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The map label for this gene is mdtA [H]

Identifier: 13472189

GI number: 13472189

Start: 1953891

End: 1954973

Strand: Direct

Name: mdtA [H]

Synonym: mlr2403

Alternate gene names: 13472189

Gene position: 1953891-1954973 (Clockwise)

Preceding gene: 13472188

Following gene: 13472190

Centisome position: 27.77

GC content: 64.36

Gene sequence:

>1083_bases
ATGCGCCTGCCATCAGGTCTGCTCCTTTCTGCCTGTATCGCCTGCCTTTGTCTTTCCGGCTGTTCTCAAGAAGAAACCGC
CGCACCATCAGCGCCTCGGCCTGCACGGGTCGTCGTGGTAACGCCTCACAAGCTCGCGCTGGTGGCGCAGGGCGCCGGCC
GCATCCGATCGCGTTATGTGAGCGCGGTCGGCTTCGAGGTCGGTGGTCGAATGCTCTCGCGACAGGTCGACATGGGCGCA
ATCGTCAAGAAAGGCCAGAAGCTCGCGGAGCTCAGCGCCGTCGACTACCAGAACAAGGTGACTGCGGCCGAGGCCGACGT
CGATGCAGCAAAGGCAGCGCTCGCCCAAGCATCCGCACAGGAGGAGCGCTTCAGAATCCTGCTCGGCAAGGGCTTCGCCA
CACATTCCCAGTACGATGAAGCGCTCAAGTCGCTGCAGAGCGCACGAGCGCAGGTCCAGGCGACCGAAGCCAATCTGCGT
ATCGCGCGGAACCAACTAAGCTATACCCAGCTCACGGCGACCGACGACGGTGTGGTGACGGCGACCGGAGCCGACCCGGG
TCAGGTCGTGGCTGCGGGCCAGATGGTCGTCGAGGTCTCCGGCAATGACGCACGCGAGGCGGTGTTCGCGGTGGCCACAA
GTGATGTCACCCGGGCAAAGCTCGGCATGGCGGTGAACGTATCGCTGCAGGGCCGTCTCGACATCGCCGTCACCGGCACT
ATCCGTGAGATTTCGCCGGAGGCCGACAGCGCGACAGGCACCTATCAGGTGAAGGTGGCGCTGGCTTCGCCGCCGTCTGA
GATGCGCCTCGGGGCCGTCGTTATCGGTCGCGTCGAAAGCGATGGCGGTCAGGAGGTTGCGACATTGCCGCCGAGCGCGC
TGCTGCAGTCCGGAGACCGCCCGCAGGTTTGGGTGGTCGGCCAAGACGACAAGGTGCAGCGCCGTGAGGTCAAGCTTGTC
GAATTCGATGCGAACTCGATTGTGGTGAGCCACGGACTGTCCGCTGGGGAGAAAGTGGTGACCGCCGGCGTCAATTCGCT
CGCCGACGGTGACCTTGTGAACCCCGAGTCGGAGGTCAAGTGA

Upstream 100 bases:

>100_bases
TTTGACTTAAAAGTTCAAAGTCAAAATTGAACAGCGGCCAGGTCGCCGCGCTCACAAAACCGCCGAACCTTTCAACCTCA
CCGTTCCAACGGAGGCTCTC

Downstream 100 bases:

>100_bases
TGACACGCTTCAATCTCTCCGAATGGGCCGTCCACAACCGCGCCCTCGTCGTCTTCCTCATGCTCATCTGCGTCATTGGC
GGAGTGAGCGCCTATGAGCG

Product: RND efflux membrane fusion protein precursor

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MRLPSGLLLSACIACLCLSGCSQEETAAPSAPRPARVVVVTPHKLALVAQGAGRIRSRYVSAVGFEVGGRMLSRQVDMGA
IVKKGQKLAELSAVDYQNKVTAAEADVDAAKAALAQASAQEERFRILLGKGFATHSQYDEALKSLQSARAQVQATEANLR
IARNQLSYTQLTATDDGVVTATGADPGQVVAAGQMVVEVSGNDAREAVFAVATSDVTRAKLGMAVNVSLQGRLDIAVTGT
IREISPEADSATGTYQVKVALASPPSEMRLGAVVIGRVESDGGQEVATLPPSALLQSGDRPQVWVVGQDDKVQRREVKLV
EFDANSIVVSHGLSAGEKVVTAGVNSLADGDLVNPESEVK

Sequences:

>Translated_360_residues
MRLPSGLLLSACIACLCLSGCSQEETAAPSAPRPARVVVVTPHKLALVAQGAGRIRSRYVSAVGFEVGGRMLSRQVDMGA
IVKKGQKLAELSAVDYQNKVTAAEADVDAAKAALAQASAQEERFRILLGKGFATHSQYDEALKSLQSARAQVQATEANLR
IARNQLSYTQLTATDDGVVTATGADPGQVVAAGQMVVEVSGNDAREAVFAVATSDVTRAKLGMAVNVSLQGRLDIAVTGT
IREISPEADSATGTYQVKVALASPPSEMRLGAVVIGRVESDGGQEVATLPPSALLQSGDRPQVWVVGQDDKVQRREVKLV
EFDANSIVVSHGLSAGEKVVTAGVNSLADGDLVNPESEVK
>Mature_360_residues
MRLPSGLLLSACIACLCLSGCSQEETAAPSAPRPARVVVVTPHKLALVAQGAGRIRSRYVSAVGFEVGGRMLSRQVDMGA
IVKKGQKLAELSAVDYQNKVTAAEADVDAAKAALAQASAQEERFRILLGKGFATHSQYDEALKSLQSARAQVQATEANLR
IARNQLSYTQLTATDDGVVTATGADPGQVVAAGQMVVEVSGNDAREAVFAVATSDVTRAKLGMAVNVSLQGRLDIAVTGT
IREISPEADSATGTYQVKVALASPPSEMRLGAVVIGRVESDGGQEVATLPPSALLQSGDRPQVWVVGQDDKVQRREVKLV
EFDANSIVVSHGLSAGEKVVTAGVNSLADGDLVNPESEVK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=368, Percent_Identity=24.4565217391304, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87082036, Length=308, Percent_Identity=25.3246753246753, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1786668, Length=361, Percent_Identity=26.0387811634349, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1789665, Length=376, Percent_Identity=25, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37514; Mature: 37514

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLPSGLLLSACIACLCLSGCSQEETAAPSAPRPARVVVVTPHKLALVAQGAGRIRSRYV
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHH
SAVGFEVGGRMLSRQVDMGAIVKKGQKLAELSAVDYQNKVTAAEADVDAAKAALAQASAQ
HHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHCC
EERFRILLGKGFATHSQYDEALKSLQSARAQVQATEANLRIARNQLSYTQLTATDDGVVT
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCEEEEEECCCCEEE
ATGADPGQVVAAGQMVVEVSGNDAREAVFAVATSDVTRAKLGMAVNVSLQGRLDIAVTGT
ECCCCCCCEEEECEEEEEECCCCHHHEEEEEECCCHHHHHCCEEEEEEECCEEEEEEEEE
IREISPEADSATGTYQVKVALASPPSEMRLGAVVIGRVESDGGQEVATLPPSALLQSGDR
EEECCCCCCCCCCEEEEEEEEECCCCHHEEEEEEEEEEECCCCCEEEECCHHHHHCCCCC
PQVWVVGQDDKVQRREVKLVEFDANSIVVSHGLSAGEKVVTAGVNSLADGDLVNPESEVK
CEEEEECCCCCCCCCEEEEEEECCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure
MRLPSGLLLSACIACLCLSGCSQEETAAPSAPRPARVVVVTPHKLALVAQGAGRIRSRYV
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCHHHHHHHHH
SAVGFEVGGRMLSRQVDMGAIVKKGQKLAELSAVDYQNKVTAAEADVDAAKAALAQASAQ
HHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHCC
EERFRILLGKGFATHSQYDEALKSLQSARAQVQATEANLRIARNQLSYTQLTATDDGVVT
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCEEEEEECCCCEEE
ATGADPGQVVAAGQMVVEVSGNDAREAVFAVATSDVTRAKLGMAVNVSLQGRLDIAVTGT
ECCCCCCCEEEECEEEEEECCCCHHHEEEEEECCCHHHHHCCEEEEEEECCEEEEEEEEE
IREISPEADSATGTYQVKVALASPPSEMRLGAVVIGRVESDGGQEVATLPPSALLQSGDR
EEECCCCCCCCCCEEEEEEEEECCCCHHEEEEEEEEEEECCCCCEEEECCHHHHHCCCCC
PQVWVVGQDDKVQRREVKLVEFDANSIVVSHGLSAGEKVVTAGVNSLADGDLVNPESEVK
CEEEEECCCCCCCCCEEEEEEECCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]