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The map label for this gene is serS

Identifier: 13471180

GI number: 13471180

Start: 904544

End: 905848

Strand: Reverse

Name: serS

Synonym: mll1081

Alternate gene names: 13471180

Gene position: 905848-904544 (Counterclockwise)

Preceding gene: 13471181

Following gene: 13471179

Centisome position: 12.87

GC content: 62.38

Gene sequence:

>1305_bases
ATGCTTGACATCAAATGGATTCGCGACAACCCGAAGGCCCTTGTCGAGGCGCTGGCCAAGCGCTCGTGGTCGGCCGGCGA
GGCGCAGTCCACGGTCGATGATTTGATCGCCAGGGACGAGGCGCGGCGCGAACACGTCACCGAACTGCAGACCAAGCAGG
AGCGCCGCAACGCTGCCTCGAAGGAGATCGGCAACGCCATGCGTTCGGGCGATGCCGCCCTTGCCGAAAAACTCAAGGCT
GAAGTCGGCGATATAAAAACCTTCATCCAGAATGGCGAGGCGCGCGAGCGCGAGCTCGACAAGGCGCTGACCGACGCGCT
GGCGGTGCTGCCCAATGTGCCGCTCGACGATGTGCCGGTCGGCAAGGACGAACACGACAATGTCGTCAAGCACATCGTTG
GCAAGGTGCCGACCCGGTCGAACTGGGTGAAGGAGCATTTCGAGATTGGCGAAGCGCTCGGCATGATGGATTTCGAGCGC
GCGGCGAAGCTGTCGGGCTCGCGCTTTACCGTGCTGAAAAGCGGCCTGGCGCGGATGGAACGCGCCATCGGCCAGTTCAT
GCTCGACCTGCACACGACCGAGCATGGCTATGAGGAAGTGATCCCGCCGCTGATGGTGCGCGACGAGGTGCTTTTCGGCA
CCAACCAGCTGCCGAAATTCGAGGAGGACCTGTTCTTCACGCCACACGGAGAGGGCAGGCTTGGCCTGATCCCGACCGCC
GAGGTGCCGCTCACCAATCTGGTGCGCGAGGAAATCACCGCGCATGAAAAACTGCCGCTGCGCTTCACCGCGCTGACGCC
GTGCTTCCGTTCGGAAGCAGGCTCGGCCGGGCGCGACACGCGCGGCATGTTGCGCCAGCACCAGTTCTACAAGGTCGAGC
TGGTGTCGATCACCGATCAGGATTCGTCGCTGGCCGAGCATGAGCGGATGACGCAATGCGCCGAGGAAGTGCTGAAGCGG
CTGGAACTGCCGTTCCGCACCATGGTGCTGTGCACCGGCGACATGGGGTTTGGCGCGCGCAAGACCTACGACATCGAGGT
CTGGCTGCCCGGCCAGAATGCCTATCGCGAAATCTCGTCCTGCTCGGTCTGCGGCGATTTTCAGGCACGCCGCATGGACG
CCCGTTACAAGGACAAAGACGGCAAGGGCAACCGCTTCGTCCATACGCTCAACGGTTCGGGCACCGCTGTCGGCCGCGCA
CTGATTGCCGTCATCGAAAACTACCAGAATGAGGATGGCAGCGTAACCATTCCTGAAGTGCTGCGGCCTTACATGGGCGG
TCTGGCAAAGATCGAAGCGAAGTAA

Upstream 100 bases:

>100_bases
TCAGCGGCGGCGGAAAACAACAACCGCCACCCAGCCTCATCTTGCATCGGTCAAGGATGCGGTTTACGCCCTCGGAGCTT
AGCTCAGGAGCGTTCAAACT

Downstream 100 bases:

>100_bases
TGCGCATTCTTCTGACCAATGACGACGGCATTCACGCCGAGGGCCTGGCGTCGCTCGAACGCGTCGCGCGTACACTCTCC
GACGATGTCTGGGTGGTGGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MLDIKWIRDNPKALVEALAKRSWSAGEAQSTVDDLIARDEARREHVTELQTKQERRNAASKEIGNAMRSGDAALAEKLKA
EVGDIKTFIQNGEARERELDKALTDALAVLPNVPLDDVPVGKDEHDNVVKHIVGKVPTRSNWVKEHFEIGEALGMMDFER
AAKLSGSRFTVLKSGLARMERAIGQFMLDLHTTEHGYEEVIPPLMVRDEVLFGTNQLPKFEEDLFFTPHGEGRLGLIPTA
EVPLTNLVREEITAHEKLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFYKVELVSITDQDSSLAEHERMTQCAEEVLKR
LELPFRTMVLCTGDMGFGARKTYDIEVWLPGQNAYREISSCSVCGDFQARRMDARYKDKDGKGNRFVHTLNGSGTAVGRA
LIAVIENYQNEDGSVTIPEVLRPYMGGLAKIEAK

Sequences:

>Translated_434_residues
MLDIKWIRDNPKALVEALAKRSWSAGEAQSTVDDLIARDEARREHVTELQTKQERRNAASKEIGNAMRSGDAALAEKLKA
EVGDIKTFIQNGEARERELDKALTDALAVLPNVPLDDVPVGKDEHDNVVKHIVGKVPTRSNWVKEHFEIGEALGMMDFER
AAKLSGSRFTVLKSGLARMERAIGQFMLDLHTTEHGYEEVIPPLMVRDEVLFGTNQLPKFEEDLFFTPHGEGRLGLIPTA
EVPLTNLVREEITAHEKLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFYKVELVSITDQDSSLAEHERMTQCAEEVLKR
LELPFRTMVLCTGDMGFGARKTYDIEVWLPGQNAYREISSCSVCGDFQARRMDARYKDKDGKGNRFVHTLNGSGTAVGRA
LIAVIENYQNEDGSVTIPEVLRPYMGGLAKIEAK
>Mature_434_residues
MLDIKWIRDNPKALVEALAKRSWSAGEAQSTVDDLIARDEARREHVTELQTKQERRNAASKEIGNAMRSGDAALAEKLKA
EVGDIKTFIQNGEARERELDKALTDALAVLPNVPLDDVPVGKDEHDNVVKHIVGKVPTRSNWVKEHFEIGEALGMMDFER
AAKLSGSRFTVLKSGLARMERAIGQFMLDLHTTEHGYEEVIPPLMVRDEVLFGTNQLPKFEEDLFFTPHGEGRLGLIPTA
EVPLTNLVREEITAHEKLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFYKVELVSITDQDSSLAEHERMTQCAEEVLKR
LELPFRTMVLCTGDMGFGARKTYDIEVWLPGQNAYREISSCSVCGDFQARRMDARYKDKDGKGNRFVHTLNGSGTAVGRA
LIAVIENYQNEDGSVTIPEVLRPYMGGLAKIEAK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=455, Percent_Identity=31.2087912087912, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI8923421, Length=438, Percent_Identity=29.9086757990868, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI225579074, Length=440, Percent_Identity=30, Blast_Score=176, Evalue=4e-44,
Organism=Escherichia coli, GI1787120, Length=436, Percent_Identity=51.3761467889908, Blast_Score=417, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17539260, Length=463, Percent_Identity=29.5896328293737, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17542084, Length=337, Percent_Identity=28.7833827893175, Blast_Score=144, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=455, Percent_Identity=31.2087912087912, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6321799, Length=401, Percent_Identity=28.6783042394015, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24581334, Length=469, Percent_Identity=30.2771855010661, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17737985, Length=348, Percent_Identity=32.7586206896552, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_RHILO (Q98LC8)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102749.1
- ProteinModelPortal:   Q98LC8
- SMR:   Q98LC8
- GeneID:   1225412
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll1081
- NMPDR:   fig|266835.1.peg.854
- HOGENOM:   HBG629391
- OMA:   ENGYTEV
- ProtClustDB:   PRK05431
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48550; Mature: 48550

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 293-293 BINDING 393-393

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKWIRDNPKALVEALAKRSWSAGEAQSTVDDLIARDEARREHVTELQTKQERRNAAS
CCCEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEIGNAMRSGDAALAEKLKAEVGDIKTFIQNGEARERELDKALTDALAVLPNVPLDDVPV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
GKDEHDNVVKHIVGKVPTRSNWVKEHFEIGEALGMMDFERAAKLSGSRFTVLKSGLARME
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHH
RAIGQFMLDLHTTEHGYEEVIPPLMVRDEVLFGTNQLPKFEEDLFFTPHGEGRLGLIPTA
HHHHHHHHHHHCCCCCHHHHCCCHHHCCHHHCCCCCCCCCCCCCEECCCCCCCEECCCCC
EVPLTNLVREEITAHEKLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFYKVELVSITDQ
CCCHHHHHHHHHHHHCCCCEEEEHHCHHHHHCCCCCCCHHHHHHHHCCEEEEEEEEEECC
DSSLAEHERMTQCAEEVLKRLELPFRTMVLCTGDMGFGARKTYDIEVWLPGQNAYREISS
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHH
CSVCGDFQARRMDARYKDKDGKGNRFVHTLNGSGTAVGRALIAVIENYQNEDGSVTIPEV
CCCCCCHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHH
LRPYMGGLAKIEAK
HHHHHCCCEEECCC
>Mature Secondary Structure
MLDIKWIRDNPKALVEALAKRSWSAGEAQSTVDDLIARDEARREHVTELQTKQERRNAAS
CCCEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEIGNAMRSGDAALAEKLKAEVGDIKTFIQNGEARERELDKALTDALAVLPNVPLDDVPV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
GKDEHDNVVKHIVGKVPTRSNWVKEHFEIGEALGMMDFERAAKLSGSRFTVLKSGLARME
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHH
RAIGQFMLDLHTTEHGYEEVIPPLMVRDEVLFGTNQLPKFEEDLFFTPHGEGRLGLIPTA
HHHHHHHHHHHCCCCCHHHHCCCHHHCCHHHCCCCCCCCCCCCCEECCCCCCCEECCCCC
EVPLTNLVREEITAHEKLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFYKVELVSITDQ
CCCHHHHHHHHHHHHCCCCEEEEHHCHHHHHCCCCCCCHHHHHHHHCCEEEEEEEEEECC
DSSLAEHERMTQCAEEVLKRLELPFRTMVLCTGDMGFGARKTYDIEVWLPGQNAYREISS
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHH
CSVCGDFQARRMDARYKDKDGKGNRFVHTLNGSGTAVGRALIAVIENYQNEDGSVTIPEV
CCCCCCHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHH
LRPYMGGLAKIEAK
HHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968