Click here to switch to the map view.

The map label for this gene is cysA [H]

Identifier: 13471558

GI number: 13471558

Start: 1305205

End: 1306320

Strand: Direct

Name: cysA [H]

Synonym: mlr1566

Alternate gene names: 13471558

Gene position: 1305205-1306320 (Clockwise)

Preceding gene: 13471540

Following gene: 13471563

Centisome position: 18.55

GC content: 62.72

Gene sequence:

>1116_bases
ATGTCCGAGACGGCAAATTCACGCGCCGCCGAACTTTCTCATTTGCGCAGCCGCGATTTCGCCAACGGCGATCCGATCCC
CTTGCCGCTGACCATGGCTTCGATCTTTCACACGCCGGGCGTCGAGACCGGGGTCGATCAATATGGCCGCTACGACAATC
CAACCTGGCGCGCCGTGGAACATGTGCTCGGCCATTTGGAAGACGCGCAATGCGTGAGTTTTCCCTCTGGAATGGGCGCG
ATTTCCTCGGTGTTTTTCGCGCTCCTGAAATCAGGCGACCGCGTGCTCCTGCCGGCGGACGGTTATCACGCGACGCGCGC
GATGGCCGAACGCTTCCTGAAGCCGCTCGGCATCACCTGCGATACCAGGCCGACGCCGACCTTCCTTGACGGCGGTTTCA
AAGGCTATTCGCTGGTCTTCGTGGAAACCCCATCCAATCCGCGGCTGGATATCTGCGACATCTCGGCGATCGCCAAGGCT
GTCCACGAACAAGGCGGGGCCCTTGTCGTCGACAACACGACGATGACGCCATTCGGTCAGCGTCCGCTCGACTTCGGCGC
CGATATCGTCGTCTCCGCCGACACCAAGGCGGTCAACGGCCATTCGGATGTACTGTTCGGCCACGTCGCCAGCCGCGACG
CTGACATCATATCCAAGGTGACGAACTGGCGCGCAATGGCCGGCGGCATTCCCGGACCGTTCGAAGCCTGGCTGGTGCAT
CGCGGCCTCGAAACACTGGAGGTGCGCTTCGACCGCATGTGCTCGTCCGCCGAAACGATCGCGCAGCGGTTGAAGGAACA
TCGCGCGGTGCGCGGCCTGCGTTTTCCCGGCCTGAACGGCGACCCGTCGCACAACCTTTCCCGCGCCCAGATGGAGCGCT
TCGGCTTCCTCATCTCCTTCGAACTCGCCTCGGAGGACAAAGCCGAGGATTTCATCAACAATTGCCCATTGATAGAGGCC
GCGACCTCCTTCGGCGGCGTCCACACTTCGGCCGAACGACGCTCGAAGCGAGGCGATGCCGTACCGCCCGGCTTTGTTCG
CCTGTCGGTCGGCTGCGAACCGGTGGAAGAGCTCTGGAAGGCCATCGAGACGTCGCTGAACGGGATCGGCGGCTAA

Upstream 100 bases:

>100_bases
CGTTTAGAGCCCGCTGGCCCAAAAGAGGTGGCTTGCCGCCGATCACCCGCGCGCATAGCGTCGAGCGACGTCTTCCGCCC
AGAAAACAAGGATCGAGCTC

Downstream 100 bases:

>100_bases
TCGCACCAGCTTCGAGCGACGGCCGGGCTTGGTTCTTACAGGCGAACGCCGAAAAGACTTGAATCGACAGGCGCGCCCGA
GGGCGCAACCTGCTGATCTC

Product: cystathionine gamma-lyase

Products: NA

Alternate protein names: Gamma-cystathionase [H]

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSETANSRAAELSHLRSRDFANGDPIPLPLTMASIFHTPGVETGVDQYGRYDNPTWRAVEHVLGHLEDAQCVSFPSGMGA
ISSVFFALLKSGDRVLLPADGYHATRAMAERFLKPLGITCDTRPTPTFLDGGFKGYSLVFVETPSNPRLDICDISAIAKA
VHEQGGALVVDNTTMTPFGQRPLDFGADIVVSADTKAVNGHSDVLFGHVASRDADIISKVTNWRAMAGGIPGPFEAWLVH
RGLETLEVRFDRMCSSAETIAQRLKEHRAVRGLRFPGLNGDPSHNLSRAQMERFGFLISFELASEDKAEDFINNCPLIEA
ATSFGGVHTSAERRSKRGDAVPPGFVRLSVGCEPVEELWKAIETSLNGIGG

Sequences:

>Translated_371_residues
MSETANSRAAELSHLRSRDFANGDPIPLPLTMASIFHTPGVETGVDQYGRYDNPTWRAVEHVLGHLEDAQCVSFPSGMGA
ISSVFFALLKSGDRVLLPADGYHATRAMAERFLKPLGITCDTRPTPTFLDGGFKGYSLVFVETPSNPRLDICDISAIAKA
VHEQGGALVVDNTTMTPFGQRPLDFGADIVVSADTKAVNGHSDVLFGHVASRDADIISKVTNWRAMAGGIPGPFEAWLVH
RGLETLEVRFDRMCSSAETIAQRLKEHRAVRGLRFPGLNGDPSHNLSRAQMERFGFLISFELASEDKAEDFINNCPLIEA
ATSFGGVHTSAERRSKRGDAVPPGFVRLSVGCEPVEELWKAIETSLNGIGG
>Mature_370_residues
SETANSRAAELSHLRSRDFANGDPIPLPLTMASIFHTPGVETGVDQYGRYDNPTWRAVEHVLGHLEDAQCVSFPSGMGAI
SSVFFALLKSGDRVLLPADGYHATRAMAERFLKPLGITCDTRPTPTFLDGGFKGYSLVFVETPSNPRLDICDISAIAKAV
HEQGGALVVDNTTMTPFGQRPLDFGADIVVSADTKAVNGHSDVLFGHVASRDADIISKVTNWRAMAGGIPGPFEAWLVHR
GLETLEVRFDRMCSSAETIAQRLKEHRAVRGLRFPGLNGDPSHNLSRAQMERFGFLISFELASEDKAEDFINNCPLIEAA
TSFGGVHTSAERRSKRGDAVPPGFVRLSVGCEPVEELWKAIETSLNGIGG

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=345, Percent_Identity=32.1739130434783, Blast_Score=161, Evalue=7e-40,
Organism=Homo sapiens, GI299473759, Length=227, Percent_Identity=34.3612334801762, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI25453487, Length=342, Percent_Identity=27.1929824561404, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1790375, Length=353, Percent_Identity=31.1614730878187, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1789383, Length=331, Percent_Identity=27.4924471299094, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17538055, Length=334, Percent_Identity=32.3353293413174, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17560056, Length=346, Percent_Identity=32.6589595375723, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71980708, Length=375, Percent_Identity=27.4666666666667, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319307, Length=365, Percent_Identity=30.4109589041096, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6321904, Length=331, Percent_Identity=25.3776435045317, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321254, Length=355, Percent_Identity=27.3239436619718, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321170, Length=296, Percent_Identity=26.3513513513513, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323333, Length=416, Percent_Identity=21.875, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI19922554, Length=359, Percent_Identity=32.033426183844, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1 [H]

Molecular weight: Translated: 40181; Mature: 40050

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETANSRAAELSHLRSRDFANGDPIPLPLTMASIFHTPGVETGVDQYGRYDNPTWRAVE
CCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHH
HVLGHLEDAQCVSFPSGMGAISSVFFALLKSGDRVLLPADGYHATRAMAERFLKPLGITC
HHHHCCCCCHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCC
DTRPTPTFLDGGFKGYSLVFVETPSNPRLDICDISAIAKAVHEQGGALVVDNTTMTPFGQ
CCCCCCCHHCCCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHCCCEEEEECCCCCCCCC
RPLDFGADIVVSADTKAVNGHSDVLFGHVASRDADIISKVTNWRAMAGGIPGPFEAWLVH
CCCCCCCCEEEECCCCCCCCCCCEEEEHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
RGLETLEVRFDRMCSSAETIAQRLKEHRAVRGLRFPGLNGDPSHNLSRAQMERFGFLISF
HCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCEEEE
ELASEDKAEDFINNCPLIEAATSFGGVHTSAERRSKRGDAVPPGFVRLSVGCEPVEELWK
EECCCCHHHHHHHCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEEECCCCHHHHHHH
AIETSLNGIGG
HHHHHHCCCCC
>Mature Secondary Structure 
SETANSRAAELSHLRSRDFANGDPIPLPLTMASIFHTPGVETGVDQYGRYDNPTWRAVE
CCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHH
HVLGHLEDAQCVSFPSGMGAISSVFFALLKSGDRVLLPADGYHATRAMAERFLKPLGITC
HHHHCCCCCHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCC
DTRPTPTFLDGGFKGYSLVFVETPSNPRLDICDISAIAKAVHEQGGALVVDNTTMTPFGQ
CCCCCCCHHCCCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHCCCEEEEECCCCCCCCC
RPLDFGADIVVSADTKAVNGHSDVLFGHVASRDADIISKVTNWRAMAGGIPGPFEAWLVH
CCCCCCCCEEEECCCCCCCCCCCEEEEHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
RGLETLEVRFDRMCSSAETIAQRLKEHRAVRGLRFPGLNGDPSHNLSRAQMERFGFLISF
HCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCEEEE
ELASEDKAEDFINNCPLIEAATSFGGVHTSAERRSKRGDAVPPGFVRLSVGCEPVEELWK
EECCCCHHHHHHHCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEEECCCCHHHHHHH
AIETSLNGIGG
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953; 8550407 [H]