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The map label for this gene is gcvT [H]

Identifier: 13471624

GI number: 13471624

Start: 1369031

End: 1371457

Strand: Reverse

Name: gcvT [H]

Synonym: mll1653

Alternate gene names: 13471624

Gene position: 1371457-1369031 (Counterclockwise)

Preceding gene: 13471625

Following gene: 13471622

Centisome position: 19.49

GC content: 65.22

Gene sequence:

>2427_bases
ATGAAATCGCATGCAAAGGTCGTGGTCATTGGCGGCGGTGTCGTCGGGTGTTCCGTGCTGTTCCATCTCGCCCGCCATGG
CTGGACCGACGTGATGCTTCTGGAGCGCGACGAGCTGACATCCGGCTCGACCTGGCACGCGGCGGGCGGCATGCACACAA
TCAATGGCGACCCCAACGTCGCCAAGCTGCAGAAATACACGATCAGCCTCTACAAGGAGATCGAGGAACTGTCGGGCCAG
GCGACCGGCGTGCACCTGACCGGCGGCGTGCTCCTCGCCGCGACCGAGGCGCGGCTGGATTGGCTGCGCGGCGTCGTCGC
CAAGGGCCGCTATCTCGGCATCGACCTGGAAGTGATCTCGCCCAACGAAGCCGCCGAGCTGATGCCGCTGCTCGACCCCA
AGCAGTTCGTCGGCGCCGTCCGCAACAAGGAGGATGGGCATCTCGATCCCTCCGGCGTCACTCACGCCTATGCCAAGGCC
GCCCGTAAACTGGGCGCCGAGGTCGAGCGCTTCACCAAGGTCGAGGACATTGTGCGGCGGCCGGATGGCATGTGGCGCGT
CATCACCAGCAAGGGTGAGGTGGTGGCCGAGCATGTCGTCAATGCCGGCGGCCTGTGGGCGCGTGAGGTCGGCCGCATGG
TCGGGCTCGAACTGCCGGTGCTGGCCATGGAGCACATGTACCTGATCACCGAGGACATGCCGGAAGTCGCCGCCTGGAAC
GCCAAGACCGGCACGGAGATCATCCATGCGGTCGATTTCGACGGCGAGCTCTATCTGCGCCAGGAGCGCGGCGGCATGCT
GATGGGCACCTACGAGAAGGCCAACAGGCCGTGGTCGGAATATCAGACGCCTTGGAATTTCGGCCATGAATTGCTGGCGC
CCGACATCGACCGCATCGCGCCGTCGCTGGAGGTCGGGTTCCGGCATTTCCCGGCCTTCCAGAACACCGGCATCAAACAG
ATCATCAACGGCCCCTTCACCTTCGCGCCCGACGGCAACCCGCTGGTCGGGCCGGTGCGCGGCCTGCCGGGTTTCTGGGT
TGCCTGCGGCGTCATGGCCGGCTTCAGCCAGGGCGGCGGCGTCGGGCTGGCGCTGTCCAACTGGATGATCGAGGGCGATC
CCGGCGCCGACATATGGGCCATGGATGTGGCGCGCTATGGCGACTGGGCGACCATGGCCTACACCAACGCCAAGGTGCGC
GAAAACTATTCCAGGCGCTTTTCGATCCGCTTCCCCAATGAGGAATTGCCCGCCGGCCGGCCGCTGAAGACGACGCCGGT
CTACGATCTATTGTCGGCCAAGGGCGCGCAGTTTGGCGTCGCCTATGGGCTCGAAGTGCCGCTCTGGTACGCGCCGGAAG
GCATCAAGGACGAGTTCTCCTGGCGGCGTTCCAGCGATTTTTCTCATGTCGCCAGGGAGGTCGCGACGGTGCGCGACGGC
GTCGGCCTGGCGGAGATTTCAAGCTTCGCCAAATACAAGGTGACGGGTGAAGGGGCGGCGGCCTGGCTCGACCGCATGCT
TGCCTGCAAACTGCCGAAACCCGGCCGCATGACGCTGGCGCCGATGCTGAAAGACGACGGCAGGCTGATCGGCGATTTCA
CACTCGCCAATCTGGGCAGCGACGGCTGGTTCCTCGCCGGTTCCGGCATTGCCGAGCAGTACCATATGCGCTGGTTCGAG
GCGCATCTGCCTGGCGACGGCTCGGTCCAGATCGAGGCGCTGGGCGCGAAGCTCACCGGCCTTGCCATTGCCGGGCCGAA
GGCGCGGGAAGTGTTGGCCAAGGTCAGCCGCGCGGACGTCTCCAACGCGGCCTTTCCGTTCATGGCGGTGGCCAGGATGG
ATATCGGCATGGCGCCGTGCCTGGTCGGCCGCGTCAGCTATACAGGCGATCTCGGCTACGAGATCTGGGTGGCGCCGGAA
TATCAACGCGCGGCGTTCAATGCTTTGATGGCGGCGGGCGAAGAATTCGGCATCGGCCTGTTCGGCTCGCGCGCGCTCAA
TGCGCTCAGGCTGGAGAAGAACTACGGCTCATGGGGGCGCGAATACCGGCCGATCTACGGGCCGCTCGAAGCCGGGCTGG
ACCGCTTCGTCGCCTATGGCAAGGAGGCGGATTTCATCGGCAAGGCGGCGGCGCTGACCGAGCGCAAGCAAGGCGGCAAA
TTGCGGCTGCGCAGCTTCATCCTCGACGCCGACGACGCCGATGTTATCGGCGACGAGCCGATCTGGTTCGACGGCGCCGT
GCGTGGCTGGGTGACGTCGGGCGGCTACGCGCATCATTCGAAAAAGTCGGTCGCCGTCGGCTATGTGCCGAAGGAGATCG
CCGACGAAAGCGACGGCTTCGAAATCGAGTTGCTAGGCAAGCGCCATGCGGCGCGCATACAGGCAACACCACTGTTCGAT
GCGAATTTCGAGCGGATGCGGGGGTGA

Upstream 100 bases:

>100_bases
TGTGGCCAGGCGCAAGGAAGCGATCGGACAGGGCGAGCCGTGATGCCTCCCATCCTGATTCATCTCACCCATCCAATCCT
TTGATATCAGAGAAAAATCC

Downstream 100 bases:

>100_bases
AAGCTCACCCCCGCGGGGACATCAGGCCTTGCCGCGATTGTCCAGCGCAAAGGCGCCGGCGCCGGCGAAGACCAGATAGA
GGAAGATGAAGCAGAAGGAG

Product: dimethylglycine dehydrogenase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 808; Mature: 808

Protein sequence:

>808_residues
MKSHAKVVVIGGGVVGCSVLFHLARHGWTDVMLLERDELTSGSTWHAAGGMHTINGDPNVAKLQKYTISLYKEIEELSGQ
ATGVHLTGGVLLAATEARLDWLRGVVAKGRYLGIDLEVISPNEAAELMPLLDPKQFVGAVRNKEDGHLDPSGVTHAYAKA
ARKLGAEVERFTKVEDIVRRPDGMWRVITSKGEVVAEHVVNAGGLWAREVGRMVGLELPVLAMEHMYLITEDMPEVAAWN
AKTGTEIIHAVDFDGELYLRQERGGMLMGTYEKANRPWSEYQTPWNFGHELLAPDIDRIAPSLEVGFRHFPAFQNTGIKQ
IINGPFTFAPDGNPLVGPVRGLPGFWVACGVMAGFSQGGGVGLALSNWMIEGDPGADIWAMDVARYGDWATMAYTNAKVR
ENYSRRFSIRFPNEELPAGRPLKTTPVYDLLSAKGAQFGVAYGLEVPLWYAPEGIKDEFSWRRSSDFSHVAREVATVRDG
VGLAEISSFAKYKVTGEGAAAWLDRMLACKLPKPGRMTLAPMLKDDGRLIGDFTLANLGSDGWFLAGSGIAEQYHMRWFE
AHLPGDGSVQIEALGAKLTGLAIAGPKAREVLAKVSRADVSNAAFPFMAVARMDIGMAPCLVGRVSYTGDLGYEIWVAPE
YQRAAFNALMAAGEEFGIGLFGSRALNALRLEKNYGSWGREYRPIYGPLEAGLDRFVAYGKEADFIGKAAALTERKQGGK
LRLRSFILDADDADVIGDEPIWFDGAVRGWVTSGGYAHHSKKSVAVGYVPKEIADESDGFEIELLGKRHAARIQATPLFD
ANFERMRG

Sequences:

>Translated_808_residues
MKSHAKVVVIGGGVVGCSVLFHLARHGWTDVMLLERDELTSGSTWHAAGGMHTINGDPNVAKLQKYTISLYKEIEELSGQ
ATGVHLTGGVLLAATEARLDWLRGVVAKGRYLGIDLEVISPNEAAELMPLLDPKQFVGAVRNKEDGHLDPSGVTHAYAKA
ARKLGAEVERFTKVEDIVRRPDGMWRVITSKGEVVAEHVVNAGGLWAREVGRMVGLELPVLAMEHMYLITEDMPEVAAWN
AKTGTEIIHAVDFDGELYLRQERGGMLMGTYEKANRPWSEYQTPWNFGHELLAPDIDRIAPSLEVGFRHFPAFQNTGIKQ
IINGPFTFAPDGNPLVGPVRGLPGFWVACGVMAGFSQGGGVGLALSNWMIEGDPGADIWAMDVARYGDWATMAYTNAKVR
ENYSRRFSIRFPNEELPAGRPLKTTPVYDLLSAKGAQFGVAYGLEVPLWYAPEGIKDEFSWRRSSDFSHVAREVATVRDG
VGLAEISSFAKYKVTGEGAAAWLDRMLACKLPKPGRMTLAPMLKDDGRLIGDFTLANLGSDGWFLAGSGIAEQYHMRWFE
AHLPGDGSVQIEALGAKLTGLAIAGPKAREVLAKVSRADVSNAAFPFMAVARMDIGMAPCLVGRVSYTGDLGYEIWVAPE
YQRAAFNALMAAGEEFGIGLFGSRALNALRLEKNYGSWGREYRPIYGPLEAGLDRFVAYGKEADFIGKAAALTERKQGGK
LRLRSFILDADDADVIGDEPIWFDGAVRGWVTSGGYAHHSKKSVAVGYVPKEIADESDGFEIELLGKRHAARIQATPLFD
ANFERMRG
>Mature_808_residues
MKSHAKVVVIGGGVVGCSVLFHLARHGWTDVMLLERDELTSGSTWHAAGGMHTINGDPNVAKLQKYTISLYKEIEELSGQ
ATGVHLTGGVLLAATEARLDWLRGVVAKGRYLGIDLEVISPNEAAELMPLLDPKQFVGAVRNKEDGHLDPSGVTHAYAKA
ARKLGAEVERFTKVEDIVRRPDGMWRVITSKGEVVAEHVVNAGGLWAREVGRMVGLELPVLAMEHMYLITEDMPEVAAWN
AKTGTEIIHAVDFDGELYLRQERGGMLMGTYEKANRPWSEYQTPWNFGHELLAPDIDRIAPSLEVGFRHFPAFQNTGIKQ
IINGPFTFAPDGNPLVGPVRGLPGFWVACGVMAGFSQGGGVGLALSNWMIEGDPGADIWAMDVARYGDWATMAYTNAKVR
ENYSRRFSIRFPNEELPAGRPLKTTPVYDLLSAKGAQFGVAYGLEVPLWYAPEGIKDEFSWRRSSDFSHVAREVATVRDG
VGLAEISSFAKYKVTGEGAAAWLDRMLACKLPKPGRMTLAPMLKDDGRLIGDFTLANLGSDGWFLAGSGIAEQYHMRWFE
AHLPGDGSVQIEALGAKLTGLAIAGPKAREVLAKVSRADVSNAAFPFMAVARMDIGMAPCLVGRVSYTGDLGYEIWVAPE
YQRAAFNALMAAGEEFGIGLFGSRALNALRLEKNYGSWGREYRPIYGPLEAGLDRFVAYGKEADFIGKAAALTERKQGGK
LRLRSFILDADDADVIGDEPIWFDGAVRGWVTSGGYAHHSKKSVAVGYVPKEIADESDGFEIELLGKRHAARIQATPLFD
ANFERMRG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0665

COG function: function code E; Glycine/D-amino acid oxidases (deaminating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=816, Percent_Identity=38.2352941176471, Blast_Score=555, Evalue=1e-158,
Organism=Homo sapiens, GI194306651, Length=829, Percent_Identity=31.0012062726176, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI197927446, Length=872, Percent_Identity=30.045871559633, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI21361378, Length=872, Percent_Identity=30.045871559633, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI44662838, Length=397, Percent_Identity=26.1964735516373, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI257796258, Length=374, Percent_Identity=27.0053475935829, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI257796256, Length=331, Percent_Identity=26.8882175226586, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI257796254, Length=231, Percent_Identity=29.4372294372294, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=24.7282608695652, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71994045, Length=821, Percent_Identity=28.136419001218, Blast_Score=303, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI71994052, Length=828, Percent_Identity=27.8985507246377, Blast_Score=301, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI32563613, Length=836, Percent_Identity=27.3923444976077, Blast_Score=261, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17560118, Length=350, Percent_Identity=24, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28571104, Length=829, Percent_Identity=28.3474065138721, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI20130091, Length=863, Percent_Identity=29.5480880648899, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI20129441, Length=391, Percent_Identity=22.7621483375959, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 88183; Mature: 88183

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSHAKVVVIGGGVVGCSVLFHLARHGWTDVMLLERDELTSGSTWHAAGGMHTINGDPNV
CCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCCEEEECCCCCH
AKLQKYTISLYKEIEELSGQATGVHLTGGVLLAATEARLDWLRGVVAKGRYLGIDLEVIS
HHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEHHHHHHHHHHHHHCCEEEEEEEEEEC
PNEAAELMPLLDPKQFVGAVRNKEDGHLDPSGVTHAYAKAARKLGAEVERFTKVEDIVRR
CCCHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDGMWRVITSKGEVVAEHVVNAGGLWAREVGRMVGLELPVLAMEHMYLITEDMPEVAAWN
CCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHEEEEECCCCHHHCCC
AKTGTEIIHAVDFDGELYLRQERGGMLMGTYEKANRPWSEYQTPWNFGHELLAPDIDRIA
CCCCCEEEEEEECCCEEEEEECCCCEEEEEHHHCCCCHHHCCCCHHCCCHHCCCCHHHHC
PSLEVGFRHFPAFQNTGIKQIINGPFTFAPDGNPLVGPVRGLPGFWVACGVMAGFSQGGG
CCHHHHHHHCCCCCCCCHHHHHCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
VGLALSNWMIEGDPGADIWAMDVARYGDWATMAYTNAKVRENYSRRFSIRFPNEELPAGR
EEEEEECEEEECCCCCCEEEEHHHHCCCEEEEEECCHHHHCCCCCEEEEECCCCCCCCCC
PLKTTPVYDLLSAKGAQFGVAYGLEVPLWYAPEGIKDEFSWRRSSDFSHVAREVATVRDG
CCCCCCHHHHHHCCCCCEEEEECCCCCEEECCCCCCCHHCCCCCCCHHHHHHHHHHHHCC
VGLAEISSFAKYKVTGEGAAAWLDRMLACKLPKPGRMTLAPMLKDDGRLIGDFTLANLGS
CCHHHHHHCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEECEECCCCEEEEEEEEECCCC
DGWFLAGSGIAEQYHMRWFEAHLPGDGSVQIEALGAKLTGLAIAGPKAREVLAKVSRADV
CCEEEECCCCHHHHHHHEEEEECCCCCCEEEEEECCEEEEEEECCCHHHHHHHHHHHCCC
SNAAFPFMAVARMDIGMAPCLVGRVSYTGDLGYEIWVAPEYQRAAFNALMAAGEEFGIGL
CCCCCHHHHHHHHCCCCCCHHHCCEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEE
FGSRALNALRLEKNYGSWGREYRPIYGPLEAGLDRFVAYGKEADFIGKAAALTERKQGGK
ECHHHHHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCC
LRLRSFILDADDADVIGDEPIWFDGAVRGWVTSGGYAHHSKKSVAVGYVPKEIADESDGF
EEEEEEEECCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCEEEECCCHHHCCCCCCE
EIELLGKRHAARIQATPLFDANFERMRG
EEEEECCCCCCEEEECCCCCCCHHHHCC
>Mature Secondary Structure
MKSHAKVVVIGGGVVGCSVLFHLARHGWTDVMLLERDELTSGSTWHAAGGMHTINGDPNV
CCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCCEEEECCCCCH
AKLQKYTISLYKEIEELSGQATGVHLTGGVLLAATEARLDWLRGVVAKGRYLGIDLEVIS
HHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEHHHHHHHHHHHHHCCEEEEEEEEEEC
PNEAAELMPLLDPKQFVGAVRNKEDGHLDPSGVTHAYAKAARKLGAEVERFTKVEDIVRR
CCCHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDGMWRVITSKGEVVAEHVVNAGGLWAREVGRMVGLELPVLAMEHMYLITEDMPEVAAWN
CCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHEEEEECCCCHHHCCC
AKTGTEIIHAVDFDGELYLRQERGGMLMGTYEKANRPWSEYQTPWNFGHELLAPDIDRIA
CCCCCEEEEEEECCCEEEEEECCCCEEEEEHHHCCCCHHHCCCCHHCCCHHCCCCHHHHC
PSLEVGFRHFPAFQNTGIKQIINGPFTFAPDGNPLVGPVRGLPGFWVACGVMAGFSQGGG
CCHHHHHHHCCCCCCCCHHHHHCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
VGLALSNWMIEGDPGADIWAMDVARYGDWATMAYTNAKVRENYSRRFSIRFPNEELPAGR
EEEEEECEEEECCCCCCEEEEHHHHCCCEEEEEECCHHHHCCCCCEEEEECCCCCCCCCC
PLKTTPVYDLLSAKGAQFGVAYGLEVPLWYAPEGIKDEFSWRRSSDFSHVAREVATVRDG
CCCCCCHHHHHHCCCCCEEEEECCCCCEEECCCCCCCHHCCCCCCCHHHHHHHHHHHHCC
VGLAEISSFAKYKVTGEGAAAWLDRMLACKLPKPGRMTLAPMLKDDGRLIGDFTLANLGS
CCHHHHHHCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEECEECCCCEEEEEEEEECCCC
DGWFLAGSGIAEQYHMRWFEAHLPGDGSVQIEALGAKLTGLAIAGPKAREVLAKVSRADV
CCEEEECCCCHHHHHHHEEEEECCCCCCEEEEEECCEEEEEEECCCHHHHHHHHHHHCCC
SNAAFPFMAVARMDIGMAPCLVGRVSYTGDLGYEIWVAPEYQRAAFNALMAAGEEFGIGL
CCCCCHHHHHHHHCCCCCCHHHCCEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEE
FGSRALNALRLEKNYGSWGREYRPIYGPLEAGLDRFVAYGKEADFIGKAAALTERKQGGK
ECHHHHHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCC
LRLRSFILDADDADVIGDEPIWFDGAVRGWVTSGGYAHHSKKSVAVGYVPKEIADESDGF
EEEEEEEECCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCEEEECCCHHHCCCCCCE
EIELLGKRHAARIQATPLFDANFERMRG
EEEEECCCCCCEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA