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The map label for this gene is tyrP [H]

Identifier: 134302725

GI number: 134302725

Start: 1807992

End: 1809197

Strand: Reverse

Name: tyrP [H]

Synonym: FTW_1927

Alternate gene names: 134302725

Gene position: 1809197-1807992 (Counterclockwise)

Preceding gene: 134302728

Following gene: 134302722

Centisome position: 95.3

GC content: 33.08

Gene sequence:

>1206_bases
ATGATTTTATCAAGAAAATTTGGCGCAGCGATGATTATATCTGGCACTTGCATTGGTGCTGGAATGTTGGCAATCCCTGC
AACAGTAGCTAGTTGCGGCTTTTTGATTGGCTCAATACTGATTGTTTGTATTTGGGCATTAATGACTTTCACAGCTTTAG
TTTTAGCAGAAGTTAATCTAAAAATGGATGATGGCGCTAATTTTGTTGAGATGACAAGTCAAACTCTTGGTCCTATTGGG
GTTGGTATTGTTTGGATTTGCTATGTGCTACTACTTTATTCACTTGTGGCTGCTTATACTGTCGGCGGTGGCTCACTCAT
CTCAACAACTCTTAGTAACCTTGGGATTACTTTATCAGAAAAAACCACGGGGATTATTTTTATCCTTATCCTTGGAGTTT
TTATATATATCAGTACTAGAATTGTTGATCATATCAATAAAATTATGTTTTCTGGTAAACTTTTAGCGTTTTTATTACTA
ATTGCTGTACTTGTACCTCATATTTCTCTAGATCATCTAAGCTATAAAATTAAAAATCCAAATTTTATTTGGGCAGCGTT
TCCAATACTACTAACTTCCTTTGGATTTCATCATATTATTCCTACGCTTAGAACCTATGTAGGATCAAATAAAAGATCTT
TACGCCAAGCAATTATAATAGGTAGCTCCATACCATTAATAGTGTATTTATTATGGATCTTTGCAACGCTTGGTTCATTG
CCAGTTGCTACACCAACAGGCATACTAGGTAAGAATTCTGGTGAAATAACCTCTGTGATAATCAATCACTTTAGTACTAG
TTCTAGCTATATTTCAACAATATCTTTTTTATTTGGTTTTTTTGCTTTAGCAACTTCTTTTCTAGGAGTAGCTCTCGGAC
TATTTGATTTTAATCGTAGCACTTATAGAATTTCAGAAAATATACATAAACATAAAATAATTGCTTTTATAATAACTTTC
TTGCCAGCATACATTTATGCTATCGCTTATCCTGATGGATTTAAAACAGCTTTAGGCTATGCCAGCATATTCGTTGCTAT
ACTTCAGGTTGCGCTACCAGTTATGATGCTATGGGTTATTAACTACCGTAAGCAAAAAGCCTTAGTTAGCACTTCTACTA
TAGCAATATTTATAATATTTATTGCAATTTTAATTATTATTTTGCAAATTATGAGCTCTTTTGATTTATTACCAACTCTA
AATTAA

Upstream 100 bases:

>100_bases
TTTTATAGAAATAACAATCTTATATAAGCTATAATAACTATATTATAAGCTTTAAAAGATAGAGTTGTGATTTTAAACTC
CAACTTTAACACAAATTAAT

Downstream 100 bases:

>100_bases
AGGCTATGATTTTTAACTTTCATATTGTAAGTCAATAAAATTACAATACCAACAAAAATAGGTAATATCACCGAAGGAAA
CAACATTAATGTAAAATACT

Product: aromatic amino acid transporter family protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MILSRKFGAAMIISGTCIGAGMLAIPATVASCGFLIGSILIVCIWALMTFTALVLAEVNLKMDDGANFVEMTSQTLGPIG
VGIVWICYVLLLYSLVAAYTVGGGSLISTTLSNLGITLSEKTTGIIFILILGVFIYISTRIVDHINKIMFSGKLLAFLLL
IAVLVPHISLDHLSYKIKNPNFIWAAFPILLTSFGFHHIIPTLRTYVGSNKRSLRQAIIIGSSIPLIVYLLWIFATLGSL
PVATPTGILGKNSGEITSVIINHFSTSSSYISTISFLFGFFALATSFLGVALGLFDFNRSTYRISENIHKHKIIAFIITF
LPAYIYAIAYPDGFKTALGYASIFVAILQVALPVMMLWVINYRKQKALVSTSTIAIFIIFIAILIIILQIMSSFDLLPTL
N

Sequences:

>Translated_401_residues
MILSRKFGAAMIISGTCIGAGMLAIPATVASCGFLIGSILIVCIWALMTFTALVLAEVNLKMDDGANFVEMTSQTLGPIG
VGIVWICYVLLLYSLVAAYTVGGGSLISTTLSNLGITLSEKTTGIIFILILGVFIYISTRIVDHINKIMFSGKLLAFLLL
IAVLVPHISLDHLSYKIKNPNFIWAAFPILLTSFGFHHIIPTLRTYVGSNKRSLRQAIIIGSSIPLIVYLLWIFATLGSL
PVATPTGILGKNSGEITSVIINHFSTSSSYISTISFLFGFFALATSFLGVALGLFDFNRSTYRISENIHKHKIIAFIITF
LPAYIYAIAYPDGFKTALGYASIFVAILQVALPVMMLWVINYRKQKALVSTSTIAIFIIFIAILIIILQIMSSFDLLPTL
N
>Mature_401_residues
MILSRKFGAAMIISGTCIGAGMLAIPATVASCGFLIGSILIVCIWALMTFTALVLAEVNLKMDDGANFVEMTSQTLGPIG
VGIVWICYVLLLYSLVAAYTVGGGSLISTTLSNLGITLSEKTTGIIFILILGVFIYISTRIVDHINKIMFSGKLLAFLLL
IAVLVPHISLDHLSYKIKNPNFIWAAFPILLTSFGFHHIIPTLRTYVGSNKRSLRQAIIIGSSIPLIVYLLWIFATLGSL
PVATPTGILGKNSGEITSVIINHFSTSSSYISTISFLFGFFALATSFLGVALGLFDFNRSTYRISENIHKHKIIAFIITF
LPAYIYAIAYPDGFKTALGYASIFVAILQVALPVMMLWVINYRKQKALVSTSTIAIFIIFIAILIIILQIMSSFDLLPTL
N

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=402, Percent_Identity=34.3283582089552, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1790145, Length=405, Percent_Identity=28.1481481481481, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789552, Length=388, Percent_Identity=26.0309278350515, Blast_Score=139, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43631; Mature: 43631

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILSRKFGAAMIISGTCIGAGMLAIPATVASCGFLIGSILIVCIWALMTFTALVLAEVNL
CCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KMDDGANFVEMTSQTLGPIGVGIVWICYVLLLYSLVAAYTVGGGSLISTTLSNLGITLSE
EECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEC
KTTGIIFILILGVFIYISTRIVDHINKIMFSGKLLAFLLLIAVLVPHISLDHLSYKIKNP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEECCC
NFIWAAFPILLTSFGFHHIIPTLRTYVGSNKRSLRQAIIIGSSIPLIVYLLWIFATLGSL
CEEHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
PVATPTGILGKNSGEITSVIINHFSTSSSYISTISFLFGFFALATSFLGVALGLFDFNRS
CCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TYRISENIHKHKIIAFIITFLPAYIYAIAYPDGFKTALGYASIFVAILQVALPVMMLWVI
CEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NYRKQKALVSTSTIAIFIIFIAILIIILQIMSSFDLLPTLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MILSRKFGAAMIISGTCIGAGMLAIPATVASCGFLIGSILIVCIWALMTFTALVLAEVNL
CCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KMDDGANFVEMTSQTLGPIGVGIVWICYVLLLYSLVAAYTVGGGSLISTTLSNLGITLSE
EECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEC
KTTGIIFILILGVFIYISTRIVDHINKIMFSGKLLAFLLLIAVLVPHISLDHLSYKIKNP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEECCC
NFIWAAFPILLTSFGFHHIIPTLRTYVGSNKRSLRQAIIIGSSIPLIVYLLWIFATLGSL
CEEHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
PVATPTGILGKNSGEITSVIINHFSTSSSYISTISFLFGFFALATSFLGVALGLFDFNRS
CCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TYRISENIHKHKIIAFIITFLPAYIYAIAYPDGFKTALGYASIFVAILQVALPVMMLWVI
CEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NYRKQKALVSTSTIAIFIIFIAILIIILQIMSSFDLLPTLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]