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The map label for this gene is groEL [H]

Identifier: 13472184

GI number: 13472184

Start: 1946838

End: 1948466

Strand: Direct

Name: groEL [H]

Synonym: mlr2394

Alternate gene names: 13472184

Gene position: 1946838-1948466 (Clockwise)

Preceding gene: 13472183

Following gene: 13472186

Centisome position: 27.67

GC content: 63.9

Gene sequence:

>1629_bases
ATGGCTGCCAAGGAAGTGAAATTCCATTCCGACGCCCGTGAGAAGATGCTGCGCGGCGTCAACATCCTCGCCGACGCGGT
GAAGGTGACGCTCGGCCCCAAGGGCCGCAACGTCGTCATCGACAAGTCGTTCGGCGCCCCGCGCATCACCAAGGACGGCG
TCACCGTCGCCAAGGAAATCGAGCTCGAGGACAAGTTCGAGAACATGGGCGCCCAGATGGTCCGCGAGGTCGCCTCGAAG
ACCAGCGATCTGGCCGGCGACGGCACCACGACTGCAACGGTGCTTGCCCAGGCGATCGTCAAGGAAGGTGCGAAGGCCGT
CGCCTCGGGGATGAACCCGATGGACCTGAAGCGCGGCATCGATAAGGCCGTCGAAGCGATTGTTCAGGAGTTGAAGACCA
ACGCCCGCAAGGTGACCAGGAATGACGAGATCGCCCAGGTCGGCACCATCTCGGCCAATGGCGACGCCGAGATCGGCCGC
TTCCTGGCCGAGGCGATGCAGAAGGTCGGCAACGAAGGCGTCATCACCGTCGAGGAAGCCAAGACCGCCGAGACCGAACT
CGAAGTCGTAGAGGGCATGCAATTCGATCGCGGCTATCTCAGCCCGTACTTCATCACCAATCAGGACAAGATGCGCGTCG
AACTCGAAGAGCCCTATGTGCTGATCCACGAGAAGAAGCTGTCCAATCTGCAGGCGCTGCTTCCGGTGCTGGAGGCCGTG
GTCCAGTCTTCCAAACCGCTGCTGATCATCGCCGAGGATGTCGAGGGCGAGGCCTTGGCCACCCTGGTCGTCAACAAGCT
GCGCGGTGGCCTTAAGGTCGCTGCCGTCAAGGCGCCCGGCTTCGGCGACCGCCGCAAGGCGATGCTGGAAGACATCGCCA
TCCTGACCGGCGGCACGGCCATCAGCGAGGATCTCGGCATCAAGCTGGAGAACGTCACGCTGGAGATGCTGGGCCGCGCC
AAGAAGGTGGTGATCGAGAAGGAGAACACCACCATCGTCGACGGCGCCGGTTCGAAGGACGAGATCCAGGGCCGCGTCAG
TCAGATCAAGTCGCAGATCGAGGAGACTACCTCCGACTACGACAAGGAAAAGCTGCAGGAGCGGCTGGCCAAGCTCGCCG
GCGGTGTCGCCGTCATCCGCGTCGGCGGCTCGACGGAGGTCGAGGTCAAGGAGCGCAAGGACCGTGTCGACGATGCCATG
CATGCGACGCGCGCTGCGGTCGAGGAAGGCGTGTTGCCAGGTGGCGGCGTGGCGCTTCTGCGTGCCGCCAAGGCACTGGA
CAGCGTGCAGGCCGAGAATGAAGACCAGAAGCACGGTATCGAGATCGTGCGCCGCGCGATCGAAGCGCCCGTGCGCCAGA
TCGCCGAGAACGCCGGCGCGGAAGGCTCGATCATCGTCGGCAAGCTGCGTGAGAAACCGGAGTTCGGCTGGGGCTGGAAC
GCACAGACCAACGCGTTCGGCGACCTCTACAACGAGGGCGTCATCGACCCGGTGAAGGTGGTGCGGACCGCGCTCCAGGA
TGCGGCATCGGTTGCCGGCCTGCTGGTAACGACGGAAGCGATGGTTGCCGAGAAGCCGAAGAAGGAACCCGCCGTTCCGG
CAATGCCGGCTGGTGGCATGGACTTCTGA

Upstream 100 bases:

>100_bases
GCGTGATCGAGCAGACCGCGACGGTCAAGAAAGCCGCCTGACCAAGGCTTTGATCCAACCGCATCCAATCAATGAAGCTG
CCTGTTGAAGGAGTGATCCA

Downstream 100 bases:

>100_bases
TGGTAACGGCTGTGTCCGCGCCCGGTGGGCGCGGACACCCTGACAAATGAGTAGAGCCATGAATGTGATGAACTTGAACG
TAATCCCCCCGCCGGCGCGT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MAAKEVKFHSDAREKMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASK
TSDLAGDGTTTATVLAQAIVKEGAKAVASGMNPMDLKRGIDKAVEAIVQELKTNARKVTRNDEIAQVGTISANGDAEIGR
FLAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNQDKMRVELEEPYVLIHEKKLSNLQALLPVLEAV
VQSSKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTAISEDLGIKLENVTLEMLGRA
KKVVIEKENTTIVDGAGSKDEIQGRVSQIKSQIEETTSDYDKEKLQERLAKLAGGVAVIRVGGSTEVEVKERKDRVDDAM
HATRAAVEEGVLPGGGVALLRAAKALDSVQAENEDQKHGIEIVRRAIEAPVRQIAENAGAEGSIIVGKLREKPEFGWGWN
AQTNAFGDLYNEGVIDPVKVVRTALQDAASVAGLLVTTEAMVAEKPKKEPAVPAMPAGGMDF

Sequences:

>Translated_542_residues
MAAKEVKFHSDAREKMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASK
TSDLAGDGTTTATVLAQAIVKEGAKAVASGMNPMDLKRGIDKAVEAIVQELKTNARKVTRNDEIAQVGTISANGDAEIGR
FLAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNQDKMRVELEEPYVLIHEKKLSNLQALLPVLEAV
VQSSKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTAISEDLGIKLENVTLEMLGRA
KKVVIEKENTTIVDGAGSKDEIQGRVSQIKSQIEETTSDYDKEKLQERLAKLAGGVAVIRVGGSTEVEVKERKDRVDDAM
HATRAAVEEGVLPGGGVALLRAAKALDSVQAENEDQKHGIEIVRRAIEAPVRQIAENAGAEGSIIVGKLREKPEFGWGWN
AQTNAFGDLYNEGVIDPVKVVRTALQDAASVAGLLVTTEAMVAEKPKKEPAVPAMPAGGMDF
>Mature_541_residues
AAKEVKFHSDAREKMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASKT
SDLAGDGTTTATVLAQAIVKEGAKAVASGMNPMDLKRGIDKAVEAIVQELKTNARKVTRNDEIAQVGTISANGDAEIGRF
LAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNQDKMRVELEEPYVLIHEKKLSNLQALLPVLEAVV
QSSKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTAISEDLGIKLENVTLEMLGRAK
KVVIEKENTTIVDGAGSKDEIQGRVSQIKSQIEETTSDYDKEKLQERLAKLAGGVAVIRVGGSTEVEVKERKDRVDDAMH
ATRAAVEEGVLPGGGVALLRAAKALDSVQAENEDQKHGIEIVRRAIEAPVRQIAENAGAEGSIIVGKLREKPEFGWGWNA
QTNAFGDLYNEGVIDPVKVVRTALQDAASVAGLLVTTEAMVAEKPKKEPAVPAMPAGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=54.7348484848485, Blast_Score=575, Evalue=1e-164,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=54.7348484848485, Blast_Score=575, Evalue=1e-164,
Organism=Homo sapiens, GI38455427, Length=523, Percent_Identity=21.414913957935, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=67.4199623352166, Blast_Score=709, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=54.3560606060606, Blast_Score=574, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI193210679, Length=239, Percent_Identity=50.2092050209205, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17564182, Length=551, Percent_Identity=23.4119782214156, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=58.0152671755725, Blast_Score=613, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6322524, Length=534, Percent_Identity=22.8464419475655, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=56.6287878787879, Blast_Score=597, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=56.6287878787879, Blast_Score=597, Evalue=1e-171,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=52.0833333333333, Blast_Score=553, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=52.0833333333333, Blast_Score=553, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=52.0833333333333, Blast_Score=553, Evalue=1e-157,
Organism=Drosophila melanogaster, GI17864606, Length=526, Percent_Identity=44.8669201520913, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24584129, Length=534, Percent_Identity=35.7677902621723, Blast_Score=341, Evalue=6e-94,
Organism=Drosophila melanogaster, GI19921262, Length=534, Percent_Identity=35.7677902621723, Blast_Score=341, Evalue=6e-94,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58045; Mature: 57914

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEVKFHSDAREKMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCCCCHHHC
ELEDKFENMGAQMVREVASKTSDLAGDGTTTATVLAQAIVKEGAKAVASGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVEAIVQELKTNARKVTRNDEIAQVGTISANGDAEIGRFLAEAMQKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHHCCCCCHHEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFITNQDKMRVELEEPYVLIHEKKLSNLQALLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHH
VQSSKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTA
HCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
ISEDLGIKLENVTLEMLGRAKKVVIEKENTTIVDGAGSKDEIQGRVSQIKSQIEETTSDY
EHHHHCCEEEHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DKEKLQERLAKLAGGVAVIRVGGSTEVEVKERKDRVDDAMHATRAAVEEGVLPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAAKALDSVQAENEDQKHGIEIVRRAIEAPVRQIAENAGAEGSIIVGKLREKPEFGWGWN
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC
AQTNAFGDLYNEGVIDPVKVVRTALQDAASVAGLLVTTEAMVAEKPKKEPAVPAMPAGGM
CCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
DF
CC
>Mature Secondary Structure 
AAKEVKFHSDAREKMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEI
CCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCCCCHHHC
ELEDKFENMGAQMVREVASKTSDLAGDGTTTATVLAQAIVKEGAKAVASGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVEAIVQELKTNARKVTRNDEIAQVGTISANGDAEIGRFLAEAMQKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHHCCCCCHHEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFITNQDKMRVELEEPYVLIHEKKLSNLQALLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHH
VQSSKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTA
HCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
ISEDLGIKLENVTLEMLGRAKKVVIEKENTTIVDGAGSKDEIQGRVSQIKSQIEETTSDY
EHHHHCCEEEHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DKEKLQERLAKLAGGVAVIRVGGSTEVEVKERKDRVDDAMHATRAAVEEGVLPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAAKALDSVQAENEDQKHGIEIVRRAIEAPVRQIAENAGAEGSIIVGKLREKPEFGWGWN
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC
AQTNAFGDLYNEGVIDPVKVVRTALQDAASVAGLLVTTEAMVAEKPKKEPAVPAMPAGGM
CCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
DF
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA