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The map label for this gene is gor [H]

Identifier: 13470737

GI number: 13470737

Start: 386976

End: 388367

Strand: Reverse

Name: gor [H]

Synonym: mll0523

Alternate gene names: 13470737

Gene position: 388367-386976 (Counterclockwise)

Preceding gene: 13470738

Following gene: 13470734

Centisome position: 5.52

GC content: 62.93

Gene sequence:

>1392_bases
ATGGCCGGTTATGACTACGATCTTTTCGTCATCGGCGGCGGCTCCGGTGGGGTGAGGGCGGCGCGCGTTGCCGCGACACT
CGGCAAGCGCGTCGGCATCGCCGAGGAATACCGATTTGGCGGCACCTGTGTCATCCGCGGCTGCGTGCCGAAAAAACTCT
ATGTCTACGCCTCGCAATTTCCGGAGCATTTTGCCGATGCCGCCGGCTATGGCTGGACGGTGCCGGAGGCCAGTTTCAAT
TGGCAGACACTGGTCGCCAACAAGGACCGCGAGATCAGCCGGCTGGAGGCAATCTACAAGAAGAATGTCGAGGGCGCCGG
CGGCGAGACCTTCCCTTCGCGGGCGATGATCGTAGACCCGCATGTGGTGCATCTCCTGGACGACGACCGCACCGTCACCG
CCGACCAAATCCTGATCGCCACCGGCGGCCGTCCGGCGGCCCACCCGGCGCTTCCCGGCCATGAGCATTGCATCTTTTCC
AACGAGGCTTTCGACCTCAAGGAACTGCCGAAGGCGATCATGATCGAGGGCGGCGGCTATATCGCGGTCGAGTTCGCCAA
CATTTTCCACGGCCTCGGCGTCGACACCACGCTGGTCTATCGCGGCAAGGAGATCCTCAGCCGCTTCGACATGGATCTGC
GCCGCACGCTGCACGAGACCATGGAAAAGAAGGGGATCAAGATACTTTGCCATGCAGTGAGCGAGCGGGTGCACAAGCGG
CCGGACGGCCGGCTCGACGCCCTTCTCACCAGCGGCCAGACCCTGACGGTGGACCAGGTCATGCTGGCCATCGGGCGCAT
TCCCAACACCGAGAATATGGGTCTGGAAGGCATCGGCCTCGAGATGACCCAAGCCGGCGCGATCAAGGTCGACGAGTACT
CCCGCACCAACATCGACAATATCTGGGCGATCGGCGACGTCACCAACCGCGTGCAGCTGACACCGGTGGCGATCCACGAA
GCGATGTGCTTTGTCGAGACGGCATTCAAGGGGAATCCGACCGCGCCCGACCACGACACCATCGCCACCGCGGTCTTCTC
GCAGCCTGAAATCGGTACTGTCGGTCTGTCGGAAGACGAAGCCGTGAAGCGTTTCGCCGATGTCGAAATCTACCGCGCCA
GCTTCCGGCCGATGCGGCATACGCTCTCGGGCCGCGACGAGAAGATGCTGATAAAGCTGGTGGTCGACGGCGCTTCCCGC
AAAGTGCTCGGCGCCCACATATTGGGGCCGGATGCCGGCGAAATGGCGCAGCTGCTCGGTATTCCGCTGAAGGCCGGCCT
GAGCAAGGATGATTTCGACCGCACAATGGCCGTGCACCCGACCGCGGCGGAAGAACTCGTCACCATGTACAAGCCGACCT
ACCGCGTGAAGGACGGCCAGCGCGTCCAGTGA

Upstream 100 bases:

>100_bases
CCTTGCGGCCATCTGTGAAGCCCGGCTTGTCCGGGCTTTTCTTTTGGCCATTGGCGGCCTACCTGTCACTCACATTTTCC
GACGTTCAAGGAGCCGCCCC

Downstream 100 bases:

>100_bases
CGAGCGCGGCTTGCTCCATAAAAGTCGACGGAAGCATCTACGGCAGGCAAGCCTGAAAGGCGGAAGCCGCCGCCGGCCAT
GGCCAGCGGCGGAGACAGCA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MAGYDYDLFVIGGGSGGVRAARVAATLGKRVGIAEEYRFGGTCVIRGCVPKKLYVYASQFPEHFADAAGYGWTVPEASFN
WQTLVANKDREISRLEAIYKKNVEGAGGETFPSRAMIVDPHVVHLLDDDRTVTADQILIATGGRPAAHPALPGHEHCIFS
NEAFDLKELPKAIMIEGGGYIAVEFANIFHGLGVDTTLVYRGKEILSRFDMDLRRTLHETMEKKGIKILCHAVSERVHKR
PDGRLDALLTSGQTLTVDQVMLAIGRIPNTENMGLEGIGLEMTQAGAIKVDEYSRTNIDNIWAIGDVTNRVQLTPVAIHE
AMCFVETAFKGNPTAPDHDTIATAVFSQPEIGTVGLSEDEAVKRFADVEIYRASFRPMRHTLSGRDEKMLIKLVVDGASR
KVLGAHILGPDAGEMAQLLGIPLKAGLSKDDFDRTMAVHPTAAEELVTMYKPTYRVKDGQRVQ

Sequences:

>Translated_463_residues
MAGYDYDLFVIGGGSGGVRAARVAATLGKRVGIAEEYRFGGTCVIRGCVPKKLYVYASQFPEHFADAAGYGWTVPEASFN
WQTLVANKDREISRLEAIYKKNVEGAGGETFPSRAMIVDPHVVHLLDDDRTVTADQILIATGGRPAAHPALPGHEHCIFS
NEAFDLKELPKAIMIEGGGYIAVEFANIFHGLGVDTTLVYRGKEILSRFDMDLRRTLHETMEKKGIKILCHAVSERVHKR
PDGRLDALLTSGQTLTVDQVMLAIGRIPNTENMGLEGIGLEMTQAGAIKVDEYSRTNIDNIWAIGDVTNRVQLTPVAIHE
AMCFVETAFKGNPTAPDHDTIATAVFSQPEIGTVGLSEDEAVKRFADVEIYRASFRPMRHTLSGRDEKMLIKLVVDGASR
KVLGAHILGPDAGEMAQLLGIPLKAGLSKDDFDRTMAVHPTAAEELVTMYKPTYRVKDGQRVQ
>Mature_462_residues
AGYDYDLFVIGGGSGGVRAARVAATLGKRVGIAEEYRFGGTCVIRGCVPKKLYVYASQFPEHFADAAGYGWTVPEASFNW
QTLVANKDREISRLEAIYKKNVEGAGGETFPSRAMIVDPHVVHLLDDDRTVTADQILIATGGRPAAHPALPGHEHCIFSN
EAFDLKELPKAIMIEGGGYIAVEFANIFHGLGVDTTLVYRGKEILSRFDMDLRRTLHETMEKKGIKILCHAVSERVHKRP
DGRLDALLTSGQTLTVDQVMLAIGRIPNTENMGLEGIGLEMTQAGAIKVDEYSRTNIDNIWAIGDVTNRVQLTPVAIHEA
MCFVETAFKGNPTAPDHDTIATAVFSQPEIGTVGLSEDEAVKRFADVEIYRASFRPMRHTLSGRDEKMLIKLVVDGASRK
VLGAHILGPDAGEMAQLLGIPLKAGLSKDDFDRTMAVHPTAAEELVTMYKPTYRVKDGQRVQ

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=38.2096069868996, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI22035672, Length=470, Percent_Identity=35.9574468085106, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI148277065, Length=474, Percent_Identity=33.7552742616034, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI33519430, Length=474, Percent_Identity=33.7552742616034, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI33519428, Length=474, Percent_Identity=33.7552742616034, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI33519426, Length=474, Percent_Identity=33.7552742616034, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI148277071, Length=474, Percent_Identity=33.7552742616034, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI291045266, Length=473, Percent_Identity=32.5581395348837, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=29.9126637554585, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI291045268, Length=471, Percent_Identity=30.5732484076433, Blast_Score=184, Evalue=2e-46,
Organism=Escherichia coli, GI1789915, Length=430, Percent_Identity=39.7674418604651, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI1786307, Length=446, Percent_Identity=25.7847533632287, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI87082354, Length=451, Percent_Identity=28.159645232816, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=27.0925110132159, Blast_Score=148, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=38.4444444444444, Blast_Score=255, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=38.4444444444444, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17557007, Length=469, Percent_Identity=29.4243070362473, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=32.8482328482328, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=29.5258620689655, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17559934, Length=189, Percent_Identity=30.1587301587302, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=462, Percent_Identity=35.9307359307359, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6321091, Length=461, Percent_Identity=28.6334056399132, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=462, Percent_Identity=26.6233766233766, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=33.1914893617021, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=33.1914893617021, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=33.1914893617021, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=32.2784810126582, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=27.4509803921569, Blast_Score=171, Evalue=1e-42,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 50621; Mature: 50489

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGYDYDLFVIGGGSGGVRAARVAATLGKRVGIAEEYRFGGTCVIRGCVPKKLYVYASQF
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHCCCCEEEEECCCCCEEEEEHHHH
PEHFADAAGYGWTVPEASFNWQTLVANKDREISRLEAIYKKNVEGAGGETFPSRAMIVDP
HHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECC
HVVHLLDDDRTVTADQILIATGGRPAAHPALPGHEHCIFSNEAFDLKELPKAIMIEGGGY
EEEEEECCCCEEEECEEEEEECCCCCCCCCCCCCCEEEECCCCCCHHHCCCEEEEECCCE
IAVEFANIFHGLGVDTTLVYRGKEILSRFDMDLRRTLHETMEKKGIKILCHAVSERVHKR
EEEEHHHHHHCCCCCEEEEECCHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
PDGRLDALLTSGQTLTVDQVMLAIGRIPNTENMGLEGIGLEMTQAGAIKVDEYSRTNIDN
CCCCCHHHEECCCEEEHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEECCCCCCCCCC
IWAIGDVTNRVQLTPVAIHEAMCFVETAFKGNPTAPDHDTIATAVFSQPEIGTVGLSEDE
EEEECCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEECCCCCCEECCCCHH
AVKRFADVEIYRASFRPMRHTLSGRDEKMLIKLVVDGASRKVLGAHILGPDAGEMAQLLG
HHHHHHHHHHEEHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEEECCCHHHHHHHHC
IPLKAGLSKDDFDRTMAVHPTAAEELVTMYKPTYRVKDGQRVQ
CCHHCCCCCCCCCCEEEECCCHHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure 
AGYDYDLFVIGGGSGGVRAARVAATLGKRVGIAEEYRFGGTCVIRGCVPKKLYVYASQF
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHCCCCEEEEECCCCCEEEEEHHHH
PEHFADAAGYGWTVPEASFNWQTLVANKDREISRLEAIYKKNVEGAGGETFPSRAMIVDP
HHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECC
HVVHLLDDDRTVTADQILIATGGRPAAHPALPGHEHCIFSNEAFDLKELPKAIMIEGGGY
EEEEEECCCCEEEECEEEEEECCCCCCCCCCCCCCEEEECCCCCCHHHCCCEEEEECCCE
IAVEFANIFHGLGVDTTLVYRGKEILSRFDMDLRRTLHETMEKKGIKILCHAVSERVHKR
EEEEHHHHHHCCCCCEEEEECCHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
PDGRLDALLTSGQTLTVDQVMLAIGRIPNTENMGLEGIGLEMTQAGAIKVDEYSRTNIDN
CCCCCHHHEECCCEEEHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEECCCCCCCCCC
IWAIGDVTNRVQLTPVAIHEAMCFVETAFKGNPTAPDHDTIATAVFSQPEIGTVGLSEDE
EEEECCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEECCCCCCEECCCCHH
AVKRFADVEIYRASFRPMRHTLSGRDEKMLIKLVVDGASRKVLGAHILGPDAGEMAQLLG
HHHHHHHHHHEEHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEEECCCHHHHHHHHC
IPLKAGLSKDDFDRTMAVHPTAAEELVTMYKPTYRVKDGQRVQ
CCHHCCCCCCCCCCEEEECCCHHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]