATARSIPIAQEISQRFASLERQREIGELKLKISGCINACGHHHVGHIGILGVEKKGS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHCCCCCCCEEEEEEEECCCC
ELYQVTLGGSADENTSVGEIIGRGFSSEEITDAIEQIVETYLGLRLNPQEKFIDAYRRVG
EEEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
PAPFKEALYAGETKAA
CCCHHHHHHCCCCCCC
>Mature Secondary Structure
MYRYDEFDHDFVQARVAEFSDQVQRRLSGEISEDQFRPLRLMNGVYLQLHAYMLRIAVPY
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCC
GTLNGKQLRMLGHIARKYDKGYGHFTTRQNIQFNWPALSDIPAILADLASVEMHAIQTSG
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHEEECCC
NCIRNVTADHFAGAAADEVADPRPYAEILRQWSSVHPEFSFLPRKFKIAVTGAERDRAAI
CHHHCCCHHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCHHCCCCEEEEEEECCCCCCHHE
QTHDIGLHLKKNAAGELGFAVYVGGGQGRTPMVARKIRDFLPEADLLSYCTAILRVYNLY
EEECCCEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GRRDNKYKARIKILVHETGVEEITRQVEAEWQDLKDAELKLPDADIRAIQAYFAPPELAD
CCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHCCCCCCCC
RPEGDQAVKLARLDSKGFSEWLDQNVVTHRHPDYAAVTISLKGIGEVPGDASDSQMEAIA
CCCCCHHEEEHHHCCCHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHH
DIAEKYAFDELRVSHEQNLILPHVARADLKAVYDALVDIGLATANSNLISDIISCPGLDY
HHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCH
CALATARSIPIAQEISQRFASLERQREIGELKLKISGCINACGHHHVGHIGILGVEKKGS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHCCCCCCCEEEEEEEECCCC
ELYQVTLGGSADENTSVGEIIGRGFSSEEITDAIEQIVETYLGLRLNPQEKFIDAYRRVG
EEEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
PAPFKEALYAGETKAA
CCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA