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The map label for this gene is uppS

Identifier: 134302593

GI number: 134302593

Start: 1659625

End: 1660347

Strand: Reverse

Name: uppS

Synonym: FTW_1765

Alternate gene names: 134302593

Gene position: 1660347-1659625 (Counterclockwise)

Preceding gene: 134302594

Following gene: 134302592

Centisome position: 87.46

GC content: 35.55

Gene sequence:

>723_bases
ATGACATCGGCTAAAGAAAATATTCTAAGGCATCTTGCTATTATTATGGATGGTAATGGTCGGTGGGCAAAGAGTAGATT
AAAGCCGAGAATATTTGGTCATAGAAATTCGGTCTCGAGTGTTGATGCAACTATAGAGTACTGTGTTGAGAATAATATAG
AAATGCTTACTCTTTTTGCATTTGGTCGAGATAATTGGTTAAGACCAGCTCAAGAAGTCAGTGATCTTATGGATCTTTTT
TATAAAACTCTAAAAGATAAAACTCCAAAGCTACATGATAATAATATTGTTGTTACTGTTGTTGGAGATCGCTCACGCTT
GTCTAATAAGCTTATTGGTATGATTGAATATAGTGAGTCATTAACTAAGTCAAATACAGGACTAAAGCTTAGATTGGCTG
TTGATTATGCTGGTCGATGGGATATAGTTGAGGCTACTAGAGCTATTGCTAGAGAAGTTGATATTGGTAAGCTTAGTGTT
GATGAGATTGATCAGAACAGTTTCGCTAAATATTTGGTTGGGGGTAATATGCCTGTCGATTTACTTATTCGTACAAGTGG
AGAAGTGCGTCTGAGTGATTTTATGTTGTGGCAGTTAGCCTATGCGGAGATGTATTTTACAGATATTATGTGGCCAGATT
TTTCTAAGCAAGAATTAACTAGAGCTGTTGAGTATTTTTATTCTCGTCAAAGAAGATTTGGCAAAAGTGGTGAACAAATT
TAA

Upstream 100 bases:

>100_bases
ATCTAATGGCTGTGTAATTGCTTAGATTTCCCAATAATAACTTGTATTTTTGTTTATTCTTTCTTATCATTTAGCTAACT
TAATTTTTTTCATAATATTT

Downstream 100 bases:

>100_bases
TTAAGAGGAATTTATGAAAGAAAGGATTGTGACTGGTATAGTTTTGGTCGCTGTGGTTTTTGGTTTTTTATTTTTTGCTT
CTGACTATCTGTTTGGTGTT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MTSAKENILRHLAIIMDGNGRWAKSRLKPRIFGHRNSVSSVDATIEYCVENNIEMLTLFAFGRDNWLRPAQEVSDLMDLF
YKTLKDKTPKLHDNNIVVTVVGDRSRLSNKLIGMIEYSESLTKSNTGLKLRLAVDYAGRWDIVEATRAIAREVDIGKLSV
DEIDQNSFAKYLVGGNMPVDLLIRTSGEVRLSDFMLWQLAYAEMYFTDIMWPDFSKQELTRAVEYFYSRQRRFGKSGEQI

Sequences:

>Translated_240_residues
MTSAKENILRHLAIIMDGNGRWAKSRLKPRIFGHRNSVSSVDATIEYCVENNIEMLTLFAFGRDNWLRPAQEVSDLMDLF
YKTLKDKTPKLHDNNIVVTVVGDRSRLSNKLIGMIEYSESLTKSNTGLKLRLAVDYAGRWDIVEATRAIAREVDIGKLSV
DEIDQNSFAKYLVGGNMPVDLLIRTSGEVRLSDFMLWQLAYAEMYFTDIMWPDFSKQELTRAVEYFYSRQRRFGKSGEQI
>Mature_239_residues
TSAKENILRHLAIIMDGNGRWAKSRLKPRIFGHRNSVSSVDATIEYCVENNIEMLTLFAFGRDNWLRPAQEVSDLMDLFY
KTLKDKTPKLHDNNIVVTVVGDRSRLSNKLIGMIEYSESLTKSNTGLKLRLAVDYAGRWDIVEATRAIAREVDIGKLSVD
EIDQNSFAKYLVGGNMPVDLLIRTSGEVRLSDFMLWQLAYAEMYFTDIMWPDFSKQELTRAVEYFYSRQRRFGKSGEQI

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=221, Percent_Identity=33.9366515837104, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI45580738, Length=221, Percent_Identity=33.9366515837104, Blast_Score=125, Evalue=3e-29,
Organism=Escherichia coli, GI1786371, Length=229, Percent_Identity=48.9082969432314, Blast_Score=241, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71993029, Length=231, Percent_Identity=37.2294372294372, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323748, Length=216, Percent_Identity=32.4074074074074, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319474, Length=217, Percent_Identity=30.8755760368664, Blast_Score=99, Evalue=5e-22,
Organism=Drosophila melanogaster, GI18857969, Length=212, Percent_Identity=31.6037735849057, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_FRATT (Q5NHX6)

Other databases:

- EMBL:   AJ749949
- RefSeq:   YP_169366.1
- ProteinModelPortal:   Q5NHX6
- SMR:   Q5NHX6
- GeneID:   3191904
- GenomeReviews:   AJ749949_GR
- KEGG:   ftu:FTT_0317
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   PRK14836
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 27622; Mature: 27491

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 34-34

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAKENILRHLAIIMDGNGRWAKSRLKPRIFGHRNSVSSVDATIEYCVENNIEMLTLFA
CCCHHHHHHHHEEEEECCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEE
FGRDNWLRPAQEVSDLMDLFYKTLKDKTPKLHDNNIVVTVVGDRSRLSNKLIGMIEYSES
ECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHEEEEEHHHH
LTKSNTGLKLRLAVDYAGRWDIVEATRAIAREVDIGKLSVDEIDQNSFAKYLVGGNMPVD
HHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHCCCCCCEE
LLIRTSGEVRLSDFMLWQLAYAEMYFTDIMWPDFSKQELTRAVEYFYSRQRRFGKSGEQI
EEEECCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TSAKENILRHLAIIMDGNGRWAKSRLKPRIFGHRNSVSSVDATIEYCVENNIEMLTLFA
CCHHHHHHHHEEEEECCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEE
FGRDNWLRPAQEVSDLMDLFYKTLKDKTPKLHDNNIVVTVVGDRSRLSNKLIGMIEYSES
ECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHEEEEEHHHH
LTKSNTGLKLRLAVDYAGRWDIVEATRAIAREVDIGKLSVDEIDQNSFAKYLVGGNMPVD
HHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHCCCCCCEE
LLIRTSGEVRLSDFMLWQLAYAEMYFTDIMWPDFSKQELTRAVEYFYSRQRRFGKSGEQI
EEEECCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA