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The map label for this gene is mdtA [H]

Identifier: 13471453

GI number: 13471453

Start: 1192309

End: 1193574

Strand: Reverse

Name: mdtA [H]

Synonym: mll1427

Alternate gene names: 13471453

Gene position: 1193574-1192309 (Counterclockwise)

Preceding gene: 13471454

Following gene: 13471452

Centisome position: 16.96

GC content: 65.64

Gene sequence:

>1266_bases
ATGCGTGGAAAAGTCATTCCTTCATTGCTTGTCGTCGCCTGTGCGGGCGCGGCCTGGCTCTATCTGTCTCCCGACACGCT
GGGCAAGGTTGAGCAGCTCATCGGCGCCAAGCAGGTCGCGGCGTCGGACAAGGCGGCAACCGACAAGCAGGCAGCCGGGG
GCAAGCAGGGGGCCGGTGGCGGTGGCGCCCGTTCGGCCTCGATCGTTTCGGCGACGGCGACCACGGCTGACTTCCCGATC
CGGCGCTACGCCATCGGCTTCGTCTCCTCACCCGCCGTGGTCAGCATCAACGCGCGGGTCTCCAGCCAGATCGTGTCGAT
CGACGTCAAGGACGGGCAGATGGTGAAGGCCGGCGACACCCTGTTCTCGCTCGACGACCGGGCGCTCAAGGCGCAACTCG
CCAAGGACCAGGCCACGCTCGCCAAGGACCAGGCGCTGCTTGCCAGTTCGAATTCCGATTTTCAGCGCGCCAAGGACCTT
GTCGCCAAGCAGGCCGGCACGCAGCAGACCTACGATCAGGCCGTGGCCGCGCAGAAGGCGGCGGCCGCGACTGTCGACGC
CGACAAGGCGACGATCGACGCGGACAATGTCCAGCTTGGCTTTGCCACAATCACGGCGCCGATCGCGGGCAGGCTCGGTG
CGGTCAACGTTGCCGTCGGCGATCTGGTGACCACCAGCAACGGCAACAGCAGTAGCTCGACACCGCTGGTGACCATCACG
CAGATGGACCCGTTGCAGGTCAACTTCAACCTGCCGGAAAGCAACCTTGCGCTGTTGCACAAGGCGCTTGCCAATCCCCA
GCAAGGGGCGGTGACGCTGACCAAGGACGGCAACCCGACGGCTATCGGCAAGGGCACGCTCGATTTCGTCGATTCCAGCG
TCGACACCGCCTCGGGCACGATCGCCACGCGCGCGAGCATACCCAATGCCGATCTTTCGCTGTGGCCGGGCCAATATGTG
AATGTCGTTCTTGACGCTGGCGTCATGCCGCAGATGACCTCCGTTCCGACCGTCGCGGTCCAGCCCAGCCAGAAGGGACC
GTTCGTCTATGTGGTCAAGCCGGACAGCACGGTCGAGATGCGGCCGGTGCAGGTAGCGCTGACGGATGGCCAAAACAGCG
CCATCAGCCAAGGCCTCAAAGCCGGCGAGAAGGTAGTCACGGAAGGCCAGACAAGGCTGAAGAATGGCGCCGCCGTGCAC
GAAGGCGCCGCGGCCGCCGCGCCCAAGGTGGCCGAGGCAACCAACGCCGGCGAGGCGGCCCGATGA

Upstream 100 bases:

>100_bases
CGTGTCCTATCTATTCGGCGAAATCGCGGCAATGAGCCGTGGATTGCGCTAGAATACGACCACCTGACTGCGGCGTGTCG
GACGGAGAGGCCTTTTGTCG

Downstream 100 bases:

>100_bases
TTTCCGAATTCTGTATTCGCAGGCCCGTCGCCACTCTCCTGATGTCGTTCGCCCTCGTGCTGGGCGGACTGTTCGCCTAC
AAATTCCTGCCGGTGGCAGC

Product: RND efflux membrane fusion protein precursor

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MRGKVIPSLLVVACAGAAWLYLSPDTLGKVEQLIGAKQVAASDKAATDKQAAGGKQGAGGGGARSASIVSATATTADFPI
RRYAIGFVSSPAVVSINARVSSQIVSIDVKDGQMVKAGDTLFSLDDRALKAQLAKDQATLAKDQALLASSNSDFQRAKDL
VAKQAGTQQTYDQAVAAQKAAAATVDADKATIDADNVQLGFATITAPIAGRLGAVNVAVGDLVTTSNGNSSSSTPLVTIT
QMDPLQVNFNLPESNLALLHKALANPQQGAVTLTKDGNPTAIGKGTLDFVDSSVDTASGTIATRASIPNADLSLWPGQYV
NVVLDAGVMPQMTSVPTVAVQPSQKGPFVYVVKPDSTVEMRPVQVALTDGQNSAISQGLKAGEKVVTEGQTRLKNGAAVH
EGAAAAAPKVAEATNAGEAAR

Sequences:

>Translated_421_residues
MRGKVIPSLLVVACAGAAWLYLSPDTLGKVEQLIGAKQVAASDKAATDKQAAGGKQGAGGGGARSASIVSATATTADFPI
RRYAIGFVSSPAVVSINARVSSQIVSIDVKDGQMVKAGDTLFSLDDRALKAQLAKDQATLAKDQALLASSNSDFQRAKDL
VAKQAGTQQTYDQAVAAQKAAAATVDADKATIDADNVQLGFATITAPIAGRLGAVNVAVGDLVTTSNGNSSSSTPLVTIT
QMDPLQVNFNLPESNLALLHKALANPQQGAVTLTKDGNPTAIGKGTLDFVDSSVDTASGTIATRASIPNADLSLWPGQYV
NVVLDAGVMPQMTSVPTVAVQPSQKGPFVYVVKPDSTVEMRPVQVALTDGQNSAISQGLKAGEKVVTEGQTRLKNGAAVH
EGAAAAAPKVAEATNAGEAAR
>Mature_421_residues
MRGKVIPSLLVVACAGAAWLYLSPDTLGKVEQLIGAKQVAASDKAATDKQAAGGKQGAGGGGARSASIVSATATTADFPI
RRYAIGFVSSPAVVSINARVSSQIVSIDVKDGQMVKAGDTLFSLDDRALKAQLAKDQATLAKDQALLASSNSDFQRAKDL
VAKQAGTQQTYDQAVAAQKAAAATVDADKATIDADNVQLGFATITAPIAGRLGAVNVAVGDLVTTSNGNSSSSTPLVTIT
QMDPLQVNFNLPESNLALLHKALANPQQGAVTLTKDGNPTAIGKGTLDFVDSSVDTASGTIATRASIPNADLSLWPGQYV
NVVLDAGVMPQMTSVPTVAVQPSQKGPFVYVVKPDSTVEMRPVQVALTDGQNSAISQGLKAGEKVVTEGQTRLKNGAAVH
EGAAAAAPKVAEATNAGEAAR

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=370, Percent_Identity=32.1621621621622, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI1789665, Length=392, Percent_Identity=29.5918367346939, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1786668, Length=347, Percent_Identity=31.1239193083574, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1789929, Length=311, Percent_Identity=28.6173633440514, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI87081951, Length=251, Percent_Identity=29.0836653386454, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42844; Mature: 42844

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKVIPSLLVVACAGAAWLYLSPDTLGKVEQLIGAKQVAASDKAATDKQAAGGKQGAGG
CCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCC
GGARSASIVSATATTADFPIRRYAIGFVSSPAVVSINARVSSQIVSIDVKDGQMVKAGDT
CCCCCCEEEEEECCCCCCCHHHEEEEEECCCEEEEEECEECEEEEEEEECCCCEEECCCC
LFSLDDRALKAQLAKDQATLAKDQALLASSNSDFQRAKDLVAKQAGTQQTYDQAVAAQKA
EEECCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AAATVDADKATIDADNVQLGFATITAPIAGRLGAVNVAVGDLVTTSNGNSSSSTPLVTIT
HHHEECCCCEEEECCCEEEEEEEEEHHHHCCCCEEEEEECCEEEECCCCCCCCCCEEEEE
QMDPLQVNFNLPESNLALLHKALANPQQGAVTLTKDGNPTAIGKGTLDFVDSSVDTASGT
ECCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEECCCCCCEECCCCHHHHCCCCCCCCCC
IATRASIPNADLSLWPGQYVNVVLDAGVMPQMTSVPTVAVQPSQKGPFVYVVKPDSTVEM
EEEECCCCCCCCEECCCCEEEEEECCCCCCCCCCCCEEEECCCCCCCEEEEECCCCCEEE
RPVQVALTDGQNSAISQGLKAGEKVVTEGQTRLKNGAAVHEGAAAAAPKVAEATNAGEAA
EEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHCCCCHHHHCCCCCCC
R
C
>Mature Secondary Structure
MRGKVIPSLLVVACAGAAWLYLSPDTLGKVEQLIGAKQVAASDKAATDKQAAGGKQGAGG
CCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCC
GGARSASIVSATATTADFPIRRYAIGFVSSPAVVSINARVSSQIVSIDVKDGQMVKAGDT
CCCCCCEEEEEECCCCCCCHHHEEEEEECCCEEEEEECEECEEEEEEEECCCCEEECCCC
LFSLDDRALKAQLAKDQATLAKDQALLASSNSDFQRAKDLVAKQAGTQQTYDQAVAAQKA
EEECCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AAATVDADKATIDADNVQLGFATITAPIAGRLGAVNVAVGDLVTTSNGNSSSSTPLVTIT
HHHEECCCCEEEECCCEEEEEEEEEHHHHCCCCEEEEEECCEEEECCCCCCCCCCEEEEE
QMDPLQVNFNLPESNLALLHKALANPQQGAVTLTKDGNPTAIGKGTLDFVDSSVDTASGT
ECCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEECCCCCCEECCCCHHHHCCCCCCCCCC
IATRASIPNADLSLWPGQYVNVVLDAGVMPQMTSVPTVAVQPSQKGPFVYVVKPDSTVEM
EEEECCCCCCCCEECCCCEEEEEECCCCCCCCCCCCEEEECCCCCCCEEEEECCCCCEEE
RPVQVALTDGQNSAISQGLKAGEKVVTEGQTRLKNGAAVHEGAAAAAPKVAEATNAGEAA
EEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHCCCCHHHHCCCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA