Click here to switch to the map view.

The map label for this gene is hyi [H]

Identifier: 13470523

GI number: 13470523

Start: 179345

End: 180142

Strand: Direct

Name: hyi [H]

Synonym: mlr0252

Alternate gene names: 13470523

Gene position: 179345-180142 (Clockwise)

Preceding gene: 13470522

Following gene: 13470524

Centisome position: 2.55

GC content: 63.41

Gene sequence:

>798_bases
ATGCCGCGTTTTTCCGCCAATCTGTCCATGCTCTTTGCCGAGCATGATTTCCTCGACCGCTTTGATGCAGCCGCCCGCGC
GGGGTTCAAGGGCGTCGAATATATCGGCCCTTACGATCATGCGCCGGAGGTGGTGGCCGCGAGGCTGAAGAAGAACGGCC
TGACACAGGTGCTGTTCAACCTGCCGGCCGGCGACTGGGGCAAGGGCGAGCGCGGCATTGCCGTGCTGCCGGACCGCGTG
CCGGAATTCCGCCAGGGCATCGCCAAGGCCATCACCTACGCACAGGCGCTCGGCTGCCAGCAGGTCAATTGCCTGGCCGG
CATCGCGCCCGCCGGCGTCGACCGCAAGGTGCTCGAGGATGTTTTCGCCGAAAACCTCGCCTTCGCGGCGGAGAAGCTGG
AACGGGTCGGAATCCGGCTGCTGATCGAGCCGATCAACACGCGCGACATTCCAGGCTTCTTCCTGAACTACTCGGACCAG
GCACTGGCGCTGATCGACCGCGTCGGCTCGAAAAACCTGTTCCTGCAATACGACATCTATCACATGCAGATCATGGAGGG
GGATCTCGCCCGTAAAATCGAGGCCAACCTCGGCCGCATCGCGCATATCCAGCTTGCGGACAATCCCGGCCGTCACGAGC
CGGGGACGGGCGAGATCAACTATCCCTTCCTCTACGATCACATCGACCGCATCGGCTATGCCGGCTGGATCGGGGCCGAA
TACAAGCCGAAAGCCGGCACCGAGGCAGGGCTGGGCTGGTTCAGGGACCTGACTGGGCAAGGGAGCGCTGCGGCTTAG

Upstream 100 bases:

>100_bases
ATGGGTACCGAGATCGACAAGATCACCGAATTCGAGGACCTCGCCGAAAGCCATGAGGACGCGCCGACCGCGATCGTGAT
GTTGGATTAGGAGAAAAAGA

Downstream 100 bases:

>100_bases
GGGCCGGCGCCGAAGCAGCCAATTTCCCCCCTCGTGGGGGAGATGTCCGGCAGGACAGAGGGGGGCGTGACAGAACGCGG
CCTAACAAAGGACGGAGAAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MPRFSANLSMLFAEHDFLDRFDAAARAGFKGVEYIGPYDHAPEVVAARLKKNGLTQVLFNLPAGDWGKGERGIAVLPDRV
PEFRQGIAKAITYAQALGCQQVNCLAGIAPAGVDRKVLEDVFAENLAFAAEKLERVGIRLLIEPINTRDIPGFFLNYSDQ
ALALIDRVGSKNLFLQYDIYHMQIMEGDLARKIEANLGRIAHIQLADNPGRHEPGTGEINYPFLYDHIDRIGYAGWIGAE
YKPKAGTEAGLGWFRDLTGQGSAAA

Sequences:

>Translated_265_residues
MPRFSANLSMLFAEHDFLDRFDAAARAGFKGVEYIGPYDHAPEVVAARLKKNGLTQVLFNLPAGDWGKGERGIAVLPDRV
PEFRQGIAKAITYAQALGCQQVNCLAGIAPAGVDRKVLEDVFAENLAFAAEKLERVGIRLLIEPINTRDIPGFFLNYSDQ
ALALIDRVGSKNLFLQYDIYHMQIMEGDLARKIEANLGRIAHIQLADNPGRHEPGTGEINYPFLYDHIDRIGYAGWIGAE
YKPKAGTEAGLGWFRDLTGQGSAAA
>Mature_264_residues
PRFSANLSMLFAEHDFLDRFDAAARAGFKGVEYIGPYDHAPEVVAARLKKNGLTQVLFNLPAGDWGKGERGIAVLPDRVP
EFRQGIAKAITYAQALGCQQVNCLAGIAPAGVDRKVLEDVFAENLAFAAEKLERVGIRLLIEPINTRDIPGFFLNYSDQA
LALIDRVGSKNLFLQYDIYHMQIMEGDLARKIEANLGRIAHIQLADNPGRHEPGTGEINYPFLYDHIDRIGYAGWIGAEY
KPKAGTEAGLGWFRDLTGQGSAAA

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=261, Percent_Identity=44.4444444444444, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI300068964, Length=243, Percent_Identity=44.4444444444444, Blast_Score=184, Evalue=5e-47,
Organism=Escherichia coli, GI1786718, Length=254, Percent_Identity=55.5118110236221, Blast_Score=283, Evalue=7e-78,
Organism=Escherichia coli, GI1789095, Length=254, Percent_Identity=44.4881889763779, Blast_Score=230, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI17552022, Length=257, Percent_Identity=38.1322957198444, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17530883, Length=259, Percent_Identity=33.2046332046332, Blast_Score=147, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 29119; Mature: 28987

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFSANLSMLFAEHDFLDRFDAAARAGFKGVEYIGPYDHAPEVVAARLKKNGLTQVLFN
CCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHEE
LPAGDWGKGERGIAVLPDRVPEFRQGIAKAITYAQALGCQQVNCLAGIAPAGVDRKVLED
CCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHH
VFAENLAFAAEKLERVGIRLLIEPINTRDIPGFFLNYSDQALALIDRVGSKNLFLQYDIY
HHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEECCCCHHHHHHHHCCCCCEEEEEEEE
HMQIMEGDLARKIEANLGRIAHIQLADNPGRHEPGTGEINYPFLYDHIDRIGYAGWIGAE
EEEECCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
YKPKAGTEAGLGWFRDLTGQGSAAA
CCCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PRFSANLSMLFAEHDFLDRFDAAARAGFKGVEYIGPYDHAPEVVAARLKKNGLTQVLFN
CCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHEE
LPAGDWGKGERGIAVLPDRVPEFRQGIAKAITYAQALGCQQVNCLAGIAPAGVDRKVLED
CCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHH
VFAENLAFAAEKLERVGIRLLIEPINTRDIPGFFLNYSDQALALIDRVGSKNLFLQYDIY
HHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEECCCCHHHHHHHHCCCCCEEEEEEEE
HMQIMEGDLARKIEANLGRIAHIQLADNPGRHEPGTGEINYPFLYDHIDRIGYAGWIGAE
EEEECCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
YKPKAGTEAGLGWFRDLTGQGSAAA
CCCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]