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The map label for this gene is clpA [C]

Identifier: 13470854

GI number: 13470854

Start: 519507

End: 521975

Strand: Reverse

Name: clpA [C]

Synonym: mll0663

Alternate gene names: 13470854

Gene position: 521975-519507 (Counterclockwise)

Preceding gene: 13470855

Following gene: 13470849

Centisome position: 7.42

GC content: 63.59

Gene sequence:

>2469_bases
ATGCCGGCTTTCTCCCAAGGCCTGGAAAAGGCGCTTCACCAGGCGCTGACGCTCGCCAATGAGCGGCACCATGAATACGC
AACCCTTGAACATCTGCTGCTCGCGTTGATCGACGACACCGAAGCGGCCGCCGTCATGCGCGCCTGCAACGTCGATCTCG
ACGAGCTGAAGCACACTGTTCTCACCTATATCGACACCGAGCTCGACAATCTGGTCACCGGCTACGACGAGGATTCCAAG
CCGACCGCCGGCTTCCAGCGCGTCATCCAGCGCGCGGTGATCCATGTCCAGTCGTCGGGCCGAGAGGAAGTGTCTGGCGC
CAACGTGCTCGTCGCCATCTTCGCCGAGCGCGAGAGCCATGCCGCCTACTTCCTGCAGGAACAGCAGATGACCCGCTACG
ACGCGGTCAACTACATCTCGCACGGCATCGCCAAGCGCCCCGGCGCATCGGAAACGCGCTCGCCGCGCGGCGCCGATGAC
GAGCAGGGCGGCCAGAACGGCGCCGAGCCGCAAGAGGAAGGCGGCAAGAAAAAGCAGCAGCAGGACGCGCTGACGGCTTA
TTGCGTCAACCTCAACAACAAGGCCAAGGCCGGCAAGATCGATCCGCTGATCGGTCGCGAGTCGGAAATCAACCGCACCA
TCCAGGTGCTGTGCCGCCGCTCCAAGAACAACCCGCTCTATGTCGGCGATCCCGGCGTCGGCAAGACGGCGATCGCCGAA
GGTCTTGCCAAGCGCATCGTCGAGGGCGACGTTCCCGAAGTGCTGCACAATGCCACCATCTTCGCGCTCGACATGGGCAC
GCTGCTGGCCGGCACGCGCTACCGCGGCGATTTCGAGGAACGGCTGAAGCAGGTCGTCAAGGAACTCGAGGACTATCCGG
GTGCGGTGCTGTTCATCGACGAGATCCACACGGTGATCGGCGCAGGGGCCACCTCAGGCGGCGCCATGGACGCGTCGAAC
CTGTTGAAGCCGGCTCTGTCGTCGGGTGCTATCCGCTGCATCGGCTCGACCACCTACAAGGAGTTCCGCCAGTTCTTCGA
GAAGGACCGCGCTCTGGTGCGGCGCTTCCAGAAGATCGACGTCAACGAACCGACCATCGAGGACGCCATCGAGATCATGA
AGGGCCTGAAGCCCTATTTCGAGGAGTTCCACAAGGTCCGCTACACCTCGGAAGCCATCAAGGCCTCGGTCGAACTGTCG
GCGCGCTACATCAACGACCGCAAGCTGCCGGACAAGGCGATCGACGTGATCGACGAGACCGGCGCCTCGCAGATGCTGGT
GCCGGAAGCCAAGCGCAAGAAGACCATCGGCATCAAGGAGATCGAAGCAACGATCGCCACCATGGCGCGTATCCCGCCGA
AGACGGTTTCGGCCGATGACGAGAAGGTGCTGCAAGGCCTCGATATCGAGCTGAAGCGCGTCGTCTATGGTCAGGATACC
GCCATCACGGCACTGACCTCGGCGATCAAGCTGGCCCGTGCCGGCCTGCGCGAACCGGAAAAGCCGATCGGCTCGTACCT
GTTCTCGGGTCCGACCGGCGTCGGCAAGACGGAAGTCGCCAAGCAGCTCGCCGCCTCGCTCGGCGTCGAGCTGATCCGCT
TCGACATGTCGGAATATATGGAACGCCACACCGTTTCGCGGCTGATCGGCGCGCCTCCCGGCTATGTCGGTTTCGACCAG
GGTGGCTTGCTCACGGACGGCGTCGACCAGCATCCGCACTGCGTGCTGCTGCTCGACGAGGTCGAGAAGGCGCATCCGGA
CCTGTTTAACATCCTGTTGCAGGTCATGGACCACGGCAAGCTGACCGACCACAACGGCAAGCAGATCGACTTCCGCAATG
TCATCCTGATCATGACCACCAATGCGGGCGCATCCGATGCGCAGCGCGCGGCGATCGGTTTCGGGTCGACCAAGCGCGAA
GGCGACGATGTCGAGGCGATCAACCGGCTGTTCACGCCGGAATTCCGCAACCGTCTCGATGCGATCATCCCGTTCGGTTC
GCTGCCGGTGCCGGTCATCCATCAGGTGGTGCAGAAGTTCGTCATGCAGCTCGAGGCGCAGCTCTCCGAGCGTGGCGTTA
CCTTCGACCTGTCGCCGGATGCGATCGCCTGGCTGGCCGACAAGGGTTATGACGAGCGCATGGGCGCTCGGCCGCTCGGC
CGTGTGATCCAGGAGCACATCAAAAAGCCGCTGGCTGACGAGGTGCTGTTCGGCAAGCTCAAGAAGGGCGGCACGGTGCG
TGTCACCGTCGAGAAGAAGGAAACCGGCGAGACCGGCCTGAAGCTCGAATCGCTGGCCGACGAGGCGCCGGTGAAGCCGA
AGAAGGAAGAGCCGGAAGACGCGCCGAAGCCGCCCAAGGCCGTGGCCAAGAAGCCTGCCGCCAAGAAGGTCGTGGCGCAG
AAGCCGGAGCCCAAGGGCAAGGATGGCGGCAAGCGCAGCCTGGTCCCGCAACTGCCGCGCAAGGGCTGA

Upstream 100 bases:

>100_bases
TACATTCGAGGTGGCCGAGACCAAAGTGTCTCAGGTCATGGATTTCGCCCGACAGAATCAGCATCCGCTGCAATGCGTGA
TGGAGAAGAAGTGAGGTAAC

Downstream 100 bases:

>100_bases
TCGGCACGCACTCGAAGAAGCCCCGGAAACGGGGCTTTTTCATTTGGGCGACAGGGTGGCTATGGCCGGTCGGTCCTCAG
CCCTGAACAGGGCGCGCAAG

Product: endopeptidase Clp ATP-binding chain A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 822; Mature: 821

Protein sequence:

>822_residues
MPAFSQGLEKALHQALTLANERHHEYATLEHLLLALIDDTEAAAVMRACNVDLDELKHTVLTYIDTELDNLVTGYDEDSK
PTAGFQRVIQRAVIHVQSSGREEVSGANVLVAIFAERESHAAYFLQEQQMTRYDAVNYISHGIAKRPGASETRSPRGADD
EQGGQNGAEPQEEGGKKKQQQDALTAYCVNLNNKAKAGKIDPLIGRESEINRTIQVLCRRSKNNPLYVGDPGVGKTAIAE
GLAKRIVEGDVPEVLHNATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDYPGAVLFIDEIHTVIGAGATSGGAMDASN
LLKPALSSGAIRCIGSTTYKEFRQFFEKDRALVRRFQKIDVNEPTIEDAIEIMKGLKPYFEEFHKVRYTSEAIKASVELS
ARYINDRKLPDKAIDVIDETGASQMLVPEAKRKKTIGIKEIEATIATMARIPPKTVSADDEKVLQGLDIELKRVVYGQDT
AITALTSAIKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLAASLGVELIRFDMSEYMERHTVSRLIGAPPGYVGFDQ
GGLLTDGVDQHPHCVLLLDEVEKAHPDLFNILLQVMDHGKLTDHNGKQIDFRNVILIMTTNAGASDAQRAAIGFGSTKRE
GDDVEAINRLFTPEFRNRLDAIIPFGSLPVPVIHQVVQKFVMQLEAQLSERGVTFDLSPDAIAWLADKGYDERMGARPLG
RVIQEHIKKPLADEVLFGKLKKGGTVRVTVEKKETGETGLKLESLADEAPVKPKKEEPEDAPKPPKAVAKKPAAKKVVAQ
KPEPKGKDGGKRSLVPQLPRKG

Sequences:

>Translated_822_residues
MPAFSQGLEKALHQALTLANERHHEYATLEHLLLALIDDTEAAAVMRACNVDLDELKHTVLTYIDTELDNLVTGYDEDSK
PTAGFQRVIQRAVIHVQSSGREEVSGANVLVAIFAERESHAAYFLQEQQMTRYDAVNYISHGIAKRPGASETRSPRGADD
EQGGQNGAEPQEEGGKKKQQQDALTAYCVNLNNKAKAGKIDPLIGRESEINRTIQVLCRRSKNNPLYVGDPGVGKTAIAE
GLAKRIVEGDVPEVLHNATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDYPGAVLFIDEIHTVIGAGATSGGAMDASN
LLKPALSSGAIRCIGSTTYKEFRQFFEKDRALVRRFQKIDVNEPTIEDAIEIMKGLKPYFEEFHKVRYTSEAIKASVELS
ARYINDRKLPDKAIDVIDETGASQMLVPEAKRKKTIGIKEIEATIATMARIPPKTVSADDEKVLQGLDIELKRVVYGQDT
AITALTSAIKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLAASLGVELIRFDMSEYMERHTVSRLIGAPPGYVGFDQ
GGLLTDGVDQHPHCVLLLDEVEKAHPDLFNILLQVMDHGKLTDHNGKQIDFRNVILIMTTNAGASDAQRAAIGFGSTKRE
GDDVEAINRLFTPEFRNRLDAIIPFGSLPVPVIHQVVQKFVMQLEAQLSERGVTFDLSPDAIAWLADKGYDERMGARPLG
RVIQEHIKKPLADEVLFGKLKKGGTVRVTVEKKETGETGLKLESLADEAPVKPKKEEPEDAPKPPKAVAKKPAAKKVVAQ
KPEPKGKDGGKRSLVPQLPRKG
>Mature_821_residues
PAFSQGLEKALHQALTLANERHHEYATLEHLLLALIDDTEAAAVMRACNVDLDELKHTVLTYIDTELDNLVTGYDEDSKP
TAGFQRVIQRAVIHVQSSGREEVSGANVLVAIFAERESHAAYFLQEQQMTRYDAVNYISHGIAKRPGASETRSPRGADDE
QGGQNGAEPQEEGGKKKQQQDALTAYCVNLNNKAKAGKIDPLIGRESEINRTIQVLCRRSKNNPLYVGDPGVGKTAIAEG
LAKRIVEGDVPEVLHNATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDYPGAVLFIDEIHTVIGAGATSGGAMDASNL
LKPALSSGAIRCIGSTTYKEFRQFFEKDRALVRRFQKIDVNEPTIEDAIEIMKGLKPYFEEFHKVRYTSEAIKASVELSA
RYINDRKLPDKAIDVIDETGASQMLVPEAKRKKTIGIKEIEATIATMARIPPKTVSADDEKVLQGLDIELKRVVYGQDTA
ITALTSAIKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLAASLGVELIRFDMSEYMERHTVSRLIGAPPGYVGFDQG
GLLTDGVDQHPHCVLLLDEVEKAHPDLFNILLQVMDHGKLTDHNGKQIDFRNVILIMTTNAGASDAQRAAIGFGSTKREG
DDVEAINRLFTPEFRNRLDAIIPFGSLPVPVIHQVVQKFVMQLEAQLSERGVTFDLSPDAIAWLADKGYDERMGARPLGR
VIQEHIKKPLADEVLFGKLKKGGTVRVTVEKKETGETGLKLESLADEAPVKPKKEEPEDAPKPPKAVAKKPAAKKVVAQK
PEPKGKDGGKRSLVPQLPRKG

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=321, Percent_Identity=33.9563862928349, Blast_Score=160, Evalue=5e-39,
Organism=Escherichia coli, GI1787109, Length=753, Percent_Identity=58.5657370517928, Blast_Score=909, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=425, Percent_Identity=41.4117647058824, Blast_Score=296, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6320464, Length=319, Percent_Identity=45.141065830721, Blast_Score=276, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6323002, Length=467, Percent_Identity=34.2612419700214, Blast_Score=247, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 90138; Mature: 90007

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAFSQGLEKALHQALTLANERHHEYATLEHLLLALIDDTEAAAVMRACNVDLDELKHTV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHH
LTYIDTELDNLVTGYDEDSKPTAGFQRVIQRAVIHVQSSGREEVSGANVLVAIFAERESH
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCH
AAYFLQEQQMTRYDAVNYISHGIAKRPGASETRSPRGADDEQGGQNGAEPQEEGGKKKQQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHH
QDALTAYCVNLNNKAKAGKIDPLIGRESEINRTIQVLCRRSKNNPLYVGDPGVGKTAIAE
HHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHH
GLAKRIVEGDVPEVLHNATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDYPGAVLFID
HHHHHHHCCCHHHHHHCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEHH
EIHTVIGAGATSGGAMDASNLLKPALSSGAIRCIGSTTYKEFRQFFEKDRALVRRFQKID
HHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCC
VNEPTIEDAIEIMKGLKPYFEEFHKVRYTSEAIKASVELSARYINDRKLPDKAIDVIDET
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
GASQMLVPEAKRKKTIGIKEIEATIATMARIPPKTVSADDEKVLQGLDIELKRVVYGQDT
CCCCEECCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEHHHEECCCH
AITALTSAIKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLAASLGVELIRFDMSEYM
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ERHTVSRLIGAPPGYVGFDQGGLLTDGVDQHPHCVLLLDEVEKAHPDLFNILLQVMDHGK
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHHCCC
LTDHNGKQIDFRNVILIMTTNAGASDAQRAAIGFGSTKREGDDVEAINRLFTPEFRNRLD
CCCCCCCEEEECCEEEEEEECCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHH
AIIPFGSLPVPVIHQVVQKFVMQLEAQLSERGVTFDLSPDAIAWLADKGYDERMGARPLG
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHCCCCHHHCCCCHHH
RVIQEHIKKPLADEVLFGKLKKGGTVRVTVEKKETGETGLKLESLADEAPVKPKKEEPED
HHHHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCCCC
APKPPKAVAKKPAAKKVVAQKPEPKGKDGGKRSLVPQLPRKG
CCCCCHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PAFSQGLEKALHQALTLANERHHEYATLEHLLLALIDDTEAAAVMRACNVDLDELKHTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHH
LTYIDTELDNLVTGYDEDSKPTAGFQRVIQRAVIHVQSSGREEVSGANVLVAIFAERESH
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCH
AAYFLQEQQMTRYDAVNYISHGIAKRPGASETRSPRGADDEQGGQNGAEPQEEGGKKKQQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHH
QDALTAYCVNLNNKAKAGKIDPLIGRESEINRTIQVLCRRSKNNPLYVGDPGVGKTAIAE
HHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHH
GLAKRIVEGDVPEVLHNATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDYPGAVLFID
HHHHHHHCCCHHHHHHCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEHH
EIHTVIGAGATSGGAMDASNLLKPALSSGAIRCIGSTTYKEFRQFFEKDRALVRRFQKID
HHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCC
VNEPTIEDAIEIMKGLKPYFEEFHKVRYTSEAIKASVELSARYINDRKLPDKAIDVIDET
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
GASQMLVPEAKRKKTIGIKEIEATIATMARIPPKTVSADDEKVLQGLDIELKRVVYGQDT
CCCCEECCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEHHHEECCCH
AITALTSAIKLARAGLREPEKPIGSYLFSGPTGVGKTEVAKQLAASLGVELIRFDMSEYM
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ERHTVSRLIGAPPGYVGFDQGGLLTDGVDQHPHCVLLLDEVEKAHPDLFNILLQVMDHGK
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHHCCC
LTDHNGKQIDFRNVILIMTTNAGASDAQRAAIGFGSTKREGDDVEAINRLFTPEFRNRLD
CCCCCCCEEEECCEEEEEEECCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHH
AIIPFGSLPVPVIHQVVQKFVMQLEAQLSERGVTFDLSPDAIAWLADKGYDERMGARPLG
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHCCCCHHHCCCCHHH
RVIQEHIKKPLADEVLFGKLKKGGTVRVTVEKKETGETGLKLESLADEAPVKPKKEEPED
HHHHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCCCC
APKPPKAVAKKPAAKKVVAQKPEPKGKDGGKRSLVPQLPRKG
CCCCCHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]