Click here to switch to the map view.

The map label for this gene is gcvT [H]

Identifier: 13471519

GI number: 13471519

Start: 1257934

End: 1260345

Strand: Reverse

Name: gcvT [H]

Synonym: mll1517

Alternate gene names: 13471519

Gene position: 1260345-1257934 (Counterclockwise)

Preceding gene: 13471521

Following gene: 13471518

Centisome position: 17.91

GC content: 65.22

Gene sequence:

>2412_bases
TTGAAGTCGCACTACCGTGCAGTCGTCATCGGGGGCGGGGTGGTCGGTGCCTCGGTGCTCTACCATCTGACGCGGTTCGG
CTGGCCTGACGTGGCACTGATCGAGCGTGCCGAACTGACCGCCGGTTCGACCTGGCATGCGGCAGCCGGGTTTCATGCGC
TCAACGCCGATCCCAACGTCGCGGCTCTGCAGGATTACACCATCAAGCTCTACCGCGAGATCGAGGCCGAATCCGGCTGG
AATATCGGCCTGCACATGACCGGTGGCGTCAACATGGCCAGCGATCCCCAGCGCTGGGAATGGTTGAAATCGGCCTGGGC
GGTATTCCAGTCGGTCGGCATCGAAACCGCCAGGCTGGTGACCCCTGACGAGATCAAGGAAATCTGTCCGATCGTCGACG
TCACTGGCGTGCTTGGTGGTCTCTACGATGCCAATGAGGGTCATCTCGACCCCTATGGCACGACGCATGCCTATGCGGGT
GCCGCCAAGAAGCGCGGCGCCGACGTGATCCTGCGCAACCGTGTCGTCGAGTTGAAGTCTCGCGCGGACGGCCATTGGGA
CGTCGTCACGGAGCAGGGCACCATCATCGCCGAGCATGTCGTCAACGCCGGCGGGCTGTGGGCCAAGCAGCTCGGCCGCA
TGGCCGGCGTCGACCTGCCGGTGACGCCGATGGAGCACCATTATTTCGTCACCGAGGACATTCCGGAGATCGCCGCTCTC
GACCGGGAGCTCGGCCTTGCGGTCGATCTCGACGGCTTTTCCTACCTGCGCCAGGAGCGCAAAGGCGTGCTGCTCGGCGT
CTACGAGCAGAACCCCAAGCATTGGAACATGGACGGCGCGCCATGGGACTACGGCATCGAGCTGATCCCGGAGGACATAG
ACCGCATCAGCCCGGAACTCGCCAAGGCGCATGAGCGCTTTCCCTGCCTGGCGAGCGCCGGCATCCGCAAATGGGTCAAC
GGCGCCTTCACCTTTACCCCCGACGGCAATCCGATCGTGGGACCGGTGCGCGGCCTGAAAAACTACTGGGTCGCCTGCGG
CGTCATGGCCGGCTTCAGTCAGGGCGGCGGCGTCGGCAAATCGCTGGCCGAATGGATGATCCATGGCGAGCCGCAGGCGG
ACATTTTCGGCATGGACATTGCGCGCTACGGCGCCTTCGCCGCCAACCGCGAATATCTCAGACAAACGACGCGGCAATTC
TATGCGCGCCGTTTCGTCATGACTTTCCCCAATGAGCGGCTGCCGGCGGGCCGGCCCTTGAAACGCCCCGGCGCCTATGA
CGGCATGAGTGCGGCGGGCTGCGAATGGACGGCGTCGTGGGGGCTGGAAATCCCGGCCTATTTCGCGCCGATGGGCTTTC
GCGAGAACACCACGCTCAAGCGCTCCAACGCCTTCGACATCGTCGGCGATGAAGCGCTGCAGGTCCGGCGCGCCGCCGGT
CTCGTCGATATCTCGGCCTATGCGCGCTATTCCGTGTCGGGGCCAAGTGCGCGGGCATGGCTCGACCGGCTGCTGGCCTG
CAGGCTGCCTAAGGCGGGACAGGCGCGGCTGGCGCCGATGCTCGGGCCGGATGGACGGCTGAAGGGCGACCTCACCGTGA
TCAACTGGGGCGACGGCGACTATTGGCTGATGGGCTCCTACTATCTCAGGGAATTCCACATGCGCTGGTTCGAGACCCGG
GCAGGAGAGGGCGTCACCGTCACCGACATCTCGGACGCGACGGGCGGCTTCCTGCTGACCGGGCCGAATGCGCGCAAAAT
CCTGGAACGTACGACGCATCAGGATGTCTCCAGTGCGGCGCTGCCCTTCATGGCCTGCGGCGCGTTCGACATCGGCATGG
TGCAGGCACGGCTTGCCCGCCTGTCCATCGCGGGCGAGCTGGGCTTCGAGATCAACTGCCCCGTGACCATGCATGCCGCG
CTGCGTGAGACGCTGCTCGCCGCCGGCGAGGATCTCGGGCTGGCCGAGATCGGCTACTACGCGCTCAACTCGCTAAGGCT
GGAGAAAAGCTTCGGCATCTGGTCGCGCGAATTCACGCAGGGTTACACGTCACGCCAGACCGGCCTCGACCGCTTTATTG
CCTTCGACAAGGGCGATTTCGTTGGCCGCGAGGCGGCGCTGAAGGAGCGCGATACCGGCACCGCGCAACGGATCGTGACG
TTGGAGATCAATGCGCTCGATGCCGACGCCAGCGGCTTCGAGCCGGTCTGGCGTGACGGCCGCCGCGTCGGCTTCGTCAC
TTCGGGCGGCTTTGGCTACACGATCGGCAGAAGCGTCGCGCTGGCGTTGGTGGACGGCGATTTTGCCGAGGAGGGTACGG
CGCTTTCGGTGCACATTGTCGGCGTCGAACGGCCGGCTCGCGTCATCGCGGCGTCACCCTACGATCCCTCGGGCAAGGCG
ATGCGGCAATGA

Upstream 100 bases:

>100_bases
TGGATCATCCCCACGCATCCGTCCGAGCCTGCAAGCGCAGTACTGGACACTTATGTCTAGTGCGTATATGGTGCGCTTCT
GACAGACCGGGAGGGAAGCC

Downstream 100 bases:

>100_bases
GGAGGATTTTGCGATGATCGATGACGCGGCACGAGACATGAGGCGCGAGCGCCGGCGTGGACGCACGGGCGAAGCCGGCA
GCGAAAGCAGCCGCCGGCCC

Product: dimethylglycine dehydrogenase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 803; Mature: 803

Protein sequence:

>803_residues
MKSHYRAVVIGGGVVGASVLYHLTRFGWPDVALIERAELTAGSTWHAAAGFHALNADPNVAALQDYTIKLYREIEAESGW
NIGLHMTGGVNMASDPQRWEWLKSAWAVFQSVGIETARLVTPDEIKEICPIVDVTGVLGGLYDANEGHLDPYGTTHAYAG
AAKKRGADVILRNRVVELKSRADGHWDVVTEQGTIIAEHVVNAGGLWAKQLGRMAGVDLPVTPMEHHYFVTEDIPEIAAL
DRELGLAVDLDGFSYLRQERKGVLLGVYEQNPKHWNMDGAPWDYGIELIPEDIDRISPELAKAHERFPCLASAGIRKWVN
GAFTFTPDGNPIVGPVRGLKNYWVACGVMAGFSQGGGVGKSLAEWMIHGEPQADIFGMDIARYGAFAANREYLRQTTRQF
YARRFVMTFPNERLPAGRPLKRPGAYDGMSAAGCEWTASWGLEIPAYFAPMGFRENTTLKRSNAFDIVGDEALQVRRAAG
LVDISAYARYSVSGPSARAWLDRLLACRLPKAGQARLAPMLGPDGRLKGDLTVINWGDGDYWLMGSYYLREFHMRWFETR
AGEGVTVTDISDATGGFLLTGPNARKILERTTHQDVSSAALPFMACGAFDIGMVQARLARLSIAGELGFEINCPVTMHAA
LRETLLAAGEDLGLAEIGYYALNSLRLEKSFGIWSREFTQGYTSRQTGLDRFIAFDKGDFVGREAALKERDTGTAQRIVT
LEINALDADASGFEPVWRDGRRVGFVTSGGFGYTIGRSVALALVDGDFAEEGTALSVHIVGVERPARVIAASPYDPSGKA
MRQ

Sequences:

>Translated_803_residues
MKSHYRAVVIGGGVVGASVLYHLTRFGWPDVALIERAELTAGSTWHAAAGFHALNADPNVAALQDYTIKLYREIEAESGW
NIGLHMTGGVNMASDPQRWEWLKSAWAVFQSVGIETARLVTPDEIKEICPIVDVTGVLGGLYDANEGHLDPYGTTHAYAG
AAKKRGADVILRNRVVELKSRADGHWDVVTEQGTIIAEHVVNAGGLWAKQLGRMAGVDLPVTPMEHHYFVTEDIPEIAAL
DRELGLAVDLDGFSYLRQERKGVLLGVYEQNPKHWNMDGAPWDYGIELIPEDIDRISPELAKAHERFPCLASAGIRKWVN
GAFTFTPDGNPIVGPVRGLKNYWVACGVMAGFSQGGGVGKSLAEWMIHGEPQADIFGMDIARYGAFAANREYLRQTTRQF
YARRFVMTFPNERLPAGRPLKRPGAYDGMSAAGCEWTASWGLEIPAYFAPMGFRENTTLKRSNAFDIVGDEALQVRRAAG
LVDISAYARYSVSGPSARAWLDRLLACRLPKAGQARLAPMLGPDGRLKGDLTVINWGDGDYWLMGSYYLREFHMRWFETR
AGEGVTVTDISDATGGFLLTGPNARKILERTTHQDVSSAALPFMACGAFDIGMVQARLARLSIAGELGFEINCPVTMHAA
LRETLLAAGEDLGLAEIGYYALNSLRLEKSFGIWSREFTQGYTSRQTGLDRFIAFDKGDFVGREAALKERDTGTAQRIVT
LEINALDADASGFEPVWRDGRRVGFVTSGGFGYTIGRSVALALVDGDFAEEGTALSVHIVGVERPARVIAASPYDPSGKA
MRQ
>Mature_803_residues
MKSHYRAVVIGGGVVGASVLYHLTRFGWPDVALIERAELTAGSTWHAAAGFHALNADPNVAALQDYTIKLYREIEAESGW
NIGLHMTGGVNMASDPQRWEWLKSAWAVFQSVGIETARLVTPDEIKEICPIVDVTGVLGGLYDANEGHLDPYGTTHAYAG
AAKKRGADVILRNRVVELKSRADGHWDVVTEQGTIIAEHVVNAGGLWAKQLGRMAGVDLPVTPMEHHYFVTEDIPEIAAL
DRELGLAVDLDGFSYLRQERKGVLLGVYEQNPKHWNMDGAPWDYGIELIPEDIDRISPELAKAHERFPCLASAGIRKWVN
GAFTFTPDGNPIVGPVRGLKNYWVACGVMAGFSQGGGVGKSLAEWMIHGEPQADIFGMDIARYGAFAANREYLRQTTRQF
YARRFVMTFPNERLPAGRPLKRPGAYDGMSAAGCEWTASWGLEIPAYFAPMGFRENTTLKRSNAFDIVGDEALQVRRAAG
LVDISAYARYSVSGPSARAWLDRLLACRLPKAGQARLAPMLGPDGRLKGDLTVINWGDGDYWLMGSYYLREFHMRWFETR
AGEGVTVTDISDATGGFLLTGPNARKILERTTHQDVSSAALPFMACGAFDIGMVQARLARLSIAGELGFEINCPVTMHAA
LRETLLAAGEDLGLAEIGYYALNSLRLEKSFGIWSREFTQGYTSRQTGLDRFIAFDKGDFVGREAALKERDTGTAQRIVT
LEINALDADASGFEPVWRDGRRVGFVTSGGFGYTIGRSVALALVDGDFAEEGTALSVHIVGVERPARVIAASPYDPSGKA
MRQ

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0665

COG function: function code E; Glycine/D-amino acid oxidases (deaminating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=804, Percent_Identity=35.8208955223881, Blast_Score=527, Evalue=1e-149,
Organism=Homo sapiens, GI197927446, Length=862, Percent_Identity=29.8143851508121, Blast_Score=351, Evalue=2e-96,
Organism=Homo sapiens, GI21361378, Length=862, Percent_Identity=29.8143851508121, Blast_Score=351, Evalue=2e-96,
Organism=Homo sapiens, GI194306651, Length=790, Percent_Identity=28.1012658227848, Blast_Score=335, Evalue=1e-91,
Organism=Escherichia coli, GI1789272, Length=330, Percent_Identity=28.1818181818182, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71994045, Length=797, Percent_Identity=29.4855708908407, Blast_Score=315, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI71994052, Length=804, Percent_Identity=29.1044776119403, Blast_Score=312, Evalue=6e-85,
Organism=Caenorhabditis elegans, GI32563613, Length=830, Percent_Identity=26.0240963855422, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI20130091, Length=857, Percent_Identity=29.0548424737456, Blast_Score=318, Evalue=8e-87,
Organism=Drosophila melanogaster, GI28571104, Length=834, Percent_Identity=26.978417266187, Blast_Score=280, Evalue=2e-75,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 87795; Mature: 87795

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSHYRAVVIGGGVVGASVLYHLTRFGWPDVALIERAELTAGSTWHAAAGFHALNADPNV
CCCCEEEEEEECCHHHHHHHHHHHHCCCCCHHHEEHHHCCCCCCEEHHCCCEEECCCCCE
AALQDYTIKLYREIEAESGWNIGLHMTGGVNMASDPQRWEWLKSAWAVFQSVGIETARLV
EEHHHHHEEEEHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEC
TPDEIKEICPIVDVTGVLGGLYDANEGHLDPYGTTHAYAGAAKKRGADVILRNRVVELKS
CHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCHHHHCCCCEEEHHHHHHHHH
RADGHWDVVTEQGTIIAEHVVNAGGLWAKQLGRMAGVDLPVTPMEHHYFVTEDIPEIAAL
CCCCCEEEEECCCCEEEHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHH
DRELGLAVDLDGFSYLRQERKGVLLGVYEQNPKHWNMDGAPWDYGIELIPEDIDRISPEL
HHHCCEEEECCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEECCHHHHHCCHHH
AKAHERFPCLASAGIRKWVNGAFTFTPDGNPIVGPVRGLKNYWVACGVMAGFSQGGGVGK
HHHHHCCCHHHHHHHHHHHCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHH
SLAEWMIHGEPQADIFGMDIARYGAFAANREYLRQTTRQFYARRFVMTFPNERLPAGRPL
HHHHHHHCCCCCCCEEECHHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCC
KRPGAYDGMSAAGCEWTASWGLEIPAYFAPMGFRENTTLKRSNAFDIVGDEALQVRRAAG
CCCCCCCCCCCCCCCEEECCCCCCCHHHCCCCCCCCCCEECCCCCEECCHHHHHHHHHCC
LVDISAYARYSVSGPSARAWLDRLLACRLPKAGQARLAPMLGPDGRLKGDLTVINWGDGD
EEEEEHHEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
YWLMGSYYLREFHMRWFETRAGEGVTVTDISDATGGFLLTGPNARKILERTTHQDVSSAA
EEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHC
LPFMACGAFDIGMVQARLARLSIAGELGFEINCPVTMHAALRETLLAAGEDLGLAEIGYY
CHHHCCCCCHHHHHHHHHHHHHEECCCCEEEECCEEHHHHHHHHHHHCCCCCCHHHHHHH
ALNSLRLEKSFGIWSREFTQGYTSRQTGLDRFIAFDKGDFVGREAALKERDTGTAQRIVT
HHHHEEEEHHCCCCHHHHHCCCCHHHHCHHHHEEECCCCCCCCHHHHHHCCCCCEEEEEE
LEINALDADASGFEPVWRDGRRVGFVTSGGFGYTIGRSVALALVDGDFAEEGTALSVHIV
EEEEEECCCCCCCCHHHHCCCEEEEEECCCCCEECCCEEEEEEECCCCCCCCCEEEEEEE
GVERPARVIAASPYDPSGKAMRQ
ECCCCCEEEEECCCCCCCHHCCC
>Mature Secondary Structure
MKSHYRAVVIGGGVVGASVLYHLTRFGWPDVALIERAELTAGSTWHAAAGFHALNADPNV
CCCCEEEEEEECCHHHHHHHHHHHHCCCCCHHHEEHHHCCCCCCEEHHCCCEEECCCCCE
AALQDYTIKLYREIEAESGWNIGLHMTGGVNMASDPQRWEWLKSAWAVFQSVGIETARLV
EEHHHHHEEEEHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEC
TPDEIKEICPIVDVTGVLGGLYDANEGHLDPYGTTHAYAGAAKKRGADVILRNRVVELKS
CHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCHHHHCCCCEEEHHHHHHHHH
RADGHWDVVTEQGTIIAEHVVNAGGLWAKQLGRMAGVDLPVTPMEHHYFVTEDIPEIAAL
CCCCCEEEEECCCCEEEHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHH
DRELGLAVDLDGFSYLRQERKGVLLGVYEQNPKHWNMDGAPWDYGIELIPEDIDRISPEL
HHHCCEEEECCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEECCHHHHHCCHHH
AKAHERFPCLASAGIRKWVNGAFTFTPDGNPIVGPVRGLKNYWVACGVMAGFSQGGGVGK
HHHHHCCCHHHHHHHHHHHCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHH
SLAEWMIHGEPQADIFGMDIARYGAFAANREYLRQTTRQFYARRFVMTFPNERLPAGRPL
HHHHHHHCCCCCCCEEECHHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCC
KRPGAYDGMSAAGCEWTASWGLEIPAYFAPMGFRENTTLKRSNAFDIVGDEALQVRRAAG
CCCCCCCCCCCCCCCEEECCCCCCCHHHCCCCCCCCCCEECCCCCEECCHHHHHHHHHCC
LVDISAYARYSVSGPSARAWLDRLLACRLPKAGQARLAPMLGPDGRLKGDLTVINWGDGD
EEEEEHHEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
YWLMGSYYLREFHMRWFETRAGEGVTVTDISDATGGFLLTGPNARKILERTTHQDVSSAA
EEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHC
LPFMACGAFDIGMVQARLARLSIAGELGFEINCPVTMHAALRETLLAAGEDLGLAEIGYY
CHHHCCCCCHHHHHHHHHHHHHEECCCCEEEECCEEHHHHHHHHHHHCCCCCCHHHHHHH
ALNSLRLEKSFGIWSREFTQGYTSRQTGLDRFIAFDKGDFVGREAALKERDTGTAQRIVT
HHHHEEEEHHCCCCHHHHHCCCCHHHHCHHHHEEECCCCCCCCHHHHHHCCCCCEEEEEE
LEINALDADASGFEPVWRDGRRVGFVTSGGFGYTIGRSVALALVDGDFAEEGTALSVHIV
EEEEEECCCCCCCCHHHHCCCEEEEEECCCCCEECCCEEEEEEECCCCCCCCCEEEEEEE
GVERPARVIAASPYDPSGKAMRQ
ECCCCCEEEEECCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA