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The map label for this gene is pccB [H]

Identifier: 13470593

GI number: 13470593

Start: 244032

End: 245654

Strand: Reverse

Name: pccB [H]

Synonym: mll0348

Alternate gene names: 13470593

Gene position: 245654-244032 (Counterclockwise)

Preceding gene: 13470595

Following gene: 13470590

Centisome position: 3.49

GC content: 61.43

Gene sequence:

>1623_bases
GTGCAGCAAAAACCGACCCGAAAGCCGACGCTTGCGCTCCCCGACGGGCATCATTACCACAAAAGCAGCTTCTATTTTGG
GGACCGAGCGATGAAGGACGTGCTGAAGGAACTCGAGCGCCGGCGCGAAATCGCCCGCATGGGTGGCGGCCAGGCCCGCA
TCGACGCCCAGCACAAGAAGGGCAAGCTCACCGCCCGCGAACGCATCGAGGTCTTTCTCGACGAAGGTTCGTTCGAGGAG
TTCGACATGTATGTCGAGCACCGCTCGACCGATTTCGGCATGGAGAAGACCAAGATCGCCGGCGATGGCGTCGTCACCGG
CTGGGGCACGGTCAATGGCCGTCCAGTGTATCTTTTCGCCAAGGATTTCACCGTGTTCGGCGGCTCTCTTTCAGAAGCCC
ATGCCGAAAAGGTCATCAAGGTGCAGGAGATGGCGCTGCGCAACCGCGCGCCGATCATCGGGCTCTACGATGCCGGCGGC
GCGCGCATCCAGGAGGGCGTCGCAGCGCTCGGCGGTTATGCCGAGATTTTTCAGCGCAATGTTCTCGCCTCCGGCGTCAT
TCCTCAGATTTCCGTGATCATGGGTCCGTGCGCCGGCGGCGACGTCTATTCGCCCGCGATGACCGACTTCATCTTCATGG
TGCGCGACACCTCCTACATGTTCGTCACCGGCCCGGATGTGGTGAAGACCGTGACCAACGAGACGGTGACCGCCGAAAGC
CTCGGCGGCGCTTCGGTGCACACGACGAAATCCTCCATCGCCGACGGCGCCTACGACAATGACGTCGAGGCGCTTTTGCA
GATGCGCCGGCTGGTCGACCTCCTGCCGGCTTCGAACACATCGGACATTCCCGAGATCGAATGCTACCAGTCGGTCACCG
ACCACGATTTGTCGCTCGACCGGCTGATTCCCGACAATGCCAACAAGCCCTACGACGTCAAGGAACTGATCCTGAAGGTC
GCCGACGAGGGCGACTTCTTTGAGATCCAGCAGAGTTTCGCCAAGAATATCGTCACTGGTTTCGGGCGCGTCGAGGGCCG
CACCGTTGGCTTCGTCGCCAACCAGCCGATGGTGCTGGCCGGCGTGCTCGATTCCGACGCCAGCCGCAAGGCGGCGCGCT
TCGTGCGCTTCTGCGATTGTTTTTCGATCCCGATCGTCACTTTCGTCGATGTGCCGGGCTTCCTGCCCGGTACCGCCCAG
GAATATGGTGGGCTGATCAAGCACGGCGCCAAGCTGTTGTTCGCCTATGCCGAAGCGACCGTGCCGAAGATCACCGTCAT
CACCAGAAAGGCCTATGGCGGCGCTTATGACGTCATGGCCTCAAAACATCTGCGCGGCGACATGAACTATGCCTGGCCGA
CGGCGCAGATCGCGGTGATGGGAGCGAGAGGCGCGGTCGAGATCATCTACCGCAAGGACATTGGCGACGCGGAAAAGATC
GCATCCCATACAAAGACTTACGAGGATCGCTTCCTGTCGCCCTTCGTCGCTGCCGAGCGCGGCTATGTCGACGAAGTGAT
CATGCCGCACTCGACCCGCCGCCGTATCGCCCGGGCGCTGCGGATGCTGCGCAACAAGGACATGCAGAACCCCTGGAAGA
AGCACGACAACATCCCGCTGTGA

Upstream 100 bases:

>100_bases
CCAGTCTCATTTGTCGAGAAGGCCGGAATCTCCCGGCCCAAGCGCCTATGGGCTGCATATGGCTGAGTTCGCCCCGGAAT
GCAAGGGGCGTCATGTTGCA

Downstream 100 bases:

>100_bases
GGCGACCGATAGGTCTCTGCCTGAGGTAGCCGCCGAACACTCATTCCTCCCCGGCCGCGCCGAACCCCGCGTCCCTGGGC
GCGCTGGTAGCGCTCGCCCA

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MQQKPTRKPTLALPDGHHYHKSSFYFGDRAMKDVLKELERRREIARMGGGQARIDAQHKKGKLTARERIEVFLDEGSFEE
FDMYVEHRSTDFGMEKTKIAGDGVVTGWGTVNGRPVYLFAKDFTVFGGSLSEAHAEKVIKVQEMALRNRAPIIGLYDAGG
ARIQEGVAALGGYAEIFQRNVLASGVIPQISVIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPDVVKTVTNETVTAES
LGGASVHTTKSSIADGAYDNDVEALLQMRRLVDLLPASNTSDIPEIECYQSVTDHDLSLDRLIPDNANKPYDVKELILKV
ADEGDFFEIQQSFAKNIVTGFGRVEGRTVGFVANQPMVLAGVLDSDASRKAARFVRFCDCFSIPIVTFVDVPGFLPGTAQ
EYGGLIKHGAKLLFAYAEATVPKITVITRKAYGGAYDVMASKHLRGDMNYAWPTAQIAVMGARGAVEIIYRKDIGDAEKI
ASHTKTYEDRFLSPFVAAERGYVDEVIMPHSTRRRIARALRMLRNKDMQNPWKKHDNIPL

Sequences:

>Translated_540_residues
MQQKPTRKPTLALPDGHHYHKSSFYFGDRAMKDVLKELERRREIARMGGGQARIDAQHKKGKLTARERIEVFLDEGSFEE
FDMYVEHRSTDFGMEKTKIAGDGVVTGWGTVNGRPVYLFAKDFTVFGGSLSEAHAEKVIKVQEMALRNRAPIIGLYDAGG
ARIQEGVAALGGYAEIFQRNVLASGVIPQISVIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPDVVKTVTNETVTAES
LGGASVHTTKSSIADGAYDNDVEALLQMRRLVDLLPASNTSDIPEIECYQSVTDHDLSLDRLIPDNANKPYDVKELILKV
ADEGDFFEIQQSFAKNIVTGFGRVEGRTVGFVANQPMVLAGVLDSDASRKAARFVRFCDCFSIPIVTFVDVPGFLPGTAQ
EYGGLIKHGAKLLFAYAEATVPKITVITRKAYGGAYDVMASKHLRGDMNYAWPTAQIAVMGARGAVEIIYRKDIGDAEKI
ASHTKTYEDRFLSPFVAAERGYVDEVIMPHSTRRRIARALRMLRNKDMQNPWKKHDNIPL
>Mature_540_residues
MQQKPTRKPTLALPDGHHYHKSSFYFGDRAMKDVLKELERRREIARMGGGQARIDAQHKKGKLTARERIEVFLDEGSFEE
FDMYVEHRSTDFGMEKTKIAGDGVVTGWGTVNGRPVYLFAKDFTVFGGSLSEAHAEKVIKVQEMALRNRAPIIGLYDAGG
ARIQEGVAALGGYAEIFQRNVLASGVIPQISVIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPDVVKTVTNETVTAES
LGGASVHTTKSSIADGAYDNDVEALLQMRRLVDLLPASNTSDIPEIECYQSVTDHDLSLDRLIPDNANKPYDVKELILKV
ADEGDFFEIQQSFAKNIVTGFGRVEGRTVGFVANQPMVLAGVLDSDASRKAARFVRFCDCFSIPIVTFVDVPGFLPGTAQ
EYGGLIKHGAKLLFAYAEATVPKITVITRKAYGGAYDVMASKHLRGDMNYAWPTAQIAVMGARGAVEIIYRKDIGDAEKI
ASHTKTYEDRFLSPFVAAERGYVDEVIMPHSTRRRIARALRMLRNKDMQNPWKKHDNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=509, Percent_Identity=61.4931237721022, Blast_Score=647, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=529, Percent_Identity=59.3572778827977, Blast_Score=635, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=503, Percent_Identity=32.0079522862823, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1788655, Length=194, Percent_Identity=27.8350515463918, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=508, Percent_Identity=60.4330708661417, Blast_Score=655, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=508, Percent_Identity=60.4330708661417, Blast_Score=654, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=518, Percent_Identity=31.8532818532818, Blast_Score=245, Evalue=5e-65,
Organism=Drosophila melanogaster, GI24586065, Length=534, Percent_Identity=32.5842696629214, Blast_Score=246, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 59703; Mature: 59703

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQKPTRKPTLALPDGHHYHKSSFYFGDRAMKDVLKELERRREIARMGGGQARIDAQHKK
CCCCCCCCCEEECCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHCC
GKLTARERIEVFLDEGSFEEFDMYVEHRSTDFGMEKTKIAGDGVVTGWGTVNGRPVYLFA
CCCCHHHEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEECCCCEEEECCCCCCEEEEEEE
KDFTVFGGSLSEAHAEKVIKVQEMALRNRAPIIGLYDAGGARIQEGVAALGGYAEIFQRN
ECEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCHHHHHHHHH
VLASGVIPQISVIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPDVVKTVTNETVTAES
HHHHCCCCEEEHEECCCCCCCCCCHHHHHEEEEEECCCEEEEECCHHHHHHCCCEEEHHC
LGGASVHTTKSSIADGAYDNDVEALLQMRRLVDLLPASNTSDIPEIECYQSVTDHDLSLD
CCCCEEECCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCHH
RLIPDNANKPYDVKELILKVADEGDFFEIQQSFAKNIVTGFGRVEGRTVGFVANQPMVLA
HCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEE
GVLDSDASRKAARFVRFCDCFSIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYAEAT
EECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHEEHHHHCC
VPKITVITRKAYGGAYDVMASKHLRGDMNYAWPTAQIAVMGARGAVEIIYRKDIGDAEKI
CCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCHHHH
ASHTKTYEDRFLSPFVAAERGYVDEVIMPHSTRRRIARALRMLRNKDMQNPWKKHDNIPL
HHHHHHHHHHHCCHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MQQKPTRKPTLALPDGHHYHKSSFYFGDRAMKDVLKELERRREIARMGGGQARIDAQHKK
CCCCCCCCCEEECCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHCC
GKLTARERIEVFLDEGSFEEFDMYVEHRSTDFGMEKTKIAGDGVVTGWGTVNGRPVYLFA
CCCCHHHEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEECCCCEEEECCCCCCEEEEEEE
KDFTVFGGSLSEAHAEKVIKVQEMALRNRAPIIGLYDAGGARIQEGVAALGGYAEIFQRN
ECEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCHHHHHHHHH
VLASGVIPQISVIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPDVVKTVTNETVTAES
HHHHCCCCEEEHEECCCCCCCCCCHHHHHEEEEEECCCEEEEECCHHHHHHCCCEEEHHC
LGGASVHTTKSSIADGAYDNDVEALLQMRRLVDLLPASNTSDIPEIECYQSVTDHDLSLD
CCCCEEECCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCHH
RLIPDNANKPYDVKELILKVADEGDFFEIQQSFAKNIVTGFGRVEGRTVGFVANQPMVLA
HCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEE
GVLDSDASRKAARFVRFCDCFSIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYAEAT
EECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHEEHHHHCC
VPKITVITRKAYGGAYDVMASKHLRGDMNYAWPTAQIAVMGARGAVEIIYRKDIGDAEKI
CCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCHHHH
ASHTKTYEDRFLSPFVAAERGYVDEVIMPHSTRRRIARALRMLRNKDMQNPWKKHDNIPL
HHHHHHHHHHHCCHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]