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The map label for this gene is gdhII [H]

Identifier: 13472198

GI number: 13472198

Start: 1965796

End: 1966662

Strand: Reverse

Name: gdhII [H]

Synonym: mll2413

Alternate gene names: 13472198

Gene position: 1966662-1965796 (Counterclockwise)

Preceding gene: 13472199

Following gene: 13472196

Centisome position: 27.95

GC content: 64.01

Gene sequence:

>867_bases
ATGTCGCTCAAGGGAAAGACGCTGTTCATCTCCGGCGGGTCGCGCGGCATCGGGCTGGCGATCGCGCTGCGGGCGGCGCG
CGACGGCGCCAATGTGACGATCGCCGCCAAGACCGCCGAGCCGCATCCGAAGCTGCCGGGAACGATCTACAGTGCGGCGC
AGGAGATCGAGCAGGCCGGCGGCAAGGCACTGCCTGTGCTGTGCGACATCCGCGAGGAGGCGCAGGTGGCCGAGGCGGTT
GCAAAGACGGTGGAGAAATTCGGCGGCATCGATATCTGCGTCAACAATGCCAGCGCCATCCAGCTCACCGGCACGCTGCA
GACCGACATGAAGCGCTACGACCTGATGCATCAGATCAACACGCGCGGCACCTTCCTGGTCTCCAAAATGTGTATTCCAC
ACCTCAAGTTAGCCGATAATCCTCACATCCTGAATCTGGCGCCGCCGCTCGACATGAAGGCCAAGTGGTTCAAGAACCAT
GTCGCCTACACCATGGCCAAGTTCGGCATGTCGATGTGCACGCTGGGGATGAGCGCCGAGTTCGCCAAGGACGGCATCGC
CGTCAATTCGCTGTGGCCGATCTCGACCATCGACACGGCGGCGGTGCGCAACCTGCTCGGCGGCGCGACGGTTGCGGCGA
TGAGCCGGTCGCCCGACATCATGGCCGACGCCGCGCATGCCATCTTCATGCGGCCGTCGCGCGAGGCATCAGGCAATTTC
TACATCGACGAAGAGGTGCTGCGCGCCGAGGGGGTCACGGATTTCTCAGCCTATGCGCCCGGCGCGACCGGGCCGCTGGC
CGGCGACTTTTTCGTGCCGGACGAGGTGTTCGCGCGCACGGGCAGCAAGATCAAGAGTATCTACTGA

Upstream 100 bases:

>100_bases
GACCCTCCGCAGCGTCACCATGGCTTCCCGCCGCAAGCTCTTGTATCCCGCTGCGGCGCGCGCAAGGATCGCGCAACAAG
ACAACGCAGGCGGAGGAAAA

Downstream 100 bases:

>100_bases
CGCCGCCCCGCGCTGCCCCTCATCCGCCTACCGGCGTTCGTCTTTCAAAGAGCCAAGTACTTGGCTCTTTGTCCGCAACG
CGGACCACGTCTCACCTCCC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: GLCDH-II [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSLKGKTLFISGGSRGIGLAIALRAARDGANVTIAAKTAEPHPKLPGTIYSAAQEIEQAGGKALPVLCDIREEAQVAEAV
AKTVEKFGGIDICVNNASAIQLTGTLQTDMKRYDLMHQINTRGTFLVSKMCIPHLKLADNPHILNLAPPLDMKAKWFKNH
VAYTMAKFGMSMCTLGMSAEFAKDGIAVNSLWPISTIDTAAVRNLLGGATVAAMSRSPDIMADAAHAIFMRPSREASGNF
YIDEEVLRAEGVTDFSAYAPGATGPLAGDFFVPDEVFARTGSKIKSIY

Sequences:

>Translated_288_residues
MSLKGKTLFISGGSRGIGLAIALRAARDGANVTIAAKTAEPHPKLPGTIYSAAQEIEQAGGKALPVLCDIREEAQVAEAV
AKTVEKFGGIDICVNNASAIQLTGTLQTDMKRYDLMHQINTRGTFLVSKMCIPHLKLADNPHILNLAPPLDMKAKWFKNH
VAYTMAKFGMSMCTLGMSAEFAKDGIAVNSLWPISTIDTAAVRNLLGGATVAAMSRSPDIMADAAHAIFMRPSREASGNF
YIDEEVLRAEGVTDFSAYAPGATGPLAGDFFVPDEVFARTGSKIKSIY
>Mature_287_residues
SLKGKTLFISGGSRGIGLAIALRAARDGANVTIAAKTAEPHPKLPGTIYSAAQEIEQAGGKALPVLCDIREEAQVAEAVA
KTVEKFGGIDICVNNASAIQLTGTLQTDMKRYDLMHQINTRGTFLVSKMCIPHLKLADNPHILNLAPPLDMKAKWFKNHV
AYTMAKFGMSMCTLGMSAEFAKDGIAVNSLWPISTIDTAAVRNLLGGATVAAMSRSPDIMADAAHAIFMRPSREASGNFY
IDEEVLRAEGVTDFSAYAPGATGPLAGDFFVPDEVFARTGSKIKSIY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254986, Length=284, Percent_Identity=57.0422535211268, Blast_Score=322, Evalue=2e-88,
Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=27.734375, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI19923817, Length=207, Percent_Identity=27.536231884058, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI209862901, Length=203, Percent_Identity=26.1083743842365, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI19923983, Length=203, Percent_Identity=26.1083743842365, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87082100, Length=278, Percent_Identity=29.4964028776978, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1789208, Length=208, Percent_Identity=27.4038461538462, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790717, Length=194, Percent_Identity=25.7731958762887, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082160, Length=198, Percent_Identity=27.7777777777778, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=269, Percent_Identity=61.3382899628253, Blast_Score=349, Evalue=9e-97,
Organism=Caenorhabditis elegans, GI17558628, Length=281, Percent_Identity=60.1423487544484, Blast_Score=329, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI17559104, Length=193, Percent_Identity=30.5699481865285, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=198, Percent_Identity=30.8080808080808, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=195, Percent_Identity=28.7179487179487, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=193, Percent_Identity=30.0518134715026, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=198, Percent_Identity=28.7878787878788, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=24.8031496062992, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=205, Percent_Identity=29.2682926829268, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=198, Percent_Identity=29.7979797979798, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=193, Percent_Identity=28.4974093264249, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=200, Percent_Identity=28.5, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=210, Percent_Identity=29.0476190476191, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=205, Percent_Identity=30.7317073170732, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=197, Percent_Identity=28.9340101522843, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=196, Percent_Identity=27.5510204081633, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21357673, Length=275, Percent_Identity=62.9090909090909, Blast_Score=359, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24644339, Length=248, Percent_Identity=27.4193548387097, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI23397609, Length=193, Percent_Identity=29.0155440414508, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357041, Length=246, Percent_Identity=29.2682926829268, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571526, Length=194, Percent_Identity=29.8969072164948, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21355319, Length=192, Percent_Identity=28.125, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.47 [H]

Molecular weight: Translated: 30681; Mature: 30550

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKGKTLFISGGSRGIGLAIALRAARDGANVTIAAKTAEPHPKLPGTIYSAAQEIEQAG
CCCCCCEEEEECCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCC
GKALPVLCDIREEAQVAEAVAKTVEKFGGIDICVNNASAIQLTGTLQTDMKRYDLMHQIN
CCCCEEEECCHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECHHHHHHHHHHHHHHC
TRGTFLVSKMCIPHLKLADNPHILNLAPPLDMKAKWFKNHVAYTMAKFGMSMCTLGMSAE
CCCCEEHHHHCCCCCEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
FAKDGIAVNSLWPISTIDTAAVRNLLGGATVAAMSRSPDIMADAAHAIFMRPSREASGNF
HHHCCEEECCCCCCCHHHHHHHHHHHCCHHEEECCCCCCHHHHHHHEEEECCCCCCCCCE
YIDEEVLRAEGVTDFSAYAPGATGPLAGDFFVPDEVFARTGSKIKSIY
EECHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHCCCHHHCCC
>Mature Secondary Structure 
SLKGKTLFISGGSRGIGLAIALRAARDGANVTIAAKTAEPHPKLPGTIYSAAQEIEQAG
CCCCCEEEEECCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCC
GKALPVLCDIREEAQVAEAVAKTVEKFGGIDICVNNASAIQLTGTLQTDMKRYDLMHQIN
CCCCEEEECCHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECHHHHHHHHHHHHHHC
TRGTFLVSKMCIPHLKLADNPHILNLAPPLDMKAKWFKNHVAYTMAKFGMSMCTLGMSAE
CCCCEEHHHHCCCCCEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
FAKDGIAVNSLWPISTIDTAAVRNLLGGATVAAMSRSPDIMADAAHAIFMRPSREASGNF
HHHCCEEECCCCCCCHHHHHHHHHHHCCHHEEECCCCCCHHHHHHHEEEECCCCCCCCCE
YIDEEVLRAEGVTDFSAYAPGATGPLAGDFFVPDEVFARTGSKIKSIY
EECHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA