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The map label for this gene is dinB2

Identifier: 13471787

GI number: 13471787

Start: 1543533

End: 1544780

Strand: Direct

Name: dinB2

Synonym: mlr1877

Alternate gene names: 13471787

Gene position: 1543533-1544780 (Clockwise)

Preceding gene: 13471785

Following gene: 13471788

Centisome position: 21.94

GC content: 68.99

Gene sequence:

>1248_bases
ATGGAAACGACAGCCACCATCCTGCATGCCGATCTCGACGCCTTCTATGCCTCGGTCGAGCAGCTGCTTGACCCGTCGCT
GCGCGGCAAGCCGATCGCGGTCGGCGGCGGCGTGGTGCTCGCCGCATCCTATGAAGCCCGGGCCTTCGGCGTGCGCGGCG
GCATGCCGGGGCGCAAGGCGCGCGAGCTTTGCCCGCAGCTGATCTTCGTCGGCGGCAATTTCAGCCACTACCAGCGGCTG
GGCGACGCGGCGATAAAAGTGCTCGACGATTTCACGCCGGTGGTCGAGCGCATTTCCATCGACGAGGCCTTCGCCGATGT
CGCCGGCTGCACGCATCTGTTCGGGCAACCGCGGGACATCGCCACGGCGATCCGCCATCGCGTGCGGGCCGAACTCGGCC
TGCCGATCTCGATCGGCGTGGCGCGCACCAAGCATCTGGCCAAGATCGCCTCGCAGGTCGCTAAGCCCGACGGGCTTGTG
GTGGTCGATCCCGGCACGGAGCTCGACTTCCTGCACGATCTGCCGGTCTCCTTGATGTGGGGCGTCGGTCCGGCGACCAA
ATCGCGGCTGGCCGAGATCGGCATCCAAACCATCGGCGAGCTGGCCAGGACGCATAGCGGAGCGCTGACACGGCTGCTCG
GTCCCGCCGCCGGCGAAAAGCTTGCCGCTCTCGCATGGAACCGCGACCCGAGGAAACTGGAGACCAGGCGCCGGGCGCAC
TCGGCCGGCGCGCAATCGGCGCTTGGCCAGAAGCCGGCCGTGGCGCGGGTGATCGTGCCCACCTTGCTGCATCTGGCCGA
TCGCGTCGCCAGCCGGCTGCGCGCCAAGGCGCGGCCCGGCCGCACGGTGACGGTGCGCGTGCGCTTTGCCGATCTCAGCG
CCGTCACGCGCTCGATCACGCTCGACCAGCCGATCTCGGCGACCACCATGCTGGCCGAGATCGCCGGCGACCTGGTGCGC
GGCGTGCTCGCCGACCATCCACGCGAAAAGACCATCTCGCTGCTGGCGATCTCGGTCTCGCATCTGGAGGAGAGCGCGGA
GCTGCAGCTCGACCTGCCGCTCGGCCTCGCCGACGAGAAGCGCCGCCCGGGCAGCAAAAAAGGCCTCGCCCGCTTCGGCG
CCGACCGCGCCATCGACAAGATCCGCGAACGTTTCGGCAAACAGGCCGTCGGCTACGGCACGGTGGCGCTGGAAGCGGCG
CGCTCGGTGCCCGACGAATTCAGGGAACTGGCGGAAAAGGAGCTGTAG

Upstream 100 bases:

>100_bases
CACAGGTGATCCAGCCCGACGCGGACACGCCGCTTGACAAATGTACATGTTATGTTCTCTATTCGTTCCTATCCATCAGC
AACCATGGATATGCAGCCGG

Downstream 100 bases:

>100_bases
ACGGAGGAGGCGCCCAGGGATTCAGGCCATGAAATCCATGACGGAGTTCTCCAAAAATCCCCGGTCAATCCACCATCGAG
CACACCTCGTTGAAGAGTCG

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV 2

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
METTATILHADLDAFYASVEQLLDPSLRGKPIAVGGGVVLAASYEARAFGVRGGMPGRKARELCPQLIFVGGNFSHYQRL
GDAAIKVLDDFTPVVERISIDEAFADVAGCTHLFGQPRDIATAIRHRVRAELGLPISIGVARTKHLAKIASQVAKPDGLV
VVDPGTELDFLHDLPVSLMWGVGPATKSRLAEIGIQTIGELARTHSGALTRLLGPAAGEKLAALAWNRDPRKLETRRRAH
SAGAQSALGQKPAVARVIVPTLLHLADRVASRLRAKARPGRTVTVRVRFADLSAVTRSITLDQPISATTMLAEIAGDLVR
GVLADHPREKTISLLAISVSHLEESAELQLDLPLGLADEKRRPGSKKGLARFGADRAIDKIRERFGKQAVGYGTVALEAA
RSVPDEFRELAEKEL

Sequences:

>Translated_415_residues
METTATILHADLDAFYASVEQLLDPSLRGKPIAVGGGVVLAASYEARAFGVRGGMPGRKARELCPQLIFVGGNFSHYQRL
GDAAIKVLDDFTPVVERISIDEAFADVAGCTHLFGQPRDIATAIRHRVRAELGLPISIGVARTKHLAKIASQVAKPDGLV
VVDPGTELDFLHDLPVSLMWGVGPATKSRLAEIGIQTIGELARTHSGALTRLLGPAAGEKLAALAWNRDPRKLETRRRAH
SAGAQSALGQKPAVARVIVPTLLHLADRVASRLRAKARPGRTVTVRVRFADLSAVTRSITLDQPISATTMLAEIAGDLVR
GVLADHPREKTISLLAISVSHLEESAELQLDLPLGLADEKRRPGSKKGLARFGADRAIDKIRERFGKQAVGYGTVALEAA
RSVPDEFRELAEKEL
>Mature_415_residues
METTATILHADLDAFYASVEQLLDPSLRGKPIAVGGGVVLAASYEARAFGVRGGMPGRKARELCPQLIFVGGNFSHYQRL
GDAAIKVLDDFTPVVERISIDEAFADVAGCTHLFGQPRDIATAIRHRVRAELGLPISIGVARTKHLAKIASQVAKPDGLV
VVDPGTELDFLHDLPVSLMWGVGPATKSRLAEIGIQTIGELARTHSGALTRLLGPAAGEKLAALAWNRDPRKLETRRRAH
SAGAQSALGQKPAVARVIVPTLLHLADRVASRLRAKARPGRTVTVRVRFADLSAVTRSITLDQPISATTMLAEIAGDLVR
GVLADHPREKTISLLAISVSHLEESAELQLDLPLGLADEKRRPGSKKGLARFGADRAIDKIRERFGKQAVGYGTVALEAA
RSVPDEFRELAEKEL

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain

Homologues:

Organism=Homo sapiens, GI154350220, Length=264, Percent_Identity=29.9242424242424, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI84043967, Length=284, Percent_Identity=27.8169014084507, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI7706681, Length=284, Percent_Identity=27.8169014084507, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI7705344, Length=106, Percent_Identity=46.2264150943396, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI5729982, Length=140, Percent_Identity=35, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786425, Length=303, Percent_Identity=33.003300330033, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1787432, Length=210, Percent_Identity=34.7619047619048, Blast_Score=108, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI193205700, Length=408, Percent_Identity=27.4509803921569, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17537959, Length=232, Percent_Identity=29.3103448275862, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI115534089, Length=120, Percent_Identity=37.5, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193205702, Length=360, Percent_Identity=24.4444444444444, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355641, Length=292, Percent_Identity=26.3698630136986, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24644984, Length=292, Percent_Identity=26.3698630136986, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19923006, Length=335, Percent_Identity=24.4776119402985, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24668444, Length=234, Percent_Identity=29.4871794871795, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPO42_RHILO (Q98JM5)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_103354.1
- ProteinModelPortal:   Q98JM5
- SMR:   Q98JM5
- GeneID:   1226015
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr1877
- NMPDR:   fig|266835.1.peg.1458
- HOGENOM:   HBG734504
- OMA:   KARELCP
- ProtClustDB:   PRK03858
- BRENDA:   2.7.7.7
- GO:   GO:0005737
- HAMAP:   MF_01113
- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880
- Gene3D:   G3DSA:3.30.1490.100
- PANTHER:   PTHR11076

Pfam domain/function: PF00817 IMS; SSF100879 DNA_pol_Y-fam_little_finger

EC number: =2.7.7.7

Molecular weight: Translated: 44509; Mature: 44509

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS50173 UMUC

Important sites: ACT_SITE 102-102

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTATILHADLDAFYASVEQLLDPSLRGKPIAVGGGVVLAASYEARAFGVRGGMPGRKA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEECCCHHEEECCCCCCCHHH
RELCPQLIFVGGNFSHYQRLGDAAIKVLDDFTPVVERISIDEAFADVAGCTHLFGQPRDI
HHHCHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ATAIRHRVRAELGLPISIGVARTKHLAKIASQVAKPDGLVVVDPGTELDFLHDLPVSLMW
HHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHCCCHHHHH
GVGPATKSRLAEIGIQTIGELARTHSGALTRLLGPAAGEKLAALAWNRDPRKLETRRRAH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHH
SAGAQSALGQKPAVARVIVPTLLHLADRVASRLRAKARPGRTVTVRVRFADLSAVTRSIT
HCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHC
LDQPISATTMLAEIAGDLVRGVLADHPREKTISLLAISVSHLEESAELQLDLPLGLADEK
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
RRPGSKKGLARFGADRAIDKIRERFGKQAVGYGTVALEAARSVPDEFRELAEKEL
CCCCCHHHHHHHCHHHHHHHHHHHHCCHHCCCHHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure
METTATILHADLDAFYASVEQLLDPSLRGKPIAVGGGVVLAASYEARAFGVRGGMPGRKA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEECCCHHEEECCCCCCCHHH
RELCPQLIFVGGNFSHYQRLGDAAIKVLDDFTPVVERISIDEAFADVAGCTHLFGQPRDI
HHHCHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ATAIRHRVRAELGLPISIGVARTKHLAKIASQVAKPDGLVVVDPGTELDFLHDLPVSLMW
HHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHCCCHHHHH
GVGPATKSRLAEIGIQTIGELARTHSGALTRLLGPAAGEKLAALAWNRDPRKLETRRRAH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHH
SAGAQSALGQKPAVARVIVPTLLHLADRVASRLRAKARPGRTVTVRVRFADLSAVTRSIT
HCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHC
LDQPISATTMLAEIAGDLVRGVLADHPREKTISLLAISVSHLEESAELQLDLPLGLADEK
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
RRPGSKKGLARFGADRAIDKIRERFGKQAVGYGTVALEAARSVPDEFRELAEKEL
CCCCCHHHHHHHCHHHHHHHHHHHHCCHHCCCHHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968