Click here to switch to the map view.

The map label for this gene is purQ

Identifier: 13470377

GI number: 13470377

Start: 48307

End: 48975

Strand: Reverse

Name: purQ

Synonym: mll0065

Alternate gene names: 13470377

Gene position: 48975-48307 (Counterclockwise)

Preceding gene: 13470378

Following gene: 13470376

Centisome position: 0.7

GC content: 64.13

Gene sequence:

>669_bases
ATGAAATCCGCTGTCGTCCTCCTGCCTGGCCTCAACCGAGACCGCGACATGATCGCGGCGCTGACCAAGATTTCGGGAAA
ACCGCCGGTCACCGTCTGGCAGACCGACACCGAGATCCCCGATGTCGACCTGATCGCCATCCCCGGCGGCTTCTCCTTCG
GCGACTATCTGCGCTGCGGCGCGATCGCCGCGCGCATGCCGGTGATGCGGGCCGTCGCCGAAAAGGCCGCCAAGGGCGTG
ACCGTCATCGGCGTCTGCAACGGTTTTCAGATCCTGGTCGAGGCCGGCCTGCTGCCGGGGGCGCTCATGCGCAACACCTC
GCTGAAGTTCGTCTGCCGGCAGATCAAGCTTGAGATCACCAACGCCAACACCATGTTCACCCGCCGTTACCAACCGGGCC
AGGTCATCCGCTCGCCGGTGGCGCACCATGACGGCAACTACTTCGCCGACGCCGAAACCCTTGCCCGCCTCGAAGGCGAA
GGCCAGGTGGTGTTCCGCTATGCCGAGGGGACCAATCCCAATGGCTCGATCAACGACATTGCCGGCATCATCAACGAGCA
GGGCAATGTGCTTGGTCTGATGCCGCATCCGGAAAACCTGATCGAAGCCGCTCATGGCGGCAGCGACGGTCGTGCGCTGT
TCGAAGGCGCGCTCGGTATCGCCGCTTGA

Upstream 100 bases:

>100_bases
CTATGGTTGTGCTCGCTCGCCAGGATGATCGGCTCGAACATATCGAACGCCGTCTCGACCTGTGCGAACTAGCCGAAGCC
CAGAGGCCTTACGAACCAAA

Downstream 100 bases:

>100_bases
CGATCTCAGCTGCGAACGCGGTTAAATTCTTAGGGACATCAAGTCCACTGCTCTGGGGAGAGAGACGGTCATGAAACTCT
ATTCGCGGCCGTTGTCGCCC

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKSAVVLLPGLNRDRDMIAALTKISGKPPVTVWQTDTEIPDVDLIAIPGGFSFGDYLRCGAIAARMPVMRAVAEKAAKGV
TVIGVCNGFQILVEAGLLPGALMRNTSLKFVCRQIKLEITNANTMFTRRYQPGQVIRSPVAHHDGNYFADAETLARLEGE
GQVVFRYAEGTNPNGSINDIAGIINEQGNVLGLMPHPENLIEAAHGGSDGRALFEGALGIAA

Sequences:

>Translated_222_residues
MKSAVVLLPGLNRDRDMIAALTKISGKPPVTVWQTDTEIPDVDLIAIPGGFSFGDYLRCGAIAARMPVMRAVAEKAAKGV
TVIGVCNGFQILVEAGLLPGALMRNTSLKFVCRQIKLEITNANTMFTRRYQPGQVIRSPVAHHDGNYFADAETLARLEGE
GQVVFRYAEGTNPNGSINDIAGIINEQGNVLGLMPHPENLIEAAHGGSDGRALFEGALGIAA
>Mature_222_residues
MKSAVVLLPGLNRDRDMIAALTKISGKPPVTVWQTDTEIPDVDLIAIPGGFSFGDYLRCGAIAARMPVMRAVAEKAAKGV
TVIGVCNGFQILVEAGLLPGALMRNTSLKFVCRQIKLEITNANTMFTRRYQPGQVIRSPVAHHDGNYFADAETLARLEGE
GQVVFRYAEGTNPNGSINDIAGIINEQGNVLGLMPHPENLIEAAHGGSDGRALFEGALGIAA

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=227, Percent_Identity=31.2775330396476, Blast_Score=75, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321498, Length=255, Percent_Identity=29.8039215686275, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582111, Length=231, Percent_Identity=28.1385281385281, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24582109, Length=231, Percent_Identity=28.1385281385281, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17137292, Length=231, Percent_Identity=28.1385281385281, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_RHILO (Q98NN0)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_101945.1
- ProteinModelPortal:   Q98NN0
- SMR:   Q98NN0
- GeneID:   1224608
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll0065
- NMPDR:   fig|266835.1.peg.50
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- ProtClustDB:   PRK03619
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF07685 GATase_3

EC number: =6.3.5.3

Molecular weight: Translated: 23626; Mature: 23626

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 196-196 ACT_SITE 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSAVVLLPGLNRDRDMIAALTKISGKPPVTVWQTDTEIPDVDLIAIPGGFSFGDYLRCG
CCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHH
AIAARMPVMRAVAEKAAKGVTVIGVCNGFQILVEAGLLPGALMRNTSLKFVCRQIKLEIT
HHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEHHHCCCCCHHHHCCHHHHEEEEEEEEEE
NANTMFTRRYQPGQVIRSPVAHHDGNYFADAETLARLEGEGQVVFRYAEGTNPNGSINDI
CCCEEEEEECCCCHHHHCCHHHCCCCEEECHHHHHHHCCCCEEEEEEECCCCCCCCHHHH
AGIINEQGNVLGLMPHPENLIEAAHGGSDGRALFEGALGIAA
HHHHCCCCCEEEECCCCHHHHHHHCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MKSAVVLLPGLNRDRDMIAALTKISGKPPVTVWQTDTEIPDVDLIAIPGGFSFGDYLRCG
CCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHH
AIAARMPVMRAVAEKAAKGVTVIGVCNGFQILVEAGLLPGALMRNTSLKFVCRQIKLEIT
HHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEHHHCCCCCHHHHCCHHHHEEEEEEEEEE
NANTMFTRRYQPGQVIRSPVAHHDGNYFADAETLARLEGEGQVVFRYAEGTNPNGSINDI
CCCEEEEEECCCCHHHHCCHHHCCCCEEECHHHHHHHCCCCEEEEEEECCCCCCCCHHHH
AGIINEQGNVLGLMPHPENLIEAAHGGSDGRALFEGALGIAA
HHHHCCCCCEEEECCCCHHHHHHHCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968