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The map label for this gene is tpm [H]

Identifier: 134302750

GI number: 134302750

Start: 1838877

End: 1839413

Strand: Reverse

Name: tpm [H]

Synonym: FTW_1959

Alternate gene names: 134302750

Gene position: 1839413-1838877 (Counterclockwise)

Preceding gene: 134302752

Following gene: 134302749

Centisome position: 96.89

GC content: 30.54

Gene sequence:

>537_bases
ATGAATAAGCTTGAAACTAATAATAATCAATATTGGCTAGATAGATGGCAAAATGATGATGTAGGTTTTTGTCAAGAATC
ACCAAATGAGTTTCTAGTTAAGCATTTTTCTAAACTAAACATAAATGATTCATCGGTATGCTTAATACCAATGTGTGGCT
GTAGTATAGATATGTTATTTTTCTTATCTAAGGGGGTTAAAGTAATTGGTATTGAGCTATCAGAAAAAGCTGTCTTATCA
TTTTTTAGCCAAAATACTATCAATTATGAAGTTATACATGGCAATGACTATAAACTCTATAAAGGCGATGATATTGAGAT
ATATGTAGCAGATATTTTTAACTTACCAAAGATAGCAAACAATTTACCAGTATTTGATATTTGGTATGATAGAGGTGCTT
ATATCGCTTTGCCTAATGACCTTAGGACTAATTATGCAAAAATGATGCTAGAAGTATGCTCTAATAATACTCAAATACTC
TTATTAGTAATGGAACATGACAAGAAATCCCAGACTATCGAAAGGCTGAAGGAATGA

Upstream 100 bases:

>100_bases
AATGAACCATAGTATAAATCGCCACATTTAAAAAGTAATATTTATCTGATCGTTCATGTTAATATGTTTAGTTAGTTAAT
AACTGTAGATTACAAACAAT

Downstream 100 bases:

>100_bases
CTGAACAATATTACACAACTTATCTAAGAAAAAAGCAATATTAGAAAAACTAGTAAAATAGTTAATCATAATACTTTTCG
GATTTAGTATGTTTTAGAAT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MNKLETNNNQYWLDRWQNDDVGFCQESPNEFLVKHFSKLNINDSSVCLIPMCGCSIDMLFFLSKGVKVIGIELSEKAVLS
FFSQNTINYEVIHGNDYKLYKGDDIEIYVADIFNLPKIANNLPVFDIWYDRGAYIALPNDLRTNYAKMMLEVCSNNTQIL
LLVMEHDKKSQTIERLKE

Sequences:

>Translated_178_residues
MNKLETNNNQYWLDRWQNDDVGFCQESPNEFLVKHFSKLNINDSSVCLIPMCGCSIDMLFFLSKGVKVIGIELSEKAVLS
FFSQNTINYEVIHGNDYKLYKGDDIEIYVADIFNLPKIANNLPVFDIWYDRGAYIALPNDLRTNYAKMMLEVCSNNTQIL
LLVMEHDKKSQTIERLKE
>Mature_178_residues
MNKLETNNNQYWLDRWQNDDVGFCQESPNEFLVKHFSKLNINDSSVCLIPMCGCSIDMLFFLSKGVKVIGIELSEKAVLS
FFSQNTINYEVIHGNDYKLYKGDDIEIYVADIFNLPKIANNLPVFDIWYDRGAYIALPNDLRTNYAKMMLEVCSNNTQIL
LLVMEHDKKSQTIERLKE

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

Organism=Homo sapiens, GI4507653, Length=163, Percent_Identity=31.2883435582822, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 20664; Mature: 20664

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLETNNNQYWLDRWQNDDVGFCQESPNEFLVKHFSKLNINDSSVCLIPMCGCSIDMLF
CCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHH
FLSKGVKVIGIELSEKAVLSFFSQNTINYEVIHGNDYKLYKGDDIEIYVADIFNLPKIAN
HHHCCCEEEEEEECHHHHHHHHHCCCEEEEEEECCCEEEEECCCCEEEEECCCCCCHHHC
NLPVFDIWYDRGAYIALPNDLRTNYAKMMLEVCSNNTQILLLVMEHDKKSQTIERLKE
CCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure
MNKLETNNNQYWLDRWQNDDVGFCQESPNEFLVKHFSKLNINDSSVCLIPMCGCSIDMLF
CCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHH
FLSKGVKVIGIELSEKAVLSFFSQNTINYEVIHGNDYKLYKGDDIEIYVADIFNLPKIAN
HHHCCCEEEEEEECHHHHHHHHHCCCEEEEEEECCCEEEEECCCCEEEEECCCCCCHHHC
NLPVFDIWYDRGAYIALPNDLRTNYAKMMLEVCSNNTQILLLVMEHDKKSQTIERLKE
CCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA