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The map label for this gene is mdmC [H]

Identifier: 13470544

GI number: 13470544

Start: 202105

End: 202770

Strand: Direct

Name: mdmC [H]

Synonym: mlr0279

Alternate gene names: 13470544

Gene position: 202105-202770 (Clockwise)

Preceding gene: 13470543

Following gene: 13470547

Centisome position: 2.87

GC content: 64.26

Gene sequence:

>666_bases
ATGAGCACGAAGACCTGGGCGGCTGTCGACGACTACATCGTCGATGCCCTGTTCGACGCGGACCTCGCCCTCGACGCCGT
TCTGGCCGCCAATCGCGACCAGGGCCTGCCACCGATCGACGTCTCGCCAGCGCAGGGCAAGCTGCTTTCACTGCTGGCGC
GCATTCGGGGTGCGAAGAAGATCCTCGAAATCGGCACGCTGGGCGGCTATTCGACGATCTGGATGGCGCGCGCCTTGCCC
ATGGACGGCAAGATCGTGACGCTTGAACTCGACCCGCATCACGCCAAGGTCGCGCGGTCGAATTTCGAACGGGCAGGGGT
GTCGGACCAAGTGGAACTGCGGGTCGGGCCGGCCCTTAAATCGCTGGCCGCGCTAAGTGCTGAAAATGCCGGGCCGTTCG
ATCTCATCTTCATCGACGCCGACAAGCCGAACAACCCGAACTACCTGTCCGGGGCCATGCGGCTTTCGCGCCCGGGGACG
GTGATAATCTGCGACAACGTCATCCGCGACGGCGCGGTGCTCGACGGCGGTGGCCATGACGCCAATGTCGTAGGCGCCCG
GGCGGCGTTCTCATTCATCGGCGGCGACAAGCGTCTGGATGGCACCGCCATCCAGACAGTCGGCGCCAAGGGCTATGATG
GCTTCGCGATTGCGATTGTCGAGTGA

Upstream 100 bases:

>100_bases
TTTTTTGTTTTCCGGAGCGTGGCGAAGTTGGTATCCATGGCGGCAAGAAAGGCCCCGGGGCCACATTTTCGCGTTTCGGC
TTTTGATCGGAGAAGAAACG

Downstream 100 bases:

>100_bases
TCATCCCACTCGTGATTGTCTGAATGACGCTGATGTCAGACCAACTCGGTCGTGCTCGCTTGTCAGCGGCTGTTCGTTTT
GACGACCGGCTTCCCCCAAT

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MSTKTWAAVDDYIVDALFDADLALDAVLAANRDQGLPPIDVSPAQGKLLSLLARIRGAKKILEIGTLGGYSTIWMARALP
MDGKIVTLELDPHHAKVARSNFERAGVSDQVELRVGPALKSLAALSAENAGPFDLIFIDADKPNNPNYLSGAMRLSRPGT
VIICDNVIRDGAVLDGGGHDANVVGARAAFSFIGGDKRLDGTAIQTVGAKGYDGFAIAIVE

Sequences:

>Translated_221_residues
MSTKTWAAVDDYIVDALFDADLALDAVLAANRDQGLPPIDVSPAQGKLLSLLARIRGAKKILEIGTLGGYSTIWMARALP
MDGKIVTLELDPHHAKVARSNFERAGVSDQVELRVGPALKSLAALSAENAGPFDLIFIDADKPNNPNYLSGAMRLSRPGT
VIICDNVIRDGAVLDGGGHDANVVGARAAFSFIGGDKRLDGTAIQTVGAKGYDGFAIAIVE
>Mature_220_residues
STKTWAAVDDYIVDALFDADLALDAVLAANRDQGLPPIDVSPAQGKLLSLLARIRGAKKILEIGTLGGYSTIWMARALPM
DGKIVTLELDPHHAKVARSNFERAGVSDQVELRVGPALKSLAALSAENAGPFDLIFIDADKPNNPNYLSGAMRLSRPGTV
IICDNVIRDGAVLDGGGHDANVVGARAAFSFIGGDKRLDGTAIQTVGAKGYDGFAIAIVE

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=156, Percent_Identity=37.1794871794872, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17565612, Length=132, Percent_Identity=36.3636363636364, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25148771, Length=132, Percent_Identity=34.0909090909091, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI72001127, Length=132, Percent_Identity=34.0909090909091, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI72001028, Length=131, Percent_Identity=35.8778625954198, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23210; Mature: 23079

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKTWAAVDDYIVDALFDADLALDAVLAANRDQGLPPIDVSPAQGKLLSLLARIRGAKK
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ILEIGTLGGYSTIWMARALPMDGKIVTLELDPHHAKVARSNFERAGVSDQVELRVGPALK
HHHCCCCCCHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECHHHH
SLAALSAENAGPFDLIFIDADKPNNPNYLSGAMRLSRPGTVIICDNVIRDGAVLDGGGHD
HHHHHCCCCCCCEEEEEEECCCCCCCCCEEHEEEECCCCEEEEECCCCCCCEEEECCCCC
ANVVGARAAFSFIGGDKRLDGTAIQTVGAKGYDGFAIAIVE
CCEEEHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEEC
>Mature Secondary Structure 
STKTWAAVDDYIVDALFDADLALDAVLAANRDQGLPPIDVSPAQGKLLSLLARIRGAKK
CCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ILEIGTLGGYSTIWMARALPMDGKIVTLELDPHHAKVARSNFERAGVSDQVELRVGPALK
HHHCCCCCCHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECHHHH
SLAALSAENAGPFDLIFIDADKPNNPNYLSGAMRLSRPGTVIICDNVIRDGAVLDGGGHD
HHHHHCCCCCCCEEEEEEECCCCCCCCCEEHEEEECCCCEEEEECCCCCCCEEEECCCCC
ANVVGARAAFSFIGGDKRLDGTAIQTVGAKGYDGFAIAIVE
CCEEEHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]