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The map label for this gene is mro [H]

Identifier: 13471248

GI number: 13471248

Start: 977754

End: 978776

Strand: Reverse

Name: mro [H]

Synonym: mll1167

Alternate gene names: 13471248

Gene position: 978776-977754 (Counterclockwise)

Preceding gene: 13471249

Following gene: 13471246

Centisome position: 13.91

GC content: 65.79

Gene sequence:

>1023_bases
ATGACGATGAAGGACGGCGAGGTTTTTGGCACGACGCAGGCGGGCGAGCCGGTGCGCCGCTTCACCATCAAGGGCGGCGG
CCTCACCGCCAACATCATCGGGCTCGGCGCGATCATCCAGGATTTGCGCCTGACCGGTCACGATGCGCCGCTGGTGCTCG
GCTATAACACTCTGGAAGCCTACGAAGCCGACAACGCCTTCTTTGGCGCGGTGGTCGGCCGCTACGCCAACCGCATCCGC
GACGGCCGCTTCACCATCGGTGGCAACCGCTACCAGACCGAGCGAAATTTCCTCGGCAAGCATACGCTGCATGGCGGCTC
ACAGGGCTATTCGCATCGGCCGTGGGCGGTTTCGCTGCATGGCCGGGACTTCGTCACGCTGACGCTGCACGATCCCGACG
GAGCGATGGGCTTTCCCGGCGCGCTCGACGTCACCTGCACCTACCGGCTGAAGATCCCCGGTACGCTGAGCGTCGAGCTG
ACTGCGACCTGCGAGGAGCCGACGCTGTGCAATCTCACCCAGCACTCCTATTTCAACCTGGACGACGGCGGCGCCGGCGA
CATTCTCGACCACAGGATGATGCTGAACGCCGGCGCCTATCTGCCGGTCGACAGCGACATGATCCCGACCGGCGTGGTCA
AGCCGGTCGACGGCACGCCCTTCGATTTCCGCCAGGCGCGGCCGCTGCGCATGGAAACCGAGGGCGAGCAGCTGCCCTAC
GACCAGAACTTCTGCCTCGCCTCGGCGCGCGGGCCGCTGCGGCAAGCGGCATGGACGCAAGGGGCGAGTTCCGGCGTCGA
GATGGAGGTCTGGACCACGGAGCCAGGCGTCCAGCTCTACACCGGCCAGTATGTGACGCCGCGCAAGGGGCTGGACGGGC
GGGACTACAAGGCCTTTTCCGCCTTCTGCCTGGAGCCGCAGATCTGGCCGGATGCGCCGAACCGGCCGTATTTCCCGCAG
GCGACGCTATGGCCGGGTGCAATTTATCACCATGTGACGGAATACCGTTTCCGCCTGCCTTGA

Upstream 100 bases:

>100_bases
GGCCTCTGATAGCTTGTCCCATAGGTCGGCGGGCCTGGCCCGCCGCCTTGGGTTGAGAAAACCAGCCGAAAATCCTTTGG
ATTAACTGACGTTTGCGGGC

Downstream 100 bases:

>100_bases
GGTCTGTTGATATTCAGGTGATGCCGGCCTGCAAATGGCTGATACCTGCGCTTCCACGTTCTACTGCGTCGCAGTAGAAC
TGGGCTCACGTACGAAAAGT

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MTMKDGEVFGTTQAGEPVRRFTIKGGGLTANIIGLGAIIQDLRLTGHDAPLVLGYNTLEAYEADNAFFGAVVGRYANRIR
DGRFTIGGNRYQTERNFLGKHTLHGGSQGYSHRPWAVSLHGRDFVTLTLHDPDGAMGFPGALDVTCTYRLKIPGTLSVEL
TATCEEPTLCNLTQHSYFNLDDGGAGDILDHRMMLNAGAYLPVDSDMIPTGVVKPVDGTPFDFRQARPLRMETEGEQLPY
DQNFCLASARGPLRQAAWTQGASSGVEMEVWTTEPGVQLYTGQYVTPRKGLDGRDYKAFSAFCLEPQIWPDAPNRPYFPQ
ATLWPGAIYHHVTEYRFRLP

Sequences:

>Translated_340_residues
MTMKDGEVFGTTQAGEPVRRFTIKGGGLTANIIGLGAIIQDLRLTGHDAPLVLGYNTLEAYEADNAFFGAVVGRYANRIR
DGRFTIGGNRYQTERNFLGKHTLHGGSQGYSHRPWAVSLHGRDFVTLTLHDPDGAMGFPGALDVTCTYRLKIPGTLSVEL
TATCEEPTLCNLTQHSYFNLDDGGAGDILDHRMMLNAGAYLPVDSDMIPTGVVKPVDGTPFDFRQARPLRMETEGEQLPY
DQNFCLASARGPLRQAAWTQGASSGVEMEVWTTEPGVQLYTGQYVTPRKGLDGRDYKAFSAFCLEPQIWPDAPNRPYFPQ
ATLWPGAIYHHVTEYRFRLP
>Mature_339_residues
TMKDGEVFGTTQAGEPVRRFTIKGGGLTANIIGLGAIIQDLRLTGHDAPLVLGYNTLEAYEADNAFFGAVVGRYANRIRD
GRFTIGGNRYQTERNFLGKHTLHGGSQGYSHRPWAVSLHGRDFVTLTLHDPDGAMGFPGALDVTCTYRLKIPGTLSVELT
ATCEEPTLCNLTQHSYFNLDDGGAGDILDHRMMLNAGAYLPVDSDMIPTGVVKPVDGTPFDFRQARPLRMETEGEQLPYD
QNFCLASARGPLRQAAWTQGASSGVEMEVWTTEPGVQLYTGQYVTPRKGLDGRDYKAFSAFCLEPQIWPDAPNRPYFPQA
TLWPGAIYHHVTEYRFRLP

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=340, Percent_Identity=40, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI1786971, Length=336, Percent_Identity=35.1190476190476, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17557428, Length=318, Percent_Identity=33.0188679245283, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI115533334, Length=318, Percent_Identity=33.0188679245283, Blast_Score=175, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6319493, Length=341, Percent_Identity=31.3782991202346, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322004, Length=356, Percent_Identity=30.6179775280899, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324399, Length=334, Percent_Identity=27.8443113772455, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24659048, Length=350, Percent_Identity=35.7142857142857, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24668282, Length=344, Percent_Identity=34.3023255813954, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24668278, Length=353, Percent_Identity=33.1444759206799, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24583720, Length=343, Percent_Identity=31.7784256559767, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24641876, Length=349, Percent_Identity=28.3667621776504, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37541; Mature: 37410

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMKDGEVFGTTQAGEPVRRFTIKGGGLTANIIGLGAIIQDLRLTGHDAPLVLGYNTLEA
CCCCCCCEEECCCCCCCEEEEEEECCCEEEEHHHHHHHHHHHHCCCCCCCEEEECCHHEE
YEADNAFFGAVVGRYANRIRDGRFTIGGNRYQTERNFLGKHTLHGGSQGYSHRPWAVSLH
ECCCCCHHHHHHHHHHHHHCCCEEEECCCEEECHHHHCCCCCCCCCCCCCCCCCEEEEEC
GRDFVTLTLHDPDGAMGFPGALDVTCTYRLKIPGTLSVELTATCEEPTLCNLTQHSYFNL
CCEEEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEEEEECCCCCEECCCCCCEEEC
DDGGAGDILDHRMMLNAGAYLPVDSDMIPTGVVKPVDGTPFDFRQARPLRMETEGEQLPY
CCCCCCCHHHHHHEECCCCCCCCCCCCCCCCCEECCCCCCCCHHCCCCCEECCCCCCCCC
DQNFCLASARGPLRQAAWTQGASSGVEMEVWTTEPGVQLYTGQYVTPRKGLDGRDYKAFS
CCCEEEECCCCCHHHHHHCCCCCCCEEEEEEECCCCCEEEECCEECCCCCCCCCCCEEEE
AFCLEPQIWPDAPNRPYFPQATLWPGAIYHHVTEYRFRLP
EEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEECC
>Mature Secondary Structure 
TMKDGEVFGTTQAGEPVRRFTIKGGGLTANIIGLGAIIQDLRLTGHDAPLVLGYNTLEA
CCCCCCEEECCCCCCCEEEEEEECCCEEEEHHHHHHHHHHHHCCCCCCCEEEECCHHEE
YEADNAFFGAVVGRYANRIRDGRFTIGGNRYQTERNFLGKHTLHGGSQGYSHRPWAVSLH
ECCCCCHHHHHHHHHHHHHCCCEEEECCCEEECHHHHCCCCCCCCCCCCCCCCCEEEEEC
GRDFVTLTLHDPDGAMGFPGALDVTCTYRLKIPGTLSVELTATCEEPTLCNLTQHSYFNL
CCEEEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEEEEECCCCCEECCCCCCEEEC
DDGGAGDILDHRMMLNAGAYLPVDSDMIPTGVVKPVDGTPFDFRQARPLRMETEGEQLPY
CCCCCCCHHHHHHEECCCCCCCCCCCCCCCCCEECCCCCCCCHHCCCCCEECCCCCCCCC
DQNFCLASARGPLRQAAWTQGASSGVEMEVWTTEPGVQLYTGQYVTPRKGLDGRDYKAFS
CCCEEEECCCCCHHHHHHCCCCCCCEEEEEEECCCCCEEEECCEECCCCCCCCCCCEEEE
AFCLEPQIWPDAPNRPYFPQATLWPGAIYHHVTEYRFRLP
EEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]