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The map label for this gene is panC

Identifier: 13470476

GI number: 13470476

Start: 133453

End: 134304

Strand: Reverse

Name: panC

Synonym: mll0196

Alternate gene names: 13470476

Gene position: 134304-133453 (Counterclockwise)

Preceding gene: 13470477

Following gene: 13470472

Centisome position: 1.91

GC content: 66.2

Gene sequence:

>852_bases
ATGAGCCGTCCCGAGGTCGTCAACAGCGTCGCTGCACTTCGCGCGCAGGTCAGTGACTGGCGGCGCGACGGCCTGCGCGT
TGCCATGGTGCCAACCATGGGCGCGCTGCATGAGGGTCATCTCTCCCTGATCAGGATCGCCAGGGAAAAAGCAGAGCGCT
GCGTGGTGTCGATCTTCGTCAACCCGACGCAATTCGCGCCGAGCGAGGATCTCGACAAGTACCCGCGCCAGCTCGCCCGC
GACCTCGACCTGCTGGCAAGGGTCAAGGCCGATCTTGCCTTCACGCCGACGGTCGGCGCGATGTATCCCGCCGGCTTTGC
CACCAGGATCTCGGTCGGCGGCCCGTCCGCCGGGCTCGAATCGGACTTCCGCCCCACCTTCTTCGAGGGCGTCGCCACCG
TGGTGGCCAAGCTTTTTCTGCAGGCGACGCCCGACTGTGCGGTCTTTGGCGAGAAGGACTACCAGCAGCTTTGCGTCGTC
AGGCAGCTCTGCCGCGACCTCGACCTTCCCGTCGAGATCATCGGCGCCCCGACCATACGCGACGCGCATGGCCTCGCAAT
GTCGTCACGCAACGCCTATCTCGACGAGGCTGAACTCGCTGTCGCCCGCCGGCTCAACGTGATCCTGCACAAGGCGGCAG
CGGCACTGGCGGCAGGCACCCATCAAGATGACGCAACCGGAGAAGCCAACCGCGCGCTCATCGCTGCAGGCTTCCAGAAG
ATCGACTATGTCGAGGCCCGCGAAAGCCTGACGCTTGCGCCCTGGCGCCGCGACCGCGCGGGCCGTGTTCTCGCCGCCGC
CTGGCTGGGCAAGACGCGACTGATCGACAATGTGGACGTTCCCGTTGCCTGA

Upstream 100 bases:

>100_bases
AGCGCTACGCAGCGGAGGTGCGAGACCGGACTTTCCCCGGCCCTAGCCATGTCTTTTCGGGTTCAAAAGCCTCTTCGGAC
TTAAACGGCGGGGATGAATC

Downstream 100 bases:

>100_bases
GCGGATCGGGCTACGCCACGCTTTGTGCCCTGGCGCCACCCATCCGCGATCTCCGGCACACGCTTACTCCTCCGTCGGCA
TATGCAGATACATCGACTGG

Product: pantoate-beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MSRPEVVNSVAALRAQVSDWRRDGLRVAMVPTMGALHEGHLSLIRIAREKAERCVVSIFVNPTQFAPSEDLDKYPRQLAR
DLDLLARVKADLAFTPTVGAMYPAGFATRISVGGPSAGLESDFRPTFFEGVATVVAKLFLQATPDCAVFGEKDYQQLCVV
RQLCRDLDLPVEIIGAPTIRDAHGLAMSSRNAYLDEAELAVARRLNVILHKAAAALAAGTHQDDATGEANRALIAAGFQK
IDYVEARESLTLAPWRRDRAGRVLAAAWLGKTRLIDNVDVPVA

Sequences:

>Translated_283_residues
MSRPEVVNSVAALRAQVSDWRRDGLRVAMVPTMGALHEGHLSLIRIAREKAERCVVSIFVNPTQFAPSEDLDKYPRQLAR
DLDLLARVKADLAFTPTVGAMYPAGFATRISVGGPSAGLESDFRPTFFEGVATVVAKLFLQATPDCAVFGEKDYQQLCVV
RQLCRDLDLPVEIIGAPTIRDAHGLAMSSRNAYLDEAELAVARRLNVILHKAAAALAAGTHQDDATGEANRALIAAGFQK
IDYVEARESLTLAPWRRDRAGRVLAAAWLGKTRLIDNVDVPVA
>Mature_282_residues
SRPEVVNSVAALRAQVSDWRRDGLRVAMVPTMGALHEGHLSLIRIAREKAERCVVSIFVNPTQFAPSEDLDKYPRQLARD
LDLLARVKADLAFTPTVGAMYPAGFATRISVGGPSAGLESDFRPTFFEGVATVVAKLFLQATPDCAVFGEKDYQQLCVVR
QLCRDLDLPVEIIGAPTIRDAHGLAMSSRNAYLDEAELAVARRLNVILHKAAAALAAGTHQDDATGEANRALIAAGFQKI
DYVEARESLTLAPWRRDRAGRVLAAAWLGKTRLIDNVDVPVA

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=282, Percent_Identity=42.5531914893617, Blast_Score=211, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6322046, Length=205, Percent_Identity=44.390243902439, Blast_Score=166, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_RHILO (Q98ND0)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102045.1
- ProteinModelPortal:   Q98ND0
- SMR:   Q98ND0
- GeneID:   1224708
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll0196
- NMPDR:   fig|266835.1.peg.150
- HOGENOM:   HBG428839
- OMA:   EDFGSYP
- BRENDA:   6.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30757; Mature: 30625

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: ACT_SITE 40-40 BINDING 64-64 BINDING 64-64 BINDING 156-156 BINDING 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPEVVNSVAALRAQVSDWRRDGLRVAMVPTMGALHEGHLSLIRIAREKAERCVVSIFV
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEEEE
NPTQFAPSEDLDKYPRQLARDLDLLARVKADLAFTPTVGAMYPAGFATRISVGGPSAGLE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCEEEEECCCCCCCCC
SDFRPTFFEGVATVVAKLFLQATPDCAVFGEKDYQQLCVVRQLCRDLDLPVEIIGAPTIR
CCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHCCCCEEEECCCCCC
DAHGLAMSSRNAYLDEAELAVARRLNVILHKAAAALAAGTHQDDATGEANRALIAAGFQK
CCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
IDYVEARESLTLAPWRRDRAGRVLAAAWLGKTRLIDNVDVPVA
HHHHHHHCCCEECCCCCCCCCCCHHHHHHCCHHCCCCCCCCCC
>Mature Secondary Structure 
SRPEVVNSVAALRAQVSDWRRDGLRVAMVPTMGALHEGHLSLIRIAREKAERCVVSIFV
CCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEEEE
NPTQFAPSEDLDKYPRQLARDLDLLARVKADLAFTPTVGAMYPAGFATRISVGGPSAGLE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCEEEEECCCCCCCCC
SDFRPTFFEGVATVVAKLFLQATPDCAVFGEKDYQQLCVVRQLCRDLDLPVEIIGAPTIR
CCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHCCCCEEEECCCCCC
DAHGLAMSSRNAYLDEAELAVARRLNVILHKAAAALAAGTHQDDATGEANRALIAAGFQK
CCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
IDYVEARESLTLAPWRRDRAGRVLAAAWLGKTRLIDNVDVPVA
HHHHHHHCCCEECCCCCCCCCCCHHHHHHCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968