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The map label for this gene is tyrB [H]

Identifier: 13470639

GI number: 13470639

Start: 292117

End: 293301

Strand: Reverse

Name: tyrB [H]

Synonym: mll0405

Alternate gene names: 13470639

Gene position: 293301-292117 (Counterclockwise)

Preceding gene: 13470645

Following gene: 13470638

Centisome position: 4.17

GC content: 67.0

Gene sequence:

>1185_bases
ATGTTCGAAGACCTGCAGCCAGCTCCCGCCGACAAGATCCTGGCCCTCATCGGCCTCTATCGCGCCGATCCGCGTCCCAA
CAAGGTCGACCTCGGCGTCGGCGTCTACAAGGATCGCGACGGCAAGACCCCAGTGATGCGCGCCGTGCGTGAGGCTGAAA
AGCGGCTGCTGAACAGCCAGGACACCAAGACCTATCTCGGGCTCGCCGGCGACACCGGCTTCAACGCGGTGATGGCCAAG
CTCGCCTTCGGCCCGGGCGCGGACATGACGCGCATTCGGGCGGCCCAGGCGCCTGGCGGCTCCGGTGCGCTTCGCCTGGT
GGCGGAGCTGCTCAAGCGGACCCGTTCGGACGCCACGATCTGGCTGTCGGACCCAACCTGGCCGAACCATATGCCGGTGA
TGCGCGCTGCCGGCCTGCAGATCCGCGAATATCCCTATTTCGACGCGGCCTCCGGTGCTGTTCGCTTCGACGACATGCTG
GCGGCGTTGCGGACGGCCAAGAGCGGCGACGTGGTGCTGCTGCACGGCTGCTGCCACAATCCAACCGGCGCCAATCTGGA
TGCGGCGCAGTGGCAGGCCGTCACCGATCTGATGGTCGAGCGCGGCCTGCTGCCATTCGTCGACATCGCCTATCAGGGCT
TTGGCGACGGCCTCGAGGCCGACGCTCTTGGCCTGCGCCTGCTGGCGGCGAAAGTTCCGGAAATGGTTGTTGCCTCGAGC
TGCTCGAAGAATTTCGCCGTCTACCGCGACCGTGTCGGCGCAGCGATGGTTTTGGCCAGGGACAGCGCGCAGGCTGACGT
GGCGATGAGCCAGATGCTGTCGGCGGCGCGCGCCATGTATTCGATGCCGCCGGACCATGGTGCCGCGGCGGTGCGCATCG
TGCTCGAAGACGCAAGCCTGCGCGCCGACTGGGAAGCCGAATTGGAAGAGATGCGCCTGCGCATGCTGAGGCTTCGCGTG
GCTTTCGCCGAGGCGCTGCGCCGGCAGTCCAACTCCGACCGCTTCGACTTCGTCGCCAGCCACCGCGGCATGTTCTCACG
GCTTGGCCTGACGGAAGCGCAGGTCGAGCGGCTGCGCGCCGAGCACGGCGTGTACATGGTCGGCGATAGCCGCATCAACG
TCGCTGGACTGCCGGAGGATGGCATGGACGCGCTCGCCAAGGCGATCGTCTCCGTGCTCGACTGA

Upstream 100 bases:

>100_bases
CCGCGCCCCTGGGTGCCGCCCTCCGTTTTGCGCAATTAAAACCGCTGGCGAAGCGCGTTCGATTTGCGTATCACTCCGCC
GCGCCAACGGAACCATAACG

Downstream 100 bases:

>100_bases
AGCGGCTCAGATGTGGACAAGGCTCCCTCGCCGGCTGACAGCATTGGCCGCGCGTCGGGCCGCAGGATAGCATCCGCCGC
ATGACGCCATCCAAAGACAT

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MFEDLQPAPADKILALIGLYRADPRPNKVDLGVGVYKDRDGKTPVMRAVREAEKRLLNSQDTKTYLGLAGDTGFNAVMAK
LAFGPGADMTRIRAAQAPGGSGALRLVAELLKRTRSDATIWLSDPTWPNHMPVMRAAGLQIREYPYFDAASGAVRFDDML
AALRTAKSGDVVLLHGCCHNPTGANLDAAQWQAVTDLMVERGLLPFVDIAYQGFGDGLEADALGLRLLAAKVPEMVVASS
CSKNFAVYRDRVGAAMVLARDSAQADVAMSQMLSAARAMYSMPPDHGAAAVRIVLEDASLRADWEAELEEMRLRMLRLRV
AFAEALRRQSNSDRFDFVASHRGMFSRLGLTEAQVERLRAEHGVYMVGDSRINVAGLPEDGMDALAKAIVSVLD

Sequences:

>Translated_394_residues
MFEDLQPAPADKILALIGLYRADPRPNKVDLGVGVYKDRDGKTPVMRAVREAEKRLLNSQDTKTYLGLAGDTGFNAVMAK
LAFGPGADMTRIRAAQAPGGSGALRLVAELLKRTRSDATIWLSDPTWPNHMPVMRAAGLQIREYPYFDAASGAVRFDDML
AALRTAKSGDVVLLHGCCHNPTGANLDAAQWQAVTDLMVERGLLPFVDIAYQGFGDGLEADALGLRLLAAKVPEMVVASS
CSKNFAVYRDRVGAAMVLARDSAQADVAMSQMLSAARAMYSMPPDHGAAAVRIVLEDASLRADWEAELEEMRLRMLRLRV
AFAEALRRQSNSDRFDFVASHRGMFSRLGLTEAQVERLRAEHGVYMVGDSRINVAGLPEDGMDALAKAIVSVLD
>Mature_394_residues
MFEDLQPAPADKILALIGLYRADPRPNKVDLGVGVYKDRDGKTPVMRAVREAEKRLLNSQDTKTYLGLAGDTGFNAVMAK
LAFGPGADMTRIRAAQAPGGSGALRLVAELLKRTRSDATIWLSDPTWPNHMPVMRAAGLQIREYPYFDAASGAVRFDDML
AALRTAKSGDVVLLHGCCHNPTGANLDAAQWQAVTDLMVERGLLPFVDIAYQGFGDGLEADALGLRLLAAKVPEMVVASS
CSKNFAVYRDRVGAAMVLARDSAQADVAMSQMLSAARAMYSMPPDHGAAAVRIVLEDASLRADWEAELEEMRLRMLRLRV
AFAEALRRQSNSDRFDFVASHRGMFSRLGLTEAQVERLRAEHGVYMVGDSRINVAGLPEDGMDALAKAIVSVLD

Specific function: Shows activities toward both dicarboxylic and aromatic substrates [H]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=397, Percent_Identity=33.5012594458438, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI4504067, Length=400, Percent_Identity=34, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI117414139, Length=383, Percent_Identity=24.8041775456919, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=50.2525252525252, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1790488, Length=398, Percent_Identity=42.2110552763819, Blast_Score=330, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI71981858, Length=395, Percent_Identity=35.6962025316456, Blast_Score=277, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI25147133, Length=395, Percent_Identity=33.6708860759494, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17569539, Length=395, Percent_Identity=34.6835443037975, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17569537, Length=395, Percent_Identity=27.3417721518987, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25147136, Length=204, Percent_Identity=35.2941176470588, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17550384, Length=262, Percent_Identity=30.5343511450382, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6323055, Length=405, Percent_Identity=33.0864197530864, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6322743, Length=427, Percent_Identity=31.3817330210773, Blast_Score=200, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24580970, Length=396, Percent_Identity=34.0909090909091, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24580972, Length=396, Percent_Identity=34.0909090909091, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI19920542, Length=389, Percent_Identity=34.1902313624679, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24654046, Length=395, Percent_Identity=32.9113924050633, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI19922362, Length=395, Percent_Identity=32.9113924050633, Blast_Score=229, Evalue=2e-60,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 42795; Mature: 42795

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEDLQPAPADKILALIGLYRADPRPNKVDLGVGVYKDRDGKTPVMRAVREAEKRLLNSQ
CCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCEEEECCCCCCHHHHHHHHHHHHHHCCC
DTKTYLGLAGDTGFNAVMAKLAFGPGADMTRIRAAQAPGGSGALRLVAELLKRTRSDATI
CCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHEECCCCCCCHHHHHHHHHHHHCCCCCEE
WLSDPTWPNHMPVMRAAGLQIREYPYFDAASGAVRFDDMLAALRTAKSGDVVLLHGCCHN
EECCCCCCCCCCHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCC
PTGANLDAAQWQAVTDLMVERGLLPFVDIAYQGFGDGLEADALGLRLLAAKVPEMVVASS
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
CSKNFAVYRDRVGAAMVLARDSAQADVAMSQMLSAARAMYSMPPDHGAAAVRIVLEDASL
CCCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCC
RADWEAELEEMRLRMLRLRVAFAEALRRQSNSDRFDFVASHRGMFSRLGLTEAQVERLRA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHCCCCHHHHHHHHH
EHGVYMVGDSRINVAGLPEDGMDALAKAIVSVLD
HCCEEEEECCEEEEECCCCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MFEDLQPAPADKILALIGLYRADPRPNKVDLGVGVYKDRDGKTPVMRAVREAEKRLLNSQ
CCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCEEEECCCCCCHHHHHHHHHHHHHHCCC
DTKTYLGLAGDTGFNAVMAKLAFGPGADMTRIRAAQAPGGSGALRLVAELLKRTRSDATI
CCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHEECCCCCCCHHHHHHHHHHHHCCCCCEE
WLSDPTWPNHMPVMRAAGLQIREYPYFDAASGAVRFDDMLAALRTAKSGDVVLLHGCCHN
EECCCCCCCCCCHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCC
PTGANLDAAQWQAVTDLMVERGLLPFVDIAYQGFGDGLEADALGLRLLAAKVPEMVVASS
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
CSKNFAVYRDRVGAAMVLARDSAQADVAMSQMLSAARAMYSMPPDHGAAAVRIVLEDASL
CCCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCC
RADWEAELEEMRLRMLRLRVAFAEALRRQSNSDRFDFVASHRGMFSRLGLTEAQVERLRA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHCCCCHHHHHHHHH
EHGVYMVGDSRINVAGLPEDGMDALAKAIVSVLD
HCCEEEEECCEEEEECCCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9058208; 9665848; 9930977 [H]