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The map label for this gene is apt

Identifier: 13472413

GI number: 13472413

Start: 2171673

End: 2172218

Strand: Reverse

Name: apt

Synonym: mll2701

Alternate gene names: 13472413

Gene position: 2172218-2171673 (Counterclockwise)

Preceding gene: 13472414

Following gene: 13472403

Centisome position: 30.87

GC content: 64.1

Gene sequence:

>546_bases
ATGAAACCTTCGCTCGAAGACACGCTGCTGGCTTCGATCCGCACCATTCCGGATTACCCGAAGCCCGGCATCCTGTTTCG
CGACATCACCACGCTGCTTGGCAATGCGCGCGCTTTCCGCCGCGCCATCGACGAACTGGTGCATCCCTATGCCGGCCAGA
AGGTCGACAAGATCGCCGGCATCGAGGCGCGCGGCTTTATCCTGGGCGGCGCCGTCGCCCACCAGCTTTCGGCCGGTTTC
GTGCCGATCCGCAAGAAGGGCAAGTTGCCGTTCGACACGGTGCGCGTCGCCTACAGTCTGGAATACGGGCTGGACGAGAT
GGAGATGCACAAGGATGGCGTTGCCCCGGGCGAAAAGGTGATCCTGGTCGACGACCTGATCGCCACCGGCGGCACCGCGG
AAGCGGCGGTCAAGCTGCTGCGCCAGATCGGCGCCGATATTCTTGCCGCTTGCTTCGTCATCGACCTGCCGGATCTTGGC
GGCCGCGCCAAGCTCGAGGCGCTTGGCGTGCCGGTAAGGACGCTGATCGGGTTCGAGGGACACTAA

Upstream 100 bases:

>100_bases
CGCCACATCGCGCTAGCCGTTGCAGGTCGCGTCGGATCATGATTGGCCCGCCGCCGTTTCACGCCCTGTCAGCCGAAGCT
GGATCATCCGGAGCCGCCTC

Downstream 100 bases:

>100_bases
GAGCGACTTCCCTTCTCCCTTGTGGGAGAAGGAAGAACCGCGCTACTCCACCTTCACCAGCACGGCGCTTTCAAACTCCA
GCACCTTGTCGCCGGTCGAA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MKPSLEDTLLASIRTIPDYPKPGILFRDITTLLGNARAFRRAIDELVHPYAGQKVDKIAGIEARGFILGGAVAHQLSAGF
VPIRKKGKLPFDTVRVAYSLEYGLDEMEMHKDGVAPGEKVILVDDLIATGGTAEAAVKLLRQIGADILAACFVIDLPDLG
GRAKLEALGVPVRTLIGFEGH

Sequences:

>Translated_181_residues
MKPSLEDTLLASIRTIPDYPKPGILFRDITTLLGNARAFRRAIDELVHPYAGQKVDKIAGIEARGFILGGAVAHQLSAGF
VPIRKKGKLPFDTVRVAYSLEYGLDEMEMHKDGVAPGEKVILVDDLIATGGTAEAAVKLLRQIGADILAACFVIDLPDLG
GRAKLEALGVPVRTLIGFEGH
>Mature_181_residues
MKPSLEDTLLASIRTIPDYPKPGILFRDITTLLGNARAFRRAIDELVHPYAGQKVDKIAGIEARGFILGGAVAHQLSAGF
VPIRKKGKLPFDTVRVAYSLEYGLDEMEMHKDGVAPGEKVILVDDLIATGGTAEAAVKLLRQIGADILAACFVIDLPDLG
GRAKLEALGVPVRTLIGFEGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=44.7058823529412, Blast_Score=146, Evalue=8e-36,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=47.9338842975207, Blast_Score=119, Evalue=2e-27,
Organism=Escherichia coli, GI1786675, Length=175, Percent_Identity=51.4285714285714, Blast_Score=187, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17509087, Length=183, Percent_Identity=42.0765027322404, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=178, Percent_Identity=41.0112359550562, Blast_Score=119, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=161, Percent_Identity=38.5093167701863, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17136334, Length=185, Percent_Identity=38.3783783783784, Blast_Score=119, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_RHILO (Q98HV0)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_103980.1
- ProteinModelPortal:   Q98HV0
- SMR:   Q98HV0
- GeneID:   1226641
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll2701
- NMPDR:   fig|266835.1.peg.2084
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19398; Mature: 19398

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPSLEDTLLASIRTIPDYPKPGILFRDITTLLGNARAFRRAIDELVHPYAGQKVDKIAG
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHC
IEARGFILGGAVAHQLSAGFVPIRKKGKLPFDTVRVAYSLEYGLDEMEMHKDGVAPGEKV
CCCCCEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCEE
ILVDDLIATGGTAEAAVKLLRQIGADILAACFVIDLPDLGGRAKLEALGVPVRTLIGFEG
EEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCHHHHCCCCC
H
C
>Mature Secondary Structure
MKPSLEDTLLASIRTIPDYPKPGILFRDITTLLGNARAFRRAIDELVHPYAGQKVDKIAG
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHC
IEARGFILGGAVAHQLSAGFVPIRKKGKLPFDTVRVAYSLEYGLDEMEMHKDGVAPGEKV
CCCCCEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCEE
ILVDDLIATGGTAEAAVKLLRQIGADILAACFVIDLPDLGGRAKLEALGVPVRTLIGFEG
EEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCHHHHCCCCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968