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The map label for this gene is degP [H]

Identifier: 13471471

GI number: 13471471

Start: 1210450

End: 1211964

Strand: Reverse

Name: degP [H]

Synonym: mll1451

Alternate gene names: 13471471

Gene position: 1211964-1210450 (Counterclockwise)

Preceding gene: 13471472

Following gene: 13471468

Centisome position: 17.23

GC content: 65.35

Gene sequence:

>1515_bases
ATGACATCCACACCCCTTTTGCGCGCGGCACGGCGGACATTGATCGCCGGCACGGCAGCGCTGCTTGTCGGCACTGTCGC
CGCCCCGTCCTTCGTGACGCCGGTCTTCGCGGCCGATGGGCCTGCTTCGGTCGCCGACCTGGCGCAGGGCGTGCTCGGCG
CGGTGGTCAACATCTCGACTTCGCAGACGGTGAAGGGCACGGAAGGGCCGGGCGCGGTGCCGATGCCGCAGCTTCCCGAG
GGCTCACCGTTCCAGGACTTCTTCGACGACTTCTTCAAGAACCGAGGCGGCGACAAGGACAATAGCGGGCAGAAGGTGCA
GTCACTGGGATCCGGCTTCGTCATCGACGCCGAGCAAGGCATCGTCGTCACCAACAACCACGTGATCGCCGACGCCGACG
ACATCGAAGTGAATTTCTCCGATGGCGTGACGCTGAAGGCGACGCTGGTCGGCACCGACACCAAGACCGACGTCGCGGTG
CTTAAAGTCGATCCGAAGGGCCACAAGCTGACCGCGGTGAAGTTCGGCGATTCCACCAAGATGCGCGTCGGCGACTGGGT
GATGGCGGTCGGCAATCCATTCGGCCTCGGTGGTACGGTCACGGTCGGCATCGTTTCGGCGCGCAACCGCGATATCAATT
CCGGTCCCTACGACGATTTCATCCAGACCGATGCCGCGATCAATCGCGGCAATTCGGGCGGGCCGCTGTTCAACAGCGCC
GGCGAAGTCATCGGCATCAACACGGCGATCATCTCGCCGTCCGGCGGCTCGATCGGCATCGGCTTCTCCATCCCCTCGCA
GCTTGCCTCGGGCGTCGTCGACCAGTTGCGCCAGTTTGGCGAGACGCGGCGCGGCTGGCTCGGCGTGCGCATCCAGCCGG
TGACGGACGACATTGCCGAAAGCCTCGGCATGGCGACAGCCAAGGGCGCGCTGGTGGCCGGCGTCATCAAGGGCGGGCCG
GTCGACAACGGCACCATCCAGGCCGGCGACGTCATCATCAAGTTCGACGGCAAGGACATCCATGAAATGCGCGACCTGCC
GCGCGTCGTCGCCGAAAGCCCCGTCGGCAAGGCCGTCGACGTGCTGATCGTGCGCAAGGGCGTCGAGCAGACGGTGAAGG
TGACGCTCGGCCGGCTCGAGGATGGCGAGAAGCTCGCCAGTGGCGGGAACGGTAATACCGACCAGGATAAGGGCAACAAG
GCTCCGGCCGTTTCGACCGCCTCGGTGCTCGGCATGACCGTCGGCGAACTCAATGACGAGACGCGCAAGAAGTTCAGCAT
CGCCGCCGATGTCTCCGGCGTCGTCATCACCGACGTGGCCAAGGACTCGGCCGCCGCCGAGCGCGGCATCCAGCCGGGTG
AGGTGATCACCGAGATCGCGCAGGAATCGGTCGCCACGCCCAAGGATGTCATGGACCGGATCGGTGCGCTCAAGGAGCAG
GGCCGCAAGAACGCGCTCCTGATGCTGGCGTCGAAGACAGGCGAGTTGCGCTTCGTGACGATCCGGATGGATTGA

Upstream 100 bases:

>100_bases
AGTCGTAGCCGCAAACGTGCCGTATTTTTTGCCAACATAGCGCAACGCGGTGTTTTCGCCGTTGCGCTTTCTCTTTCAGA
AAGACCGGGAGGCTTCTCGA

Downstream 100 bases:

>100_bases
GATTTCAATCCGGCGACCTCAAAAAAGGCGGCTAACCGGCCGCCTTTTTTCTTGCCTGCCAATCCTCGCGCGAAAGCCGG
TAGAGCACATGCCGCTTGAG

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MTSTPLLRAARRTLIAGTAALLVGTVAAPSFVTPVFAADGPASVADLAQGVLGAVVNISTSQTVKGTEGPGAVPMPQLPE
GSPFQDFFDDFFKNRGGDKDNSGQKVQSLGSGFVIDAEQGIVVTNNHVIADADDIEVNFSDGVTLKATLVGTDTKTDVAV
LKVDPKGHKLTAVKFGDSTKMRVGDWVMAVGNPFGLGGTVTVGIVSARNRDINSGPYDDFIQTDAAINRGNSGGPLFNSA
GEVIGINTAIISPSGGSIGIGFSIPSQLASGVVDQLRQFGETRRGWLGVRIQPVTDDIAESLGMATAKGALVAGVIKGGP
VDNGTIQAGDVIIKFDGKDIHEMRDLPRVVAESPVGKAVDVLIVRKGVEQTVKVTLGRLEDGEKLASGGNGNTDQDKGNK
APAVSTASVLGMTVGELNDETRKKFSIAADVSGVVITDVAKDSAAAERGIQPGEVITEIAQESVATPKDVMDRIGALKEQ
GRKNALLMLASKTGELRFVTIRMD

Sequences:

>Translated_504_residues
MTSTPLLRAARRTLIAGTAALLVGTVAAPSFVTPVFAADGPASVADLAQGVLGAVVNISTSQTVKGTEGPGAVPMPQLPE
GSPFQDFFDDFFKNRGGDKDNSGQKVQSLGSGFVIDAEQGIVVTNNHVIADADDIEVNFSDGVTLKATLVGTDTKTDVAV
LKVDPKGHKLTAVKFGDSTKMRVGDWVMAVGNPFGLGGTVTVGIVSARNRDINSGPYDDFIQTDAAINRGNSGGPLFNSA
GEVIGINTAIISPSGGSIGIGFSIPSQLASGVVDQLRQFGETRRGWLGVRIQPVTDDIAESLGMATAKGALVAGVIKGGP
VDNGTIQAGDVIIKFDGKDIHEMRDLPRVVAESPVGKAVDVLIVRKGVEQTVKVTLGRLEDGEKLASGGNGNTDQDKGNK
APAVSTASVLGMTVGELNDETRKKFSIAADVSGVVITDVAKDSAAAERGIQPGEVITEIAQESVATPKDVMDRIGALKEQ
GRKNALLMLASKTGELRFVTIRMD
>Mature_503_residues
TSTPLLRAARRTLIAGTAALLVGTVAAPSFVTPVFAADGPASVADLAQGVLGAVVNISTSQTVKGTEGPGAVPMPQLPEG
SPFQDFFDDFFKNRGGDKDNSGQKVQSLGSGFVIDAEQGIVVTNNHVIADADDIEVNFSDGVTLKATLVGTDTKTDVAVL
KVDPKGHKLTAVKFGDSTKMRVGDWVMAVGNPFGLGGTVTVGIVSARNRDINSGPYDDFIQTDAAINRGNSGGPLFNSAG
EVIGINTAIISPSGGSIGIGFSIPSQLASGVVDQLRQFGETRRGWLGVRIQPVTDDIAESLGMATAKGALVAGVIKGGPV
DNGTIQAGDVIIKFDGKDIHEMRDLPRVVAESPVGKAVDVLIVRKGVEQTVKVTLGRLEDGEKLASGGNGNTDQDKGNKA
PAVSTASVLGMTVGELNDETRKKFSIAADVSGVVITDVAKDSAAAERGIQPGEVITEIAQESVATPKDVMDRIGALKEQG
RKNALLMLASKTGELRFVTIRMD

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=279, Percent_Identity=35.84229390681, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4506141, Length=289, Percent_Identity=34.9480968858132, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI24308541, Length=265, Percent_Identity=32.8301886792453, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI7019477, Length=262, Percent_Identity=35.4961832061069, Blast_Score=119, Evalue=7e-27,
Organism=Escherichia coli, GI1786356, Length=451, Percent_Identity=37.2505543237251, Blast_Score=253, Evalue=3e-68,
Organism=Escherichia coli, GI1789629, Length=464, Percent_Identity=37.0689655172414, Blast_Score=244, Evalue=9e-66,
Organism=Escherichia coli, GI1789630, Length=288, Percent_Identity=39.2361111111111, Blast_Score=176, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324206, Length=298, Percent_Identity=27.5167785234899, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24646839, Length=298, Percent_Identity=32.8859060402685, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 52129; Mature: 51997

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTPLLRAARRTLIAGTAALLVGTVAAPSFVTPVFAADGPASVADLAQGVLGAVVNIST
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEECCCCHHHHHHHHHHHHHEEECCC
SQTVKGTEGPGAVPMPQLPEGSPFQDFFDDFFKNRGGDKDNSGQKVQSLGSGFVIDAEQG
CCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEECCCC
IVVTNNHVIADADDIEVNFSDGVTLKATLVGTDTKTDVAVLKVDPKGHKLTAVKFGDSTK
EEEECCEEEECCCCEEEEECCCCEEEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCC
MRVGDWVMAVGNPFGLGGTVTVGIVSARNRDINSGPYDDFIQTDAAINRGNSGGPLFNSA
EEECCEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHCCHHHCCCCCCCCCCCCC
GEVIGINTAIISPSGGSIGIGFSIPSQLASGVVDQLRQFGETRRGWLGVRIQPVTDDIAE
CCEEEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHH
SLGMATAKGALVAGVIKGGPVDNGTIQAGDVIIKFDGKDIHEMRDLPRVVAESPVGKAVD
HHCCCHHCCCEEEEEECCCCCCCCEEEECCEEEEECCCHHHHHHHHHHHHHCCCCCCHHH
VLIVRKGVEQTVKVTLGRLEDGEKLASGGNGNTDQDKGNKAPAVSTASVLGMTVGELNDE
HEEEHHCHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHH
TRKKFSIAADVSGVVITDVAKDSAAAERGIQPGEVITEIAQESVATPKDVMDRIGALKEQ
HHHHEEEEECCCCEEEEECCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHC
GRKNALLMLASKTGELRFVTIRMD
CCCCEEEEEEECCCCEEEEEEEEC
>Mature Secondary Structure 
TSTPLLRAARRTLIAGTAALLVGTVAAPSFVTPVFAADGPASVADLAQGVLGAVVNIST
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEECCCCHHHHHHHHHHHHHEEECCC
SQTVKGTEGPGAVPMPQLPEGSPFQDFFDDFFKNRGGDKDNSGQKVQSLGSGFVIDAEQG
CCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEECCCC
IVVTNNHVIADADDIEVNFSDGVTLKATLVGTDTKTDVAVLKVDPKGHKLTAVKFGDSTK
EEEECCEEEECCCCEEEEECCCCEEEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCC
MRVGDWVMAVGNPFGLGGTVTVGIVSARNRDINSGPYDDFIQTDAAINRGNSGGPLFNSA
EEECCEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHCCHHHCCCCCCCCCCCCC
GEVIGINTAIISPSGGSIGIGFSIPSQLASGVVDQLRQFGETRRGWLGVRIQPVTDDIAE
CCEEEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHH
SLGMATAKGALVAGVIKGGPVDNGTIQAGDVIIKFDGKDIHEMRDLPRVVAESPVGKAVD
HHCCCHHCCCEEEEEECCCCCCCCEEEECCEEEEECCCHHHHHHHHHHHHHCCCCCCHHH
VLIVRKGVEQTVKVTLGRLEDGEKLASGGNGNTDQDKGNKAPAVSTASVLGMTVGELNDE
HEEEHHCHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHH
TRKKFSIAADVSGVVITDVAKDSAAAERGIQPGEVITEIAQESVATPKDVMDRIGALKEQ
HHHHEEEEECCCCEEEEECCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHC
GRKNALLMLASKTGELRFVTIRMD
CCCCEEEEEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]