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The map label for this gene is accC [H]

Identifier: 13470483

GI number: 13470483

Start: 137648

End: 138991

Strand: Reverse

Name: accC [H]

Synonym: mll0203

Alternate gene names: 13470483

Gene position: 138991-137648 (Counterclockwise)

Preceding gene: 13470484

Following gene: 13470482

Centisome position: 1.98

GC content: 62.65

Gene sequence:

>1344_bases
ATGTTCCAGAAGATCCTCATCGCCAATCGCGGCGAAATCGCGCTTCGGGTGCTGCGCGCCTGCAAGGAACTCGGCATCCA
GACGGTGGTGGTGCATTCGACCGCCGACGCCGACGCCATGCATGTGCGGCTTGCCGACGAGAGCGTCTGCATTGGCCCGC
CGCCATCGCGCGACAGCTATCTCAACATCCATCAGATCGTCGCGGCCTGCGAGATCACCGGCGCCGACGCAGTGCATCCG
GGCTATGGATTCCTGTCTGAGAATGCCAAGTTCGCCGACATATTGGCCGCGCACAACATCACCTTCATCGGCCCGTCCGG
CGATCATATCCGCATCATGGGCGACAAGATCGAGGCCAAGCGCACCGCCAAGCGCCTCGGCATTCCGGTGGTGCCCGGTT
CCGACGGCGCGGTGACCGAGGAGAAGGAAGCCAAGCGCATCGCCGCCGAAATCGGCTATCCCGTGATCATCAAGGCTTCG
GCCGGCGGCGGCGGGCGCGGCATGAAGGTCGCGCACAGCGAGGCCGACCTCGAGGTCGCCCTGCAGACGGCGCGCTCGGA
AGCAGGCGCGGCTTTTGGCGACGACGCCGTCTACATCGAGAAGTACCTGCAGAAGCCGCGGCACATCGAAGTGCAAGTGT
TCGGCGACGGATTTGGCCGCGGCGTGCATTTTGGTGAGCGCGACTGTTCGCTGCAACGGCGTCACCAGAAGGTCTGGGAA
GAGGCCAATTCGCCGGCGCTCAACGCCGAGGAGCGGTCCCGCATCGGCGGCATCTGCGCCAAGGCCATTGCCGATCTCGG
CTATTCCGGCGCCGGCACGATCGAGTTCCTCTACGAGAATGGCGAGTTCTATTTCATCGAGATGAACACGCGCCTGCAGG
TCGAGCATCCGGTGACGGAAGCAATCACCGGCATCGATCTCGTGCATGAACAGATCCGCGTCGCTTCCGGCGGCGGTCTT
TCGGTCAAGCAGGAAGACATCAAGTTCAATGGCCACGCCATCGAATGCCGTATCAATGCCGAGGATCCGCGCACCTTCAC
CCCCTCGCCCGGCACCATCACGCATTTCCACACGCCAGGCGGTCTCGGCATCCGCGTCGATTCCGGCGTCTATTCCGGCT
ACAAGATCCCGCCCTATTACGACAGCCTGATCGGCAAGCTGATCGTGCATGGGCGCAACCGCGTCGAATGCATGATGCGG
CTGCGCCGGGCGCTGGATGAATTCGTCGTCGACGGCATCAAGACGACGTTGCCGCTGTTTCGCGATCTGGTCGGCAATGC
CGACATCGCCAATGGCGACTATGACATCCACTGGCTGGAAAAATACCTGGCCAAGGAAGAGTAG

Upstream 100 bases:

>100_bases
CCCTCGCCGCGCGCCGGCACCGTGACGGCGATCCTGTTCGAGGATGCGACGCCGGTCGAATACGGCATGCCGCTCGTCGT
GATCGAGTAGAGCGGGCCGG

Downstream 100 bases:

>100_bases
TCCGGGGACGCGATGACCCGCCCTTACGCGCCTGGCTATCGCATCCCTACCGACCTTCTGCTCAAGGCCTACGCTTCGGG
CGTCTTCCCGATGGCCGAAA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MFQKILIANRGEIALRVLRACKELGIQTVVVHSTADADAMHVRLADESVCIGPPPSRDSYLNIHQIVAACEITGADAVHP
GYGFLSENAKFADILAAHNITFIGPSGDHIRIMGDKIEAKRTAKRLGIPVVPGSDGAVTEEKEAKRIAAEIGYPVIIKAS
AGGGGRGMKVAHSEADLEVALQTARSEAGAAFGDDAVYIEKYLQKPRHIEVQVFGDGFGRGVHFGERDCSLQRRHQKVWE
EANSPALNAEERSRIGGICAKAIADLGYSGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAITGIDLVHEQIRVASGGGL
SVKQEDIKFNGHAIECRINAEDPRTFTPSPGTITHFHTPGGLGIRVDSGVYSGYKIPPYYDSLIGKLIVHGRNRVECMMR
LRRALDEFVVDGIKTTLPLFRDLVGNADIANGDYDIHWLEKYLAKEE

Sequences:

>Translated_447_residues
MFQKILIANRGEIALRVLRACKELGIQTVVVHSTADADAMHVRLADESVCIGPPPSRDSYLNIHQIVAACEITGADAVHP
GYGFLSENAKFADILAAHNITFIGPSGDHIRIMGDKIEAKRTAKRLGIPVVPGSDGAVTEEKEAKRIAAEIGYPVIIKAS
AGGGGRGMKVAHSEADLEVALQTARSEAGAAFGDDAVYIEKYLQKPRHIEVQVFGDGFGRGVHFGERDCSLQRRHQKVWE
EANSPALNAEERSRIGGICAKAIADLGYSGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAITGIDLVHEQIRVASGGGL
SVKQEDIKFNGHAIECRINAEDPRTFTPSPGTITHFHTPGGLGIRVDSGVYSGYKIPPYYDSLIGKLIVHGRNRVECMMR
LRRALDEFVVDGIKTTLPLFRDLVGNADIANGDYDIHWLEKYLAKEE
>Mature_447_residues
MFQKILIANRGEIALRVLRACKELGIQTVVVHSTADADAMHVRLADESVCIGPPPSRDSYLNIHQIVAACEITGADAVHP
GYGFLSENAKFADILAAHNITFIGPSGDHIRIMGDKIEAKRTAKRLGIPVVPGSDGAVTEEKEAKRIAAEIGYPVIIKAS
AGGGGRGMKVAHSEADLEVALQTARSEAGAAFGDDAVYIEKYLQKPRHIEVQVFGDGFGRGVHFGERDCSLQRRHQKVWE
EANSPALNAEERSRIGGICAKAIADLGYSGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAITGIDLVHEQIRVASGGGL
SVKQEDIKFNGHAIECRINAEDPRTFTPSPGTITHFHTPGGLGIRVDSGVYSGYKIPPYYDSLIGKLIVHGRNRVECMMR
LRRALDEFVVDGIKTTLPLFRDLVGNADIANGDYDIHWLEKYLAKEE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=51.3574660633484, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=51.3574660633484, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=51.3574660633484, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI116805327, Length=442, Percent_Identity=45.2488687782805, Blast_Score=400, Evalue=1e-112,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=46.9798657718121, Blast_Score=387, Evalue=1e-108,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=46.9798657718121, Blast_Score=387, Evalue=1e-108,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=46.9798657718121, Blast_Score=387, Evalue=1e-108,
Organism=Homo sapiens, GI134142062, Length=519, Percent_Identity=30.635838150289, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI38679974, Length=515, Percent_Identity=29.126213592233, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI38679971, Length=515, Percent_Identity=29.126213592233, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI38679960, Length=515, Percent_Identity=29.126213592233, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI38679977, Length=515, Percent_Identity=29.126213592233, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI38679967, Length=515, Percent_Identity=29.126213592233, Blast_Score=219, Evalue=4e-57,
Organism=Escherichia coli, GI1789654, Length=448, Percent_Identity=59.5982142857143, Blast_Score=543, Evalue=1e-155,
Organism=Escherichia coli, GI1786216, Length=246, Percent_Identity=28.4552845528455, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=46.8325791855204, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=434, Percent_Identity=47.0046082949309, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=43.7777777777778, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=28.8617886178862, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71997168, Length=508, Percent_Identity=27.5590551181102, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=508, Percent_Identity=27.5590551181102, Blast_Score=192, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6319685, Length=449, Percent_Identity=43.2071269487751, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319695, Length=441, Percent_Identity=43.3106575963719, Blast_Score=326, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6321376, Length=441, Percent_Identity=43.5374149659864, Blast_Score=317, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6324343, Length=521, Percent_Identity=29.9424184261036, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6323863, Length=479, Percent_Identity=31.3152400835073, Blast_Score=216, Evalue=7e-57,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=47.427293064877, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=47.427293064877, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=47.427293064877, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=47.427293064877, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=47.427293064877, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=47.427293064877, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=47.427293064877, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=47.427293064877, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=47.427293064877, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=47.427293064877, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651757, Length=430, Percent_Identity=44.8837209302326, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24651759, Length=394, Percent_Identity=43.9086294416244, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI161076407, Length=509, Percent_Identity=28.2907662082515, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24586460, Length=509, Percent_Identity=28.2907662082515, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24586458, Length=509, Percent_Identity=28.2907662082515, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI161076409, Length=509, Percent_Identity=28.2907662082515, Blast_Score=201, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48769; Mature: 48769

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKILIANRGEIALRVLRACKELGIQTVVVHSTADADAMHVRLADESVCIGPPPSRDSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEECCCCCCCCCC
LNIHQIVAACEITGADAVHPGYGFLSENAKFADILAAHNITFIGPSGDHIRIMGDKIEAK
EEHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCHHHHH
RTAKRLGIPVVPGSDGAVTEEKEAKRIAAEIGYPVIIKASAGGGGRGMKVAHSEADLEVA
HHHHHCCCEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCCCCHHHH
LQTARSEAGAAFGDDAVYIEKYLQKPRHIEVQVFGDGFGRGVHFGERDCSLQRRHQKVWE
HHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
EANSPALNAEERSRIGGICAKAIADLGYSGAGTIEFLYENGEFYFIEMNTRLQVEHPVTE
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AITGIDLVHEQIRVASGGGLSVKQEDIKFNGHAIECRINAEDPRTFTPSPGTITHFHTPG
HHHHHHHHHHHHEEECCCCCEEECCCEEECCEEEEEEECCCCCCEECCCCCEEEEEECCC
GLGIRVDSGVYSGYKIPPYYDSLIGKLIVHGRNRVECMMRLRRALDEFVVDGIKTTLPLF
CEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDLVGNADIANGDYDIHWLEKYLAKEE
HHHHCCCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MFQKILIANRGEIALRVLRACKELGIQTVVVHSTADADAMHVRLADESVCIGPPPSRDSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEECCCCCCCCCC
LNIHQIVAACEITGADAVHPGYGFLSENAKFADILAAHNITFIGPSGDHIRIMGDKIEAK
EEHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCHHHHH
RTAKRLGIPVVPGSDGAVTEEKEAKRIAAEIGYPVIIKASAGGGGRGMKVAHSEADLEVA
HHHHHCCCEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCCCCHHHH
LQTARSEAGAAFGDDAVYIEKYLQKPRHIEVQVFGDGFGRGVHFGERDCSLQRRHQKVWE
HHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
EANSPALNAEERSRIGGICAKAIADLGYSGAGTIEFLYENGEFYFIEMNTRLQVEHPVTE
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AITGIDLVHEQIRVASGGGLSVKQEDIKFNGHAIECRINAEDPRTFTPSPGTITHFHTPG
HHHHHHHHHHHHEEECCCCCEEECCCEEECCEEEEEEECCCCCCEECCCCCEEEEEECCC
GLGIRVDSGVYSGYKIPPYYDSLIGKLIVHGRNRVECMMRLRRALDEFVVDGIKTTLPLF
CEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDLVGNADIANGDYDIHWLEKYLAKEE
HHHHCCCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]