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The map label for this gene is penA [H]

Identifier: 13471555

GI number: 13471555

Start: 1301222

End: 1302931

Strand: Reverse

Name: penA [H]

Synonym: mll1561

Alternate gene names: 13471555

Gene position: 1302931-1301222 (Counterclockwise)

Preceding gene: 13471556

Following gene: 13471554

Centisome position: 18.52

GC content: 61.05

Gene sequence:

>1710_bases
ATGATCGGCAAACTGCTGAAGCGTCGCGCCAGGACGGGTGAAGATGGATCGATCGTCGTCGAGGGCGCCCGCAAGGCGAC
CGGCGGCAAGGGCAAGGCGCGCATCGTGATGACGATGGCGGTGTTCTTCGGCATCTTCTCGACCATTTCTGGGCGGCTGG
TCTATCTCGGCTTCCAGACGCCTGACCTGTCGGGCGGCCCACAGAGCCGGATCACCGCCTCGCGGCCCGATATTGTCGAC
CGCAATGGCGAAGTGCTTGCGACCGACATCAAGACAGCGTCGCTCTTCGCCGAGCCGCGCCGCATCGTCGATGCCGACGA
GGCGATCGAGAAGCTGTCGACCGTGCTGCCCGAGATCGATTACGAGCAGACCTACCACAAGCTCAAGAGCGGCGCCGGCT
TCGTCTGGCTGCAGCGGCAGCTGACGCCCAAGCAGCAGGCCGACATCATGCAGCTCGGCATTCCCGGTTTCGGCTTCCGC
ACGGAGAAGCGCCGTTTCTATCCGAGCGGCGAAACCTCGTCCTACATTGTCGGCCTGACCAACATCGACAACCAGGGCAT
CTCCGGCATGGAGAAATATATCGACGAGCAGGGCCTGAGCGACCTGCAGGCGTCGGGCCTGGCGGTGGCCAAGGATCTCA
AGCCGGTGAAGCTGTCGATCGATCTGCGCGTCCAGCATGTGGTGCGCGACGAAATCGCCGCCGGACTGGAGCGCTATCGC
GCAATCGGCGCCGGCGCCGTCGTGCTCAACGTCAAGACCGGCGAAGTGATCGCCATGGCCTCGGTGCCGGATTTCGATCC
GAACAACCCTTACAATGCACAGGAGAAGGACCGGCTGAACCGTATGTCGGCGGGCCTCTATGAGATGGGCTCGACCTTCA
AGAGCTTCACCTCGGCCATGGCGCTCGATTCCGGCAAGGCGACGATGAACAGTCGTTTCGACGCTTCGCATCCGATCCGG
GTCGGCCATCAGGCCATTCACGATTTCCACGGCAAGAACCGTGTGCTGTCGCTGCCGGAGGTGTTCCTCTATTCGTCCAA
CATCGGGTCGGCCAGGGAGGCCGAACTGGTCGGCATCGAAGGCCACCGGGAATTCCTGCATCGTCTTGGCATTCTGGAAA
GGATGCAGACCGAACTGCCGGAAGTCGCCCGTCCGACCGAACCGAAGGTCTGGAAACAGGTTAATTCGTTCACCATCGCC
TTCGGTCATGGCGTGTCGACGACGCCGCTGCAGGCGGCTGTTGGCTGCGCGGCGCTGATGAATGGCGGCTATTTGATGAA
TCCGACCTTCCTGGTGCGCACCCAGCAGGAGGCAATGGCGATCGCCAAAAAAGTCGTCAGCGAAAAGACGGTCGAGGGCA
TGCGCTACCTCTATTCGCTCAACGCCGAGAAGGGTTCGGCCAGGAACGCCAGAGTCCCCGGCTACCGAGTTGGCGGCAAG
ACCGGAACGGCTGAGAAGGTCATTAACGGTCGCTACTCTAAGGAATTGAATTTCAACACCTTCGTCGCCGCCTTCCCGAT
AGAGGATCCACAATATCTGGTGTTTACGATCGCCGATGCTCCCCACCCGGAAAAGCCCGGGATGACCGACGTCGCGGCCG
CGAATGCGGGGGTCATGGCGGGTAATATCATCAGACGGTCGGCAGCCATGCTTGGCGTGAAACCAGATTTCAGCCATGAA
AATGGTGCAACGTTGGTTTCCTATGAGTGA

Upstream 100 bases:

>100_bases
TCCAGGACATTCTGAACGGACGCCAGGGCGGCATGGCCGACAATTCCGACAAGGCGCCTGCGGACGGCAAGGATCCCGTC
GTGACCGGAGGCATCGCCCA

Downstream 100 bases:

>100_bases
TTCTTAGGGCGCGCCGGCGACTGCGCGCTATTTTATTGCGGTGAACGGAACTCGATGAAGCTCAGAGATCTAGCCGGTGT
CCTGCCAGTCGAAGGAACAG

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MIGKLLKRRARTGEDGSIVVEGARKATGGKGKARIVMTMAVFFGIFSTISGRLVYLGFQTPDLSGGPQSRITASRPDIVD
RNGEVLATDIKTASLFAEPRRIVDADEAIEKLSTVLPEIDYEQTYHKLKSGAGFVWLQRQLTPKQQADIMQLGIPGFGFR
TEKRRFYPSGETSSYIVGLTNIDNQGISGMEKYIDEQGLSDLQASGLAVAKDLKPVKLSIDLRVQHVVRDEIAAGLERYR
AIGAGAVVLNVKTGEVIAMASVPDFDPNNPYNAQEKDRLNRMSAGLYEMGSTFKSFTSAMALDSGKATMNSRFDASHPIR
VGHQAIHDFHGKNRVLSLPEVFLYSSNIGSAREAELVGIEGHREFLHRLGILERMQTELPEVARPTEPKVWKQVNSFTIA
FGHGVSTTPLQAAVGCAALMNGGYLMNPTFLVRTQQEAMAIAKKVVSEKTVEGMRYLYSLNAEKGSARNARVPGYRVGGK
TGTAEKVINGRYSKELNFNTFVAAFPIEDPQYLVFTIADAPHPEKPGMTDVAAANAGVMAGNIIRRSAAMLGVKPDFSHE
NGATLVSYE

Sequences:

>Translated_569_residues
MIGKLLKRRARTGEDGSIVVEGARKATGGKGKARIVMTMAVFFGIFSTISGRLVYLGFQTPDLSGGPQSRITASRPDIVD
RNGEVLATDIKTASLFAEPRRIVDADEAIEKLSTVLPEIDYEQTYHKLKSGAGFVWLQRQLTPKQQADIMQLGIPGFGFR
TEKRRFYPSGETSSYIVGLTNIDNQGISGMEKYIDEQGLSDLQASGLAVAKDLKPVKLSIDLRVQHVVRDEIAAGLERYR
AIGAGAVVLNVKTGEVIAMASVPDFDPNNPYNAQEKDRLNRMSAGLYEMGSTFKSFTSAMALDSGKATMNSRFDASHPIR
VGHQAIHDFHGKNRVLSLPEVFLYSSNIGSAREAELVGIEGHREFLHRLGILERMQTELPEVARPTEPKVWKQVNSFTIA
FGHGVSTTPLQAAVGCAALMNGGYLMNPTFLVRTQQEAMAIAKKVVSEKTVEGMRYLYSLNAEKGSARNARVPGYRVGGK
TGTAEKVINGRYSKELNFNTFVAAFPIEDPQYLVFTIADAPHPEKPGMTDVAAANAGVMAGNIIRRSAAMLGVKPDFSHE
NGATLVSYE
>Mature_569_residues
MIGKLLKRRARTGEDGSIVVEGARKATGGKGKARIVMTMAVFFGIFSTISGRLVYLGFQTPDLSGGPQSRITASRPDIVD
RNGEVLATDIKTASLFAEPRRIVDADEAIEKLSTVLPEIDYEQTYHKLKSGAGFVWLQRQLTPKQQADIMQLGIPGFGFR
TEKRRFYPSGETSSYIVGLTNIDNQGISGMEKYIDEQGLSDLQASGLAVAKDLKPVKLSIDLRVQHVVRDEIAAGLERYR
AIGAGAVVLNVKTGEVIAMASVPDFDPNNPYNAQEKDRLNRMSAGLYEMGSTFKSFTSAMALDSGKATMNSRFDASHPIR
VGHQAIHDFHGKNRVLSLPEVFLYSSNIGSAREAELVGIEGHREFLHRLGILERMQTELPEVARPTEPKVWKQVNSFTIA
FGHGVSTTPLQAAVGCAALMNGGYLMNPTFLVRTQQEAMAIAKKVVSEKTVEGMRYLYSLNAEKGSARNARVPGYRVGGK
TGTAEKVINGRYSKELNFNTFVAAFPIEDPQYLVFTIADAPHPEKPGMTDVAAANAGVMAGNIIRRSAAMLGVKPDFSHE
NGATLVSYE

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=561, Percent_Identity=27.807486631016, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1786854, Length=539, Percent_Identity=23.5621521335807, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 61999; Mature: 61999

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGKLLKRRARTGEDGSIVVEGARKATGGKGKARIVMTMAVFFGIFSTISGRLVYLGFQT
CHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHCCCEEEEEEECC
PDLSGGPQSRITASRPDIVDRNGEVLATDIKTASLFAEPRRIVDADEAIEKLSTVLPEID
CCCCCCCCCCEECCCCCCCCCCCCEEEEECHHHHHHHCCHHHCCHHHHHHHHHHHCCCCC
YEQTYHKLKSGAGFVWLQRQLTPKQQADIMQLGIPGFGFRTEKRRFYPSGETSSYIVGLT
HHHHHHHHHCCCCEEEEECCCCCHHHCCHHHCCCCCCCCCCCCCEECCCCCCCCEEEEEE
NIDNQGISGMEKYIDEQGLSDLQASGLAVAKDLKPVKLSIDLRVQHVVRDEIAAGLERYR
CCCCCCCHHHHHHHHHCCCHHHHHCCCEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHH
AIGAGAVVLNVKTGEVIAMASVPDFDPNNPYNAQEKDRLNRMSAGLYEMGSTFKSFTSAM
HHCCCEEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALDSGKATMNSRFDASHPIRVGHQAIHDFHGKNRVLSLPEVFLYSSNIGSAREAELVGIE
HCCCCCCHHCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCEEEEECCCCCCCCCEEEECC
GHREFLHRLGILERMQTELPEVARPTEPKVWKQVNSFTIAFGHGVSTTPLQAAVGCAALM
HHHHHHHHHHHHHHHHHHCHHHCCCCCCHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHH
NGGYLMNPTFLVRTQQEAMAIAKKVVSEKTVEGMRYLYSLNAEKGSARNARVPGYRVGGK
CCCEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCEEECCC
TGTAEKVINGRYSKELNFNTFVAAFPIEDPQYLVFTIADAPHPEKPGMTDVAAANAGVMA
CCCHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHCCCCHHH
GNIIRRSAAMLGVKPDFSHENGATLVSYE
HHHHHHHHHHCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MIGKLLKRRARTGEDGSIVVEGARKATGGKGKARIVMTMAVFFGIFSTISGRLVYLGFQT
CHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHCCCEEEEEEECC
PDLSGGPQSRITASRPDIVDRNGEVLATDIKTASLFAEPRRIVDADEAIEKLSTVLPEID
CCCCCCCCCCEECCCCCCCCCCCCEEEEECHHHHHHHCCHHHCCHHHHHHHHHHHCCCCC
YEQTYHKLKSGAGFVWLQRQLTPKQQADIMQLGIPGFGFRTEKRRFYPSGETSSYIVGLT
HHHHHHHHHCCCCEEEEECCCCCHHHCCHHHCCCCCCCCCCCCCEECCCCCCCCEEEEEE
NIDNQGISGMEKYIDEQGLSDLQASGLAVAKDLKPVKLSIDLRVQHVVRDEIAAGLERYR
CCCCCCCHHHHHHHHHCCCHHHHHCCCEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHH
AIGAGAVVLNVKTGEVIAMASVPDFDPNNPYNAQEKDRLNRMSAGLYEMGSTFKSFTSAM
HHCCCEEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALDSGKATMNSRFDASHPIRVGHQAIHDFHGKNRVLSLPEVFLYSSNIGSAREAELVGIE
HCCCCCCHHCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCEEEEECCCCCCCCCEEEECC
GHREFLHRLGILERMQTELPEVARPTEPKVWKQVNSFTIAFGHGVSTTPLQAAVGCAALM
HHHHHHHHHHHHHHHHHHCHHHCCCCCCHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHH
NGGYLMNPTFLVRTQQEAMAIAKKVVSEKTVEGMRYLYSLNAEKGSARNARVPGYRVGGK
CCCEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCEEECCC
TGTAEKVINGRYSKELNFNTFVAAFPIEDPQYLVFTIADAPHPEKPGMTDVAAANAGVMA
CCCHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHCCCCHHH
GNIIRRSAAMLGVKPDFSHENGATLVSYE
HHHHHHHHHHCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]