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The map label for this gene is purC1

Identifier: 13470379

GI number: 13470379

Start: 49533

End: 50327

Strand: Reverse

Name: purC1

Synonym: mll0069

Alternate gene names: 13470379

Gene position: 50327-49533 (Counterclockwise)

Preceding gene: 13470382

Following gene: 13470378

Centisome position: 0.72

GC content: 60.75

Gene sequence:

>795_bases
ATGAAAAATCGCCGCCGCATTTATGAAGGCAAGGCCAAGATCCTCTATGAGGGACCGGAGCCGGGTACCCTCATCCAGTT
CTTCAAGGATGACGCCACCGCTTTCAACAAGAAGAAACACGAGGTTGTCGACGGCAAGGGCGTGCTCAACAACCGCATTT
CCGAGCACATCTTCAACCACTTGAACCGCATGGGCATCCCGACCCACTTCATCCGCCGGCTCAACATGCGTGAGCAGCTG
ATCAAGGAAGTCGAGATCATTCCACTCGAAGTGGTGGTGCGAAATGTCGCCGCCGGCTCGCTGTCCAAGCGCCTCGGCAT
CGAGGAAGGCACCGTCCTGCCGCGCTCGATCATCGAATTCTACTACAAGGCCGACGCGCTCGACGATCCGATGGTGTCGG
AAGAGCACATCACCGCCTTCGGTTGGGCAAGCCCGCAGGAGATCGACGACGTGATGGCGCTCGCCATCCGCGTCAACGAC
TTCCTCTCCGGCCTGTTCATGGGCGTCGGCATCCAGCTCGTCGACTTCAAGATCGAATGTGGCCGCCTGTTCGAGGGCGA
CATGATGCGCATCGTCGTGGCCGACGAGATTTCGCCGGACTCCTGCCGCCTGTGGGATGTGGCGACACAGGACAAGCTCG
ACAAGGACCGTTTCCGCCGCGACATGGGTGGTCTCGTCGAGGCCTACCAGGAAGTCGCCCGCCGCCTCGGCATCATGAAC
GAGAACGAGCCGCCGCGCCCGACCGGTCCGGTTCTTGTCGCCTCGACCGATGTCGTCAAAGGCAAGCCGCACTGA

Upstream 100 bases:

>100_bases
ATAGACCCGGCATTGAACCCAACCGTCGCCGCACTAATATAGGCAGACGGACAGGAACTGGTCGCTTGCCGCCTGCCCAC
AAATCCAGAGAAAAAATCAG

Downstream 100 bases:

>100_bases
TAGCGGCTTGCGATCCGATACTTAGAACAGGAGCATGTCCAGCGTGATCAAGGCCCGCATTACCGTCACCCTCAAGAACG
GCGTCCTCGACCCGCAAGGC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase 1

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKNRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVVDGKGVLNNRISEHIFNHLNRMGIPTHFIRRLNMREQL
IKEVEIIPLEVVVRNVAAGSLSKRLGIEEGTVLPRSIIEFYYKADALDDPMVSEEHITAFGWASPQEIDDVMALAIRVND
FLSGLFMGVGIQLVDFKIECGRLFEGDMMRIVVADEISPDSCRLWDVATQDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
ENEPPRPTGPVLVASTDVVKGKPH

Sequences:

>Translated_264_residues
MKNRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVVDGKGVLNNRISEHIFNHLNRMGIPTHFIRRLNMREQL
IKEVEIIPLEVVVRNVAAGSLSKRLGIEEGTVLPRSIIEFYYKADALDDPMVSEEHITAFGWASPQEIDDVMALAIRVND
FLSGLFMGVGIQLVDFKIECGRLFEGDMMRIVVADEISPDSCRLWDVATQDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
ENEPPRPTGPVLVASTDVVKGKPH
>Mature_264_residues
MKNRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVVDGKGVLNNRISEHIFNHLNRMGIPTHFIRRLNMREQL
IKEVEIIPLEVVVRNVAAGSLSKRLGIEEGTVLPRSIIEFYYKADALDDPMVSEEHITAFGWASPQEIDDVMALAIRVND
FLSGLFMGVGIQLVDFKIECGRLFEGDMMRIVVADEISPDSCRLWDVATQDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
ENEPPRPTGPVLVASTDVVKGKPH

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=226, Percent_Identity=33.6283185840708, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI5453539, Length=226, Percent_Identity=33.6283185840708, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI119220559, Length=235, Percent_Identity=32.7659574468085, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=44.9579831932773, Blast_Score=209, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17531275, Length=236, Percent_Identity=31.7796610169492, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI18860083, Length=237, Percent_Identity=29.1139240506329, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583917, Length=207, Percent_Identity=26.5700483091787, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR71_RHILO (Q98NM8)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_101947.1
- ProteinModelPortal:   Q98NM8
- SMR:   Q98NM8
- GeneID:   1224610
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll0069
- NMPDR:   fig|266835.1.peg.52
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BRENDA:   6.3.2.6
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 29949; Mature: 29949

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVVDGKGVLNNRISEHIFNH
CCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHH
LNRMGIPTHFIRRLNMREQLIKEVEIIPLEVVVRNVAAGSLSKRLGIEEGTVLPRSIIEF
HHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YYKADALDDPMVSEEHITAFGWASPQEIDDVMALAIRVNDFLSGLFMGVGIQLVDFKIEC
HHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEC
GRLFEGDMMRIVVADEISPDSCRLWDVATQDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
CCCCCCCEEEEEEECCCCCCCEEEEECCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
ENEPPRPTGPVLVASTDVVKGKPH
CCCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MKNRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVVDGKGVLNNRISEHIFNH
CCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHH
LNRMGIPTHFIRRLNMREQLIKEVEIIPLEVVVRNVAAGSLSKRLGIEEGTVLPRSIIEF
HHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YYKADALDDPMVSEEHITAFGWASPQEIDDVMALAIRVNDFLSGLFMGVGIQLVDFKIEC
HHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEC
GRLFEGDMMRIVVADEISPDSCRLWDVATQDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
CCCCCCCEEEEEEECCCCCCCEEEEECCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
ENEPPRPTGPVLVASTDVVKGKPH
CCCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968