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The map label for this gene is envZ [H]

Identifier: 13472445

GI number: 13472445

Start: 2201842

End: 2203248

Strand: Direct

Name: envZ [H]

Synonym: mlr2741

Alternate gene names: 13472445

Gene position: 2201842-2203248 (Clockwise)

Preceding gene: 13472444

Following gene: 13472449

Centisome position: 31.29

GC content: 66.6

Gene sequence:

>1407_bases
ATGAAACGTCTCCTGCCGCAGACCTTGCCTGCCTGGGTGCTGCTGATCGTCATTGCCGGCCTTCTGATCAGCCAGGTCGC
GACCCTCTATATCGTGTCGCGCGACCGCGCCGTCGCCAACGACGTGGTCGACCTCTACCGGCTCAACGACCGCGCCTTCT
CTTTGGTGCAGCTGATGAGCGGCGCCACGCCGGAAGAGCGCAAGGCAACCGCGGCGGGCCTGTTCAACTCGACCTACGCG
CTTACCGTCTCGGACACGCCCGCCGTCACCTCCTCGATCGCCGGCGACGACGAACTGGCCGAACTCGAGGATATCCTCGT
TGGCCGGCTGTCGAAGTTCGGCGTCACCGACGCGCGCGTGCGGCGCGATCCGGCGACGCGCGAGGCCGACGACGCCAGCA
CCGTATCCGGCCCCGACATCGGCCAGGTCGAGCGCGACCTCCTGGTGCTCGCCGCCAATTTCGCCCAGAGCGACAAGCTG
ACGGCTTCCTTGCGCTTCGCCGACGGCCAGTGGCTGAACTTCACCGAGCCGATTACGCCGGTCGGCCCGATCCTGAGCTT
CGACAGCCTGCCGCTCTATTCGCTGATCGCCGGCCTGGTGGTGATCATGTCGATCTGGTCGCTGCGCCGGCTGACCGCGC
CCTACCGGATGATGGAAACCGCCGTGAACCGGATCGGCAAGGATTTGAAGAGCCCGCCGATCACCGAATCGGGCAGCCGC
GAGGTGCGGGCCGCCGCCAGGGCGATCAACGCCATGCAGACGAGGTTGCGCGAATATGTCGAGGACCGCGAACATCTTGC
CGCAGCACTTGCGCATGATTTGCGCACGCCGATGACGCGCATGCGGCTGCGGCTCGAACTGTTGCGCAAATCGGCGGTCC
GCGAGGCGCTGGCGCACGATCTCGCCGATGTCGAGAGCATCGCCAGCTCGGTGATCGACTTCGCCACTTTCGAGGTGAAC
GAGGAGAAAGCCGAGCGCATCGACTTCTGGTCGTTCGTGGAATCGATCGCCGACCCCTATCCGGAGGTCTCGTTCGACAA
TGACGACACCCGTTCGCGCGGCCTGATCTGCATGGCGCGGCCGGTGGCGCTCAGGCGCTGCGTCACCAATCTGGTGCAGA
ACGCCGTCACTTACGGCAAGAAGGCGCATCTGAGCCTGCACCGCTCGGACGGTACGATCACGCTCACCATCCGCGACGAA
GGACCCGGCATACCGCAGGCCCAGATCGATGCCGTGTTCGGCTCCTTCGTGCGCCTCGAACAGTCCCGCAACCGCCAGAC
CGGCGGCCTCGGCCTGGGACTCACCATCGCCCGCAACATCGCGCGCGCCGCCGGCGGCGAGATCCGCCTGTCCAACCATC
CCGACGGCGGGCTGCTGACCGAGCTGCGCCTACCGCTGGCGGCCTGA

Upstream 100 bases:

>100_bases
GCCGGCTGCGGCGCAAGATGGAAGATGACCCAAAAACGCCGAAACTGATCCTGACGGTGCGCAGCGGCGGCTACCAGTTC
CTGCCCGAGACGACCTCCGA

Downstream 100 bases:

>100_bases
ACCGCCTACCTTCTCAACACCGCGCTCAGCACATCCCTGATGCCGATGGCCCCGACGAAGCGGGACTGTTCGTCGAACAG
CGCCACCGGTGCGGTCTGCG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKRLLPQTLPAWVLLIVIAGLLISQVATLYIVSRDRAVANDVVDLYRLNDRAFSLVQLMSGATPEERKATAAGLFNSTYA
LTVSDTPAVTSSIAGDDELAELEDILVGRLSKFGVTDARVRRDPATREADDASTVSGPDIGQVERDLLVLAANFAQSDKL
TASLRFADGQWLNFTEPITPVGPILSFDSLPLYSLIAGLVVIMSIWSLRRLTAPYRMMETAVNRIGKDLKSPPITESGSR
EVRAAARAINAMQTRLREYVEDREHLAAALAHDLRTPMTRMRLRLELLRKSAVREALAHDLADVESIASSVIDFATFEVN
EEKAERIDFWSFVESIADPYPEVSFDNDDTRSRGLICMARPVALRRCVTNLVQNAVTYGKKAHLSLHRSDGTITLTIRDE
GPGIPQAQIDAVFGSFVRLEQSRNRQTGGLGLGLTIARNIARAAGGEIRLSNHPDGGLLTELRLPLAA

Sequences:

>Translated_468_residues
MKRLLPQTLPAWVLLIVIAGLLISQVATLYIVSRDRAVANDVVDLYRLNDRAFSLVQLMSGATPEERKATAAGLFNSTYA
LTVSDTPAVTSSIAGDDELAELEDILVGRLSKFGVTDARVRRDPATREADDASTVSGPDIGQVERDLLVLAANFAQSDKL
TASLRFADGQWLNFTEPITPVGPILSFDSLPLYSLIAGLVVIMSIWSLRRLTAPYRMMETAVNRIGKDLKSPPITESGSR
EVRAAARAINAMQTRLREYVEDREHLAAALAHDLRTPMTRMRLRLELLRKSAVREALAHDLADVESIASSVIDFATFEVN
EEKAERIDFWSFVESIADPYPEVSFDNDDTRSRGLICMARPVALRRCVTNLVQNAVTYGKKAHLSLHRSDGTITLTIRDE
GPGIPQAQIDAVFGSFVRLEQSRNRQTGGLGLGLTIARNIARAAGGEIRLSNHPDGGLLTELRLPLAA
>Mature_468_residues
MKRLLPQTLPAWVLLIVIAGLLISQVATLYIVSRDRAVANDVVDLYRLNDRAFSLVQLMSGATPEERKATAAGLFNSTYA
LTVSDTPAVTSSIAGDDELAELEDILVGRLSKFGVTDARVRRDPATREADDASTVSGPDIGQVERDLLVLAANFAQSDKL
TASLRFADGQWLNFTEPITPVGPILSFDSLPLYSLIAGLVVIMSIWSLRRLTAPYRMMETAVNRIGKDLKSPPITESGSR
EVRAAARAINAMQTRLREYVEDREHLAAALAHDLRTPMTRMRLRLELLRKSAVREALAHDLADVESIASSVIDFATFEVN
EEKAERIDFWSFVESIADPYPEVSFDNDDTRSRGLICMARPVALRRCVTNLVQNAVTYGKKAHLSLHRSDGTITLTIRDE
GPGIPQAQIDAVFGSFVRLEQSRNRQTGGLGLGLTIARNIARAAGGEIRLSNHPDGGLLTELRLPLAA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=288, Percent_Identity=29.8611111111111, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790346, Length=275, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787894, Length=257, Percent_Identity=28.7937743190661, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=27.3381294964029, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=350, Percent_Identity=24, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081816, Length=341, Percent_Identity=24.9266862170088, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786912, Length=304, Percent_Identity=28.2894736842105, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI145693157, Length=228, Percent_Identity=25.4385964912281, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789149, Length=321, Percent_Identity=22.7414330218069, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786783, Length=285, Percent_Identity=23.5087719298246, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786600, Length=206, Percent_Identity=25.7281553398058, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51269; Mature: 51269

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLLPQTLPAWVLLIVIAGLLISQVATLYIVSRDRAVANDVVDLYRLNDRAFSLVQLMS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHCHHHHHHHHHHH
GATPEERKATAAGLFNSTYALTVSDTPAVTSSIAGDDELAELEDILVGRLSKFGVTDARV
CCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHH
RRDPATREADDASTVSGPDIGQVERDLLVLAANFAQSDKLTASLRFADGQWLNFTEPITP
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCC
VGPILSFDSLPLYSLIAGLVVIMSIWSLRRLTAPYRMMETAVNRIGKDLKSPPITESGSR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCH
EVRAAARAINAMQTRLREYVEDREHLAAALAHDLRTPMTRMRLRLELLRKSAVREALAHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
LADVESIASSVIDFATFEVNEEKAERIDFWSFVESIADPYPEVSFDNDDTRSRGLICMAR
HHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEC
PVALRRCVTNLVQNAVTYGKKAHLSLHRSDGTITLTIRDEGPGIPQAQIDAVFGSFVRLE
HHHHHHHHHHHHHHHHHCCCHHEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHH
QSRNRQTGGLGLGLTIARNIARAAGGEIRLSNHPDGGLLTELRLPLAA
HHCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHCCCCCC
>Mature Secondary Structure
MKRLLPQTLPAWVLLIVIAGLLISQVATLYIVSRDRAVANDVVDLYRLNDRAFSLVQLMS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHCHHHHHHHHHHH
GATPEERKATAAGLFNSTYALTVSDTPAVTSSIAGDDELAELEDILVGRLSKFGVTDARV
CCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHH
RRDPATREADDASTVSGPDIGQVERDLLVLAANFAQSDKLTASLRFADGQWLNFTEPITP
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCC
VGPILSFDSLPLYSLIAGLVVIMSIWSLRRLTAPYRMMETAVNRIGKDLKSPPITESGSR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCH
EVRAAARAINAMQTRLREYVEDREHLAAALAHDLRTPMTRMRLRLELLRKSAVREALAHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
LADVESIASSVIDFATFEVNEEKAERIDFWSFVESIADPYPEVSFDNDDTRSRGLICMAR
HHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEC
PVALRRCVTNLVQNAVTYGKKAHLSLHRSDGTITLTIRDEGPGIPQAQIDAVFGSFVRLE
HHHHHHHHHHHHHHHHHCCCHHEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHH
QSRNRQTGGLGLGLTIARNIARAAGGEIRLSNHPDGGLLTELRLPLAA
HHCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]