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The map label for this gene is pcm [H]

Identifier: 13472360

GI number: 13472360

Start: 2126259

End: 2126984

Strand: Reverse

Name: pcm [H]

Synonym: mll2628

Alternate gene names: 13472360

Gene position: 2126984-2126259 (Counterclockwise)

Preceding gene: 13472368

Following gene: 13472359

Centisome position: 30.23

GC content: 61.98

Gene sequence:

>726_bases
ATGGTGGCCAATCGCGGCGAGGATCCGAAGTTTTTGGCGCAGCGATTCGATCGCTTCCAGATCATGGTCTACAACAAGGA
CGTGCTGGACGACCGCAACAAGCGCGCCTTCCTTTTGACTCCGCGTGAGGAATTCGTGCTGCCGCAGAATCTGGGGCGCG
CCTACGACCATGCCTTCCTCGACATCGGCTATGGCGTGACGATTTCGGGTCCGCACCTGGTCGGGCGGATGACGACGGCG
ATCGACGTGCAATTCGGCGAGGCCGTACTCGAGATCGGCACCGGTTCGGGTTACCAGTCGGCCTATCTCGCCAACCTCAC
CGACAAGGTGCACACGATCGAGATCATCAATCCGCTGGCGCAGCGCACGCGGCGCACCTATGACGGGCTGGTCGAGCGCG
GCTACAGCGAATTCGGTTCGGTCACCAGCCGCAATGCCGACGGCTATTATGGCTGGGAAAGCGTCGGCCCGTTCGACAAG
ATCATCGTCACCTGCGGCATCGACCACATTCCGCCGTCGCTGCTGCAGCAGTTGAAGCCCAATGGCGTGATGGTCATTCC
GGTCGGCCCGCCGGGCGCGCAGCACGTGCTCAAGGTGACCAAGCAGCAGCTCGCGGACGGCACGTTCAACATCGTCCGCT
CGGACATCTACAATGGCAAGGTGGTGCCGTTCGTGCCGTTCACCAAGCTGGAAGGCGACCAGATCGTCGGCACGCACAAC
AGCTGA

Upstream 100 bases:

>100_bases
GTTCTCCATTCTTCCAGCCATGGTCAGGGCCAACGTGCCGGTGCCCTACGACCGCAACGCCGAAGTGCCGTTCAACGACA
AAAAATCGTTCATCGACTGG

Downstream 100 bases:

>100_bases
GTTGCCGTGCTGTCGGGCTAAGCCGCCGCATCAAGGGGCCTGAATGACGGCTGTTGTATCGACCTCTCGACCAAGCATCA
CCTCGCTTGAGGCGCCTCGG

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MVANRGEDPKFLAQRFDRFQIMVYNKDVLDDRNKRAFLLTPREEFVLPQNLGRAYDHAFLDIGYGVTISGPHLVGRMTTA
IDVQFGEAVLEIGTGSGYQSAYLANLTDKVHTIEIINPLAQRTRRTYDGLVERGYSEFGSVTSRNADGYYGWESVGPFDK
IIVTCGIDHIPPSLLQQLKPNGVMVIPVGPPGAQHVLKVTKQQLADGTFNIVRSDIYNGKVVPFVPFTKLEGDQIVGTHN
S

Sequences:

>Translated_241_residues
MVANRGEDPKFLAQRFDRFQIMVYNKDVLDDRNKRAFLLTPREEFVLPQNLGRAYDHAFLDIGYGVTISGPHLVGRMTTA
IDVQFGEAVLEIGTGSGYQSAYLANLTDKVHTIEIINPLAQRTRRTYDGLVERGYSEFGSVTSRNADGYYGWESVGPFDK
IIVTCGIDHIPPSLLQQLKPNGVMVIPVGPPGAQHVLKVTKQQLADGTFNIVRSDIYNGKVVPFVPFTKLEGDQIVGTHN
S
>Mature_241_residues
MVANRGEDPKFLAQRFDRFQIMVYNKDVLDDRNKRAFLLTPREEFVLPQNLGRAYDHAFLDIGYGVTISGPHLVGRMTTA
IDVQFGEAVLEIGTGSGYQSAYLANLTDKVHTIEIINPLAQRTRRTYDGLVERGYSEFGSVTSRNADGYYGWESVGPFDK
IIVTCGIDHIPPSLLQQLKPNGVMVIPVGPPGAQHVLKVTKQQLADGTFNIVRSDIYNGKVVPFVPFTKLEGDQIVGTHN
S

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI226530908, Length=162, Percent_Identity=29.6296296296296, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1789100, Length=204, Percent_Identity=36.7647058823529, Blast_Score=123, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 26728; Mature: 26728

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS01279 PCMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVANRGEDPKFLAQRFDRFQIMVYNKDVLDDRNKRAFLLTPREEFVLPQNLGRAYDHAFL
CCCCCCCCHHHHHHHCCCEEEEEECCHHHCCCCCEEEEECCHHHCCCCHHHCHHHHHHEE
DIGYGVTISGPHLVGRMTTAIDVQFGEAVLEIGTGSGYQSAYLANLTDKVHTIEIINPLA
EECCCEEECCCHHEEEHEEEEEEECCCEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHH
QRTRRTYDGLVERGYSEFGSVTSRNADGYYGWESVGPFDKIIVTCGIDHIPPSLLQQLKP
HHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCHHHEEEEECCCCCCHHHHHHCCC
NGVMVIPVGPPGAQHVLKVTKQQLADGTFNIVRSDIYNGKVVPFVPFTKLEGDQIVGTHN
CCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCEECCCCEEECCCC
S
C
>Mature Secondary Structure
MVANRGEDPKFLAQRFDRFQIMVYNKDVLDDRNKRAFLLTPREEFVLPQNLGRAYDHAFL
CCCCCCCCHHHHHHHCCCEEEEEECCHHHCCCCCEEEEECCHHHCCCCHHHCHHHHHHEE
DIGYGVTISGPHLVGRMTTAIDVQFGEAVLEIGTGSGYQSAYLANLTDKVHTIEIINPLA
EECCCEEECCCHHEEEHEEEEEEECCCEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHH
QRTRRTYDGLVERGYSEFGSVTSRNADGYYGWESVGPFDKIIVTCGIDHIPPSLLQQLKP
HHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCHHHEEEEECCCCCCHHHHHHCCC
NGVMVIPVGPPGAQHVLKVTKQQLADGTFNIVRSDIYNGKVVPFVPFTKLEGDQIVGTHN
CCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCEECCCCEEECCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA