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The map label for this gene is icd [H]

Identifier: 13470357

GI number: 13470357

Start: 29133

End: 30344

Strand: Reverse

Name: icd [H]

Synonym: mll0036

Alternate gene names: 13470357

Gene position: 30344-29133 (Counterclockwise)

Preceding gene: 13470358

Following gene: 13470356

Centisome position: 0.43

GC content: 60.15

Gene sequence:

>1212_bases
ATGGCGAAGATCAAGGTGGCGAACCCGGTCGTCGAGCTCGACGGCGACGAGATGACCCGCATCATCTGGCAGTTCATCAA
GGACAAGCTGATCCACCCTTATCTCGACCTGAAGCTCGAATATTACGATCTCGGCATCGAGCATCGTGACGCCACCAACG
ACCAGGTGACCATCGATTCGGCCAACGCCATCAAGAAATACGGCGTCGGCGTGAAGTGCGCGACGATCACCCCCGACGAA
CAGCGCGTCGAGGAGTTCAAGCTGAAGAAGATGTGGAAGTCGCCGAATGGCACCATCCGCAACATCCTTGGCGGCACCAT
CTTCCGCGAGCCGATCATCATGAAGAACGTGCCGCGCCTGGTGCCCGGCTGGACCAAGCCGATCATCGTCGGCCGCCACG
CCTTCGGCGACCAGTACCGCGCCACCGATTTCCGCTTCCCCGGCAAGGGCAAGCTGACGATCAAGTTCGTCGGTGAAGAC
GGAAAGGTCATCGAGCATGACGTGTTCGACGCACCCGGCGCCGGCGTCGCCATGGCCATGTACAATCTCGACGAGTCGAT
CCGCGAGTTTGCCCGCGCCTCGCTGAATTACGGCCTGCTGCGCAACTATCCGGTCTATCTGTCGACCAAGAACACCATCC
TGAAAGCCTATGACGGCCGCTTCAAGGACATTTTCCAGGAAGTCTACGAGGCTGAATTCGAGGCCGACTTCAAGTCGAAG
AAGCTGTGGTACGAACACCGCCTGATCGACGACATGGTGGCGTCCAGTCTGAAATGGTCGGGCGGCTATGTCTGGGCCTG
CAAGAACTATGACGGCGACGTCCAGTCCGATACCGTGGCGCAAGGTTTCGGCTCGCTCGGCCTTATGACTTCGGTGCTGA
TGACGCCGGACGGCAAGACGGTGGAAGCCGAAGCCGCGCACGGCACCGTAACCCGCCACTACCGCCAGCACCAGAAGGGC
GAGGAAACCTCGACCAATTCGATCGCCTCGATCTTCGCCTGGACGCGCGGGCTGGCCCACCGCGCCAAGCTCGACGACAA
TGCGGAGCTGAAGCGCTTTGCCGAGACGCTGGAAAAGGTCTGTATCCAGACCGTCGAGTCCGGCTTCATGACCAAGGACC
TGTCGCTGTTGATCGGTCCCGATCAGCCCTGGCTCTCGACCACCGGCTTCCTCGACAAGATCGACGAAAACTTGCAGAAG
GCGATGGCGTAA

Upstream 100 bases:

>100_bases
CCAGGTTTGCGCCGCCCGGATCGCTTTGCTATAGGCGAAGTCCCTATCCTGGCGGGGCCGGCCCCGCCATCCCCCAACTG
TTGAACGAGGCATTCTTTCC

Downstream 100 bases:

>100_bases
GAACCCAGATTTCCACATGCCGAAGGCTCCGAAAGGAGCCTTCGCTTTTTTGGGCCAGCGAAAGCGAAGAGCTGACAGCA
TGACCAGGCCAATCCTCTAT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLKLEYYDLGIEHRDATNDQVTIDSANAIKKYGVGVKCATITPDE
QRVEEFKLKKMWKSPNGTIRNILGGTIFREPIIMKNVPRLVPGWTKPIIVGRHAFGDQYRATDFRFPGKGKLTIKFVGED
GKVIEHDVFDAPGAGVAMAMYNLDESIREFARASLNYGLLRNYPVYLSTKNTILKAYDGRFKDIFQEVYEAEFEADFKSK
KLWYEHRLIDDMVASSLKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG
EETSTNSIASIFAWTRGLAHRAKLDDNAELKRFAETLEKVCIQTVESGFMTKDLSLLIGPDQPWLSTTGFLDKIDENLQK
AMA

Sequences:

>Translated_403_residues
MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLKLEYYDLGIEHRDATNDQVTIDSANAIKKYGVGVKCATITPDE
QRVEEFKLKKMWKSPNGTIRNILGGTIFREPIIMKNVPRLVPGWTKPIIVGRHAFGDQYRATDFRFPGKGKLTIKFVGED
GKVIEHDVFDAPGAGVAMAMYNLDESIREFARASLNYGLLRNYPVYLSTKNTILKAYDGRFKDIFQEVYEAEFEADFKSK
KLWYEHRLIDDMVASSLKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG
EETSTNSIASIFAWTRGLAHRAKLDDNAELKRFAETLEKVCIQTVESGFMTKDLSLLIGPDQPWLSTTGFLDKIDENLQK
AMA
>Mature_402_residues
AKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLKLEYYDLGIEHRDATNDQVTIDSANAIKKYGVGVKCATITPDEQ
RVEEFKLKKMWKSPNGTIRNILGGTIFREPIIMKNVPRLVPGWTKPIIVGRHAFGDQYRATDFRFPGKGKLTIKFVGEDG
KVIEHDVFDAPGAGVAMAMYNLDESIREFARASLNYGLLRNYPVYLSTKNTILKAYDGRFKDIFQEVYEAEFEADFKSKK
LWYEHRLIDDMVASSLKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKGE
ETSTNSIASIFAWTRGLAHRAKLDDNAELKRFAETLEKVCIQTVESGFMTKDLSLLIGPDQPWLSTTGFLDKIDENLQKA
MA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=68.1372549019608, Blast_Score=582, Evalue=1e-166,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=66.8292682926829, Blast_Score=570, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17540874, Length=402, Percent_Identity=69.9004975124378, Blast_Score=590, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=67.0761670761671, Blast_Score=572, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6323203, Length=408, Percent_Identity=62.9901960784314, Blast_Score=535, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6320137, Length=407, Percent_Identity=63.3906633906634, Blast_Score=531, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=60.9336609336609, Blast_Score=521, Evalue=1e-149,
Organism=Drosophila melanogaster, GI21356561, Length=409, Percent_Identity=64.7921760391198, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI221330987, Length=409, Percent_Identity=64.7921760391198, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI221330985, Length=409, Percent_Identity=64.7921760391198, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI28574947, Length=409, Percent_Identity=64.7921760391198, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24660849, Length=409, Percent_Identity=64.7921760391198, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24660856, Length=409, Percent_Identity=64.7921760391198, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI221330983, Length=409, Percent_Identity=64.7921760391198, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24660868, Length=409, Percent_Identity=64.7921760391198, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24660860, Length=409, Percent_Identity=64.7921760391198, Blast_Score=558, Evalue=1e-159,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45545; Mature: 45413

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLKLEYYDLGIEHRDATNDQVTIDS
CCEEEECCCEEEECCHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCCCCCEEEEEC
ANAIKKYGVGVKCATITPDEQRVEEFKLKKMWKSPNGTIRNILGGTIFREPIIMKNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHCCHHHHCCCCC
VPGWTKPIIVGRHAFGDQYRATDFRFPGKGKLTIKFVGEDGKVIEHDVFDAPGAGVAMAM
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCHHHHH
YNLDESIREFARASLNYGLLRNYPVYLSTKNTILKAYDGRFKDIFQEVYEAEFEADFKSK
HHHHHHHHHHHHHHCCCCHHCCCCEEEECCCCEEEHHCCHHHHHHHHHHHHHHCCCCHHH
KLWYEHRLIDDMVASSLKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKT
HHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDDNAELKRFAETLEKV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CIQTVESGFMTKDLSLLIGPDQPWLSTTGFLDKIDENLQKAMA
HHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLKLEYYDLGIEHRDATNDQVTIDS
CEEEECCCEEEECCHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCCCCCEEEEEC
ANAIKKYGVGVKCATITPDEQRVEEFKLKKMWKSPNGTIRNILGGTIFREPIIMKNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHCCHHHHCCCCC
VPGWTKPIIVGRHAFGDQYRATDFRFPGKGKLTIKFVGEDGKVIEHDVFDAPGAGVAMAM
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCHHHHH
YNLDESIREFARASLNYGLLRNYPVYLSTKNTILKAYDGRFKDIFQEVYEAEFEADFKSK
HHHHHHHHHHHHHHCCCCHHCCCCEEEECCCCEEEHHCCHHHHHHHHHHHHHHCCCCHHH
KLWYEHRLIDDMVASSLKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKT
HHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDDNAELKRFAETLEKV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CIQTVESGFMTKDLSLLIGPDQPWLSTTGFLDKIDENLQKAMA
HHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]