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The map label for this gene is pyrF [H]

Identifier: 134302762

GI number: 134302762

Start: 1852361

End: 1852984

Strand: Direct

Name: pyrF [H]

Synonym: FTW_1973

Alternate gene names: 134302762

Gene position: 1852361-1852984 (Clockwise)

Preceding gene: 134302761

Following gene: 134302763

Centisome position: 97.57

GC content: 35.58

Gene sequence:

>624_bases
ATGTTCTCAGCAGATGGTATCTCTAAGTCAGATTTAGAGAAAACAGCCACTGTATCAAAGTATGTTGACTGTGTTAAGAT
TGGTCATATTCTATGCTCAACGTTATCTTTTAAAGAAATTCATGAGCTAGTAGGCGACAAAGATATTTTCCTAGACTTTA
AGTTACACGATATCCCAAATACAGTTAAAACTGCAATTGAAAATTATTCAAAAGCTATTCCAAATTTTAAATATTTTACA
TTTCATGGTACTGCTAGTGATGAGATGATAAAAGCAGCCCTTACGGCAGATACTCAAGCTATACCATTAGCTGTGATTAC
ACTTAGTAGTGATGCTAATTTTGATAAGGCAGATAGCCTTGCTAAATTTCAAAGATGTGTGGATTTAGGTGTGGAAAACT
TTATATGTCATCCACATTTAGTTGCTGATGTCAGAGCTAAATTTGGCGATAAAATCAAGCTATATGTCCCAGGTGTAAGG
CTTGAGAGTGATCTAAGTGATGATCATTTTAACGCTTTGACCCCTAAAAAAGCCAAAGAGCTTGGCGTTGATTACATTAT
TGTAGGTAGGCCGCTATTACGCGCTGAAAATATCGTTGAGAAGCTAAAAGAGTTTGAGTGCTAA

Upstream 100 bases:

>100_bases
ATGAAAGTAACAAATTTAAAATATAGTTTACTATCACCACAAATTAAACTAATATATAGTTTCAACATCGATTAATCATT
TGAGAAACTCAATGAAAATA

Downstream 100 bases:

>100_bases
GATGCAAAATCAAGATCTTAAAAGAATAATAATCTCGCCACCGTTTGGTAAATATCTTAAATTTAAAGAAACTTCGAATG
TTTATGGTTCTTTTACTGTG

Product: orotidine 5'-phosphate decarboxylase

Products: NA

Alternate protein names: OMP decarboxylase; OMPDCase; OMPdecase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MFSADGISKSDLEKTATVSKYVDCVKIGHILCSTLSFKEIHELVGDKDIFLDFKLHDIPNTVKTAIENYSKAIPNFKYFT
FHGTASDEMIKAALTADTQAIPLAVITLSSDANFDKADSLAKFQRCVDLGVENFICHPHLVADVRAKFGDKIKLYVPGVR
LESDLSDDHFNALTPKKAKELGVDYIIVGRPLLRAENIVEKLKEFEC

Sequences:

>Translated_207_residues
MFSADGISKSDLEKTATVSKYVDCVKIGHILCSTLSFKEIHELVGDKDIFLDFKLHDIPNTVKTAIENYSKAIPNFKYFT
FHGTASDEMIKAALTADTQAIPLAVITLSSDANFDKADSLAKFQRCVDLGVENFICHPHLVADVRAKFGDKIKLYVPGVR
LESDLSDDHFNALTPKKAKELGVDYIIVGRPLLRAENIVEKLKEFEC
>Mature_207_residues
MFSADGISKSDLEKTATVSKYVDCVKIGHILCSTLSFKEIHELVGDKDIFLDFKLHDIPNTVKTAIENYSKAIPNFKYFT
FHGTASDEMIKAALTADTQAIPLAVITLSSDANFDKADSLAKFQRCVDLGVENFICHPHLVADVRAKFGDKIKLYVPGVR
LESDLSDDHFNALTPKKAKELGVDYIIVGRPLLRAENIVEKLKEFEC

Specific function: Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) [H]

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OMP decarboxylase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787537, Length=201, Percent_Identity=28.8557213930348, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR014732
- InterPro:   IPR018089
- InterPro:   IPR001754
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase [H]

EC number: =4.1.1.23 [H]

Molecular weight: Translated: 23027; Mature: 23027

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00156 OMPDECASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSADGISKSDLEKTATVSKYVDCVKIGHILCSTLSFKEIHELVGDKDIFLDFKLHDIPN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEEECCCCH
TVKTAIENYSKAIPNFKYFTFHGTASDEMIKAALTADTQAIPLAVITLSSDANFDKADSL
HHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHH
AKFQRCVDLGVENFICHPHLVADVRAKFGDKIKLYVPGVRLESDLSDDHFNALTPKKAKE
HHHHHHHHHCHHHHCCCCHHHHHHHHHCCCEEEEEECCEEECCCCCCCCCCCCCCHHHHH
LGVDYIIVGRPLLRAENIVEKLKEFEC
CCCCEEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFSADGISKSDLEKTATVSKYVDCVKIGHILCSTLSFKEIHELVGDKDIFLDFKLHDIPN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEEECCCCH
TVKTAIENYSKAIPNFKYFTFHGTASDEMIKAALTADTQAIPLAVITLSSDANFDKADSL
HHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHH
AKFQRCVDLGVENFICHPHLVADVRAKFGDKIKLYVPGVRLESDLSDDHFNALTPKKAKE
HHHHHHHHHCHHHHCCCCHHHHHHHHHCCCEEEEEECCEEECCCCCCCCCCCCCCHHHHH
LGVDYIIVGRPLLRAENIVEKLKEFEC
CCCCEEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA