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The map label for this gene is napA [H]

Identifier: 13472086

GI number: 13472086

Start: 1827506

End: 1829719

Strand: Direct

Name: napA [H]

Synonym: mlr2268

Alternate gene names: 13472086

Gene position: 1827506-1829719 (Clockwise)

Preceding gene: 13472085

Following gene: 13472095

Centisome position: 25.97

GC content: 66.98

Gene sequence:

>2214_bases
ATGGGCGGCTCGGCCGAGGGCCTGTTCGTCGCGGAGATCGTGCTTCTCCTACTGGTCGGCCGCGGCCTCGGCGAAATCTT
CCAGCGCGACGGCCAGCCGGCGATCATGGGCCAGCTGATCGGCGGCATCCTGCTCGGGCCATCGCTGTTCGGCTGGATTT
GGCCCGACGGCCAGCACCTGATCTTCTCCAGCGATCCGGCGCAGAAGGGCATGATCGATGCCGTCTCCCAGCTCGGCATC
CTGCTGCTCCTGCTCCTGACCGGCATGGAGACGGACCTGCGCCTGGTGCGCCGCGTCGGGGCGGCCTGTTTTTCGATCTC
GATCACCGGCGTCGTCGTGCCTTTCGTCTGCGGCTTCGCGCTGGCGCAGTTCCTGCCGGACGCGCTGCTGCCCGACCCGA
GACAGCGCGTCGTTGCCGGGCTGTTCCTCGGCACGGCGCTGTCGATCTCCTCCGTCAAGATCGTCGCCATGGTGGTGCGC
GAGATGAACTTCATGCGCCGCAATCTCGGCCAGGTCATCATCTCCTCGGCCATCATCGAGGACACGATCGGCTGGCTGAT
CATCGCCGTCACCTTCGGCATCGCCACCAATGGCAGCCTGCAGGTCCTGCCGCTCATCACCACCGTGGCCGAGGTGGCGC
TGTTCATGGCGTTTTCCTTCACCATCGGCCGCCGGCTTGTCTTCACGCTGATCCGCTGGAGCAACGACTCTTTCCGCAGC
GAATATGCCGTCATCACCGTCATCCTCATCATCATGGGCGTGATGGCGCTGATCACCAACCTGATCGGCGTCCACACGGT
GCTCGGCGCCTTCGTCGCCGGCATACTGGTCGGGGAATCGCCGATCCTGTCCGACCACATCGAGAGCCAGTTGCGCGGCC
TCATCACCGCGCTGTTCATGCCGGTGTTCTTCGGCATGGCCGGCCTGTCCGCCGACCTCACCGTGCTCACCGACCCGACG
CTGGCATTGCTGACGCTGGCATTGGTCGCCATCGCCAGCATCGGCAAGTTCGGCGGCGCTTTCATCGGCGGCCGGCTGGC
CGGCATGTCGCTGAAGGAAGCCACCGCCGTCGGCAGCGCCATGAACGCCCGCGGCTCGACCGAAGTCATCGTCGCCAGCA
TCGGCCTGTCGATGAACATCCTGTCCCACAATCTGTTCACGATGATCGTCACCATGGCCGTCATCACCACGCTGGCCATG
CCGCCCATGCTGCGCTGGGCGCTCGGCCATCTGCCGGTCGGGCATGCCGAGAAGCAGCGCGTCGACCGCGAACTGCTCGA
CGAGCGCGGCTTCGTCTCCGGGCTGGAGCGCCTGCTGCTGCTGGTCGACGACAGCCCGGTCGGCAAATTCACCGCCTACC
TTGCGGGCTTGATCAGCGGCGGCAGCGGCATGCCGACCACACTGCTTCATCTCCAGGACGGCGAGCTCGCCGGGCAGGCC
GGCGACAAAGGTCCGGAACGGGCATCCAGGGAGGTCAAGAAAGGTGCCGCCAGGAGTGCAAGGGCCGTCAGCAAGGCCGA
GGACACGCTTGTCGACAAGGTCCACCTCACAGCCCGCACCGAGCTTGAGGCCAGCGCCGAGACAATCGCCGCGGAAGCCC
GCAAGGGCTATGGACTTCTGCTGGCCGGGCTGGAGAACACCCTGACCGACAAAGGCACCTTCAGCGGCGCGCTGAAGGAC
ATCAGCAGCGGTTTCGACGGCCCGCTCTGCCTCGTGCTGAACGGCGCCAGGGCCAATGGAAAGATGCCGGTGCTAAGCGC
CGGAACGACGATACTGGTCCCCGTCAACGGCACCGAAGTCGCCCGCCGCGCCGCCGATTTCGCGCTGGCGCTGGCGCGGC
CGCACCGGACCCGCGTCAAGGTACTCTATGTCTCGCAAGCCAGGCAAGGAAGCCGGCCGGGCTCGGTGTCGCACCGCCGG
GAGGAAGCCGTGCTCAAGGATGTCGCCGATCTCGCCGACCGCTACGGCGTCGCCGTCGACACCGCGATCCGCACGCGAGC
CACGGCGGACAGGGCGATCGCCAGGGAGGTGGCCAAAGGGGCCGCCATGGTGGTCATGGGTGTCACCCAACGGCCGGGCG
AAGAGCTGTTCTTCGGCGACACCGCGACAGCCGTGCTCGCTGCGGTCGCCTGCCCGGTCGTGCTTCTGGCCAGCGAACGC
GTCAAGCGGGCCGATGCCAATGCCGAGGAGGCGGCGGCCGAAATCAGTGCCTGA

Upstream 100 bases:

>100_bases
AAGGTCACACGGAGTTGCGGCCTTGCTTCTGCTAACCGCGTCCTTGCTGGCACCGGCAAGTAACGCCTTCGCCGCCCAGG
CGCCCGGACATGCCTCGGGC

Downstream 100 bases:

>100_bases
TCCTTCCGGCTCGGCTATCGGAACCTACAGGCCGAAGAACTGTCGTCCGATCATGTACCCCAGCGCCGCCGCGACGAGCG
GAAACAGCGCCGGCGCGGCC

Product: Na/H antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 737; Mature: 736

Protein sequence:

>737_residues
MGGSAEGLFVAEIVLLLLVGRGLGEIFQRDGQPAIMGQLIGGILLGPSLFGWIWPDGQHLIFSSDPAQKGMIDAVSQLGI
LLLLLLTGMETDLRLVRRVGAACFSISITGVVVPFVCGFALAQFLPDALLPDPRQRVVAGLFLGTALSISSVKIVAMVVR
EMNFMRRNLGQVIISSAIIEDTIGWLIIAVTFGIATNGSLQVLPLITTVAEVALFMAFSFTIGRRLVFTLIRWSNDSFRS
EYAVITVILIIMGVMALITNLIGVHTVLGAFVAGILVGESPILSDHIESQLRGLITALFMPVFFGMAGLSADLTVLTDPT
LALLTLALVAIASIGKFGGAFIGGRLAGMSLKEATAVGSAMNARGSTEVIVASIGLSMNILSHNLFTMIVTMAVITTLAM
PPMLRWALGHLPVGHAEKQRVDRELLDERGFVSGLERLLLLVDDSPVGKFTAYLAGLISGGSGMPTTLLHLQDGELAGQA
GDKGPERASREVKKGAARSARAVSKAEDTLVDKVHLTARTELEASAETIAAEARKGYGLLLAGLENTLTDKGTFSGALKD
ISSGFDGPLCLVLNGARANGKMPVLSAGTTILVPVNGTEVARRAADFALALARPHRTRVKVLYVSQARQGSRPGSVSHRR
EEAVLKDVADLADRYGVAVDTAIRTRATADRAIAREVAKGAAMVVMGVTQRPGEELFFGDTATAVLAAVACPVVLLASER
VKRADANAEEAAAEISA

Sequences:

>Translated_737_residues
MGGSAEGLFVAEIVLLLLVGRGLGEIFQRDGQPAIMGQLIGGILLGPSLFGWIWPDGQHLIFSSDPAQKGMIDAVSQLGI
LLLLLLTGMETDLRLVRRVGAACFSISITGVVVPFVCGFALAQFLPDALLPDPRQRVVAGLFLGTALSISSVKIVAMVVR
EMNFMRRNLGQVIISSAIIEDTIGWLIIAVTFGIATNGSLQVLPLITTVAEVALFMAFSFTIGRRLVFTLIRWSNDSFRS
EYAVITVILIIMGVMALITNLIGVHTVLGAFVAGILVGESPILSDHIESQLRGLITALFMPVFFGMAGLSADLTVLTDPT
LALLTLALVAIASIGKFGGAFIGGRLAGMSLKEATAVGSAMNARGSTEVIVASIGLSMNILSHNLFTMIVTMAVITTLAM
PPMLRWALGHLPVGHAEKQRVDRELLDERGFVSGLERLLLLVDDSPVGKFTAYLAGLISGGSGMPTTLLHLQDGELAGQA
GDKGPERASREVKKGAARSARAVSKAEDTLVDKVHLTARTELEASAETIAAEARKGYGLLLAGLENTLTDKGTFSGALKD
ISSGFDGPLCLVLNGARANGKMPVLSAGTTILVPVNGTEVARRAADFALALARPHRTRVKVLYVSQARQGSRPGSVSHRR
EEAVLKDVADLADRYGVAVDTAIRTRATADRAIAREVAKGAAMVVMGVTQRPGEELFFGDTATAVLAAVACPVVLLASER
VKRADANAEEAAAEISA
>Mature_736_residues
GGSAEGLFVAEIVLLLLVGRGLGEIFQRDGQPAIMGQLIGGILLGPSLFGWIWPDGQHLIFSSDPAQKGMIDAVSQLGIL
LLLLLTGMETDLRLVRRVGAACFSISITGVVVPFVCGFALAQFLPDALLPDPRQRVVAGLFLGTALSISSVKIVAMVVRE
MNFMRRNLGQVIISSAIIEDTIGWLIIAVTFGIATNGSLQVLPLITTVAEVALFMAFSFTIGRRLVFTLIRWSNDSFRSE
YAVITVILIIMGVMALITNLIGVHTVLGAFVAGILVGESPILSDHIESQLRGLITALFMPVFFGMAGLSADLTVLTDPTL
ALLTLALVAIASIGKFGGAFIGGRLAGMSLKEATAVGSAMNARGSTEVIVASIGLSMNILSHNLFTMIVTMAVITTLAMP
PMLRWALGHLPVGHAEKQRVDRELLDERGFVSGLERLLLLVDDSPVGKFTAYLAGLISGGSGMPTTLLHLQDGELAGQAG
DKGPERASREVKKGAARSARAVSKAEDTLVDKVHLTARTELEASAETIAAEARKGYGLLLAGLENTLTDKGTFSGALKDI
SSGFDGPLCLVLNGARANGKMPVLSAGTTILVPVNGTEVARRAADFALALARPHRTRVKVLYVSQARQGSRPGSVSHRRE
EAVLKDVADLADRYGVAVDTAIRTRATADRAIAREVAKGAAMVVMGVTQRPGEELFFGDTATAVLAAVACPVVLLASERV
KRADANAEEAAAEISA

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=387, Percent_Identity=24.2894056847545, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6322367, Length=404, Percent_Identity=27.970297029703, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 77557; Mature: 77426

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGSAEGLFVAEIVLLLLVGRGLGEIFQRDGQPAIMGQLIGGILLGPSLFGWIWPDGQHL
CCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHCCHHHEEECCCCCEE
IFSSDPAQKGMIDAVSQLGILLLLLLTGMETDLRLVRRVGAACFSISITGVVVPFVCGFA
EEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAQFLPDALLPDPRQRVVAGLFLGTALSISSVKIVAMVVREMNFMRRNLGQVIISSAIIE
HHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTIGWLIIAVTFGIATNGSLQVLPLITTVAEVALFMAFSFTIGRRLVFTLIRWSNDSFRS
HHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
EYAVITVILIIMGVMALITNLIGVHTVLGAFVAGILVGESPILSDHIESQLRGLITALFM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
PVFFGMAGLSADLTVLTDPTLALLTLALVAIASIGKFGGAFIGGRLAGMSLKEATAVGSA
HHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHCCHHCCCCHHHHHHHHHH
MNARGSTEVIVASIGLSMNILSHNLFTMIVTMAVITTLAMPPMLRWALGHLPVGHAEKQR
HCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHH
VDRELLDERGFVSGLERLLLLVDDSPVGKFTAYLAGLISGGSGMPTTLLHLQDGELAGQA
HHHHHHHHCHHHHHHHHHEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCC
GDKGPERASREVKKGAARSARAVSKAEDTLVDKVHLTARTELEASAETIAAEARKGYGLL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
LAGLENTLTDKGTFSGALKDISSGFDGPLCLVLNGARANGKMPVLSAGTTILVPVNGTEV
EECCHHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCCEEEEECCCHHH
ARRAADFALALARPHRTRVKVLYVSQARQGSRPGSVSHRREEAVLKDVADLADRYGVAVD
HHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
TAIRTRATADRAIAREVAKGAAMVVMGVTQRPGEELFFGDTATAVLAAVACPVVLLASER
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHH
VKRADANAEEAAAEISA
HHHCCCCHHHHHHHCCC
>Mature Secondary Structure 
GGSAEGLFVAEIVLLLLVGRGLGEIFQRDGQPAIMGQLIGGILLGPSLFGWIWPDGQHL
CCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHCCHHHEEECCCCCEE
IFSSDPAQKGMIDAVSQLGILLLLLLTGMETDLRLVRRVGAACFSISITGVVVPFVCGFA
EEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAQFLPDALLPDPRQRVVAGLFLGTALSISSVKIVAMVVREMNFMRRNLGQVIISSAIIE
HHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTIGWLIIAVTFGIATNGSLQVLPLITTVAEVALFMAFSFTIGRRLVFTLIRWSNDSFRS
HHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
EYAVITVILIIMGVMALITNLIGVHTVLGAFVAGILVGESPILSDHIESQLRGLITALFM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
PVFFGMAGLSADLTVLTDPTLALLTLALVAIASIGKFGGAFIGGRLAGMSLKEATAVGSA
HHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHCCHHCCCCHHHHHHHHHH
MNARGSTEVIVASIGLSMNILSHNLFTMIVTMAVITTLAMPPMLRWALGHLPVGHAEKQR
HCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHH
VDRELLDERGFVSGLERLLLLVDDSPVGKFTAYLAGLISGGSGMPTTLLHLQDGELAGQA
HHHHHHHHCHHHHHHHHHEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCC
GDKGPERASREVKKGAARSARAVSKAEDTLVDKVHLTARTELEASAETIAAEARKGYGLL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
LAGLENTLTDKGTFSGALKDISSGFDGPLCLVLNGARANGKMPVLSAGTTILVPVNGTEV
EECCHHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCCEEEEECCCHHH
ARRAADFALALARPHRTRVKVLYVSQARQGSRPGSVSHRREEAVLKDVADLADRYGVAVD
HHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
TAIRTRATADRAIAREVAKGAAMVVMGVTQRPGEELFFGDTATAVLAAVACPVVLLASER
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHH
VKRADANAEEAAAEISA
HHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]