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The map label for this gene is envZ [H]

Identifier: 13472388

GI number: 13472388

Start: 2148682

End: 2150097

Strand: Direct

Name: envZ [H]

Synonym: mlr2667

Alternate gene names: 13472388

Gene position: 2148682-2150097 (Clockwise)

Preceding gene: 13472387

Following gene: 13472389

Centisome position: 30.54

GC content: 64.97

Gene sequence:

>1416_bases
ATGGCAACGACGGAACTGGAAGGGCCGGGACCTGACGGCTTGAGCGCACGCGCCAAGCGAACGCTCAAGGCGGTGCCGCG
CATCTGGAACCGGTTCTGGCGCCTCGTTTCTCTCTACATGCCCAAGCGCCTTTACGCGCGCTCGCTGATCATCGTCATCG
CGCCGATGATCCTGCTGCAATCGGTGGTCGCTTTCGTCTTCATGGAGCGCCATTGGGCAACGGTGACGCAGCGCCTGTCG
CAGGCCACCGTGCGCGACATCGCCGCCATCATCGACCTGATCGAGACCTACCCGCACGACGCCGACTACGCCAACGTCAT
CCGCATCGCCCAGGACCGCATGCAGCTGAAGGTCGATCTGCTGCCGCCGGATCCCTTGCCGCCGCCCGGTCCCAAACCGT
TCTTCTCGATCCTCGACGATGTTCTCTCCTCGGAGATCACCCGCCAGATCAACCGGCCGTTCTGGATCGACACGGTCGGC
AATTCCAACATCGTCGAGGTGCGCGTCCAGCTCGAGAACAAGGTGCTGCGCGTCTTCGTGCGCCGTAGCCAGGCCTATGC
CTCCAACACCCACATCTTCCTGATCTGGATGGTCGGCACCTCGCTGGTGCTGCTGATGATCGCCATCCCCTTCCTGCGCA
ACCAGATCCGGCCGATCCTAACGCTTGCCGAGGCCGCCGAAAGCTTCGGCAAGGGCCGGCCGATGCCGCGCGATTTTCGC
CCGCGCGGCGCCGAAGAGGTGCGCCGCGCCGGCTTTGCCTTCATCCAGATGCGCGAGCGCATCGAGCGCCAGATCGACCA
GCGCACCGCCATGCTGACGGGCGTCAGCCATGATCTCAGGACCATCCTCACCCGCTTCAAGCTGCAGCTGGCGCTGGCCG
GCGGCAAAACCGAGACCAAGGCGGCGCTCAACCAGGATATCGACGACATGCAGTCGATGCTGGAAGGCTATCTGGCCTTT
GCCCGCGGCGAAGCCTCGGAGGACCCGGGACGTTTCGATCTCGAAGCCTATTTCCAGAAGCTCAGCGACGAAGCCGCCTT
GCGCAAATGCAAGCTGTCGACGACGCTTTCCGGCGATCCGACCGTGCATGTGCGGCCGAATGCCTTCGCACGGCTGTTGT
CCAACGTCATCGGCAACGCCTTCCGCTATGCCAAGACGGTGGAAGTCAGCGCCGATCATGGCCGTGGCTCGCTCGTGGTC
ACCATCGACGACAACGGTCCCGGCATTCCGGCCGACAGGCGCGAGGACGTGTTCAAGCCCTTCGTGCGGCTCGACGAAGC
CCGCAACCTCGATGCCAGCGGCACCGGGCTCGGCCTGTCGATCGCCCGCGACATCGCCCGCAGCCATGGCGGCGACATCA
CCCTCGGCGACAGCCCGCTCGGCGGCCTGCGCGCGGTGATCAAGGTTCCAGCCTAG

Upstream 100 bases:

>100_bases
TTTTCGGAAAAGATCATGCTCCAACAAAGAGTTAGATCAGAAGACGATCCAACGGAATCGTCATCCTGATCGAGGGCCGC
GGGCGAAATGAAAAGAGCCA

Downstream 100 bases:

>100_bases
GCGGAGCATGATCCCGAAAAGTGGAAACCGGTTTTCGGATAAGATCATGCTCCCAGAAGGACTGCTTCATCCGCGCGTCA
TGAAATCATGGTGAAGAGCG

Product: two-component sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MATTELEGPGPDGLSARAKRTLKAVPRIWNRFWRLVSLYMPKRLYARSLIIVIAPMILLQSVVAFVFMERHWATVTQRLS
QATVRDIAAIIDLIETYPHDADYANVIRIAQDRMQLKVDLLPPDPLPPPGPKPFFSILDDVLSSEITRQINRPFWIDTVG
NSNIVEVRVQLENKVLRVFVRRSQAYASNTHIFLIWMVGTSLVLLMIAIPFLRNQIRPILTLAEAAESFGKGRPMPRDFR
PRGAEEVRRAGFAFIQMRERIERQIDQRTAMLTGVSHDLRTILTRFKLQLALAGGKTETKAALNQDIDDMQSMLEGYLAF
ARGEASEDPGRFDLEAYFQKLSDEAALRKCKLSTTLSGDPTVHVRPNAFARLLSNVIGNAFRYAKTVEVSADHGRGSLVV
TIDDNGPGIPADRREDVFKPFVRLDEARNLDASGTGLGLSIARDIARSHGGDITLGDSPLGGLRAVIKVPA

Sequences:

>Translated_471_residues
MATTELEGPGPDGLSARAKRTLKAVPRIWNRFWRLVSLYMPKRLYARSLIIVIAPMILLQSVVAFVFMERHWATVTQRLS
QATVRDIAAIIDLIETYPHDADYANVIRIAQDRMQLKVDLLPPDPLPPPGPKPFFSILDDVLSSEITRQINRPFWIDTVG
NSNIVEVRVQLENKVLRVFVRRSQAYASNTHIFLIWMVGTSLVLLMIAIPFLRNQIRPILTLAEAAESFGKGRPMPRDFR
PRGAEEVRRAGFAFIQMRERIERQIDQRTAMLTGVSHDLRTILTRFKLQLALAGGKTETKAALNQDIDDMQSMLEGYLAF
ARGEASEDPGRFDLEAYFQKLSDEAALRKCKLSTTLSGDPTVHVRPNAFARLLSNVIGNAFRYAKTVEVSADHGRGSLVV
TIDDNGPGIPADRREDVFKPFVRLDEARNLDASGTGLGLSIARDIARSHGGDITLGDSPLGGLRAVIKVPA
>Mature_470_residues
ATTELEGPGPDGLSARAKRTLKAVPRIWNRFWRLVSLYMPKRLYARSLIIVIAPMILLQSVVAFVFMERHWATVTQRLSQ
ATVRDIAAIIDLIETYPHDADYANVIRIAQDRMQLKVDLLPPDPLPPPGPKPFFSILDDVLSSEITRQINRPFWIDTVGN
SNIVEVRVQLENKVLRVFVRRSQAYASNTHIFLIWMVGTSLVLLMIAIPFLRNQIRPILTLAEAAESFGKGRPMPRDFRP
RGAEEVRRAGFAFIQMRERIERQIDQRTAMLTGVSHDLRTILTRFKLQLALAGGKTETKAALNQDIDDMQSMLEGYLAFA
RGEASEDPGRFDLEAYFQKLSDEAALRKCKLSTTLSGDPTVHVRPNAFARLLSNVIGNAFRYAKTVEVSADHGRGSLVVT
IDDNGPGIPADRREDVFKPFVRLDEARNLDASGTGLGLSIARDIARSHGGDITLGDSPLGGLRAVIKVPA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=279, Percent_Identity=34.0501792114695, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=32.0754716981132, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1787894, Length=282, Percent_Identity=30.4964539007092, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=26.0869565217391, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=31.063829787234, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787374, Length=99, Percent_Identity=39.3939393939394, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87082128, Length=288, Percent_Identity=24.6527777777778, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786783, Length=256, Percent_Identity=26.5625, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788279, Length=302, Percent_Identity=25.4966887417219, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=296, Percent_Identity=26.0135135135135, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=294, Percent_Identity=25.5102040816327, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI48994928, Length=225, Percent_Identity=25.3333333333333, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52544; Mature: 52412

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTELEGPGPDGLSARAKRTLKAVPRIWNRFWRLVSLYMPKRLYARSLIIVIAPMILLQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVVAFVFMERHWATVTQRLSQATVRDIAAIIDLIETYPHDADYANVIRIAQDRMQLKVDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEE
LPPDPLPPPGPKPFFSILDDVLSSEITRQINRPFWIDTVGNSNIVEVRVQLENKVLRVFV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEHHHHHHHHHH
RRSQAYASNTHIFLIWMVGTSLVLLMIAIPFLRNQIRPILTLAEAAESFGKGRPMPRDFR
HHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PRGAEEVRRAGFAFIQMRERIERQIDQRTAMLTGVSHDLRTILTRFKLQLALAGGKTETK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEECCCCHHH
AALNQDIDDMQSMLEGYLAFARGEASEDPGRFDLEAYFQKLSDEAALRKCKLSTTLSGDP
HHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEECCCCC
TVHVRPNAFARLLSNVIGNAFRYAKTVEVSADHGRGSLVVTIDDNGPGIPADRREDVFKP
EEEECCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHH
FVRLDEARNLDASGTGLGLSIARDIARSHGGDITLGDSPLGGLRAVIKVPA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHEECCC
>Mature Secondary Structure 
ATTELEGPGPDGLSARAKRTLKAVPRIWNRFWRLVSLYMPKRLYARSLIIVIAPMILLQ
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVVAFVFMERHWATVTQRLSQATVRDIAAIIDLIETYPHDADYANVIRIAQDRMQLKVDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEE
LPPDPLPPPGPKPFFSILDDVLSSEITRQINRPFWIDTVGNSNIVEVRVQLENKVLRVFV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEHHHHHHHHHH
RRSQAYASNTHIFLIWMVGTSLVLLMIAIPFLRNQIRPILTLAEAAESFGKGRPMPRDFR
HHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PRGAEEVRRAGFAFIQMRERIERQIDQRTAMLTGVSHDLRTILTRFKLQLALAGGKTETK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEECCCCHHH
AALNQDIDDMQSMLEGYLAFARGEASEDPGRFDLEAYFQKLSDEAALRKCKLSTTLSGDP
HHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEECCCCC
TVHVRPNAFARLLSNVIGNAFRYAKTVEVSADHGRGSLVVTIDDNGPGIPADRREDVFKP
EEEECCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHH
FVRLDEARNLDASGTGLGLSIARDIARSHGGDITLGDSPLGGLRAVIKVPA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]