Click here to switch to the map view.

The map label for this gene is mlhB [H]

Identifier: 13470513

GI number: 13470513

Start: 170538

End: 171488

Strand: Direct

Name: mlhB [H]

Synonym: mlr0240

Alternate gene names: 13470513

Gene position: 170538-171488 (Clockwise)

Preceding gene: 13470512

Following gene: 13470514

Centisome position: 2.42

GC content: 65.93

Gene sequence:

>951_bases
ATGATGACGATCCATCCCCTCTCGCCTGAAGACGCACCAGCGCTGGCCGCGATGCGACAGGCCGCCTCGGCCCACAAGGG
TGAGAAACTCGGGCCCGAGGCACGGCCGATGTTCGACGCCATGTTTGCCGCAACACCCGCTGCGGCGGATGTCCAGGTCG
AGGCTGCGACGGCCGGAGGCATTGCCGGCTTCTGGCTTCGGCCGGTGAGTGCACGATCGGGCGCGCACATCCTCTATCTT
CATGGTGGTGGCTATGTGCTCGGCTCAGCCGGGGCGCTCACCAACTTCGCGGGTCAGATCGCATCACGTGTCGGCGCCGA
TACCTTTGTCCCTGACTACCGGCTCGCACCCGAACACCCATTCCCGGCAGCCATCGACGATGCGGTCGCCGCCTATCGTG
GTCTCGTTGCGGACGGTGCCGAACGGATCGTGGTTGTAGGTGACTCTGCCGGCGGCGGTTTGACGCTGTCGCTGCTGTCG
GCCCTCGCTGCCGACAAAACGAACGGCATGGTGCAACCAGTCGGCGCAGCGGTGATGTCGCCCTGGACCGACCTTGCGCT
CACCGGTGACAGCCTCGGGACCAGGGCGGAGGCGGACCCGATCTTCACGGGCGGCGTGCTCCAGGGCTTCGCGGACATGT
ATCTTCAGGGCCAGGATGCGAAGAACCCGAAGGCATCACCGCTCTATGCTCGGCTGAACGGCCTGCCGCCGATCCGGATC
GATGTCGGAGATGACGAATTGCTGCTCGCGGATTCCGTGCGCTACGCCGACCGGGCGAGGGCGGCAGGGGTGGAGGTCAC
GCTGTCGGTCTGGCAGGGCATGCCACATGTCTTCCAGTCTTCCCTCGGCCACTTTCTCGCGGCCGAGCGCTCGGTGGACG
CCATCGTTGACTTCCTCCGCCAGCGGCTCGTCGGTACTTCCCCGTCCAACAGCACAGCTTCGGAGGCTTGA

Upstream 100 bases:

>100_bases
CCACGCGCCCCGCTCCTATACCGCTTTTGCCAGGGATGCCGCCGCCCAGTGGACGAAGGGCTGAACCCGCACCTTTACCC
CCCAACCAAGGAGACCTGCC

Downstream 100 bases:

>100_bases
AATGAAAATTCTGGTATTGGGCGCCACTGGCGCAACCGGCCGGCTGATCGTCGCTAAGGCCATCGCGGAGGGACACAACG
TCGTAGCCCTCGTTCGCTCC

Product: esterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MMTIHPLSPEDAPALAAMRQAASAHKGEKLGPEARPMFDAMFAATPAAADVQVEAATAGGIAGFWLRPVSARSGAHILYL
HGGGYVLGSAGALTNFAGQIASRVGADTFVPDYRLAPEHPFPAAIDDAVAAYRGLVADGAERIVVVGDSAGGGLTLSLLS
ALAADKTNGMVQPVGAAVMSPWTDLALTGDSLGTRAEADPIFTGGVLQGFADMYLQGQDAKNPKASPLYARLNGLPPIRI
DVGDDELLLADSVRYADRARAAGVEVTLSVWQGMPHVFQSSLGHFLAAERSVDAIVDFLRQRLVGTSPSNSTASEA

Sequences:

>Translated_316_residues
MMTIHPLSPEDAPALAAMRQAASAHKGEKLGPEARPMFDAMFAATPAAADVQVEAATAGGIAGFWLRPVSARSGAHILYL
HGGGYVLGSAGALTNFAGQIASRVGADTFVPDYRLAPEHPFPAAIDDAVAAYRGLVADGAERIVVVGDSAGGGLTLSLLS
ALAADKTNGMVQPVGAAVMSPWTDLALTGDSLGTRAEADPIFTGGVLQGFADMYLQGQDAKNPKASPLYARLNGLPPIRI
DVGDDELLLADSVRYADRARAAGVEVTLSVWQGMPHVFQSSLGHFLAAERSVDAIVDFLRQRLVGTSPSNSTASEA
>Mature_316_residues
MMTIHPLSPEDAPALAAMRQAASAHKGEKLGPEARPMFDAMFAATPAAADVQVEAATAGGIAGFWLRPVSARSGAHILYL
HGGGYVLGSAGALTNFAGQIASRVGADTFVPDYRLAPEHPFPAAIDDAVAAYRGLVADGAERIVVVGDSAGGGLTLSLLS
ALAADKTNGMVQPVGAAVMSPWTDLALTGDSLGTRAEADPIFTGGVLQGFADMYLQGQDAKNPKASPLYARLNGLPPIRI
DVGDDELLLADSVRYADRARAAGVEVTLSVWQGMPHVFQSSLGHFLAAERSVDAIVDFLRQRLVGTSPSNSTASEA

Specific function: Lactone hydrolase that is required for the degradation of monocyclic monoterpenes such as menthol and carvone. Catalyzes the ring opening of lactones formed during degradation of monocyclic monoterpenes. Can hydrolyze epsilon-caprolactone, the lactone der

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21328446, Length=102, Percent_Identity=37.2549019607843, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17567059, Length=283, Percent_Identity=25.0883392226148, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.83 [H]

Molecular weight: Translated: 32647; Mature: 32647

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTIHPLSPEDAPALAAMRQAASAHKGEKLGPEARPMFDAMFAATPAAADVQVEAATAGG
CEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCC
IAGFWLRPVSARSGAHILYLHGGGYVLGSAGALTNFAGQIASRVGADTFVPDYRLAPEHP
CHHHHCCCCCCCCCCEEEEEECCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
FPAAIDDAVAAYRGLVADGAERIVVVGDSAGGGLTLSLLSALAADKTNGMVQPVGAAVMS
CCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHC
PWTDLALTGDSLGTRAEADPIFTGGVLQGFADMYLQGQDAKNPKASPLYARLNGLPPIRI
CCCCEEEECCCCCCCCCCCCCEECHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEEE
DVGDDELLLADSVRYADRARAAGVEVTLSVWQGMPHVFQSSLGHFLAAERSVDAIVDFLR
ECCCCCEEEECCHHHHHHHHHCCCEEEEHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
QRLVGTSPSNSTASEA
HHHCCCCCCCCCCCCC
>Mature Secondary Structure
MMTIHPLSPEDAPALAAMRQAASAHKGEKLGPEARPMFDAMFAATPAAADVQVEAATAGG
CEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCC
IAGFWLRPVSARSGAHILYLHGGGYVLGSAGALTNFAGQIASRVGADTFVPDYRLAPEHP
CHHHHCCCCCCCCCCEEEEEECCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
FPAAIDDAVAAYRGLVADGAERIVVVGDSAGGGLTLSLLSALAADKTNGMVQPVGAAVMS
CCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHC
PWTDLALTGDSLGTRAEADPIFTGGVLQGFADMYLQGQDAKNPKASPLYARLNGLPPIRI
CCCCEEEECCCCCCCCCCCCCEECHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEEE
DVGDDELLLADSVRYADRARAAGVEVTLSVWQGMPHVFQSSLGHFLAAERSVDAIVDFLR
ECCCCCEEEECCHHHHHHHHHCCCEEEEHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
QRLVGTSPSNSTASEA
HHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA